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3390 Establishing the prevalence of prescriptions for pharmacogenetic testable medications in a geriatric medicine inpatient cohort 3390在老年医学住院患者队列中确定药物遗传学检测药物处方的流行程度
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.166
M Patel, H Dillon, R Moore, C Barry
Introduction Genetic testing in medical practice is becoming increasingly commonplace. Particularly relevant to geriatric medicine and polypharmacy is the science of pharmacogenetics; the testing of an individual patient to check for drug-gene interactions, which can determine if a new or existing prescription is a good fit for them. We wanted to establish the prevalence of prescriptions for medicines that have a known pharmacogenetic target in a population of people admitted to a geriatric medicine department at a UK teaching hospital. Methods We conducted a retrospective cohort analysis, using a year’s worth of electronic prescribing records (1/6/23–31/05/24), for patients admitted under the care of any named geriatrician at a single site teaching hospital in the UK. We cross referenced those prescriptions against a reference list of pharmacogenetic medications (PGxMed) with a known applicable pharmacogenetic test. Results The department recorded 9115 admissions over this time period. Most patients received at least one PGxMed prescription, with nearly two thirds (61%, or 5528 out of 9115) of admissions in one year being associated with at least one PGx medication. 6 was the highest number of PGxMed prescriptions recorded against a single patient (3 instances). ‘Cholesterol lowering,’ ‘Analgesic’ and ‘Anticoagulant’ were the top three classes of medication by frequency respectively. Conclusions Prescriptions for PGxMeds are highly prevalent in geriatric medicine in-patients, and more research is required to determine what the most cost-effective PGx testing approach is. There could be a role for PGx to help identify ineffective or harmful medication in this patient group. Given that geriatricians possess an acknowledged expertise in medication review, whilst PGx is still a nascent field of testing from a UK perspective, it is one for them to be aware of since it is likely to become of more relevance in clinical practice over the next few years.
基因检测在医学实践中变得越来越普遍。与老年医学和综合药学特别相关的是药物遗传学;对个别病人进行药物基因相互作用的检查,以确定新的或现有的处方是否适合他们。我们希望在英国一家教学医院的老年医学部门收治的人群中,建立具有已知药物遗传靶点的药物处方的流行程度。方法:我们对在英国某一教学医院接受任何老年病专家治疗的患者进行回顾性队列分析,使用一年的电子处方记录(1/6/23-31/05/24)。我们将这些处方与药物遗传药物参考清单(PGxMed)进行交叉对照,并进行已知适用的药物遗传测试。结果该系在此期间记录了9115名招生。大多数患者至少接受了一种PGxMed处方,一年内近三分之二(61%,或9115人中有5528人)的入院患者至少接受了一种PGx药物。6是针对单个患者记录的PGxMed处方的最高数量(3例)。“降胆固醇药”、“镇痛药”和“抗凝血药”分别是使用频率最高的三类药物。结论PGxMeds处方在老年住院患者中非常普遍,需要更多的研究来确定最具成本效益的PGx检测方法。PGx可能会在这一患者群体中发挥作用,帮助识别无效或有害的药物。鉴于老年病医生在药物审查方面拥有公认的专业知识,而从英国的角度来看,PGx仍然是一个新兴的测试领域,他们应该意识到这一点,因为在未来几年里,它可能会在临床实践中变得更加相关。
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引用次数: 0
3754 EAGLEcare: reducing healthcare utilisation for nursing home residents at the end of life 3754 EAGLEcare:减少养老院居民临终时的医疗保健利用
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.052
M H Tun, F L Ng, K Y Yee, Y-P Wong, S G Nathan, K-L Wong, L T Ang, T T Yang, CT-C Lien
Introduction Older people living in Nursing Homes (NH) are often admitted to Acute Hospitals (AH) towards their end-of-life (EOL) due to the limited capacity to manage exacerbations and symptoms within NHs. The EAGLEcare (Enhancing Advance care planning, Geriatric and End-of-Life care in NHs in the East) Programme was set up to improve in-NH care and to reduce avoidable AH admissions and their unintended consequences. Methods A system of proactive case-finding for residents with specific and general indicators of advanced life-limiting illnesses was developed in collaboration with NH partners, to enable early symptom recognition and timely response(s), supported by NH General Practitioners (GPs) and an interdisciplinary team from the AH, with out of hours coverage by a collaborating home palliative care service. We retrospectively studied a cohort of residents who passed away between January 2019 and December 2023 from five NHs during their final 6 months of life. Parameters including hospital admissions, emergency department (ED) visits, length of stay (LOS), and specialist outpatient clinic (SOC) visits were compared between EAGLEcare-enrolled and non-enrolled residents. Propensity score matching (1:5 ratio) was used to balance baseline characteristics, and negative binomial regression was employed to assess programme impact. Results After matching, 369 enrolled and 393 non-enrolled residents were analysed. Residents enrolled in the EAGLEcare Programme had significantly lower rates of hospital admissions (aIRR = 0.86, 95% CI: 0.77–0.97, p = 0.016), ED visits (aIRR = 0.82, 95% CI: 0.73–0.93, p = 0.001), and shorter LOS (aIRR = 0.82, 95% CI: 0.69–0.97, p = 0.024). However, SOC visit rates remained similar between groups. Conclusion(s) The EAGLEcare Programme effectively reduced hospitalizations and ED visits among NH residents at the EOL, supporting the need for integrated care models. Expanding such initiatives could improve EOL care, reduce healthcare burden, and enhance patient outcomes.
