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Impact of a nurse-led intervention on the capacity for self-care of the person with Chronic Obstructive Pulmonary Disease - Systematic Review of Literature 护士主导的干预对慢性阻塞性肺疾病患者自我护理能力的影响——文献系统综述
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1278
M. Pereira, Filipa Moreira, P. Machado, M. Padilha
Background: Exercise training is a major component of Respiratory Rehabilitation included in the non-pharmacological treatment of the person with COPD which has shown to reduce the number of exacerbations of the disease and to improve the quality of life (GOLD,2019). However, little is known about the impact of the nurse-led intervention on the capacity for self-care of the person with COPD. Methods: Systematic literature review based on Cochrane model. We used the PICOT method with the main starting question: what is the impact of a nurse-led intervention on the capacity for self-care of the person with COPD? Database search was conducted before February 4, 2019, in CINAHL; MEDLINE; EMBASE and Web of Science and SCOPUS. Four independent reviewers assessed methodologic quality and reviewed the studies. Results: We identified 24 articles and 14 thesis. After removing the duplicates (n=5) and reading 19 articles by title and abstract, 13 were excluded. Six articles were submitted a full text reading to assess the inclusion criteria. One article was included. Nurse-led intervention in respiratory rehabilitation enhance quality of life, activity of daily living performance and reduce fatigue. Conclusion: This systematic literature review shows the need to develop robust studies focused on assessing the impact of nurse-led interventions on the capacity for self-care of people with COPD in order to broaden the body of disciplinary nursing knowledge.
背景:运动训练是COPD患者非药物治疗中呼吸康复的主要组成部分,已被证明可以减少疾病恶化次数并改善生活质量(GOLD,2019)。然而,对护士主导的干预对慢性阻塞性肺病患者自我护理能力的影响知之甚少。方法:采用Cochrane模型进行系统文献综述。我们使用PICOT方法的主要问题是:护士主导的干预对慢性阻塞性肺病患者自我护理能力的影响是什么?数据库检索于2019年2月4日前在CINAHL进行;MEDLINE;EMBASE、Web of Science和SCOPUS。四名独立评审员评估了方法学质量并对研究进行了评审。结果:共检索到文献24篇,论文14篇。在去除重复(n=5)并按标题和摘要阅读19篇文章后,排除了13篇。提交了六篇文章的全文阅读,以评估纳入标准。其中包括一篇文章。以护士为主导的呼吸康复干预可提高生活质量、日常生活活动能力和减轻疲劳。结论:本系统的文献综述表明,需要开展强有力的研究,重点评估护士主导的干预措施对慢性阻塞性肺病患者自我护理能力的影响,以扩大学科护理知识体系。
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引用次数: 1
Care left undone in patients with chronic respiratory diseases admitted to medical wards: an observational study 住院慢性呼吸系统疾病患者未完成的护理:一项观察性研究
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1271
A. Bagnasco, G. Catania, M. Zanini, Silvia Rossi, N. Dasso, G. Aleo, Loredana Sasso
Background: Chronic respiratory diseases are among the most common causes of mortality and comorbidity in the world. In the medical wards there are often inpatients with complex conditions, who cannot be admitted to a specialized unit due to their complex clinical and nursing needs. Nurses in this context play an important role and are responsible for the surveillance and prevention of complications in these inpatients. Aims: To describe the frequency and patterns of care left undone in medical wards in Italy. Methodology: Data were extracted from the RN4CAST@IT study, a larger cross-sectional observational study conducted in 2015, involving nurses, through convenience sampling of 40 hospitals. For this analysis we considered nurses involved (n=2082) in medical wards or similar. We surveyed which activities, from a list of 13, were necessary but left undone because of lack of time during the last shift worked. Results: The most frequent care left undone activity was ‘oral hygiene’ (47.6%), ‘frequent mobilisation of bedridden patient’ (47.3%), ‘comforting and talking with patients’ (45.8%), ‘information and education’ (45.1%). Conclusion: Care left undone is an error of omission that has a negative impact on patient outcomes. Omitting basic care, such as ‘oral hygiene’, leads to an increase of the workload for nurses and negative clinical outcomes in frail patients admitted to medical wards, especially when patients are affected by chronic respiratory diseases.
