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The OPTIMATE Multi-centre Clinical Trial: A Definitive Intervention to Reduce Clinically Important Adverse Effects of Polypharmacy in Multimorbid Older Adults OPTIMATE多中心临床试验:一种明确的干预措施,以减少多种疾病老年人服用多种药物的临床重要不良反应
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.022
Denis O'Mahony, John Cooke, Mirko Petrovic, Annemie Somers, Stephen Byrne, Kieran Dalton, Ruth Daunt, Siobhan McGettigan, Paula Fuller, Alice O'Donoghue, Ornaith Keane, Kevin Casey, Bronagh Bolger, Ine Simal, Hilde Vlieghe, Jen O'Sullivan, Darren Dahly, Brendan Palmer
Background Older patients with multimorbidity and polypharmacy experience excess adverse drug reactions which contribute to frequent emergency department (ED) attendance, unscheduled readmission and increased mortality. Implementing medication optimization strategies through STOPP/START criteria and drug-drug interaction (DDI) avoidance could mitigate these adverse clinical outcomes. Methods We designed a comprehensive medication-optimizing definitive intervention (DI) based on STOPP/STARTv3 criteria and Stockley’s®DDI checker and evaluated it by randomized clinical trial in 3 large university hospitals. We enrolled 636 older patients (mean age=80.3, 49.5% female) with ≥3 chronic conditions and polypharmacy (≥5 daily medications) admitted acutely in 2023-24. Patients were randomized to standard pharmaceutical care arm (n=217), physician-delivered-DI arm (n=210) or pharmacist-delivered-DI arm (n=209). For DI patients, written and verbal medication optimization advice was delivered to senior attending doctors at admission and pre-discharge. Prioritized STOPP/STARTv3/Stockley’s®DDI medication advice was further discussed with DI-arm patients’ general practitioners at 10+/-3 days post-discharge. Primary endpoints determined at 30+/-7 days (T4) and 90-180 days (T5) post-discharge were ED attendance, readmission and all-cause mortality. Composite endpoints included (i) ED attendance, readmission or all-cause mortality, and (ii) ED attendance or readmission. Data were evaluated by logistic regression analysis with results expressed as odds ratios (OR’s) with 95% confidence intervals (CI’s). Results Both composite endpoints (i) and (ii) were significantly reduced in the combined DI arms versus controls (adjusted OR=0.68 [95%CI 0.46-0.99], p<0.05; adjusted OR = 0.65 [95%CI 0.44-0.96], p=0.03 respectively). Composite endpoint (i) was also significantly reduced in the pharmacist-delivered DI arm versus controls at T5 (adjusted OR=0.59 [95%CI 0.37-0.94], p=0.03). ED attendance was significantly reduced at T4 in the physician-delivered DI arm versus controls (adjusted OR=0.53 [95%CI 0.28-0.98], p<0.05). We found no significant endpoint differences between the two DI arms. Conclusion Implementing clinically relevant STOPP/STARTv3 inappropriate prescribing criteria and Stockley’s® DDI recommendations reduced adverse clinical outcomes in older multimorbid patients with polypharmacy.