由于NHs管理病情恶化和症状的能力有限,生活在养老院(NH)的老年人经常被送往急性医院(AH),直到他们的生命终结(EOL)。制定了EAGLEcare(加强东部国家保健制度的预先护理计划、老年和临终护理)方案,以改善国家保健制度内的护理,减少可避免的急性心脏病住院及其意外后果。方法与NH合作伙伴合作开发了一套针对具有晚期限制生命疾病具体和一般指标的居民的主动病例发现系统,以实现早期症状识别和及时响应,由NH全科医生(gp)和AH的跨学科团队提供支持,并由合作的家庭姑息治疗服务提供非工作时间服务。我们回顾性地研究了一组在2019年1月至2023年12月期间从五个NHs中去世的居民,他们在生命的最后6个月里去世。参数包括住院次数、急诊科(ED)访问量、住院时间(LOS)和专科门诊(SOC)访问量在eaglecare登记和非登记居民之间进行比较。倾向评分匹配(1:5比例)用于平衡基线特征,负二项回归用于评估项目影响。结果对369名登记居民和393名未登记居民进行匹配分析。参加EAGLEcare计划的居民住院率(aIRR = 0.86, 95% CI: 0.77-0.97, p = 0.016)、急诊科就诊率(aIRR = 0.82, 95% CI: 0.73-0.93, p = 0.001)和LOS (aIRR = 0.82, 95% CI: 0.69-0.97, p = 0.024)显著降低。然而,各组之间的SOC访问率保持相似。结论(5)EAGLEcare计划有效地减少了EOL的NH居民的住院和急诊科就诊,支持了综合护理模式的需求。扩大此类举措可以改善EOL护理,减轻医疗负担,并提高患者的治疗效果。
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引用次数: 0
3689 Enhancing coordination of bone protection plans in ortho-geriatric patients: a quality improvement project 3689加强老年患者骨保护计划的协调:一项质量改进项目
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.017
K Finch, Ð Alićehajić-Bečić
Introduction Bone health assessment forms a standard aspect of orthogeriatric care in line with NHFD* and NOGG**. Current recommendation is to administer first dose of bone protection medication during hospital stay due to high imminent fracture risk. We identified several cases where the first dose was delayed, including near misses and adverse events with potential for patient harm. Methods A process map of 20 patients was conducted to collect data on decision-making, documentation, and implementation of bone protection plans. A staff questionnaire identified key shortcomings and areas for improvement. A teaching session on the importance of bone protection was delivered to the ACM*** department. Trust guidelines were developed to support clinical decision making, and electronic system note redesigned for uniformity of documentation. This was included in the induction for incoming orthogeriatric team members. A re-audit was performed to assess whether patients received their first dose of bone protection prior to discharge. Result Of the sample initially collected 90% had a bone health plan made, however only 33% of these received their first dose before discharge. There were several barriers highlighted including lack of clarity/variation in documentation, inadequate replacement of vitamin D/Ca, not obtaining consent during the admission. This meant treatment was delayed in 56% and was not given in 10% of the cohort. Qualitative data collected from the questionnaire highlighted the causes in delays including requiring improvements in ‘clear communication and documentation,’ prioritising ‘early consent,’ and ‘clearer understanding of roles’ of members of the team. Following implementation of the interventions, 100% of the sample had a bone health plan made, of these 81.25% were given their first dose of iv bisphosphonate prior to discharge, thus showing a 48.25% improvement. Conclusion The improvements achieved reduction in imminent fracture risk and decreased delays in first dose of bone protective medication being administered. *National Hip Fracture Database. **National Osteoporosis Guideline Group. ***Ageing and Complex Medicine.
骨健康评估形成了符合NHFD*和NOGG**的正畸护理的一个标准方面。目前的建议是在住院期间给予第一剂骨保护药物,因为即将发生骨折的风险很高。我们确定了几例首次剂量被延迟的病例,包括差点错过和可能对患者造成伤害的不良事件。方法对20例患者进行过程图分析,收集骨保护计划的制定、记录和实施情况。一份工作人员调查表查明了主要缺点和有待改进的领域。在ACM***部门进行了一次关于骨骼保护重要性的教学。制定了信任指南以支持临床决策,并重新设计了电子系统笔记以实现文件的一致性。这包括在新入职的骨科团队成员的入门。再次审核患者是否在出院前接受了第一剂骨保护。结果在最初采集的样本中,90%的人制定了骨骼健康计划,但只有33%的人在出院前接受了第一剂治疗。有几个突出的障碍,包括文件缺乏清晰度/差异,维生素D/Ca的替代不足,在入院期间未获得同意。这意味着56%的患者延迟接受治疗,10%的患者未接受治疗。从问卷中收集的定性数据强调了延迟的原因,包括需要改进“清晰的沟通和文档”,优先考虑“早期同意”,以及“更清楚地了解团队成员的角色”。实施干预措施后,100%的样本制定了骨骼健康计划,其中81.25%的样本在出院前给予第一剂静脉注射双膦酸盐,从而显示出48.25%的改善。结论该方法降低了即将发生骨折的风险,减少了首次给药的延迟。*国家髋部骨折数据库。**国家骨质疏松指南小组。***老龄化和复杂医学。
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引用次数: 0
3822 Hearing aid support for older adult patients 3822老年患者助听器支持
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.075
O C Cobb, H M Aung, L White
Introduction Hearing aids often appear broken and whether due to the battery or earwax simple fixes can allow patients to hear. This project aimed to improve hearing impaired patients’ experience and healthcare by providing support for hearing aids across Elderly Medicine wards in a large teaching hospital in Leeds. Method A survey evaluated the proportion of patients with non-functional hearing aids, with qualitative questions to evaluate the impact. The first intervention was a toolkit showing how to check if a hearing aid worked, how to fix common issues, to go alongside spare batteries with a QR code link for further information. As a second intervention, teaching sessions were arranged for ward staff to improve knowledge and encourage staff to fix issues. Results 101, 100 and 102 inpatients were surveyed for the baseline data collection, 1st re-audit and 2nd reaudit respectively. 1 in 4 patients had hearing aids with them and the primary outcome measure of ‘Are both hearing aids working’ improved from 56% to 70% to 87% after each intervention. The most common issue found was a flat battery and the prevalence reduced from 5 to 2 to 1. When asked what difference a working hearing aid makes: ‘It makes all the difference, I wouldn’t manage, I don’t want to miss anything,’ with one relative stating ‘I think it’s hugely important, people may just think she’s confused if she can’t hear what you’re saying, when she’s as sharp as a tack in there.’ Conclusion There was a clear improvement in the proportion of working hearing aids after each intervention and feedback from patients reinforced how impactful having a working hearing aid is. This has shown that providing hearing aid support is a practical and meaningful way of improving patient care that can be easily implemented elsewhere.