背景:慢性呼吸系统疾病是世界上最常见的死亡和合并症原因之一。在医疗病房中,往往有病情复杂的住院病人,由于其复杂的临床和护理需要,他们无法入住专科病房。护士在这方面发挥着重要作用,负责监测和预防这些住院患者的并发症。目的:描述意大利医疗病房未完成护理的频率和模式。方法:数据来自RN4CAST@IT研究,该研究是2015年开展的一项更大的横断面观察性研究,涉及护士,通过40家医院的方便抽样。在本分析中,我们考虑了住院病房或类似病房的护士(n=2082)。我们从13项活动中调查了哪些是必要的,但由于在上一个班次工作中缺乏时间而没有完成的活动。结果:最常见的未完成护理活动是“口腔卫生”(47.6%)、“卧床病人的频繁动员”(47.3%)、“安慰和与病人交谈”(45.8%)、“信息和教育”(45.1%)。结论:未完成的护理是一种疏忽的错误,对患者的预后有负面影响。忽略基本护理,如"口腔卫生",会增加护士的工作量,对住院的体弱病人,特别是患有慢性呼吸系统疾病的病人,造成不利的临床结果。
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引用次数: 0
Innovation in Nursing education - ECare-COPD. Self-management promotion in people with COPD 护理教育的创新——护理慢性阻塞性肺病。促进COPD患者的自我管理
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1277
M. Padilha, A. I. Ribeiro, José Ramos, P. Machado
Background: ECare-COPD is a project that aims to improve the nurse’s skills for the promotion of self-management of the disease in people with COPD. We developed an e-learning training programme (sponsored by the European Union). This innovative e-learning programme integrates education modules on self-management, pulmonary rehabilitation, supported by video and a web clinical virtual simulator (CVS). Method: Participatory action research based on a cyclical process divided into five phases: diagnosis, action planning, implementation, assessment and identification of what was acquired. A systematic literature review and scientometric analysis were performed to identify the contents to be included in the programme. These programme contents and clinical scenarios for the CVS (n=8) were organized and developed with the collaboration of a group of nurses with respiratory expertise. We assessed the easiness, usefulness and intention of nurses and nursing students to use the programme. Results: The training programme was made available in three modules. The initial programme for nursing degree students was organized in 6 modules with 18 lessons; the intermediate programme for nurses was organized in 13 modules with 61 lessons; and the advanced programme for nursing specialists was organized in 19 modules with 82 lessons. The training programme was supported by more than 90 videos. The users showed easiness, usefulness and intention to use this programme in their nursing education. Conclusion: This training programme responds to the demand for the dematerialization of nursing education and the intention of nurses to use information and communication technologies in education and lifelong learning.
背景:care -COPD是一个旨在提高护士技能以促进COPD患者疾病自我管理的项目。我们开发了一个电子学习培训项目(由欧盟赞助)。这一创新的电子学习计划整合了自我管理、肺部康复的教育模块,由视频和网络临床虚拟模拟器(CVS)提供支持。方法:参与式行动研究基于一个循环过程,分为五个阶段:诊断、行动计划、实施、评估和确定所获得的成果。进行了系统的文献回顾和科学计量学分析,以确定将被纳入计划的内容。这些CVS的计划内容和临床场景(n=8)是由一组具有呼吸专业知识的护士合作组织和制定的。我们评估了护士和护生使用程序的容易程度、有用性和意向。结果:培训方案分为三个模块。护理学位学生的初始课程分为6个模块,共18节课;护士中级课程分为13个单元,共61节课;护理专家高级课程分为19个模块,共82节课。培训方案得到了90多部录像带的支持。使用者在护理教育中表现出使用简易、实用和意向。结论:该培训方案响应了护理教育非物质化的需求和护士在教育和终身学习中使用信息通信技术的意愿。
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引用次数: 1
Maternal consumption of tobacco and pregnancy 母亲吸烟与怀孕
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1264
Lidia Perera Lopez, R. Garcia-Tenorio, Teresa Lopez Ruiz, Auxiliadora Romero, Asunción Martín Hernández, Margarita Izquierdo Nazar, Joaquín Salamanca Blanco, Julio César Vargas Espinal, P. Lozano, Angela Gomez Del Aguila
