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Influence of Comorbidities on the Length of Stay of Covid-19 Patients in Kenyatta National Hospital – Infectious Disease Unit (KNH–IDU), Nairobi County, Kenya 合并症对肯尼亚内罗毕县肯雅塔国立医院传染病科(KNH-IDU)Covid-19 患者住院时间的影响
Pub Date : 2024-07-12 DOI: 10.47672/ajhmn.2199
Dr. Vivian Manyeki, Sr. Dr. Margaret Nyongesa, Dorcas Maina
Purpose: To determine the influence of comorbidities on the LOS of COVID-19 patients in KNH-IDU between 1st June 2020 and 30th November 2020 Materials and Methods: This retrospective cohort study comprised of 558 COVID-19 patients of which 69% survived and 31% died. The overall median LOS was 7.5 days (IQR: 0-183) – 8 days (IQR: 1-171) for the survivors, and 6 days (IQR: 0-183) for the non survivors. Data was extracted from hospital records using a questionnaire and analyzed with STATA version 15. Chi-square tests determined associations, while regression analysis examined LOS determinants based on model coefficients and significance. Findings: Significant differences were seen in age (p<0.01), with more survivors aged 20-40 years and non-survivors aged over 40 years. Non-survivors had higher referral rates (p<.001), ICU admissions (p<.001), and intubation needs (p<.001). Diabetes and hypertension were more common in non-survivors (p<.001). Non-survivors also had higher WBC counts (p<.001), higher neutrophil counts (p<.01), lower lymphocyte counts (p<.001), and lower platelet counts (p<.001). Implications to Theory, Practices and Policy: Practically, the findings underscore the need for targeted clinical management strategies, particularly for younger patients and those with severe disease, to optimize LOS and improve survival rates.
目的:确定 2020 年 6 月 1 日至 2020 年 11 月 30 日期间合并症对 KNH-IDU COVID-19 患者 LOS 的影响:这项回顾性队列研究包括 558 名 COVID-19 患者,其中 69% 存活,31% 死亡。存活患者的总住院时间中位数为 7.5 天(IQR:0-183)--8 天(IQR:1-171),非存活患者的总住院时间中位数为 6 天(IQR:0-183)。数据通过调查问卷从医院记录中提取,并使用 STATA 15 版进行分析。卡方检验确定了相关性,而回归分析则根据模型系数和显著性检验了 LOS 的决定因素。研究结果年龄差异显著(p<0.01),幸存者多为 20-40 岁,非幸存者多为 40 岁以上。非幸存者的转诊率(p<.001)、重症监护室入院率(p<.001)和插管需求(p<.001)均较高。糖尿病和高血压在非幸存者中更为常见(p<.001)。非幸存者的白细胞计数更高(p<.001),中性粒细胞计数更高(p<.01),淋巴细胞计数更低(p<.001),血小板计数更低(p<.001)。对理论、实践和政策的影响:在实践中,研究结果强调了有针对性的临床管理策略的必要性,尤其是针对年轻患者和病情严重的患者,以优化患者的生命周期并提高存活率。
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引用次数: 0
Review Article: Life Expectancy of Multiple Sclerosis in the US 评论文章:美国多发性硬化症患者的预期寿命
Pub Date : 2024-07-12 DOI: 10.47672/ajhmn.2203
Dr Shabrez Tariq, Dr Areeb Ahmed, Dr Zainab Shamim
Purpose: Comprehending the life expectancy of individuals afflicted with MS is crucial for patient counseling and devising effective healthcare plans accordingly. Materials and Methods: In this review, we amalgamate findings from several key studies published between 2014 and 2024, using Scopus, Google Scholar, and PubMed to provide insight into the mortality and life expectancy associated with MS. Findings: Multiple sclerosis (MS) is a progressive, immune-mediated, neurodegenerative disease that incurs demyelination of the axons. MS impacts approximately 900,000 young adults in the United States, with an average onset age ranging from 20 to 30 years. MS population has been frequently associated with declining quality of life (QOL) as opposed to other chronic disease populations. Though, studies suggest physical impairment including weakness, gait disorders, or visual or emotional disturbances are pivotal determinants of life expectancy in MS patients. We will discuss each factor that influences the longevity of individuals with MS in detail below. Literature shows that 90% of cases with early disease experience relapses and remissions characteristically. While a small percentage of individuals follow a mostly benign course over an extended period, the majority establishes a secondary-progressive disease as soon as 6-7 years after the onset. Although a minor segment of MS manifests an "aggressive" disease, life expectancy is mostly unaffected with the disease course often prevailing over a period of 30 years on average, unless the patient’s comorbidities, compliance to treatment, or genetic predisposition are unfavourable. Implications to Theory, Practice and Policy: We aim to enhance understanding of this disease and its multifaceted aspects for advance management strategies, better quality of life hence improved patient outcomes.