助听器经常出现坏掉的情况,无论是由于电池还是耳垢的原因,简单的修复就可以让患者恢复听力。该项目旨在通过为利兹一家大型教学医院的老年医学病房提供助听器,改善听障患者的体验和医疗保健。方法采用问卷调查的方法对患者配戴非功能性助听器的比例进行评估,用定性问题评价其影响。第一项干预措施是提供一个工具包,展示如何检查助听器是否正常工作,如何解决常见问题,并在备用电池旁边附带一个二维码链接,以获取更多信息。第二项干预措施是为病房员工安排教学课程,以提高他们的知识,并鼓励员工解决问题。结果对101例、100例和102例住院患者分别进行基线资料收集、第一次复核和第二次复核。每4名患者中就有1人佩戴助听器,每次干预后,“助听器是否都有效”的主要结果指标从56%提高到70%到87%。最常见的问题是电池没电,患病率从5降到2到1。当被问及正常工作的助听器会带来什么不同时,一位亲戚说:“它会带来很大的不同,我不会这么做,我不想错过任何东西。”一位亲戚说:“我认为这非常重要,如果她听不到你说的话,人们可能会认为她很困惑,其实她在里面像钉子一样敏锐。”结论:每次干预后,助听器的使用比例都有明显提高,患者的反馈强化了助听器的使用效果。这表明,提供助听器支持是改善患者护理的一种实用而有意义的方式,可以很容易地在其他地方实施。
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引用次数: 0
3323 ‘I’m worried I won’t truly understand how to help them’: medical students’ perceptions of communicating with confused patients 3323“我担心我不会真正理解如何帮助他们”:医学生对与困惑的病人交流的看法
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.103
S Wentzel, O Hodge
Introduction Hospital inpatients can present as confused for a multitude of reasons, thus learning how to effectively communicate with confused patients is a key skill for medical students. Fourth year is the first clinical year at our medical school. A verbal feedback session with fourth year medical student year representatives identified confidence in communicating with confused patients as a key concern of the cohort. Methods 40 fourth year medical students were surveyed using an online form. The students rated their confidence in communicating with confused patients on a Likert scale and were asked to explain this answer in under 100 words. These responses were collated into a Microsoft Excel Spreadsheet, and then thematic analysis using NVivo 12 software was applied to identify key themes. Results 20% (8/40) of students rated themselves as ‘very unconfident,’ 33% (13/40) as ‘somewhat unconfident,’ 38% (15/40) as ‘neither confident or unconfident,’ 7% (3/40) as ‘somewhat confident,’ and 2% (1/40) as ‘very confident.’ Key challenges identified by students included: unclear patient understanding or capacity (16 references), student communication style (15 references), patient distress or agitation (9 references), obtaining accurate information (7 references), and misunderstanding the patient (7 references). An e-learning resource including videoed simulated scenarios was created to attempt to address these challenges. 24 students who undertook the e-learning were surveyed at the end of the module. 4% (1/24) rated themselves as ‘neither confident or unconfident,’ 88% (21/24) as ‘somewhat confident,’ and 8% (2/24) as ‘very confident,’ with no students rating themselves as ‘very unconfident’ or ‘somewhat unconfident.’ Conclusion Medical students at the beginning of their clinical years lack confidence and identify several key challenges in communicating with confused patients. An understanding of these challenges is important for those working in Geriatric Medicine, particularly those involved in medical education. E-learning and utilising technology can be a helpful tool in developing students’ learning and confidence in this area.