Methods: We’ve reviewed the clinical and smoking histories of pregnant smokers. In this unit, they were applied the same assistance program:offering pharmacological treatment, nicotine replacement therapy (NRT), and psychological, which includes the development of cognitive-behavioral techniques designed specifically for this group of smokers in 9 consultations, over 6months of tracing. The characteristics of smoking in all subjects were analyzed. Results: 22 pregnant women. The average age was 34.27 yrs and they were approximately at week 17 gestation (mean value). Through an analog-visual scale they showed a high motivation to stop smoking (average 8.66 pts). Characteristics of smoking, smoked 17.18yrs(±5.21), the index of packets years was 19.86 and 64% of them smoked for negative reward. Average score in the Fagerstrom Test: 6.68±1.93; more than 80% of them lit the 1 cigarette of the day in the 1 half hour. Before becoming pregnant, they smoked an average of 23.13cig/day and after finding out that they were pregnant their consumption dropped to an average of 9.63cig/day; despite them the CO in expired air was 21.27 ppm (±9.25ppm) (See figure 1). Pharmacological treatment was received by 20 of them in the form of chewing gum and nicotine tablets. The abstinence rate at 6 mths was 27%, the same as the rate of failure (27%). The worrying fact is that 46% of them left in the 1 consultation Conclusions: It was high degree of physical dependence due to nicotine in the pregnant women who attended. Before pregnancy, they smoked an average of 23cig/day and after being pregnant they smoked an average of 10cig/day that is not related to the carbon monoxide figures. Abstinence rate27%. The 46% of them abandoned the treatment after the first consultation.
方法:回顾怀孕吸烟者的临床和吸烟史。在这个单元中,他们接受了相同的帮助计划:提供药理学治疗、尼古丁替代疗法(NRT)和心理治疗,其中包括专门为这组吸烟者设计的认知行为技术的发展,在6个月的追踪中进行了9次咨询。分析所有受试者的吸烟特征。结果:22名孕妇。平均年龄34.27岁,约为妊娠第17周(平均值)。通过模拟视觉量表,他们表现出很高的戒烟动机(平均8.66分)。吸烟特征:吸烟17.18年(±5.21),包年指数为19.86,负奖励吸烟占64%。Fagerstrom测验平均分:6.68±1.93;超过80%的人在半小时内点燃了一天中的一支烟。怀孕前平均吸烟量为23.13 g/d,怀孕后平均吸烟量降至9.63 g/d;尽管如此,过期空气中的CO含量为21.27 ppm(±9.25ppm)(见图1)。其中20人接受了口香糖和尼古丁片的药物治疗。6个月时的戒断率为27%,与失败率(27%)相同。令人担忧的事实是,在1次咨询中,有46%的人离开了。结论:参加咨询的孕妇由于尼古丁存在高度的身体依赖。怀孕前,她们平均每天吸烟23支,怀孕后,她们平均每天吸烟10支,这与一氧化碳的数据无关。禁欲rate27%。其中46%的人在第一次咨询后放弃了治疗。
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引用次数: 0
Low maximum inspiratory flow index in patients with inhaler therapy 吸入器治疗患者的最大吸气流量指数低
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1266
W. I. G. Matute, Margarita Hernandez Yañez, Rosa Maria Rojas Moreno-Tomé, María Gallardo Bermejo, M. Rubio, L. P. Maestú
Introduction and Objective: Low peak inspiratory flow rate (PIFR) can cause suboptimal inhaler usage, leading to ineffective bronchodilation.1 This study aim was to determine the frequency of PIFR with a manual inspiratory flow meter in patients using inhaler devices. Methods: A descriptive, cross-sectional study including adult patients assisting lung function laboratory on their routine follow-up of their chronic respiratory disease using inhaled medication. In-Check DIAL G16® device was used to simulate the resistance of the inhaler and determine the patient’s PIFR. Results: Total number was 155 patients, mean age of 63±15.2 years, 58.1% women. 64 (41.3%) patients used inhalers with an optimal PIFR greater than 60 L/ minute. The specific values of each one are observed in table 1, finding statistically significant differences by both group comparisons (p Conclusions: Low PIFR was frequently determined in patients using various inhalers devices, and consequently, not reaching its optimal value for adequate treatment. 1Kawamatawong T., et. al. Peak inspiratory flow rate measurements by using In-Check Dial for the different inhaler devices in elderly with obstructive airway diseases. Journal of Asthma and Allergy 2017: 10; 17-21.