目的:了解多发性硬化症患者的预期寿命对患者咨询和制定有效的医疗保健计划至关重要。材料与方法:在本综述中,我们利用 Scopus、Google Scholar 和 PubMed 对 2014 年至 2024 年间发表的几项重要研究的结果进行了整合,以深入了解与多发性硬化症相关的死亡率和预期寿命。研究结果:多发性硬化症(MS)是一种进行性、免疫介导的神经退行性疾病,会导致轴突脱髓鞘。多发性硬化症影响着美国约 90 万青壮年,平均发病年龄在 20 至 30 岁之间。与其他慢性疾病患者相比,多发性硬化症患者的生活质量(QOL)经常下降。尽管研究表明,包括虚弱、步态障碍、视觉或情绪障碍在内的身体损伤是决定多发性硬化症患者预期寿命的关键因素。下面我们将详细讨论影响多发性硬化症患者寿命的各个因素。文献显示,90% 的早期病例都会经历复发和缓解的过程。虽然有一小部分患者在较长时间内的病程基本是良性的,但大多数患者在发病后 6-7 年就会出现继发性进展疾病。虽然有一小部分多发性硬化症表现为 "侵袭性 "疾病,但除非患者的并发症、治疗依从性或遗传倾向不利,否则患者的预期寿命大多不受影响,病程通常平均持续 30 年。对理论、实践和政策的影响:我们的目标是加强对该疾病及其多方面问题的了解,以制定先进的管理策略,提高生活质量,从而改善患者的预后。
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引用次数: 0
Adolescent Pregnancy: A Concept Analysis 青少年怀孕:概念分析
Pub Date : 2024-07-12 DOI: 10.47672/ajhmn.2202
Atanga Vivian Manka’ah, Socpa Antoine, M. Atanga, Ginyu Innocentia Kwalar
Purpose: Adolescent pregnancy (ADOPREG), despite its serious public health & social concerns, are highly neglected worldwide especially in developing countries with restrictive abortion laws. While the concept of ADOPREG may have the same label across disciplines, locations & contexts, its representations and how it is lived vary greatly. Despite diverse representations, ADOPREG is still plagued with great debates and serious public health and socio-economic concerns including persistently high rates and associated consequences even lifetime. Thus this concept analysis of Adolescent pregnancy aimed at clarifying the meaning of the concept and develop an operational definition for it which is believed will lay a common ground for mutual understanding among stakeholders & ameliorate adolescent care. Materials and Methods: The 8-stage concept analysis theoretical model of Walker and Avant (1994) was used for this work. There was a systematic search & selection of literature in 4 phases:broad preliminary search, Mesh controlled language, revision using Boolean Logic operators OR, “AND” and “Not”. Secondly, literature search on 9 electronic databases, then manual search & finally experts’ consultation. Study selection was done by a review process guided by PRISMA. Quality appraisal was then done for each selected study separately using appropriate standard tools. Totally, 4090 record were identified & 68 included in final study. Findings: Key results revealed: ADOPREG has uses in Etymology, Literature; Health, Politics, & Sociology. As Attributes-prevalence, peripartum care, teenage friendly health centres, & role of health practitioner in reducing ADOPREG. As antecedents among others -biological factors (genes), demographic & socio-cultural factors (marital status,) & Health factors (contraception) ; non-constitutive family factors and socio-political factors.  Short-term consequences of among others include increased frequency of neonatal complications (LBW) & maternal complications (hemmorhage, abortion), & low rates of CS. Major long-term consequences are socio-economic (rejection); health (suicide) & political (taxpayers drain). Empirical referents-pregnancy rates etc. Conclusively, ADOPREG here is defined as a state in which there is the development of a human being in an individual aged 10-19 from time of conception; thus, aligning with the embryologic definition. However, the dynamic nature of this concept cannot be totally ignored. Implications to Theory, Practice and Policy: More high quality concept analyses should be carried out on related issues to ADOPREG to better inform policy makers who should work collaboratively on better and operational definitions of adolescent pregnancy and its related issues.