医院的住院病人会因为多种原因而表现出困惑,因此学习如何有效地与困惑的病人沟通是医学生的一项关键技能。四年级是我们医学院的第一个临床学年。与四年级医学生代表的口头反馈会议确定了与困惑患者沟通的信心是该队列的关键问题。方法对40名四年级医学生进行问卷调查。学生们用李克特量表评估了他们与困惑的病人交流的信心,并被要求在100个单词内解释这个答案。将这些回答整理成Microsoft Excel电子表格,然后使用NVivo 12软件进行主题分析,以确定关键主题。结果20%(8/40)的学生认为自己“非常不自信”,33%(13/40)的学生认为自己“有点不自信”,38%(15/40)的学生认为自己“既不自信也不自信”,7%(3/40)的学生认为自己“有点自信”,2%(1/40)的学生认为自己“非常自信”。学生确定的主要挑战包括:不清楚患者的理解或能力(16篇文献),学生的沟通方式(15篇文献),患者的痛苦或激动(9篇文献),获得准确的信息(7篇文献),以及误解患者(7篇文献)。创建了包括视频模拟场景在内的电子学习资源,试图解决这些挑战。在该模块结束时,对24名参与电子学习的学生进行了调查。4%(1/24)的学生认为自己“既不自信也不自信”,88%(21/24)的学生认为自己“有点自信”,8%(2/24)的学生认为自己“非常自信”,没有学生认为自己“非常不自信”或“有点不自信”。结论:医学生刚开始临床生活时缺乏自信,在与困惑的病人沟通时,他们无法确定几个关键的挑战。了解这些挑战对那些从事老年医学工作的人,特别是那些从事医学教育的人来说非常重要。电子学习和利用技术可以成为培养学生在这一领域的学习和信心的有用工具。
{"title":"3323 ‘I’m worried I won’t truly understand how to help them’: medical students’ perceptions of communicating with confused patients","authors":"S Wentzel, O Hodge","doi":"10.1093/ageing/afaf368.103","DOIUrl":"https://doi.org/10.1093/ageing/afaf368.103","url":null,"abstract":"Introduction Hospital inpatients can present as confused for a multitude of reasons, thus learning how to effectively communicate with confused patients is a key skill for medical students. Fourth year is the first clinical year at our medical school. A verbal feedback session with fourth year medical student year representatives identified confidence in communicating with confused patients as a key concern of the cohort. Methods 40 fourth year medical students were surveyed using an online form. The students rated their confidence in communicating with confused patients on a Likert scale and were asked to explain this answer in under 100 words. These responses were collated into a Microsoft Excel Spreadsheet, and then thematic analysis using NVivo 12 software was applied to identify key themes. Results 20% (8/40) of students rated themselves as ‘very unconfident,’ 33% (13/40) as ‘somewhat unconfident,’ 38% (15/40) as ‘neither confident or unconfident,’ 7% (3/40) as ‘somewhat confident,’ and 2% (1/40) as ‘very confident.’ Key challenges identified by students included: unclear patient understanding or capacity (16 references), student communication style (15 references), patient distress or agitation (9 references), obtaining accurate information (7 references), and misunderstanding the patient (7 references). An e-learning resource including videoed simulated scenarios was created to attempt to address these challenges. 24 students who undertook the e-learning were surveyed at the end of the module. 4% (1/24) rated themselves as ‘neither confident or unconfident,’ 88% (21/24) as ‘somewhat confident,’ and 8% (2/24) as ‘very confident,’ with no students rating themselves as ‘very unconfident’ or ‘somewhat unconfident.’ Conclusion Medical students at the beginning of their clinical years lack confidence and identify several key challenges in communicating with confused patients. An understanding of these challenges is important for those working in Geriatric Medicine, particularly those involved in medical education. E-learning and utilising technology can be a helpful tool in developing students’ learning and confidence in this area.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"110 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3694 Upholding equitable access to secondary fracture prevention for adults 80 years and older 3694支持80岁及以上老年人公平获得二级骨折预防
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.093
A Singh, P Anthonypillai, A Williams, S Maggs, C Edwards, I Singh
Introduction Fragility fractures increase re-fracture and mortality risk, especially within two years. Fracture Liaison Services (FLS) aim to prevent secondary fractures by ensuring quality care for patients over 50. This study assesses equity of care in an existing FLS for patients above and below 80 years and evaluates re-fracture and mortality outcomes. Methods We retrospectively reviewed 2190 patients seen by Aneurin Bevan Fracture Liaison Service (AB-FLS) from January–December 2023 using national FLS Database (FLS-DB) data. After excluding 14 patients with missing data, 2176 were categorised as: below 80 and above 80 years. Data on previous fractures, re-fractures, and fracture type (hip/femur, spine, wrist, humerus, pelvis, others) were collected. Patients were followed until March 31, 2025, for re-fractures and mortality. Results The cohort’s mean age was 78.6 years (range: 50–103), with a significant female predominance (76.9%, p < 0.0001). Prior fractures were recorded in 50.7% (n = 1104), with a mean interval of 6 years (range: 0–36). Most (93.3%) lived in the community, 6.7% were in care homes. AB-FLS reviewed 1103 (50.7%) patients aged 50–80 and 1073 (49.3%) aged over 80, with no significant group differences. Female distribution was similar (78.8% vs. 75%). Bone treatment was initiated in 1207 (55.2%) patients. Over 27 months follow-up, 1801 (82.8%) had no re-fracture. Overall, 17.2% (n = 374) re-fractured (mean time: 253 days, range: 2–767 days). A significantly higher patients re-fractured in over 80 years (n = 209, 55.9%, mean 235 days) as compared to under 80 years (n = 165, 44.1%, mean 276 days, p = 0.023). At 12 months, 264 (12.1%) re-fractured: 154 (58.3%) over 80 (mean 137 days) and 110 (41.7%) under 80 (mean 151 days, p = 0.008). By 27 months, 503 patients had died. One-year mortality was 18.6% (n = 387), significantly higher in those over 80s (75.7%, n = 293) than under 80 (24.3%, n = 94, p < 0.0001). Conclusion The AB-FLS has demonstrated equitable care over the consecutive twelve-month period; however, further assessment over a longer timeframe is needed for confirmation. Given the significantly higher risk of re-fracture and mortality in older patients, secondary fracture services should be tailored to better address the needs of this population, ensuring true equity in healthcare.