背景:患有多种疾病和多种药物的老年患者会出现过多的药物不良反应,导致频繁的急诊(ED)就诊,计划外再入院和死亡率增加。通过STOPP/START标准和药物-药物相互作用(DDI)避免实施药物优化策略可以减轻这些不良临床结果。方法基于STOPP/STARTv3标准和Stockley®DDI检查仪设计综合药物优化明确干预(DI),并在3所大型大学医院进行随机临床试验。我们纳入了636例老年患者(平均年龄为80.3岁,49.5%为女性),这些患者在2023-24年间急性住院,患有≥3种慢性疾病且每天服用≥5种药物。患者被随机分为标准药学护理组(n=217)、医生提供di组(n=210)和药剂师提供di组(n=209)。对于DI患者,在入院和出院前向高级主治医生提供书面和口头的药物优化建议。在出院后10+/-3天,与di臂患者的全科医生进一步讨论优先STOPP/STARTv3/Stockley®DDI用药建议。出院后30+/-7天(T4)和90-180天(T5)确定的主要终点是急诊就诊、再入院和全因死亡率。复合终点包括(i)急诊科出勤、再入院或全因死亡率,以及(ii)急诊科出勤或再入院。数据通过逻辑回归分析进行评估,结果以比值比(OR’s)和95%置信区间(CI’s)表示。结果与对照组相比,联合DI组的复合终点(i)和(ii)均显著降低(调整OR=0.68 [95%CI 0.46-0.99], p<0.05;调整OR= 0.65 [95%CI 0.44-0.96], p=0.03)。与对照组相比,在T5时,药剂师给药的DI组的综合终点(i)也显著降低(调整后OR=0.59 [95%CI 0.37-0.94], p=0.03)。与对照组相比,医生提供的DI组在T4时ED出勤率显著降低(调整后OR=0.53 [95%CI 0.28-0.98], p<0.05)。我们发现两个DI组之间没有显著的终点差异。结论实施临床相关的STOPP/STARTv3不适当的处方标准和Stockley®DDI建议可减少老年多病多药患者的不良临床结果。
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引用次数: 0
An Audit Of Fall Risk Screening, Using The 3 Key Questions, In Physiotherapy Initial Assessment Documentation In Primary Care 在初级保健的物理治疗初始评估文件中,使用3个关键问题对跌倒风险筛查的审计
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.060
Anita Hayes, Edel Tierney, Sarah McMahon, Lynne O'Keeffe, Lucy Curtayne, Marie Lydon, Olwyn Hanley
Background Falls and fall-related injuries are the most common reportable incident in the HSE. The World Guidelines for Falls Prevention (Montero-Odasso et al 2022) highlight the importance of opportunistic case finding. They recommend that clinicians ask all older adults the 3 Key Questions (3KQ) annually. The questions are: 1: “Have you fallen in the past 12 months”, 2: “Do you feel unsteady when standing or walking?” and 3: “Do you worry about falling”. Tools, like the 3KQ, that assess multiple fall risk factors are more sensitive at predicting risk. This helps identify more older adults at intermediate or high risk of falls with a goal of primary/secondary prevention of falls. The aim of this audit was to evaluate the inclusion and documentation of opportunistic case finding using the 3KQ in initial physiotherapy assessments for adults 65 years and over. Methods Physiotherapy initial assessment documentation for patients 65 years and over across 6 Primary Care teams were audited. The standard was opportunistic case finding as per the World Guidelines for Falls Prevention. The criterion was: All adults 65 years and older should be asked the 3KQ. If they answer yes to any of the questions, they should be assessed for falls risk severity and referred for tailored interventions. Results 60 charts were audited. There was 70% compliance for Question 1, 36.7% compliance for Question 2 and 23.3% compliance for Question 3. 66.7% included detail of follow-up actions and clinical decisions based on responses to the questions that were asked. Conclusion Primary care physiotherapists do not routinely ask the 3KQ during an initial assessment. Interventions post audit include: inclusion of the 3KQ on physiotherapy assessment forms; a copy of the World Fall Guidelines Risk Stratification Algorithm displayed in treatment rooms; and guidance for staff on where to refer patients for further assessment/intervention if required.