目的:尽管少女怀孕(ADOPREG)引起了严重的公共卫生和社会问题,但在世界范围内,尤其是在堕胎法限制严格的发展中国家,少女怀孕问题却极易被忽视。虽然 "青少年怀孕 "这一概念在不同学科、不同地区和不同背景下可能有相同的标签,但其表现形式和生活方式却大相径庭。尽管表述各异,但 "青少年流产 "仍是一个争论不休的问题,也是一个严重的公共卫生和社会经济问题,包括居高不下的流产率和相关后果,甚至是终生的后果。因此,本次青少年怀孕概念分析旨在澄清这一概念的含义,并为其制定可操作的定义,相信这将为利益相关者之间的相互理解奠定共同基础,并改善青少年护理工作。材料和方法:这项工作采用了 Walker 和 Avant(1994 年)的 8 阶段概念分析理论模型。分四个阶段对文献进行了系统的搜索和筛选:广泛的初步搜索、网状控制语言、使用布尔逻辑运算符 "或"、"与 "和 "非 "进行修订。其次是在 9 个电子数据库中进行文献检索,然后是人工检索,最后是专家咨询。在 PRISMA 的指导下,通过审查流程对研究进行筛选。然后,使用适当的标准工具对每项选定的研究分别进行质量评估。总共确定了 4090 条记录,其中 68 条被纳入最终研究。研究结果主要结果显示ADOPREG 可用于词源学、文学、卫生学、政治学和社会学。作为属性--患病率、围产期护理、青少年友好型保健中心和保健医生在减少 ADOPREG 方面的作用。作为前因,包括生物因素(基因)、人口和社会文化因素(婚姻状况)、健康因素(避孕措施)、非组成家庭因素和社会政治因素。 短期后果包括新生儿并发症(低体重儿)和产妇并发症(子宫出血、流产)的发生率增加,以及分娩率降低。主要的长期后果是社会经济后果(排斥)、健康后果(自杀)和政治后果(纳税人流失)。经验参考--怀孕率等。总之,ADOPREG 在这里被定义为 10-19 岁的个体从受孕时开始发育成人类的状态,因此与胚胎学的定义一致。然而,不能完全忽视这一概念的动态性质。对理论、实践和政策的影响:应就与 ADOPREG 相关的问题开展更多高质量的概念分析,以便为决策者提供更好的信息,而决策者则应合作制定更好的、可操作的少女怀孕及其相关问题的定义。
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引用次数: 0
Outcomes of a Series of Sudanese Patients with Uterine Rupture 一系列苏丹子宫破裂患者的治疗结果
Pub Date : 2024-06-06 DOI: 10.47672/ajhmn.2077
Haitham Abdalla Ali Ismail, Ahmed Elnour Adam Zakaria, Nawal Ali Ahmed Mohamed, Mohammed Adam Mohammed Ali, Abuelez Hassan Ibrahem Abdallah, Hussain Gadelkarim Ahmed, Eldaw B. S. Mohamed
Purpose: Uterine rupture during pregnancy is rare, often fatal, and can cause serious complications for both mother and fetus. Therefore, this study evaluated the outcomes of a group of Sudanese patients who experienced uterine rupture. Materials and Methods: This study comprised a group of 26 female individuals who had a uterine rupture and received medical care at the maternity department of El-Obeid Teaching Hospital in Sudan's North Kordofan state. The patients were admitted over the course of one year. We obtained the requisite identifying data and demographic characteristics from every subject. Findings: The majority of cases have normal hospital stays (65%). About 35% of patients have prolonged hospital stays. The most common postoperative complication experienced was venous thromboembolism (VTE) (31%). Most patients presented with labor pain followed by vaginal bleeding and abdominal pain, constituting (57.7%), (27%), and (11.5%), in that order. Implications to Theory, Practice and Policy: Sudan experiences a high prevalence of uterine rupture, which leads to quite high rates of adverse outcomes during childbirth, despite having relatively low rates of premature death. The most unfavorable outcomes are extended hospitalization, venous thromboembolism (VTE), and the need for blood transfusion. Careful follow-up during pregnancy and choosing the appropriate delivery mode is important.
目的:妊娠期子宫破裂非常罕见,通常是致命的,会对母亲和胎儿造成严重的并发症。因此,本研究对一组经历过子宫破裂的苏丹患者的预后进行了评估。材料和方法:本研究包括 26 名子宫破裂并在苏丹北科尔多凡州 El-Obeid 教学医院产科接受治疗的女性患者。这些患者的入院时间长达一年。我们从每个受试者那里获得了必要的身份识别数据和人口统计学特征。研究结果大多数病例的住院时间正常(65%)。约 35% 的患者住院时间较长。最常见的术后并发症是静脉血栓栓塞(VTE)(31%)。大多数患者表现为分娩疼痛,其次是阴道出血和腹痛,依次占(57.7%)、(27%)和(11.5%)。对理论、实践和政策的启示:苏丹的子宫破裂发生率很高,尽管早产死亡率相对较低,但这导致了相当高的分娩不良后果发生率。最不利的后果是住院时间延长、静脉血栓栓塞(VTE)和需要输血。在怀孕期间进行仔细的随访并选择适当的分娩方式非常重要。
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引用次数: 0
Perceived Predisposition Factors of Diabetes and Hypertension in the Shai-Osudoku District of Ghana 加纳沙伊-奥苏德地区糖尿病和高血压的易感因素
Pub Date : 2024-02-20 DOI: 10.47672/ajhmn.1798
Michael Amponsah Kodom
Purpose: This study examined the perceived predisposition factors of diabetes and hypertension in the Shai-Osudoku district of Ghana. The research design adopted by the study was qualitative approach. Face-to-face semi-structured interviews were used to collect the data.   Materials and Methods: A total of fifty-two (52) participants made up of thirty-five (35) without any diabetes or hypertension and ten (10) with only hypertension and eight (8) with both diabetes and hypertension were involved in the study. For participants without diabetes or hypertension, the process of selection was simple random sampling while those with either hypertension and diabetes or only hypertension, snow ball process was used to identify them. Content analysis with coding of the information was used to analysis the data. Findings: The paper identified a number of perceptions and firmly held beliefs about the predisposition causes of diabetes and hypertension. These include spiritual means of contracting diabetes and hypertension, the type of work one does, the kind of foods one eats, the age of a person, from parents to children, eating habits of a person, and lack of exercise/physical activities. Two theories of causes of disease conditions were used in this study. These are: the Health Believe Model (HBM) and General Susceptibility Causes of Disease (GSCD). Comparing the above findings in the context of the two theories, it can therefore be said that, the participants’ opinion regarding behavioural risk factors of diabetes and hypertension are in consistance with the theories used for the study. Implications to Theory, Practice and Policy: Based on the findings, it is recommended that, the Ministry of Health and Ghana Health Service should engage social scientists such as sociologists and psychologists at the various healthcare centers to assist health professionals to improve the understanding of their patients; especially those with medical complications such as diabetes and hypertension in order to increase patient adherence to treatment. This is because if diabetic or hypertensive patient has a belief that his/her condition is caused by spiritual means, it presupposes that it can only be cured through spiritual means and therefore he/she will not adhere to routine medications as the case may be.