脆弱性骨折增加了再骨折和死亡风险,尤其是在两年内。骨折联络服务(FLS)旨在通过确保50岁以上患者的优质护理来预防继发性骨折。本研究评估了现有FLS对80岁以上和80岁以下患者的护理公平性,并评估了再骨折和死亡率结果。方法使用国家FLS数据库(FLS- db)对2023年1 - 12月在动脉瘤Bevan骨折联络服务(AB-FLS)就诊的2190例患者进行回顾性分析。在排除14例数据缺失的患者后,2176例被分类为:80岁以下和80岁以上。收集既往骨折、再骨折和骨折类型(髋/股骨、脊柱、手腕、肱骨、骨盆等)的数据。随访至2025年3月31日,观察患者的再骨折和死亡率。结果该队列平均年龄为78.6岁(范围:50-103岁),女性占明显优势(76.9%,p < 0.0001)。50.7% (n = 1104)有骨折史,平均间隔6年(范围:0-36)。大多数(93.3%)住在社区,6.7%住在护理院。AB-FLS回顾了50-80岁患者1103例(50.7%)和80岁以上患者1073例(49.3%),组间无显著差异。女性分布相似(78.8% vs. 75%)。1207例(55.2%)患者接受骨治疗。在27个月的随访中,1801例(82.8%)未发生再骨折。总体而言,17.2% (n = 374)再次骨折(平均时间:253天,范围:2-767天)。80岁以上患者再骨折发生率(n = 209, 55.9%,平均235天)明显高于80岁以下患者(n = 165, 44.1%,平均276天,p = 0.023)。12个月时,264例(12.1%)再次骨折,154例(58.3%)超过80(平均137天),110例(41.7%)低于80(平均151天,p = 0.008)。到27个月时,已有503名患者死亡。1年死亡率为18.6% (n = 387), 80岁以上患者(75.7%,n = 293)显著高于80岁以下患者(24.3%,n = 94, p < 0.0001)。结论AB-FLS在连续12个月期间表现出公平的护理;但是,需要在较长的时间范围内进行进一步评估才能得到确认。考虑到老年患者的再骨折风险和死亡率明显较高,二次骨折服务应量身定制,以更好地满足这一人群的需求,确保医疗保健的真正公平性。
{"title":"3694 Upholding equitable access to secondary fracture prevention for adults 80 years and older","authors":"A Singh, P Anthonypillai, A Williams, S Maggs, C Edwards, I Singh","doi":"10.1093/ageing/afaf368.093","DOIUrl":"https://doi.org/10.1093/ageing/afaf368.093","url":null,"abstract":"Introduction Fragility fractures increase re-fracture and mortality risk, especially within two years. Fracture Liaison Services (FLS) aim to prevent secondary fractures by ensuring quality care for patients over 50. This study assesses equity of care in an existing FLS for patients above and below 80 years and evaluates re-fracture and mortality outcomes. Methods We retrospectively reviewed 2190 patients seen by Aneurin Bevan Fracture Liaison Service (AB-FLS) from January–December 2023 using national FLS Database (FLS-DB) data. After excluding 14 patients with missing data, 2176 were categorised as: below 80 and above 80 years. Data on previous fractures, re-fractures, and fracture type (hip/femur, spine, wrist, humerus, pelvis, others) were collected. Patients were followed until March 31, 2025, for re-fractures and mortality. Results The cohort’s mean age was 78.6 years (range: 50–103), with a significant female predominance (76.9%, p &amp;lt; 0.0001). Prior fractures were recorded in 50.7% (n = 1104), with a mean interval of 6 years (range: 0–36). Most (93.3%) lived in the community, 6.7% were in care homes. AB-FLS reviewed 1103 (50.7%) patients aged 50–80 and 1073 (49.3%) aged over 80, with no significant group differences. Female distribution was similar (78.8% vs. 75%). Bone treatment was initiated in 1207 (55.2%) patients. Over 27 months follow-up, 1801 (82.8%) had no re-fracture. Overall, 17.2% (n = 374) re-fractured (mean time: 253 days, range: 2–767 days). A significantly higher patients re-fractured in over 80 years (n = 209, 55.9%, mean 235 days) as compared to under 80 years (n = 165, 44.1%, mean 276 days, p = 0.023). At 12 months, 264 (12.1%) re-fractured: 154 (58.3%) over 80 (mean 137 days) and 110 (41.7%) under 80 (mean 151 days, p = 0.008). By 27 months, 503 patients had died. One-year mortality was 18.6% (n = 387), significantly higher in those over 80s (75.7%, n = 293) than under 80 (24.3%, n = 94, p &amp;lt; 0.0001). Conclusion The AB-FLS has demonstrated equitable care over the consecutive twelve-month period; however, further assessment over a longer timeframe is needed for confirmation. Given the significantly higher risk of re-fracture and mortality in older patients, secondary fracture services should be tailored to better address the needs of this population, ensuring true equity in healthcare.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"47 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3749 Clinical determinants of 180-day hospital readmission and mortality in older adults with dementia: a UK-based cohort study 3749 .老年痴呆患者180天再入院和死亡率的临床决定因素:一项英国队列研究
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.092
B Browne, E Ford, I Rogers, K Ali, N Tabet
Introduction Older adults with dementia occupy approximately one quarter of acute hospital beds in England. The risk of hospital readmission within six months of discharge increases with multiple long-term conditions, reduced mobility, and limited interdisciplinary collaboration between primary and secondary care. Subsequently, hospital readmission can increase the risk of mortality in this population. This study aimed to quantify the clinical determinants of readmission and subsequent mortality in older adults with dementia in England. Method A retrospective cohort study was conducted using anonymised data from adults in England aged 65 and over with a recorded diagnosis of dementia. Cases were identified through primary care electronic health records in the Clinical Practice Research Datalink (CPRD) GOLD, between April 1997 and November 2018. Readmissions within 180 days were identified using linked Hospital Episode Statistics. Adjusted logistic regression assessed factors associated with readmission, and Cox proportional hazards regression identified predictors of one-year mortality following readmission. Results The cohort included 24,956 patients from 253 general practices (mean age 81.93 years; 61.6% female). Chronic obstructive pulmonary disease (odds ratio [OR] = 1.26, 95% confidence interval [CI]: 1.15–1.39), diabetes mellitus (OR = 1.21, CI: 1.13–1.30), and chronic kidney disease (OR = 1.14, CI: 1.07–1.22) were strongly associated with readmission. Medication review in primary care within one year prior to admission (OR = 1.08, CI: 1.02–1.14), and primary care consultation within two weeks of discharge (OR = 1.21, CI: 1.15–1.28) were also associated with readmission. One-year mortality following readmission was associated with age (hazard ratio [HR] = 3.20, CI: 2.49–4.11 for ages 90+ versus 65–69), multiple long-term conditions (HR = 1.21, CI: 1.05–1.41 for 4–5 conditions versus none), prescriptions for antipsychotic medication (HR = 1.37, CI: 1.22–1.53), and care home residence (HR = 1.33, CI: 1.10–1.62). Conclusion Knowledge of clinical factors associated with readmission and mortality can inform advanced care planning between health and social care professionals, older adults with dementia and their families.
