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Interferon assays: some new problems and possibilities. 干扰素检测:一些新问题和新可能性。
Texas reports on biology and medicine
Pub Date : 1981-01-01
M D Johnston, N B Finter
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引用次数: 0
Interferons: chemical properties. 干扰素:化学性质。
Texas reports on biology and medicine
Pub Date : 1981-01-01
K H Fantes

HuIFN-alpha has been found to consist of a family of 8-10 components. Their amino acid (165 and 166 residues) and nucleotide sequences are similar and also reveal some relationship to that of HuIFN-beta and even to those of murine alpha- and beta-interferons. It is thus likely that all mammalian interferons have originated from a common ancestral gene. Human beta- and some alpha-interferons have been obtained by genetic engineering in E.coli. All interferons seem to contain a relatively high proportion of hydrophobic amino acids and some of the components are glycosylated. The N-terminal residue of all HuIFN-alpha members is probably cysteine, that of the major HuIFN-beta peptide methionine and that of MuIFN-alpha and-beta probably alanine and isoleucine. Very little is known about the chemistry of any of the gamma-interferon species.

已经发现huifn - α由8-10个成分组成。它们的氨基酸(165和166个残基)和核苷酸序列相似，并且与huifn - β甚至小鼠α和β干扰素有一定的关系。因此，很可能所有的哺乳动物干扰素都起源于一个共同的祖先基因。人类干扰素和一些干扰素已经通过基因工程在大肠杆菌中获得。所有干扰素似乎都含有相对较高比例的疏水氨基酸，其中一些成分被糖基化。所有huifn - α成员的n端残基可能是半胱氨酸，主要的huifn - β肽的残基可能是蛋氨酸，muifn - α和- β的残基可能是丙氨酸和异亮氨酸。人们对γ -干扰素的化学性质知之甚少。
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引用次数: 0
Regulation of the human interferon system. 人类干扰素系统的调节。
Texas reports on biology and medicine
Pub Date : 1981-01-01
Y H Tan, F H Ruddle, D Slate
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引用次数: 0
The producer cell of interferon in murine lymphocyte cultures. 小鼠淋巴细胞中干扰素的产生细胞。
Texas reports on biology and medicine
Pub Date : 1981-01-01
H Kirchner, F Marcucci, P H Krammer, S Landolfo, R Zawatzky, M M Simon
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引用次数: 0
Antiviral and anticellular effects of interferon. 干扰素的抗病毒和抗细胞作用。
Texas reports on biology and medicine
Pub Date : 1981-01-01
H Dahl
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引用次数: 0
Effect of interferon on retrovirus replication. 干扰素对逆转录病毒复制的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
P M Pitha, J A Bilello, C H Riggin

Interferon block of retrovirus replication can be explained as a consequence of interferon induced changes in physiology (e.g. fluidity) of cellular plasma membranes. Thus, both the membrane associated virus uptake and assembly of progency virus are altered in interferon treated cells (Fig. 1). The relative unsensitivity of retroviral mRNA to the enzymatic systems alternating efficiency of viral mRNA translation in interferon treated cells may be only a relative phenomenon, since the inhibition of viral protein synthesis is observed under conditions of limited viral expression.

干扰素阻断逆转录病毒复制可以解释为干扰素诱导的细胞膜生理变化(如流动性)的结果。因此，在干扰素处理的细胞中，膜相关病毒的摄取和源病毒的组装都发生了改变(图1)。在干扰素处理的细胞中，逆转录病毒mRNA对酶系统的相对不敏感，病毒mRNA翻译的交替效率可能只是一种相对现象，因为在病毒表达有限的条件下观察到病毒蛋白合成的抑制。
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引用次数: 0
Structure-activity relationships for interferon induction and inhibition of protein synthesis by polynucleotides. 干扰素诱导和多核苷酸抑制蛋白合成的构效关系。
Texas reports on biology and medicine
Pub Date : 1981-01-01
E De Clercq, P F Torrence
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引用次数: 0
Induction of the interferon protein in vivo: viral inducers. 体内干扰素蛋白的诱导:病毒诱导剂。
Texas reports on biology and medicine
Pub Date : 1981-01-01
P Jameson
{"title":"Induction of the interferon protein in vivo: viral inducers.","authors":"P Jameson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"135-43"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17248750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioisotopes labeling of interferons. 干扰素的放射性同位素标记。
Texas reports on biology and medicine
Pub Date : 1981-01-01
E Knight
{"title":"Radioisotopes labeling of interferons.","authors":"E Knight","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"209-12"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17248756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of anti-interferon antibody on infections of animals. 抗干扰素抗体对动物感染的影响。
Texas reports on biology and medicine
Pub Date : 1981-01-01
B Fauconnier
{"title":"Effect of anti-interferon antibody on infections of animals.","authors":"B Fauconnier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"522-5"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17253607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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