简介与目的:低峰值吸气流量(PIFR)可导致吸入器使用不理想,导致支气管扩张无效本研究的目的是在使用吸入器装置的患者中,用手动吸气流量计确定PIFR的频率。方法:一项描述性横断面研究,包括成年患者协助肺功能实验室使用吸入药物对其慢性呼吸系统疾病进行常规随访。使用In-Check DIAL G16®装置模拟吸入器的阻力并确定患者的PIFR。结果:患者总数155例,平均年龄63±15.2岁,女性占58.1%。64例(41.3%)患者使用最佳PIFR大于60 L/分钟的吸入器。表1中观察了每一项的具体值,发现两组比较具有统计学意义(p)。结论:使用各种吸入器装置的患者经常检测到低PIFR,因此,没有达到适当治疗的最佳值。1Kawamatawong,等。使用in - check Dial测量不同吸入器对老年阻塞性气道疾病患者的峰值吸入流量。哮喘与过敏杂志2017:10;17-21。
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引用次数: 0
The National Asthma and COPD Audit Programme in East Kent Hospitals University NHS Foundation Trust – The first year 国家哮喘和慢性阻塞性肺病审计计划在东肯特医院大学NHS基金会信托-第一年
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1262
Samantha Halliwell, Heidi Groombridge, A. Scott
Background: –The National Asthma and COPD Audit Programme (NACAP) aims to drive improvements in the quality of care and services provided forRespiratory patients in England and Wales (RCP / BTS 2017) –Part of this programme is the continuous audit of admission to hospital for those patients with COPD –This commenced in April 2017 and currently is scheduled to continue until March 2019 –Best Practice Tariff (BPT) was introduced to improve the proportion of patients who receive specialist respiratory input to their care within 24 hours of admission and completion of a COPD discharge bundle. Aims: –Primary aim was to deliver on the COPD BPT –Secondary aim was to improve the inpatient experience and deliver evidence based care –This would be evidenced by length of stay, readmission rates and inpatient mortality rates Methods: Recruited Associate Practitioners, Registered Nurse and Physiotherapist to into Specialist Practioner Roles. Results: Development of an Inpatient Respiratory Practitioner Team has enabled the Trust to achieve the required 60% for BPT by quarter 3 (Oct-Dec 2017) and thus qualification for the enhanced tariff
背景:-国家哮喘和慢性阻塞性肺病审计计划(NACAP)旨在提高英格兰和威尔士呼吸系统患者的护理和服务质量(RCP / BTS 2017) -该计划的一部分是对慢性阻塞性肺病患者入院的持续审计-该计划于2017年4月开始,目前计划持续到2019年3月-引入最佳实践收费(BPT)以提高接受专科呼吸系统输入的患者比例入院24小时内的护理和完成COPD出院包。目的:-主要目的是提供COPD BPT -次要目的是改善住院患者体验并提供基于证据的护理-这将通过住院时间,再入院率和住院患者死亡率来证明方法:招募副执业医师,注册护士和物理治疗师成为专科执业医师角色。结果:住院呼吸医生团队的发展使信托基金在第三季度(2017年10月至12月)达到了60%的BPT要求,从而获得了提高关税的资格
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引用次数: 0
Barriers and facilitators at attending mindfulness-based intervention programs of people with COPD. A systematic qualitative review COPD患者参加正念干预项目的障碍和促进因素。系统的定性评价
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1265
M. Clari, Roberto Fontanella, D. Ivziku, V. Dimonte, M. Matarese
Introduction: A growing number of qualitative and quantitative studies have been conducted applying mindfulness-based interventions (MBIs) to treat psychological and physical manifestations in people with Chronic Obstructive Pulmonary Disease (COPD). Evidence on their effectiveness is still conflicting. Understanding the experiences of people affected by COPD attending the MBI program could help to design interventions suitable to these population and improve their effectiveness. Aim: A qualitative systematic review was conducted aimed at exploring the barriers and facilitators at the participation of MBI programs from the perspective of people with COPD. Methods: Systematic research on relevant databases was conducted including COPD individuals at any disease stage and any MBI program. Qualitative study designs were included. A meta-aggregative approach was used following the Joanna Briggs Institute approach. Results: Three qualitative and two mixed methods studies were identified and included. The participation at mindfulness-based programs was hampered by psychological barriers, such as disbelief and lack of trust, and practical barriers, such as difficulties in attending the classes. Also, cultural barriers hinder trusting the programs Having shorter sessions, distance session via skype and compassionate coaches could promote the retention and the adherence at the mindfulness practice. The absence of group physical presence could deter individuals to continuing the programs. Conclusion: Specific MBI programs considering COPD patients’ preferences should be tested to optimise the retention and adherence and to maximise their effectiveness.