在英格兰,老年痴呆症患者约占急性医院床位的四分之一。出院后6个月内再入院的风险随着多种长期疾病、流动性降低以及初级和二级保健之间的跨学科合作有限而增加。随后,再次住院可增加这一人群的死亡风险。本研究旨在量化英国老年痴呆患者再入院和随后死亡率的临床决定因素。方法回顾性队列研究使用英国65岁及以上有痴呆记录的成年人的匿名数据。病例是通过1997年4月至2018年11月期间临床实践研究数据链(CPRD) GOLD中的初级保健电子健康记录确定的。180天内的再入院使用相关的医院事件统计数据进行识别。调整后的逻辑回归评估了与再入院相关的因素,Cox比例风险回归确定了再入院后一年死亡率的预测因素。结果纳入253家全科医院24956例患者(平均年龄81.93岁,女性61.6%)。慢性阻塞性肺病(优势比[OR] = 1.26, 95%可信区间[CI]: 1.15-1.39)、糖尿病(OR = 1.21, CI: 1.13-1.30)和慢性肾脏疾病(OR = 1.14, CI: 1.07-1.22)与再入院密切相关。入院前一年内的初级保健用药回顾(OR = 1.08, CI: 1.02-1.14)和出院后两周内的初级保健咨询(OR = 1.21, CI: 1.15-1.28)也与再入院有关。再入院后一年的死亡率与年龄(风险比[HR] = 3.20, 90岁以上的CI为2.49-4.11,65-69岁的CI为2.49-4.11)、多种长期状况(风险比[HR] = 1.21, 4-5岁的CI为1.05-1.41,无风险比为1.41)、抗精神病药物处方(风险比= 1.37,CI为1.22-1.53)和养老院居住(风险比= 1.33,CI为1.10-1.62)相关。结论了解与再入院和死亡率相关的临床因素可以为卫生和社会护理专业人员、老年痴呆患者及其家属制定高级护理计划提供信息。
{"title":"3749 Clinical determinants of 180-day hospital readmission and mortality in older adults with dementia: a UK-based cohort study","authors":"B Browne, E Ford, I Rogers, K Ali, N Tabet","doi":"10.1093/ageing/afaf368.092","DOIUrl":"https://doi.org/10.1093/ageing/afaf368.092","url":null,"abstract":"Introduction Older adults with dementia occupy approximately one quarter of acute hospital beds in England. The risk of hospital readmission within six months of discharge increases with multiple long-term conditions, reduced mobility, and limited interdisciplinary collaboration between primary and secondary care. Subsequently, hospital readmission can increase the risk of mortality in this population. This study aimed to quantify the clinical determinants of readmission and subsequent mortality in older adults with dementia in England. Method A retrospective cohort study was conducted using anonymised data from adults in England aged 65 and over with a recorded diagnosis of dementia. Cases were identified through primary care electronic health records in the Clinical Practice Research Datalink (CPRD) GOLD, between April 1997 and November 2018. Readmissions within 180 days were identified using linked Hospital Episode Statistics. Adjusted logistic regression assessed factors associated with readmission, and Cox proportional hazards regression identified predictors of one-year mortality following readmission. Results The cohort included 24,956 patients from 253 general practices (mean age 81.93 years; 61.6% female). Chronic obstructive pulmonary disease (odds ratio [OR] = 1.26, 95% confidence interval [CI]: 1.15–1.39), diabetes mellitus (OR = 1.21, CI: 1.13–1.30), and chronic kidney disease (OR = 1.14, CI: 1.07–1.22) were strongly associated with readmission. Medication review in primary care within one year prior to admission (OR = 1.08, CI: 1.02–1.14), and primary care consultation within two weeks of discharge (OR = 1.21, CI: 1.15–1.28) were also associated with readmission. One-year mortality following readmission was associated with age (hazard ratio [HR] = 3.20, CI: 2.49–4.11 for ages 90+ versus 65–69), multiple long-term conditions (HR = 1.21, CI: 1.05–1.41 for 4–5 conditions versus none), prescriptions for antipsychotic medication (HR = 1.37, CI: 1.22–1.53), and care home residence (HR = 1.33, CI: 1.10–1.62). Conclusion Knowledge of clinical factors associated with readmission and mortality can inform advanced care planning between health and social care professionals, older adults with dementia and their families.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"301 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3771 Improving clinical frailty score documentation in oncology wards 3771改进肿瘤病房的临床虚弱评分记录
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.029
L Manokaran, P Biju
Introduction The Clinical Frailty Score (CFS) allows appropriate frailty assessment to guide management plans for oncology patients. CFS documentation is not standard at our trust. We aimed to introduce CFS documentation in the Acute Oncology Service (AOS) clerking proforma and evaluate its use in patients aged &gt;65 to help guide management. Methods Data was obtained from inpatients on the oncology wards via NerveCentre. Three PDSA cycles were completed: Cycle 1: An evaluation to identify how many patients had a documented CFS. Based on this, a poster was created, emailed to oncology staff, and displayed around the ward. Cycle 2: A teaching presentation was delivered to junior doctors on the oncology ward. Cycle 3: Nursing staff were informed and encouraged to discuss CFS during morning board rounds. Data was collected after each cycle. Results There was a total increase of 20% in documentation after all three interventions. The initial documentation rate was 4.4%. This rose to 6.6% after posters were introduced, increased to 15.5% following junior doctor teaching, and reached 24.4% after involving nursing staff in PDSA Cycle 3. Conclusion Educating junior doctors and involving nurses in discussions around CFS helped improve documentation. It has been noted that identifying the CFS on admission increases the likelihood of it being recorded. Since the improvement is still modest, we now plan to incorporate the CFS into the AOS clerking proforma to increase compliance and make documentation part of routine practice.