目的:本研究探讨了加纳沙伊-奥苏德地区糖尿病和高血压的易感因素。本研究采用的研究设计是定性方法。采用面对面半结构式访谈收集数据。 材料和方法:共有五十二(52)名参与者参与了研究,其中三十五(35)名没有任何糖尿病或高血压,十(10)名仅患有高血压,八(8)名同时患有糖尿病和高血压。对于没有糖尿病或高血压的参与者,采用了简单的随机抽样方法,而对于患有高血压和糖尿病或仅有高血压的参与者,则采用了雪球法来确定他们的身份。在分析数据时,采用了对信息进行编码的内容分析法。研究结果本文确定了一些关于糖尿病和高血压易感原因的看法和坚定信念。这些原因包括感染糖尿病和高血压的精神因素、工作类型、饮食种类、年龄(从父母到子女)、饮食习惯以及缺乏锻炼/体育活动。本研究采用了两种疾病病因理论。它们是:健康相信模型(HBM)和疾病的一般易感原因(GSCD)。根据这两种理论对上述研究结果进行比较,可以说,参与者对糖尿病和高血压行为风险因素的看法与本研究采用的理论是一致的。对理论、实践和政策的启示:根据研究结果,建议卫生部和加纳卫生局在各医疗中心聘请社会学家和心理学家等社会科学家,协助医疗专业人员增进对患者的了解,尤其是对糖尿病和高血压等并发症患者的了解,以提高患者的治疗依从性。这是因为,如果糖尿病或高血压患者认为自己的病情是由精神因素造成的,那么他/她就会认为只有通过精神因素才能治愈,因此他/她就不会坚持常规药物治疗。
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引用次数: 0
Effectiveness of Tactile and Auditory Stimulation on Physiological Parameters among Preterm Neonates at NICU - a RCT Study Design 触觉和听觉刺激对新生儿重症监护室早产新生儿生理参数的影响 - RCT 研究设计
Pub Date : 2024-01-31 DOI: 10.47672/ajhmn.1752
Majella Livingston, Dr. Alber. M. Mathiarasu
Purpose: To evaluate the effectiveness of tactile & auditory stimulation on physiological parameters weight, temperature, heart rate, respiratory rate, oxygen saturation, feeding pattern, sleeping hours, crying spells and urination among preterm neonates. Material and Methods: A quantitative research approach with true experimental research design was adopted for this study Samples: 120 preterm neonates who got admission and present in the NICU or postnatal unit of KKMCH, who satisfied inclusion criteria. Tool: The tool was developed, validated by experts and checked for its reliability Sample Size:  Open Epi, Version 3, open source calculator Sample Size for Comparing Two Means from pilot study. Total sample size 120. Among them 60 preterm neonates were assigned to experimental group and control group each randomly. Statistical analysis used: Demographic data using frequency and percentage distribution. Physiological parameters were analyzed by using mean, standard deviation, paired T test.  Structured interview schedule by Chi Square test. Association by Multiple Logistic Regression. Findings: Out of 120 preterm neonates, 48.3 % males, 51.7 % females and 42.5 % Hindus, 52.5% Christians and 5 % Muslims. Gestational age 18.33 % between 28 – 30 weeks, 40 % between 31 – 33 weeks and 41.67 % between 34 – 36 weeks. The paired difference of mean in pre term neonates on post - intervention 3rd day and 5th day in experimental and control group in weight gain were 109.83, 176.33 grams & 78.16, 118.33 grams, temperature were 0.270, 0.870Celsius & 0.150, 0.310 Celsius, heart rate were 10.17, 9.30 & 4.63, 3.93 beats/ minute , respiratory rate were 5.70, 11.23 & 3.00 , 5.80 breaths / minute ,mean oxygen saturation were 2.47, 4.65% & 1.12, 2.23 % . The .mean pre intervention Vs post intervention on 5th day  among over all physiological parameter consists of structured interview schedule in experimental group and control group includes increased feeding  pattern by 50% and 11.7%  (X2 = 26.612), increased sucking pattern  by 55% and 10%  (X2 = 30.572), increased duration per sleep by 68.3% and 5% (X2 = 56.885), increased sleeping pattern by 61.7% and 6.7%  (X2 = 43.364), decreased crying pattern by 60% and 1.7% (X2 = 48.553) and increased urination pattern by 73.3% and 6.7%  (X2 = 58.989) than control group.  The present study findings concluded that the tactile and auditory stimulation had positive effects on growth and maturation in preemies. It can be used in any clinical and community settings to maintain the physiological parameters among preterm neonates.  Implications to Theory, Practice and Policy: Since massage therapy is a cost effective therapeutic technique it should be encouraged in all community especially rural poor pre term babies. Health education about massage & music therapies should be given to NICU nurses, staff nurses, village health nurses, Auxiliary nurse midwife in order to promote these therapies as a routine care in the management