越来越多的定性和定量研究已经应用正念干预(mbi)来治疗慢性阻塞性肺疾病(COPD)患者的心理和身体表现。关于其有效性的证据仍然相互矛盾。了解COPD患者参加MBI项目的经历可以帮助设计适合这些人群的干预措施并提高其有效性。目的:进行一项定性系统评价,旨在从COPD患者的角度探讨参与MBI计划的障碍和促进因素。方法:对COPD患者各疾病阶段、各MBI方案的相关数据库进行系统研究。包括定性研究设计。根据乔安娜·布里格斯研究所的方法,采用了元聚合方法。结果:确定并纳入了三个定性研究和两个混合方法研究。参与以正念为基础的课程受到心理障碍的阻碍,例如不信任和缺乏信任,以及实际障碍,例如上课困难。此外,文化障碍也阻碍了对项目的信任。较短的课程、通过skype进行的远程课程和富有同情心的教练可以促进正念练习的保留和坚持。缺乏集体的实际存在可能会阻止个人继续这些计划。结论:考虑到COPD患者的偏好,应该测试特定的MBI方案,以优化保留和依从性,并最大化其有效性。
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引用次数: 0
The success of obtaining the induced sputum of patients with COPD 慢性阻塞性肺病患者诱导痰的成功提取
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1270
Valentina Fiket, A. Savovic
Background: Does type of inhalation and stages of COPD influence on quality of cells in induced sputum. Aims and Objectives: Determination of the performance of induced sputum by the amount and quality of cells in patients at COPD gold stages and in healthy populations. Methods: The study was conducted from Mar 2014 to Jun 2016. In the study participated 210 patients. The population of patients suffering from all four stages of COPD and a healthy population was included. Criteria were: population older than 40 years, FEV1 above 0.8 l, absence of other comorbidities. We collected sputum by induction using an inhaler with 0.9% NaCl solution, 3%, 4% and 5% hypertonic solution. Each inhalation lasted 7 minutes, and the patient was coughing between and after each inhalation. Results: 1) Distribution of patients by categories; GOLD 1 (27%), GOLD 2 (27%), GOLD 3 (22%), GOLD 4 (4%) and control group (20%) (N=146). 2) 80% of respondents managed to give an adequate sputum sample (N=146). 3) Distribution of patients by categories that managed to give an adequate sputum sample; GOLD 1 (67%), GOLD 2 (80%), GOLD 3 (97%), GOLD 4 (83%) and control group (79%) (N=146). Conclusion: Based on the results, there were no major differences in the percentage of patients who managed to give an adequate sputum sample. Only a small number of patients in the GOLD 1 category could successfully provide an adequate sputum pattern.