在HSE中,跌倒和跌倒相关伤害是最常见的报告事件。《世界预防跌倒指南》(Montero-Odasso et al 2022)强调了机会性病例发现的重要性。他们建议临床医生每年向所有老年人询问3个关键问题(3KQ)。这些问题包括:1:“你在过去的12个月里跌倒过吗?”2:“你在站立或行走时是否感到不稳?”3:“你是否担心摔倒?”像3KQ这样评估多种跌倒风险因素的工具在预测风险方面更为敏感。这有助于识别更多处于中等或高度跌倒风险的老年人,并以一级/二级预防跌倒为目标。本次审核的目的是评估在65岁及以上成人的初始物理治疗评估中使用3KQ的机会性病例发现的纳入和记录。方法对6个初级保健小组65岁及以上患者的物理治疗初始评估文件进行审核。这个标准是根据世界预防跌倒指南发现的机会性病例。标准是:所有65岁及以上的成年人都应该被问及3KQ。如果他们对任何一个问题的回答是肯定的,他们应该被评估跌倒风险的严重程度,并转介进行量身定制的干预。结果共审核60张图表。问题1的依从性为70%,问题2的依从性为36.7%,问题3的依从性为23.3%。66.7%包括基于对所问问题的回答的随访行动和临床决策的细节。结论:初级保健物理治疗师在初始评估时不会例行询问3KQ。审核后的干预措施包括:将3KQ纳入物理治疗评估表格;在治疗室展示的《世界跌倒指南风险分层算法》副本;并指导工作人员在需要时将患者转介到何处进行进一步评估/干预。
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引用次数: 0
Patient’s experience of using a communal dining space in Tymon North Rehabilitation Unit: A Pilot Project 病人使用泰蒙北康复中心公共用餐空间的经验:一个试点项目
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.046
Eimear Duffy, Molly Curtis, Sinead Feehan
Background The ‘Mealtimes Matter’ framework and best practice guidelines (BPGs) emphasise the importance of providing adequate mealtime assistance, a pleasant dining environment, and shared mealtimes for older adults in institutionalised settings. A ‘Mealtimes Matter’ audit completed in Tymon North showed poor compliance with the provision of mealtime assistance to patients. The study aims were to pilot a communal dining room initiative in order to better align with BPGs, and to assess patients’ experience of the dining room. Methods Data was collected over three weeks in May 2024. Patients were invited to attend the dining room each day. Mealtime observations were completed by the dietetic therapy assistant. Qualitative data on patient’s experience were collected in a separate interview and analysed by a dietitian. Results In total, 26 patients attended the dining room during the study period and 16 patients provided feedback. The mean age was 81 years old (range 63 – 91 years); 62% of attendees were female (n=16). Two main themes emerged from the qualitative data: the significance of the social aspect of dining, and the impact of environment and ambience on mealtime experience. Almost all patients (94%) reported enjoying eating in the company of others, describing the dining room atmosphere as ‘good’ or ‘very good’. Most patients (82%) expressed preference for communal dining. All attendees reported receiving adequate mealtime assistance in the dining room, whilst only 64% reported having enough help when eating in their room. One-third (35%) of patients reported disliking eating in their bedrooms, citing reasons such as loneliness and inadequate assistance. Conclusion The introduction of a communal dining room in Tymon North allowed better alignment with BPGs by supporting the provision of adequate mealtime assistance, a pleasant dining environment and shared mealtimes for patients.
“用餐时间很重要”框架和最佳实践指南(bpg)强调了为制度化环境中的老年人提供充足的用餐时间协助、愉快的用餐环境和共享用餐时间的重要性。在Tymon North完成的一项“用餐时间问题”审计显示,对患者提供的用餐时间援助的遵守情况很差。这项研究的目的是试点一个公共餐厅的倡议,以便更好地与bpg保持一致,并评估患者对餐厅的体验。方法于2024年5月进行为期3周的数据采集。病人每天都被邀请到餐厅用餐。用餐时间观察由饮食治疗助理完成。在单独的访谈中收集了患者体验的定性数据,并由营养师进行了分析。结果研究期间共有26例患者到餐厅就餐,16例患者提供反馈。平均年龄81岁(63 ~ 91岁);62%的参与者是女性(n=16)。定性数据中出现了两个主要主题:用餐社交方面的重要性,以及环境和氛围对用餐体验的影响。几乎所有的患者(94%)都表示喜欢和别人一起吃饭,并称餐厅的气氛“好”或“非常好”。大多数患者(82%)表示更喜欢公共用餐。所有与会者都表示在餐厅用餐时得到了足够的帮助,而只有64%的人表示在自己的房间用餐时得到了足够的帮助。三分之一(35%)的患者报告说,他们不喜欢在卧室里吃饭,理由是孤独和缺乏帮助。Tymon North的公共餐厅的引入通过支持提供充足的用餐时间协助、愉快的用餐环境和患者共享用餐时间,从而更好地与bpg保持一致。
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引用次数: 0
Complex Co-Morbidities in Nursing Home Residents: Hospital Admissions and Outcomes 疗养院居民的复杂合并症:住院率和结果
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.186
Claire Noonan, Cherhasna Rampaul, Josephine Soh