临床虚弱评分(CFS)允许适当的虚弱评估来指导肿瘤患者的管理计划。在我们看来,CFS文件不是标准的。我们的目的是在急性肿瘤服务(AOS)的书面形式中引入CFS文件,并评估其在老年患者中的应用。帮助指导管理。方法通过神经中心对肿瘤病房住院患者进行数据采集。完成了三个PDSA周期:周期1:评估确定有多少患者有记录的CFS。在此基础上,我们制作了一张海报,通过电子邮件发给肿瘤科的工作人员,并在病房里展示。第二周期:给肿瘤病房的初级医生做教学报告。第3周期:护理人员被告知并鼓励在上午的董事会查房中讨论慢性疲劳综合症。每个周期结束后收集数据。结果三种干预措施后,患者的文献记录均增加了20%。初始文件率为4.4%。在引入海报后,这一比例上升到6.6%,在初级医生教学后,这一比例上升到15.5%,在PDSA Cycle 3中,有护理人员参与后,这一比例达到24.4%。结论对初级医生进行教育,并让护士参与到CFS的讨论中,有助于改善文献记录。我们注意到,在入院时确认是否患有慢性疲劳综合症会增加其被记录的可能性。由于改善仍然有限,我们现计划将中心纳入AOS职员表格,以提高合规性,并使文件成为日常工作的一部分。
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引用次数: 0
3724 An audit of inpatient falls—are we adequately addressing bone health? 3724住院病人跌倒的审计——我们是否充分关注骨骼健康?
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.022
A Ahmed
Background Falls in older adults frequently result in osteoporotic fractures, leading to longer stays, greater dependency, and long-term morbidity. Fragility fractures are estimated to cost the UK around £4.5 billion annually. Despite these serious implications, tools like FRAX, and routine assessments such as calcium and vitamin D levels, are still underused in the inpatient setting, especially following a fall. The National Osteoporosis Guideline Group (NOGG) recommends using the FRAX tool to estimate 10-year fracture risk and guide bone protection. Objective To evaluate: • Was a FRAX score calculated for patients who fell while in hospital? • Was bone protection initiated appropriately based on FRAX risk? • Was a vitamin D level checked within one year of the fall? Method A retrospective case review of 35 in-patients falls during April–May 2023 across the Trust was done. Patients identified via DATIX and then randomly selected. A custom-designed proforma was used to assess completion of post-fall assessment form, FRAX score, risk stratification and bone health management decisions. Results Most falls occurred in patients aged 70–90, consistent with NICE data indicating that 30% of people over 65 and 50% over 80 fall annually. Falls assessment sheet was completed in over 80% of cases. FRAX score was calculated in only 33.3% of cases. Among those, 60% of the patients were at intermediate risk, 20% at high risk and 10% at very high risk of future fractures. Among high-risk patients only 50% received oral bisphosphonates. Among patients without a FRAX assessment retrospective calculation showed 60% were very high risk and missed the opportunity for bone protection. Key Findings High compliance with Trust guidelines in completing post-fall assessments. Suboptimal FRAX score documentation, with more than half of fallers not being assessed for fracture risk. Retrospective FRAX scoring revealed many of these were at moderate or high risk and could have benefited from intervention. Calcium and vitamin D checks were performed more frequently than FRAX but still fell short of optimal levels. Concerns regarding bisphosphonate use in patients with renal impairment. Only 50% of intermediate-risk patients had safe creatinine clearance for bisphosphonates, and less than 10% of high-risk patients were eligible. Recommendations ‘Falls Alert Stickers’ were introduced in high-risk areas. These include checkboxes for Calcium, Vitamin D, FRAX, and Creatinine Clearance, and a QR code linking to guidance for easy access. Clinician education on bone health management should be enhanced through Grand Rounds and departmental meetings, especially given the high proportion of elderly admissions. Post falls proforma was updated with a separate bone health assessment section and a QR code linked to guidelines. Conclusion: Falls remain a major issue in older inpatients, often resulting in serious fractures and long-term disability. Improving adherence to NICE and NOGG guidel