背景:慢性阻塞性肺病的吸入类型和分期对诱导痰细胞的质量有影响吗?目的和目的:通过COPD黄金期患者和健康人群中细胞的数量和质量来确定诱导痰的性能。方法:研究时间为2014年3月至2016年6月。该研究共有210名患者参与。包括患有所有四个阶段COPD的患者和健康人群。标准为:年龄大于40岁,FEV1大于0.8 l,无其他合并症。我们用吸入器吸入0.9% NaCl溶液、3%、4%和5%高渗溶液的痰液。每次吸入持续7分钟,患者在每次吸入之间和之后咳嗽。结果:1)患者的分类分布;GOLD 1组(27%)、GOLD 2组(27%)、GOLD 3组(22%)、GOLD 4组(4%)和对照组(20%)(N=146)。2) 80%的应答者能够提供足够的痰样(N=146)。3)能够提供足够痰样本的患者按类别分布;GOLD 1组(67%)、GOLD 2组(80%)、GOLD 3组(97%)、GOLD 4组(83%)和对照组(79%)(N=146)。结论:根据结果,在设法提供足够痰样本的患者百分比方面没有重大差异。只有一小部分GOLD 1类患者能够成功地提供足够的痰样。
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引用次数: 0
Uncontrolled asthma on GINA step 4-5 treatment increases healthcare utilization – report from the population-based OLIN-studies GINA第4-5步治疗中不受控制的哮喘增加了医疗保健利用率——基于人群的olin研究报告
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1263
C. Stridsman, H. Backman, L. Hedman, E. Rönmark
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引用次数: 0
Problems of Importance in Severe Asthma: A Patient Perspective 严重哮喘的重要问题:病人的观点
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa271
V. McDonald, Vanessa L. Clark, Olivia J Mcdonald, P. Gibson
Background: Despite major advances in severe asthma management, patients continue to suffer an excessive symptom burden and impaired quality of life (QoL). We sought to determine the most important problems related to severe asthma from the patients’ perspective. Methods: People (n=140) with severe refractory asthma were recruited to a cross sectional study and underwent a multidimensional assessment of their disease. As part of the assessment participants were asked “What is/are the biggest problem/s you experience as a result of your breathing problem?”. Results: Participants were predominately female (62.1%), with a mean (SD) age of 55.7 (14.7) years. They had experienced 3.1 (3.2) exacerbations in the past year, and had a mean asthma control questionnaire score (ACQ-5) of 2.0 (1.1). Patients most frequently offered dyspnoea (39.0%), limited activity (17.1%), and cough (10.3%) as their primary problem of importance. These symptoms were often presented as a cluster. At least one symptom from this cluster was reported in 51.4% of participants, 29.3% reported two and 2.9% reported all three symptoms. The self-identification of two or more of these symptoms compared to one or no symptoms, was associated with significant impairment in asthma control, ACQ-5 2.3 (1.2) vs 1.9 (1.1) p=0.04; increased depression score 6.0 (3.9) vs 4.3 (3.3) p=0.01; worse asthma QoL, AQLQ 4.4 (1.3) vs 5.1 (1.1) p=0.02, and more comorbidities, 6.7 (2.5) vs 5.6 (2.7) p=0.02. Conclusion: Dyspnoea, limited activity and cough were problems of most importance to patients with severe asthma. Few interventions have been tested in severe asthma that specifically target these symptoms, suggesting a need to develop new targeted approaches.
背景:尽管重症哮喘管理取得了重大进展,但患者仍然承受着过重的症状负担和生活质量(QoL)的下降。我们试图从患者的角度确定与严重哮喘相关的最重要的问题。方法:招募严重难治性哮喘患者(n=140)进行横断面研究,并对其疾病进行多维评估。作为评估的一部分,参与者被问及“由于呼吸问题,你遇到的最大问题是什么?”结果:参与者以女性为主(62.1%),平均(SD)年龄为55.7(14.7)岁。他们在过去一年中经历了3.1次(3.2次)恶化,平均哮喘控制问卷得分(ACQ-5)为2.0(1.1)。患者最常见的问题是呼吸困难(39.0%)、活动受限(17.1%)和咳嗽(10.3%)。这些症状通常以群集的形式出现。51.4%的参与者报告了至少一种症状,29.3%报告了两种症状,2.9%报告了所有三种症状。与一种或无症状相比,两种或多种上述症状的自我识别与哮喘控制的显著损害相关,ACQ-5 2.3 (1.2) vs 1.9 (1.1) p=0.04;抑郁评分增加6.0 (3.9)vs 4.3 (3.3) p=0.01;更差的哮喘生活质量,AQLQ 4.4 (1.3) vs 5.1 (1.1) p=0.02,更多的合并症,6.7 (2.5)vs 5.6 (2.7) p=0.02。结论:呼吸困难、活动受限和咳嗽是重症哮喘患者最重要的问题。很少有针对这些症状的干预措施在严重哮喘中得到测试,这表明需要开发新的靶向方法。
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引用次数: 1
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