Background Nursing home residents (NHRs) are a medically complex and vulnerable population. Despite often presenting to emergency departments (EDs) with seemingly straightforward complaints, their underlying health issues frequently reveal significant medical, psychological, and social complexities. This underscores the need for comprehensive and specialised geriatric care. Methods This retrospective study examined hospital admissions of NHRs over a six-month period (June–December 2024) at a University Teaching Hospital. Key variables included admission diagnoses, Charlson Comorbidity Index (CCI) scores, and mortality outcomes. Results Of 312 NHRs who presented to the ED, 63.8% (n=199) were admitted. Among these, 68.3% (n=136) were admitted under geriatric services, while 31.7% (n=63) were managed by other specialties. Overall, 88% (n=175) of admitted residents had a CCI score ≥5, indicating high medical complexity. This figure rose to 91% among those under geriatric care, compared to 84% in other services. The average length of stay was 8 days. Upon discharge, 80% (n=109) had two or more diagnoses, and 25% had four or more. Common discharge diagnoses included lower respiratory tract infections (n=56), falls (n=36), acute kidney injury (n=33), urinary tract infections (n=30), aspiration pneumonia (n=29), and constipation (n=20). The in-hospital mortality rate was 8.8% (n=12), with a three-month post-discharge mortality rate of 15% (n=19). Dementia was present in 47% of admitted residents, and 9% had mild cognitive impairment. Delirium occurred in 25% of cases. Conclusion Nursing home residents admitted to hospital present with high levels of medical complexity and multiple co-morbidities, contributing to significant morbidity and mortality. These findings highlight the urgent need for enhanced, multidisciplinary acute geriatric care models to better address the complex needs of this population and improve clinical outcomes.
疗养院居民是一个医学复杂的弱势群体。尽管经常出现在急诊科(ed)看似直截了当的抱怨,他们潜在的健康问题往往揭示了重大的医疗,心理和社会复杂性。这强调了全面和专门的老年护理的必要性。方法回顾性分析某大学附属教学医院6个月(2024年6月- 12月)的住院病例。关键变量包括入院诊断、Charlson合并症指数(CCI)评分和死亡率结果。结果312例就诊于急诊科的nhr中,63.8% (n=199)住院。其中68.3% (n=136)属于老年科,31.7% (n=63)属于其他专科。总体而言,88% (n=175)住院居民CCI评分≥5,表明医疗复杂性高。在接受老年护理的人中,这一数字上升到91%,而在其他服务中,这一数字为84%。平均住院时间为8天。出院时,80% (n=109)有2种或以上诊断,25%有4种或以上诊断。常见的出院诊断包括下呼吸道感染(56例)、跌倒(36例)、急性肾损伤(33例)、尿路感染(30例)、吸入性肺炎(29例)和便秘(20例)。住院死亡率为8.8% (n=12),出院后3个月死亡率为15% (n=19)。47%的住院病人有痴呆,9%有轻度认知障碍。25%的病例出现谵妄。结论疗养院住院居民医疗复杂性高,合并症多,发病率和死亡率高。这些发现强调迫切需要加强,多学科急性老年护理模式,以更好地解决这一人群的复杂需求和改善临床结果。
{"title":"Complex Co-Morbidities in Nursing Home Residents: Hospital Admissions and Outcomes","authors":"Claire Noonan, Cherhasna Rampaul, Josephine Soh","doi":"10.1093/ageing/afaf318.186","DOIUrl":"https://doi.org/10.1093/ageing/afaf318.186","url":null,"abstract":"Background Nursing home residents (NHRs) are a medically complex and vulnerable population. Despite often presenting to emergency departments (EDs) with seemingly straightforward complaints, their underlying health issues frequently reveal significant medical, psychological, and social complexities. This underscores the need for comprehensive and specialised geriatric care. Methods This retrospective study examined hospital admissions of NHRs over a six-month period (June–December 2024) at a University Teaching Hospital. Key variables included admission diagnoses, Charlson Comorbidity Index (CCI) scores, and mortality outcomes. Results Of 312 NHRs who presented to the ED, 63.8% (n=199) were admitted. Among these, 68.3% (n=136) were admitted under geriatric services, while 31.7% (n=63) were managed by other specialties. Overall, 88% (n=175) of admitted residents had a CCI score ≥5, indicating high medical complexity. This figure rose to 91% among those under geriatric