背景老年人跌倒经常导致骨质疏松性骨折,导致住院时间更长,依赖性更大,长期发病率更高。据估计,英国每年因脆性骨折造成的损失约为45亿英镑。尽管有这些严重的影响,像FRAX这样的工具,以及钙和维生素D水平的常规评估,在住院患者环境中仍然没有得到充分的应用,尤其是在跌倒之后。国家骨质疏松指南小组(NOGG)建议使用FRAX工具来评估10年骨折风险并指导骨骼保护。•是否对住院期间跌倒的患者进行FRAX评分?•骨骼保护是否基于FRAX风险适当启动?•是否在秋天的一年内检查了维生素D水平?方法回顾性分析我院2023年4 - 5月收治的35例住院患者的跌倒情况。通过DATIX识别患者,然后随机选择。使用定制设计的表格来评估跌倒后评估表格的完成情况、FRAX评分、风险分层和骨骼健康管理决策。大多数跌倒发生在70-90岁的患者中,这与NICE的数据一致,该数据显示,每年有30%的65岁以上的患者和50%的80岁以上的患者跌倒。超过80%的病例完成了跌倒评估表。仅33.3%的病例计算了FRAX评分。其中,60%的患者未来骨折的风险为中等,20%为高风险,10%为极高风险。在高危患者中,只有50%接受了口服双膦酸盐治疗。在未进行FRAX评估的患者中,回顾性计算显示60%的患者风险非常高,错过了骨保护的机会。主要发现在完成跌倒后评估时高度遵守信托准则。FRAX评分不够理想,超过一半的患者没有进行骨折风险评估。回顾性FRAX评分显示,其中许多患者处于中度或高风险,可以从干预中获益。钙和维生素D的检查比FRAX更频繁,但仍达不到最佳水平。对肾损害患者使用双膦酸盐的关注。只有50%的中危患者有安全的肌酸酐清除双膦酸盐,不到10%的高危患者符合条件。在高风险地区引入了“跌倒警报贴纸”的建议。其中包括钙、维生素D、FRAX和肌酐清除率的复选框,以及一个链接到指南的二维码,方便访问。应通过大查房和科室会议加强对临床医生的骨健康管理教育,特别是考虑到老年人入院比例较高。摔倒后的形式更新了一个单独的骨骼健康评估部分和一个链接到指南的QR码。结论:跌倒仍然是老年住院患者的主要问题,经常导致严重骨折和长期残疾。提高对NICE和NOGG指南的依从性,特别是通过常规使用FRAX和在开骨保护处方时注意肾脏安全,可以改善预后。实施跌倒警报贴纸、临床医生参与和修订跌倒后形式是改善实践的重要步骤。引用1。皇家内科医学院。住院病人跌倒国家审计:审计报告2023。伦敦:RCP, 2023,[在线]可从:https://www.rcplondon.ac.uk/projects/national-audit-inpatient-falls获取。2. 皇家骨质疏松症学会。英国骨质疏松性骨折的成本。巴斯:ROS, 2022,[在线]可从:https://theros.org.uk获取。3. 国家骨质疏松指南组(NOGG)。骨质疏松症防治临床指南。谢菲尔德:NOGG, 2021,[在线]可从:https://www.nogg.org.uk获取。4. 国家健康和护理卓越研究所(NICE)。老年人跌倒:风险评估与预防[CG161]。伦敦:NICE, 2013,[更新于2022年]。可从:https://www.nice.org.uk/guidance/cg161。
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引用次数: 0
3715 A qualitative evaluation exploring co-production in care homes 3715探讨养老院合作生产的定性评估
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1093/ageing/afaf368.126
F Hallam-Bowles, A Kilby, A L Gordon, S Timmons, P A Logan, L Rees, W Lawry, , K Robinson
Introduction Co-production approaches are increasingly used in research. However, they are not often evaluated in care home settings. The study aimed to explore how co-production occurred in a series of workshops around falls management in care homes. Methods Sixteen stakeholders (care home residents and relatives, care home staff, health and social care professionals) participating in co-production workshops in a systematic action research study were invited to take part in a qualitative evaluation. The workshops were developing a model for delivering falls training in care homes across Nottinghamshire. Non-participant observations of workshops explored stakeholder interactions. Nine stakeholders participated in reflection meetings to share their experiences of the process. Framework analysis mapped key themes to the National Institute for Health and Care Research’s (NIHR) co-production principles. Results Nine themes were identified. Sharing power was influenced by opportunities to challenge dominant voices, resulting from the influence of the research team and separate stakeholder groups, and wider integration challenges across the health and social care system. Inclusion of all perspectives was affected by variable involvement of key stakeholders in the workshops and supported by a flexible approach. Respecting and valuing knowledge was influenced by self-confidence and supported by appreciating diverse stakeholder expertise and experiences. All stakeholders reported benefits of participating in co-production workshops, for example helping others and learning about falls management. However, reputational concerns and fatigue were potential harms of participation. Team dynamics changed as relationships developed. Conclusions Co-production was largely a positive experience for stakeholders and the NIHR’s key principles were partially achieved based on our qualitative findings. Co-production in care home settings is a complex process affected by multiple factors, including the individuals involved, stakeholder relationships, organisational priorities, and integration across the system. Future research should consider organisational power dynamics at all stages and create safe spaces for inclusive participation.
合作生产方法越来越多地用于研究。然而,他们并不经常在养老院进行评估。这项研究的目的是探索在养老院的跌倒管理的一系列研讨会中如何进行合作生产。方法采用系统的行动研究方法,邀请参与合作制作工作坊的16名利益相关者(护理院居民及其亲属、护理院工作人员、卫生和社会护理专业人员)参与定性评价。讲习班正在开发一种模式,以便在整个诺丁汉郡的养老院提供跌倒培训。研讨会的非参与者观察探讨了利益相关者的相互作用。九个利益相关者参加了反思会议,分享了他们在这一过程中的经验。框架分析将关键主题映射到国家卫生和保健研究所(NIHR)的合作制作原则。结果确定了9个主题。权力分享受到挑战主导声音的机会的影响,这些机会来自研究团队和独立的利益相关者群体的影响,以及整个卫生和社会保健系统中更广泛的整合挑战。主要利益攸关方对讲习班的不同参与影响了所有观点的纳入,并得到了灵活方法的支持。尊重和重视知识受到自信的影响,并得到欣赏不同利益相关者专业知识和经验的支持。所有利益攸关方都报告了参加联合制作讲习班的好处,例如帮助他人和学习跌倒管理。然而,声誉方面的担忧和疲劳是参与的潜在危害。随着人际关系的发展,团队动力也发生了变化。对于利益相关者来说,合作制作在很大程度上是一种积极的体验,根据我们的定性发现,国家卫生研究院的关键原则部分实现了。养老院环境中的合作生产是一个复杂的过程,受多种因素的影响,包括参与的个人、利益相关者关系、组织优先事项和整个系统的整合。未来的研究应考虑各个阶段的组织权力动力学,并为包容性参与创造安全空间。
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Age and ageing
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