目的:评估触觉和听觉刺激对早产新生儿体重、体温、心率、呼吸频率、血氧饱和度、喂养模式、睡眠时间、哭闹和排尿等生理指标的影响。材料和方法:本研究采用真实实验设计的定量研究方法:120 名符合纳入标准的早产新生儿,这些新生儿入住了九龙玛丽医院的新生儿重症监护室或产后病房。工具:工具:该工具由专家开发、验证并检查其可靠性: Open Epi,版本 3,开源计算器 试点研究中比较两个均值的样本量。样本量共计 120 个。其中 60 名早产新生儿被随机分配到实验组和对照组。统计分析人口统计学数据采用频率和百分比分布。生理参数采用平均值、标准差和配对 T 检验进行分析。 结构化访谈表采用卡方检验。通过多重逻辑回归进行关联分析。研究结果在 120 名早产新生儿中,男性占 48.3%,女性占 51.7%,印度教徒占 42.5%,基督教徒占 52.5%,穆斯林占 5%。胎龄在 28-30 周之间的占 18.33%,31-33 周之间的占 40%,34-36 周之间的占 41.67%。干预后第 3 天和第 5 天,实验组和对照组早产新生儿体重增加的配对平均值分别为 109.83 克、176.33 克和 78.16 克、118.33 克,体温分别为 0.270 摄氏度、0.870 摄氏度和 0.870 摄氏度。心率分别为 10.17、9.30 和 4.63、3.93 次/分钟,呼吸频率分别为 5.70、11.23 和 3.00、5.80 次/分钟,平均血氧饱和度分别为 2.47、4.65% 和 1.12、2.23%。根据结构化访谈表,实验组和对照组干预前和干预后第 5 天的所有生理参数的平均值分别为:喂养模式增加了 50%和 11.7%(X2 = 26.612),吸吮模式增加了 55%和 10%(X2 = 30.572),每次睡眠持续时间增加了 10%(X2 = 30.572)。与对照组相比,实验组和对照组的喂养模式分别增加了 50%和 11.7%(X2 = 26.612),吸吮模式分别增加了 55%和 10%(X2 = 30.572),每次睡眠时间分别增加了 68.3%和 5%(X2 = 56.885),睡眠模式分别增加了 61.7%和 6.7%(X2 = 43.364),哭闹模式分别减少了 60%和 1.7%(X2 = 48.553),排尿模式分别增加了 73.3%和 6.7%(X2 = 58.989)。 本研究结果表明,触觉和听觉刺激对早产儿的生长和成熟有积极影响。它可用于任何临床和社区环境,以维持早产新生儿的生理参数。 对理论、实践和政策的意义:由于按摩疗法是一种经济有效的治疗技术,因此应在所有社区,尤其是农村贫困早产儿中推广。应向新生儿重症监护室护士、护士长、乡村保健护士、助产士辅助护士提供有关按摩和音乐疗法的健康教育,以便将这些疗法作为早产新生儿和低出生体重儿的常规护理方法加以推广。
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引用次数: 0
A Comprehensive Review on the Surgical Landscape in Breast Cancer Management 全面回顾乳腺癌手术治疗的现状
Pub Date : 2024-01-11 DOI: 10.47672/ajhmn.1737
Alya Saeed Ali Khamis Alteneiji, A. Almheiri, Mohamed Saleh
Purpose: The purpose of this narrative review is to examine the literature on the topic of breast surgery and its benefits for women with metastatic breast cancer. Breast surgery can involve either a mastectomy, which involves removing the entire breast along with lymph nodes, nipple, and areola, or a lumpectomy, which involves removing breast tissue and tumour but leaving the nipple and areola intact. Methodology: We included any English-language study published between 2000 and 2021 that looked at the effects of breast surgery on survival or quality of life for women with metastatic breast cancer, whether it was an interventional study or an observational study. We utilised a combination of keywords like "Breast surgery," "mastectomy," "lumpectomy," "metastatic disease," "survival," "observational studies," "intervention studies," and "quality of life" to scour sources like PubMed and Embase. We considered randomised controlled trials that contrasted hormonal therapy, radiation, chemotherapy, biologic therapy, and supportive care with breast surgery alone or in combination with systemic therapy. A variety of outcomes were considered, including overall survival, quality of life, toxicity from local treatment as measured by one-month mortality, survival without progression, and survival specific to breast cancer. Findings: The evidence from randomised controlled trials is limited and not conclusive, while observational studies do suggest that breast surgery may benefit with metastatic breast cancer. Since observational studies are prone to problems like selection bias and unmeasured confounding, it is difficult to draw any conclusions regarding the advantages of breast surgery without solid proof from RCTs. Implications to Theory, Practice and Policy: Each woman diagnosed with metastatic breast cancer should be considered individually when deciding whether or not to undergo surgery. This should be done until results from big ongoing RCTs are available. When considering treatment options, the patient and doctor must weigh the pros and cons of each, as well as the associated costs. The current lack of strong evidence calls for more randomised controlled trials (RCTs) in both developing and developed nations, with bigger sample sizes.