care, compared to 84% in other services. The average length of stay was 8 days. Upon discharge, 80% (n=109) had two or more diagnoses, and 25% had four or more. Common discharge diagnoses included lower respiratory tract infections (n=56), falls (n=36), acute kidney injury (n=33), urinary tract infections (n=30), aspiration pneumonia (n=29), and constipation (n=20). The in-hospital mortality rate was 8.8% (n=12), with a three-month post-discharge mortality rate of 15% (n=19). Dementia was present in 47% of admitted residents, and 9% had mild cognitive impairment. Delirium occurred in 25% of cases. Conclusion Nursing home residents admitted to hospital present with high levels of medical complexity and multiple co-morbidities, contributing to significant morbidity and mortality. These findings highlight the urgent need for enhanced, multidisciplinary acute geriatric care models to better address the complex needs of this population and improve clinical outcomes.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"33 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incontinence, Frailty and Care Needs in Community-Dwelling Older Adults: Findings from an ICPOP Community Specialist Team 社区居住老年人的尿失禁、虚弱和护理需求:来自ICPOP社区专家团队的调查结果
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.037
Aidan Stankard, Fiona Mulligan, Anna Healy, Emily Buckley, Alison Murphy, Amy Phillips, Caoimhe Reilly, Caroline Curran, Caroline Fox, Deirdre McNally, Elizabeth Hancock, Jodie Keating, Linda Davidson Lee, Maeve Doyle, Neasa Malone, Niamh McDonagh, Nicola Gibbons, Róisín Lyons, Aoife Fallon, Paul McElwaine
Background Incontinence is a common condition among older adults and has been linked to adverse outcomes such as falls, infections, psychological distress, functional decline, institutionalisation, and caregiver burden. Despite its clinical significance, the impact of incontinence among community-dwelling older adults in Ireland remains poorly characterised. This study aimed to evaluate and compare the clinical characteristics and care-related outcomes of older adults with incontinence with those who are continent, using data from comprehensive geriatric assessments (CGA) conducted by an Integrated Care Programme for Older Persons (ICPOP) community specialist team (CST). Methods This was a retrospective cross-sectional study involving older adults who underwent CGA over a six-month period. Data was collected on continence status, demographic and clinical characteristics, functional ability, and caregiver involvement. Emergency department presentations and hospital admissions within 90 days of CGA were recorded. Incontinence was defined as the presence of either urinary or bowel incontinence. Statistical analysis was performed using STATA v18.0. Results Of the 146 participants, 76 (52%) were classified as incontinent. Compared to continent individuals, those with incontinence had significantly lower Barthel scores (median 85 vs 95, p &lt; 0.001) and higher levels of frailty (median CFS 6 vs 5, p &lt; 0.001). Incontinence was significantly associated with the presence of a carer (p = 0.012). No significant differences were observed in age, acute care utilisation, or socioeconomic indicators. Conclusion Incontinence was highly prevalent in this cohort and associated with greater frailty, functional dependence, and increased presence of caregivers. These findings highlight the need for early identification and proactive management of incontinence, and for investment in multidisciplinary supports. Efforts should also recognise and support the essential role of both formal and informal caregivers in enabling older adults with incontinence to remain living at home safely and with dignity.
