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Interferon, an antiviral drug for use in man. 干扰素，一种用于人体的抗病毒药物。
Texas reports on biology and medicine
Pub Date : 1981-01-01
M Myers, G Galasso
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引用次数: 0
2',5'-oligoadenylate synthetase in interferon-treated chick cells. 干扰素处理的鸡细胞中的2'，5'-寡聚腺苷酸合成酶。
Texas reports on biology and medicine
Pub Date : 1981-01-01
L A Ball, D K West

Chick embryo cells respond to interferon by producing very high levels of 2-5A synthetase. From inhibitor studies, it appears that the response involves the controlled derepression of an interferon-inducible gene. Continuous interaction of the cells with interferon seems to be necessary to maintain maximal enzyme induction. Partial purification of the synthetase indicates that it is probably composed of a single polypeptide of 56,000 MW. Upon activation by binding to dsRNA, this polypeptide catalyzes a nucleotidyl transferase reaction in which 5'-AMP residues are transferred from ATP to the 2' position of appropriate acceptors. A number of naturally occurring small molecules (in addition to 2-5A itself) that can function as adenylate acceptors have been identified, but the physiological significance of these adenylylation reactions remain to be established.

鸡胚细胞对干扰素的反应是产生非常高水平的2-5A合成酶。从抑制剂的研究来看，这种反应似乎涉及到干扰素诱导基因的抑制。细胞与干扰素的持续相互作用似乎是维持最大酶诱导所必需的。该合成酶的部分纯化表明，它可能由56,000 MW的单个多肽组成。在与dsRNA结合激活后，该多肽催化核苷酸转移酶反应，其中5'-AMP残基从ATP转移到适当受体的2'位置。许多天然存在的小分子(除了2-5A本身)可以作为腺苷酸受体，但这些腺苷化反应的生理意义仍有待确定。
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引用次数: 0
Modulation of interferons inhibitory effect on cell growth by the mitogenic stimulus. 有丝分裂刺激对干扰素抑制细胞生长作用的调节。
Texas reports on biology and medicine
Pub Date : 1981-01-01
J Taylor-Papadimitriou, E Rozengurt
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引用次数: 0
Prospects in interferon research. 干扰素研究展望。
Texas reports on biology and medicine
Pub Date : 1981-01-01
M Krim
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引用次数: 0
Antigenic properties of interferons. 干扰素的抗原特性。
Texas reports on biology and medicine
Pub Date : 1981-01-01
C A Ogburn, B J Dalton
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引用次数: 0
Problems in standardization: an Interferon Standards Committee report. 标准化中的问题:干扰素标准委员会报告。
Texas reports on biology and medicine
Pub Date : 1981-01-01
S E Grossberg, G J Galasso
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引用次数: 0
Effect of interferon on cell-mediated immunity. 干扰素对细胞免疫的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
E De Maeyer, J De Maeyer-Guignard
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引用次数: 0
Trials of interferon in respiratory infections in man. 干扰素治疗人类呼吸道感染的试验。
Texas reports on biology and medicine
Pub Date : 1981-01-01
S B Greenberg, M W Harmon, D A Tyrrell, G M Scott

It is not yet clear from these recent volunteer studies (8) and from the results of Merigan et al. (14) what the optimal method and schedule for administering HuIFN should be. Taken together, the results with relatively low doses of interferon (1 to 4 X 10(6) units) plus antihistamine pretreatment, and with multiple doses of HuIFN alpha (total 14 X 10(6) units) indicate the need for better methods of delivery. However, it is of interest that protection was achieved by extremely small amounts of HuIFN alpha protein - Merigan (14) used only about 160 mcg. We anticipate that with better supplies of interferon from HuIFN genes cloned in bacteria, we may seek more efficient means of delivery and obtain better protection of volunteers against respiratory virus infections.

从这些最近的志愿者研究(8)和Merigan等人(14)的结果来看，尚不清楚施用HuIFN的最佳方法和时间表应该是什么。综上所述，相对低剂量的干扰素(1 ~ 4 × 10(6)单位)加抗组胺预处理，以及多剂量的HuIFN α(总计14 × 10(6)单位)的结果表明，需要更好的给药方法。然而，有趣的是，保护作用是通过极少量的HuIFN α蛋白实现的——Merigan(14)只使用了大约160微克。我们预计，随着从细菌中克隆的HuIFN基因中获得干扰素的更好供应，我们可能会寻求更有效的递送手段，并更好地保护志愿者免受呼吸道病毒感染。
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引用次数: 0
Local application of interferon to malignant brain tumors. 干扰素在恶性脑肿瘤中的局部应用。
Texas reports on biology and medicine
Pub Date : 1981-01-01
M Nagai, T Arai, S Kohno, M Kohase
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引用次数: 0
Inhibitor(s) of virus replication (IVR) and localization of viruses in plants. 病毒复制抑制剂（IVR）和病毒在植物中的定位。
Texas reports on biology and medicine
Pub Date : 1981-01-01
G Loebenstein, A Gera

A substance(s) inhibiting virus replication (IVR) is released into the medium from tobacco mosaic virus-infected protoplasts of a cultivar in which the infection in the intact plant is localized. IVR inhibited virus replication in protoplasts from both resistant (Samsun NN) and susceptible (Samsun) plants, when applied up to 18 h after inoculation. It was not produced in protoplasts from susceptible plants or from noninoculated protoplasts of the resistant cultivar. IVR was partially purified using ZnAc2 precipitation, and yielded two biologically active principles with molecular weights of about 26,000 and 56,000 daltons. Preliminary results indicate that IVR inhibits replication of TMV and several other non-related viruses when applied to inoculated leaf disks.

一种抑制病毒复制的物质（IVR）从烟草花叶病毒感染的栽培品种原生质体中释放到培养基中，该栽培品种的原生质体在完整植株中的感染是局部的。在接种后 18 小时内，IVR 可抑制抗性植株（Samsun NN）和易感植株（Samsun）原生质体中病毒的复制。易感植株的原生质体或抗性栽培品种未接种的原生质体中不会产生 IVR。利用 ZnAc2 沉淀法对 IVR 进行了部分纯化，得到了分子量约为 26,000 和 56,000 道尔顿的两种生物活性物质。初步结果表明，将 IVR 应用于接种的叶盘时，可抑制 TMV 和其他几种非相关病毒的复制。
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引用次数: 0
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