目的:本综述旨在研究有关乳房手术及其对转移性乳腺癌妇女益处的文献。乳房手术可以是乳房切除术,即切除整个乳房以及淋巴结、乳头和乳晕;也可以是肿块切除术,即切除乳房组织和肿瘤,但保留乳头和乳晕。研究方法:我们收录了 2000 年至 2021 年间发表的所有关于乳房手术对转移性乳腺癌女性患者的生存或生活质量影响的英文研究,无论是干预性研究还是观察性研究。我们使用了 "乳房手术"、"乳房切除术"、"肿块切除术"、"转移性疾病"、"生存"、"观察性研究"、"干预性研究 "和 "生活质量 "等关键词来搜索 PubMed 和 Embase 等资料来源。我们考虑了将激素疗法、放疗、化疗、生物疗法和支持性护理与乳腺手术单独或与系统疗法相结合进行对比的随机对照试验。我们考虑了各种结果,包括总生存率、生活质量、局部治疗的毒性(以一个月的死亡率来衡量)、无进展的生存率以及乳腺癌特有的生存率。研究结果:随机对照试验提供的证据有限,且不具决定性,但观察性研究确实表明,乳房手术可能对转移性乳腺癌患者有益。由于观察性研究容易出现选择偏差和未测量混杂等问题,因此在没有随机对照试验的确凿证据之前,很难就乳房手术的优势得出结论。对理论、实践和政策的影响:在决定是否接受手术治疗时,应单独考虑每位确诊为转移性乳腺癌的妇女。在目前正在进行的大型研究性临床试验得出结果之前,应该这样做。在考虑治疗方案时,患者和医生必须权衡每种方案的利弊以及相关费用。由于目前缺乏有力的证据,因此需要在发展中国家和发达国家开展更多的随机对照试验(RCT),并扩大样本量。
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引用次数: 0
Obstacles Encountered by Medical Students in Conducting Academic Research - A Cross-Sectional Study 医学生在开展学术研究时遇到的障碍--一项横断面研究
Pub Date : 2023-12-20 DOI: 10.47672/ajhmn.1705
A. Bashir, Qasim Raza, Danish Hussain, Syeda Amna Iqbal, Akram Ali, Muhammad Azhar, Kaiynat Shafique, Iqra Tahir
Purpose: Research is the most important aspect for the betterment and enhancement of medical services that are provided to the community. Health training research is regarded as a critical activity in current medical training at the undergraduate level. The aim of this investigation was to identify the key obstacles that medical students face when performing academic research and to see if these issues differ between female and male students. Materials and Methods: A cross-sectional research was carried out, encompassing 164 participants, wherein a modified questionnaire was deployed for data acquisition. Employing a simple random sampling methodology, data was gathered exclusively from final year undergraduate medical students from government and private universities of Faisalabad. Exclusions were made for individuals exhibiting isolated personalities, lack of willingness to participate in research, and those presenting psychological concerns. Data was analyzed using SPSS version 22 and presented in form of tables and graphs. Findings: Participants mean age was 20.73±1.7. Out of 164 students, 60.4% were females and 39.6% were males. Most prominent obstacles were found to be limited monetary support or lack of funding for research, family responsibilities, lack of guidance from university professors, demotivating university authorities, social responsibilities, and lack of knowledge about statistical methods, limited availability of information sources, limited time, insufficient understanding of research procedures, and insufficient research abilities. There were no statistical significant differences found between male and female students regarding these perceived obstacles. Implications to Theory, Practice and Policy: Institutes need to organize a variety of research-related activities, and teachers must encourage students to participate in research activities. International and local seminars should be organized for students to emphasize the importance of medical research. Teachers should involve students in research projects so that they can expand their knowledge.  Because the sample size in this study was small, it must be replicated with a larger sample size in future studies. It is recommended that additional research be conducted to investigate the perspectives of university professors, research mentors, and university authorities in order to gain a comprehensive understanding of the challenges and potential solutions. Collaborate with university administration to identify potential sources of financial support for student research projects.