背景:尿失禁是老年人的常见病,与跌倒、感染、心理困扰、功能下降、住院和照顾者负担等不良后果有关。尽管它的临床意义,尿失禁的影响在社区居住的老年人在爱尔兰仍然很差的特征。本研究旨在评估和比较失禁老年人和失禁老年人的临床特征和护理相关结果,使用由老年人综合护理计划(ICPOP)社区专家团队(CST)进行的综合老年病学评估(CGA)的数据。方法:这是一项回顾性横断面研究,涉及6个月以上接受CGA的老年人。收集有关失禁状况、人口学和临床特征、功能能力和护理人员参与的数据。记录CGA 90天内的急诊科报告和住院情况。尿失禁被定义为存在尿失禁或肠失禁。使用STATA v18.0进行统计分析。结果146例患者中,76例(52%)为尿失禁。与尿失禁个体相比,尿失禁患者的Barthel评分明显较低(中位85比95,p < 0.001),虚弱程度较高(中位CFS为6比5,p < 0.001)。尿失禁与护理人员的存在显著相关(p = 0.012)。在年龄、急性护理利用或社会经济指标方面没有观察到显著差异。结论:尿失禁在该队列中非常普遍,并与更大的虚弱、功能依赖和护理人员的增加有关。这些发现强调了早期识别和主动管理尿失禁的必要性,以及对多学科支持的投资。还应努力承认和支持正式和非正式护理人员在使失禁的老年人能够安全和有尊严地在家中生活方面发挥的重要作用。
{"title":"Incontinence, Frailty and Care Needs in Community-Dwelling Older Adults: Findings from an ICPOP Community Specialist Team","authors":"Aidan Stankard, Fiona Mulligan, Anna Healy, Emily Buckley, Alison Murphy, Amy Phillips, Caoimhe Reilly, Caroline Curran, Caroline Fox, Deirdre McNally, Elizabeth Hancock, Jodie Keating, Linda Davidson Lee, Maeve Doyle, Neasa Malone, Niamh McDonagh, Nicola Gibbons, Róisín Lyons, Aoife Fallon, Paul McElwaine","doi":"10.1093/ageing/afaf318.037","DOIUrl":"https://doi.org/10.1093/ageing/afaf318.037","url":null,"abstract":"Background Incontinence is a common condition among older adults and has been linked to adverse outcomes such as falls, infections, psychological distress, functional decline, institutionalisation, and caregiver burden. Despite its clinical significance, the impact of incontinence among community-dwelling older adults in Ireland remains poorly characterised. This study aimed to evaluate and compare the clinical characteristics and care-related outcomes of older adults with incontinence with those who are continent, using data from comprehensive geriatric assessments (CGA) conducted by an Integrated Care Programme for Older Persons (ICPOP) community specialist team (CST). Methods This was a retrospective cross-sectional study involving older adults who underwent CGA over a six-month period. Data was collected on continence status, demographic and clinical characteristics, functional ability, and caregiver involvement. Emergency department presentations and hospital admissions within 90 days of CGA were recorded. Incontinence was defined as the presence of either urinary or bowel incontinence. Statistical analysis was performed using STATA v18.0. Results Of the 146 participants, 76 (52%) were classified as incontinent. Compared to continent individuals, those with incontinence had significantly lower Barthel scores (median 85 vs 95, p &amp;lt; 0.001) and higher levels of frailty (median CFS 6 vs 5, p &amp;lt; 0.001). Incontinence was significantly associated with the presence of a carer (p = 0.012). No significant differences were observed in age, acute care utilisation, or socioeconomic indicators. Conclusion Incontinence was highly prevalent in this cohort and associated with greater frailty, functional dependence, and increased presence of caregivers. These findings highlight the need for early identification and proactive management of incontinence, and for investment in multidisciplinary supports. Efforts should also recognise and support the essential role of both formal and informal caregivers in enabling older adults with incontinence to remain living at home safely and with dignity.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"204 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Social and Demographic Factors in Shaping Frailty in Europe 社会和人口因素在欧洲脆弱性形成中的作用
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.036
Giulia Cavrini, Agostino Stavolo, Viviana Egidi, Román Romero-Ortuño
Background Using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE), this study aims to examine the prevalence and progression of frailty among older adults across Europe, explore regional disparities, and identify key sociodemographic and social factors, such as loneliness, social engagement, and family support, associated with frailty status. Methods A cross-sectional analysis of SHARE data from Waves 6 and 8 (release 9.0.0) was conducted, including non-institutionalised individuals aged 50 or older at both time points, across 17 European countries. Frailty was operationalised using variables defined by Santos-Eggimann (muscle weakness, exhaustion, unintentional weight loss, slowness, and low physical activity). One point was assigned for each criterion met, and participants were categorised as: Non-frail (0 points), Pre-frail (1-2 points), Frail (3-5 points). Adjusted Multilevel Multinomial Logistic regression models were then estimated for the frail and pre-frail groups, using the non-frail group as the reference category, to identify the explanatory factors that underlie individual and country-level effects, focusing on welfare characteristics as a country-level predictor of frailty. Results Significant differences in frailty prevalence were observed across countries. Multilevel multinomial logistic regression indicated that approximately 20% of the variability in frailty prevalence could be attributed to differences at the national level. Frailty and pre-frailty were more common among older adults, women, and individuals with lower educational attainment. Perceived loneliness and limited participation in social activities emerged as the most significant social variables associated with frailty. Notably, the poverty index accounted for about 8% of this between-country variability. Conclusion Our findings reveal substantial variability in frailty prevalence across European countries, where significantly higher rates of frailty and pre-frailty are observed in Southern Europe. These geographic disparities suggest that psychosocial and cultural factors, along with the structure and strength of national welfare characteristics, may play a critical role in influencing frailty outcomes.
