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Role of membrane receptors in the biological effects of interferon. 膜受体在干扰素生物学效应中的作用。
Texas reports on biology and medicine
Pub Date : 1981-01-01
C Chany, S Rousset, F Chany-Fournier

The model of IFN receptor system which we initially proposed in 1973 is now better documented. The receptor system seems to consist of an IFN species specific glycoprotein, which could be the high affinity receptor (30) to which IFN has to bind in order to act. The glycoprotein is thus the activator site. Furthermore, IFN can bind to gangliosides in a non-specific manner. Cooperation between these membrane elements requires the free mobility of the membrane constituents in the plane of the membrane and the integrity of the cytoskeleton. Decay of these constituents during some virus-induced or malignant transformation processes could result in a defect in the synthesis of one of these constituents, causing in parallel a loss of IFN sensitivity. Sodium butyrate, which restores the cytoskeleton, enhances simultaneously the response to IFN. The modulatory effect of IFN on the cell membrane is thus a major step in the regulatory action of IFN on the different phenotypic expressions of the cell. This property of IFN could be one of its principal physiological roles.

我们最初在1973年提出的IFN受体系统模型现在有了更好的记录。受体系统似乎由IFN物种特异性的糖蛋白组成，它可能是IFN必须结合才能起作用的高亲和力受体(30)。因此糖蛋白是激活位点。此外，IFN可以以非特异性的方式与神经节苷脂结合。这些膜元素之间的合作需要膜成分在膜平面上的自由移动和细胞骨架的完整性。在一些病毒诱导的或恶性转化过程中，这些成分的衰变可能导致其中一种成分的合成缺陷，同时导致干扰素敏感性的丧失。丁酸钠可以恢复细胞骨架，同时增强对IFN的反应。因此，IFN对细胞膜的调节作用是IFN调控细胞不同表型表达的重要步骤。IFN的这一特性可能是其主要生理作用之一。
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引用次数: 0
Interferon inhibition of cellular differentiation. 干扰素抑制细胞分化。
Texas reports on biology and medicine
Pub Date : 1981-01-01
S E Grossberg, J L Sabran
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引用次数: 0
Modulation of phagocytosis. 吞噬作用的调节。
Texas reports on biology and medicine
Pub Date : 1981-01-01
K Huang

In conclusion, the earlier reports on the phagocytosis-enhancing effect of interferon have now been widely confirmed. Interferon not only activates non-Fc-receptor-mediated phagocytosis such as colloidal carbon or latex beads, but also stimulates Fc-receptor-mediated ingestion of IgG-coated erythrocytes. However, it should be cautioned that all inducers of interferon do not depend on the interferon they stimulate to activate macrophages. The notion that interferon may be a very nonspecific yet crucial factor in the basic defense mechanisms of the body has been further reinforced.

总之，早期关于干扰素增强吞噬作用的报道现已得到广泛证实。干扰素不仅激活非fc受体介导的吞噬作用，如胶体碳或乳胶珠，而且还刺激fc受体介导的igg包被红细胞的摄入。然而，需要注意的是，并非所有干扰素诱导剂都依赖于它们所刺激的干扰素来激活巨噬细胞。干扰素可能是人体基本防御机制中一个非常非特异性但至关重要的因素，这一观点得到了进一步的加强。
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引用次数: 0
Characteristics of HuIFN-gamma and HuIFN-beta induced by mitogenic stimulation of human leukocytes. 人白细胞有丝分裂刺激诱导huifn - γ和huifn - β的特性。
Texas reports on biology and medicine
Pub Date : 1981-01-01
A Billiau, J Van Damme, M De Ley, P De Somer
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引用次数: 0
Effects of interferons on cell membranes. 干扰素对细胞膜的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
R M Friedman
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引用次数: 0
Pharmacokinetics of interferons. A reappraisal. 干扰素的药代动力学。重新评价。
Texas reports on biology and medicine
Pub Date : 1981-01-01
V Bocci
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引用次数: 0
Mechanisms of interferon induction by viruses. 病毒诱导干扰素的机制。
Texas reports on biology and medicine
Pub Date : 1981-01-01
D C Burke
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引用次数: 0
The effect of interferon in herpes simplex infections in man. 干扰素对人类单纯疱疹感染的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
J A Armstrong
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引用次数: 0
Interferon and natural killer (NK) cells. 干扰素和自然杀伤(NK)细胞。
Texas reports on biology and medicine
Pub Date : 1981-01-01
R B Herberman, J R Ortaldo, T Timonen, C W Reynolds, J Y Djeu, S Pestka, J Stanton
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引用次数: 0
Interferons and lymphocyte-mediated cytotoxicity. 干扰素和淋巴细胞介导的细胞毒性。
Texas reports on biology and medicine
Pub Date : 1981-01-01
G Trinchieri, B Perussia
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引用次数: 0
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