目的:研究是改善和提高为社区提供的医疗服务的最重要方面。健康培训研究被视为当前本科医学培训的一项重要活动。本调查旨在确定医科学生在进行学术研究时所面临的主要障碍,并了解这些问题在女生和男生之间是否存在差异。材料与方法:本研究进行了一项横断面研究,共有 164 人参加,采用修改过的调查问卷获取数据。采用简单的随机抽样方法,从费萨拉巴德公立和私立大学医学专业的应届本科生中收集数据。不包括性格孤僻、不愿意参与研究以及有心理问题的人。数据使用 SPSS 22 版进行分析,并以表格和图表的形式呈现。研究结果参与者的平均年龄为(20.73±1.7)岁。在 164 名学生中,女性占 60.4%,男性占 39.6%。发现最突出的障碍是金钱支持有限或缺乏研究经费、家庭责任、缺乏大学教授的指导、大学当局打击积极性、社会责任,以及缺乏统计方法知识、信息来源有限、时间有限、对研究程序了解不足和研究能力不足。在这些认知障碍方面,男生和女生之间没有明显的统计学差异。对理论、实践和政策的影响:院校需要组织各种与研究相关的活动,教师必须鼓励学生参与研究活动。应为学生组织国际和本地研讨会,强调医学研究的重要性。教师应让学生参与研究项目,以扩大他们的知识面。 由于本研究的样本量较小,因此在今后的研究中必须以更大的样本量进行重复。建议开展更多研究,调查大学教授、研究导师和大学当局的观点,以便全面了解挑战和潜在的解决方案。与大学管理部门合作,确定学生研究项目的潜在资金支持来源。
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引用次数: 0
The Role of Facial Fillers in Non-Surgical Rhinoplasty: A Systematic Review of Safety and Efficacy 面部填充物在非手术鼻整形中的作用:安全性和有效性系统回顾
Pub Date : 2023-12-19 DOI: 10.47672/ajhmn.1693
Ali Mohamed Alsari Almheiri, Majid Alhammadi, Khaled Al Zaman
Purpose: Facial fillers, also alluded to as dermal fillers, consist of injectable chemicals as portion of a minimally invasive strategy to incidentally enhance the aesthetic and appearance of facial highlights by correcting volumes. Non-surgical rhinoplasty, also called liquid rhinoplasty, includes the utilize of dermal fillers to improve the shape of the nose. Non-surgical rhinoplasty is picking up popularity over the surgical choice on account of its ease of application, cheaper cost, better safety profile, less adverse effects, and faster recuperation time. Nevertheless, with the complex nasal arterial vasculature and structure, complications have been detailed within the literature. In this review, we examine the distributed applications of facial fillers in non-surgical rhinoplasty and its viability and security profile as compared to the surgical alternative. Materials and Methods: A comprehensive literature review of articles on facial fillers in non-surgical rhinoplasty was performed. Search results were filtered to incorporate articles and studies that were distributed within the last five years, to increase the relevance of the results to current practices. Search results were then reviewed for significance to the utilize of facial or dermal fillers in non-surgical rhinoplasty only. Studies that detailed the role of face fillers in areas unrelated to rhinoplasty and nose defects were excluded. Findings: Seven articles met the inclusion criteria and discussed the role, security and viability of facial or dermal fillers in non-surgical rhinoplasty. Of these, three were designed to illustrate particular techniques embraced in non-surgical rhinoplasty as well as the common uses of diverse and common fillers. The remaining three reviewed the safety and viability of particular filler sorts: one article inspected the use of Hyaluronic corrosive based dermal fillers in non-surgical rhinoplasty, another reviewed the strategy of PMMA-collagen gel in non-surgical rhinoplasty absconds, and finally, a study analyzed the utilize of a hybrid nasal filler which combined agarose gel and hyaluronic corrosive. The remaining article from the literature reviewed a case from a patient who detailed persistent headache and migraine-like indications following non-surgical rhinoplasty. Conclusions: Facial fillers are compelling and safe options for patients who wish to rectify or enhance their nasal shape or form, without going for surgery. Although the results are not as permanent as with the surgical alternative, non-surgical rhinoplasty offers a better recovery time, and cheaper cost. Given the distinctive properties ascribed to each filler type, and the diverse cases of nasal deformities, the filler choice and area should be chosen on a patient-specific basis. Compared to surgical rhinoplasty, the complications and adverse occasions from the non-surgical injections are as a rule mild and self-limiting. While severe complications are uncommon, deep knowled
