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Modulation of phagocytosis. 吞噬作用的调节。
Texas reports on biology and medicine
Pub Date : 1981-01-01
K Huang

In conclusion, the earlier reports on the phagocytosis-enhancing effect of interferon have now been widely confirmed. Interferon not only activates non-Fc-receptor-mediated phagocytosis such as colloidal carbon or latex beads, but also stimulates Fc-receptor-mediated ingestion of IgG-coated erythrocytes. However, it should be cautioned that all inducers of interferon do not depend on the interferon they stimulate to activate macrophages. The notion that interferon may be a very nonspecific yet crucial factor in the basic defense mechanisms of the body has been further reinforced.

总之，早期关于干扰素增强吞噬作用的报道现已得到广泛证实。干扰素不仅激活非fc受体介导的吞噬作用，如胶体碳或乳胶珠，而且还刺激fc受体介导的igg包被红细胞的摄入。然而，需要注意的是，并非所有干扰素诱导剂都依赖于它们所刺激的干扰素来激活巨噬细胞。干扰素可能是人体基本防御机制中一个非常非特异性但至关重要的因素，这一观点得到了进一步的加强。
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引用次数: 0
Effect of interferon on antibody formation. 干扰素对抗体形成的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
H M Johnson

Virus induced IFN (IFN alpha or beta) suppresses the antibody response in both mouse and human. The suppression may be related to IFN effect on intermediary metabolism (inhibition of hexose monophosphate shunt) which could result in activation of protein kinase activities. Immune IFN (IFN gamma) also suppresses the antibody response with purified IFN gamma more effective than crude, suggesting that crude IFN gamma preparations contain an antagonist. The cellular interactions that regulate IFN gamma production are similar to those for antibody production with helper and suppressor cell activities. T-cell growth factor or interleukin 2 will mediate helper cell requirements and appears to be an absolute requirement for IFN gamma production.

病毒诱导的干扰素(干扰素α或β)抑制小鼠和人的抗体反应。这种抑制可能与IFN对中间代谢(抑制单磷酸己糖分流)的影响有关，这可能导致蛋白激酶活性的激活。免疫干扰素(IFN γ)也抑制抗体反应，纯化的IFN γ比粗品更有效，这表明粗品IFN γ制剂含有拮抗剂。调节IFN γ产生的细胞相互作用类似于具有辅助和抑制细胞活性的抗体产生。t细胞生长因子或白细胞介素2将介导辅助细胞的需求，似乎是IFN γ产生的绝对需要。
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引用次数: 0
Molecular mechanisms of interferon action: interferon-mediated phosphorylation of ribosome-associated protein P1 and protein synthesis initiation factor eIF-2. 干扰素作用的分子机制:干扰素介导的核糖体相关蛋白P1和蛋白合成起始因子eIF-2的磷酸化。
Texas reports on biology and medicine
Pub Date : 1981-01-01
C E Samuel
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引用次数: 0
Clinical trials with interferon in Japan. 干扰素在日本的临床试验。
Texas reports on biology and medicine
Pub Date : 1981-01-01
J Imanishi, T Kishida
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引用次数: 0
Effects of interferons on cell membranes. 干扰素对细胞膜的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
R M Friedman
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引用次数: 0
The effect of interferon in herpes simplex infections in man. 干扰素对人类单纯疱疹感染的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
J A Armstrong
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引用次数: 0
Interferon and natural killer (NK) cells. 干扰素和自然杀伤(NK)细胞。
Texas reports on biology and medicine
Pub Date : 1981-01-01
R B Herberman, J R Ortaldo, T Timonen, C W Reynolds, J Y Djeu, S Pestka, J Stanton
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引用次数: 0
Interferons and lymphocyte-mediated cytotoxicity. 干扰素和淋巴细胞介导的细胞毒性。
Texas reports on biology and medicine
Pub Date : 1981-01-01
G Trinchieri, B Perussia
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引用次数: 0
Characteristics of HuIFN-gamma and HuIFN-beta induced by mitogenic stimulation of human leukocytes. 人白细胞有丝分裂刺激诱导huifn - γ和huifn - β的特性。
Texas reports on biology and medicine
Pub Date : 1981-01-01
A Billiau, J Van Damme, M De Ley, P De Somer
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引用次数: 0
Pharmacokinetics of interferons. A reappraisal. 干扰素的药代动力学。重新评价。
Texas reports on biology and medicine
Pub Date : 1981-01-01
V Bocci
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引用次数: 0
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