本研究利用欧洲健康、老龄化和退休调查(SHARE)的数据,旨在研究欧洲老年人虚弱的患病率和进展,探索区域差异,并确定与虚弱状态相关的关键社会人口统计学和社会因素,如孤独、社会参与和家庭支持。方法对来自Waves 6和8 (release 9.0.0)的SHARE数据进行横断面分析,包括17个欧洲国家在两个时间点50岁或以上的非机构个体。虚弱的操作使用Santos-Eggimann定义的变量(肌肉无力、疲惫、意外体重减轻、行动迟缓和低体力活动)。每达到一个标准就得一分,参与者被分为:非虚弱(0分)、预虚弱(1-2分)、虚弱(3-5分)。然后,利用非体弱群体作为参考类别,对体弱和体弱前群体进行调整后的多水平多项Logistic回归模型估计,以确定个人和国家层面影响的解释因素,重点关注福利特征作为国家层面的虚弱预测因子。结果不同国家的虚弱患病率存在显著差异。多水平多项逻辑回归表明,大约20%的虚弱患病率变异可归因于国家层面的差异。在老年人、女性和受教育程度较低的人群中,虚弱和前虚弱更为常见。感知到的孤独和有限的社会活动参与成为与脆弱相关的最重要的社会变量。值得注意的是,贫困指数约占国家间差异的8%。结论:我们的研究结果揭示了欧洲国家虚弱患病率的巨大差异,南欧国家的虚弱和虚弱前患病率明显较高。这些地域差异表明,社会心理和文化因素,以及国家福利特征的结构和强度,可能在影响脆弱性结果方面发挥关键作用。
{"title":"The Role of Social and Demographic Factors in Shaping Frailty in Europe","authors":"Giulia Cavrini, Agostino Stavolo, Viviana Egidi, Román Romero-Ortuño","doi":"10.1093/ageing/afaf318.036","DOIUrl":"https://doi.org/10.1093/ageing/afaf318.036","url":null,"abstract":"Background Using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE), this study aims to examine the prevalence and progression of frailty among older adults across Europe, explore regional disparities, and identify key sociodemographic and social factors, such as loneliness, social engagement, and family support, associated with frailty status. Methods A cross-sectional analysis of SHARE data from Waves 6 and 8 (release 9.0.0) was conducted, including non-institutionalised individuals aged 50 or older at both time points, across 17 European countries. Frailty was operationalised using variables defined by Santos-Eggimann (muscle weakness, exhaustion, unintentional weight loss, slowness, and low physical activity). One point was assigned for each criterion met, and participants were categorised as: Non-frail (0 points), Pre-frail (1-2 points), Frail (3-5 points). Adjusted Multilevel Multinomial Logistic regression models were then estimated for the frail and pre-frail groups, using the non-frail group as the reference category, to identify the explanatory factors that underlie individual and country-level effects, focusing on welfare characteristics as a country-level predictor of frailty. Results Significant differences in frailty prevalence were observed across countries. Multilevel multinomial logistic regression indicated that approximately 20% of the variability in frailty prevalence could be attributed to differences at the national level. Frailty and pre-frailty were more common among older adults, women, and individuals with lower educational attainment. Perceived loneliness and limited participation in social activities emerged as the most significant social variables associated with frailty. Notably, the poverty index accounted for about 8% of this between-country variability. Conclusion Our findings reveal substantial variability in frailty prevalence across European countries, where significantly higher rates of frailty and pre-frailty are observed in Southern Europe. These geographic disparities suggest that psychosocial and cultural factors, along with the structure and strength of national welfare characteristics, may play a critical role in influencing frailty outcomes.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"15 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supporting Ageing at Home: Developing Ireland’s Home Care Workforce 支持家庭养老:发展爱尔兰的家庭护理队伍