目的:面部填充剂,又称皮肤填充剂,由可注射的化学物质组成,作为微创策略的一部分,通过修正体积来偶然增强面部亮点的美感和外观。非手术隆鼻术又称液体隆鼻术,包括利用皮肤填充剂来改善鼻形。非手术隆鼻术比手术隆鼻术更受欢迎,因为非手术隆鼻术易于应用、成本更低、安全性更高、不良反应更少、恢复时间更快。然而,由于鼻腔动脉血管和结构复杂,文献中对并发症也有详细介绍。在这篇综述中,我们研究了面部填充物在非手术鼻整形中的分布应用,以及与手术替代方法相比的可行性和安全性。材料和方法:对非手术鼻整形中面部填充物的相关文章进行了全面的文献综述。对搜索结果进行了筛选,纳入了过去五年内发表的文章和研究,以提高结果与当前实践的相关性。然后对搜索结果进行审查,以确定其是否与在非手术鼻整形术中使用面部或皮肤填充剂有关。详细描述面部填充剂在与鼻整形术和鼻部缺陷无关的领域中的作用的研究被排除在外。研究结果:有七篇文章符合纳入标准,并讨论了面部或皮肤填充剂在非手术鼻整形中的作用、安全性和可行性。其中,三篇文章旨在说明非手术隆鼻术中采用的特定技术,以及各种常见填充物的常见用途。其余三篇文章审查了特定填充物种类的安全性和可行性:一篇文章检查了基于透明质酸的皮肤填充物在非手术隆鼻中的使用情况,另一篇文章审查了 PMMA-胶原凝胶在非手术隆鼻手术中的策略,最后,一项研究分析了结合了琼脂糖凝胶和透明质酸的混合鼻填充物的使用情况。其余一篇文献回顾了一例患者的病例,该患者详细描述了非手术隆鼻术后出现的持续性头痛和类似偏头痛的症状。结论:对于那些希望不通过手术来矫正或改善鼻形或鼻部形态的患者来说,面部填充物是一种令人信服且安全的选择。虽然非手术隆鼻的效果不如手术隆鼻永久,但它的恢复时间更长,费用更低。鉴于每种填充物的特性各不相同,而且鼻部畸形的情况也多种多样,因此应根据患者的具体情况选择填充物和填充部位。与手术隆鼻相比,非手术注射隆鼻的并发症和不良反应通常较轻,且具有自限性。虽然严重的并发症并不常见,但对鼻部解剖和血管的深入了解以及广泛的培训,仍是将并发症降至最低并提高患者安全性和满意度的主要途径。对理论、实践和政策的影响:严重并发症并不常见,对鼻腔解剖和血管的深入了解以及广泛的培训仍是最大限度减少并发症、提高患者安全性和满意度的主要途径。无论如何,还需要更多的研究来明确确定皮肤填充物的安全性,尤其是长期安全性。
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引用次数: 0
Correlation Between Central Corneal Thickness and Intraocular Pressure with the Goldmann Applanation Tonometer 使用戈德曼角膜曲率计测量角膜中央厚度与眼压之间的相关性
Pub Date : 2023-12-13 DOI: 10.47672/ajhmn.1681
Fayez Alshehri, Badriah Alrashidi
Purpose: The aim of this review is to investigate the correlation between central corneal thickness (CCT) and Intraocular pressure with the Goldmann applanation tonometer (GAT). Materials and Methods: A literature search using Medline database was conducted for the years 1946 to 2022 to explore the relationship between central corneal thickness and Intraocular pressure measured by the Goldmann applanation tonometer. The search was restricted to studies published in English language. The first 80 articles were reviewed and five relevant studies were selected in this analysis. Findings: Impacts of central corneal thickness on Intraocular pressure were investigated in five studies. Overestimation of intraocular pressure is associated with thick cornea while underestimation of intraocular pressure was associated with thin cornea Implications to Theory, Practice and Policy: Central corneal thickness can affect the result of Intraocular pressure measurement with the Goldmann applanation tonometer (GAT) . Assessment of central corneal thickness (CCT) is necessary for correct interpretation of IOP measurements obtained with the Goldmann applanation tonometer (GAT).
目的:本综述旨在通过戈德曼角膜屈光计(GAT)研究中央角膜厚度(CCT)与眼压之间的相关性。材料和方法:使用 Medline 数据库对 1946 年至 2022 年的文献进行了检索,以探讨中心角膜厚度与使用戈德曼角膜屈光计测量的眼压之间的关系。搜索仅限于以英语发表的研究。对前 80 篇文章进行了审查,并选择了 5 项相关研究进行分析。研究结果五项研究调查了中央角膜厚度对眼压的影响。高估眼压与角膜过厚有关,而低估眼压与角膜过薄有关 对理论、实践和政策的启示:中心角膜厚度会影响使用戈德曼眼压计(GAT)测量眼压的结果。评估中心角膜厚度(CCT)是正确解释使用戈德曼角膜屈光计(GAT)测量眼压的必要条件。
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引用次数: 0
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American Journal of Health, Medicine and Nursing Practice
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