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.161
Elizabeth Morrow, Mary Lynch, Edward Naessens, Carmel Kelly, Clodagh Killeen
Background As populations age, there is a growing global shift toward supporting older adults to live independently at home rather than in institutional settings. Health systeworldwide are grappling with how to deliver effective, person-centred home care while ensuring safety, sustainability, and workforce stability. A major barrier is the limited professional recognition, training opportunities, and career development available to home support workers, contributing to high staff turnover and persistent recruitment difficulties. In Ireland, these issues have created significant service backlogs, leaving thousands of older people waiting for essential home support. This scoping review examined international evidence and best practices to inform the development of a structured career pathway for Ireland’s home support workforce, aligned with training and system-wide workforce development priorities. Methods A scoping review was undertaken using Joanna Briggs Institute methodology, with structured searches across relevant databases and grey literature. Inclusion criteria and relevance grading were applied, and findings were thematically analysed using a “what works, for whom, when, and why” lens. Results The 261 included articles highlight the global significance of the issues. Four overarching themes were identified: 1) Attract and develop a competent and motivated workforce 2) Enhance working lives and retention 3) Utilise career pathways for quality and impact 4) Invest in data and digital for home care. Conclusion Based on the evidence, a Green Paper was developed proposing a safe, sustainable model for ageing in place. Following stakeholder consultation, which confirmed the proposals’ relevance, a White Paper was produced. It integrates feedback and presents recommendations grounded in the best available evidence and stakeholder input on advancing a career pathway for home support workers—targeted at providers, policymakers, educators, workers, clients, and family caregivers. Key aspects includes roles and responsibilities, career progression, training and development, quality careers and data analysis.
随着人口老龄化,全球越来越倾向于支持老年人在家中独立生活,而不是在机构中生活。世界各地的卫生系统正在努力解决如何提供有效的、以人为本的家庭护理,同时确保安全性、可持续性和劳动力稳定性。一个主要障碍是家庭支助工作人员的专业认识、培训机会和职业发展有限,造成工作人员高流失率和持续的征聘困难。在爱尔兰,这些问题造成了大量的服务积压,使成千上万的老年人等待必要的家庭支持。这项范围审查审查了国际证据和最佳实践,为爱尔兰家庭支持劳动力的结构化职业道路的发展提供信息,与培训和全系统劳动力发展优先事项保持一致。方法采用乔安娜布里格斯研究所的方法,对相关数据库和灰色文献进行结构化检索,进行范围综述。应用纳入标准和相关性分级,并使用“什么有效,对谁有效,何时有效,为什么有效”的镜头对研究结果进行主题分析。结果纳入的261篇文章突出了该问题的全球意义。确定了四个总体主题:1)吸引和发展一支有能力、有动力的员工队伍2)改善工作生活和留住员工3)利用职业道路提高质量和影响力4)投资于家庭护理的数据和数字。基于这些证据,制定了一份绿皮书,提出了一种安全、可持续的老龄化模式。在与利益相关者协商后,确认了这些建议的相关性,并制作了一份白皮书。它整合了反馈意见,并根据现有最佳证据和利益相关者的意见提出建议,以推进家庭支助工作者的职业发展道路,目标对象是提供者、政策制定者、教育工作者、工人、客户和家庭照顾者。关键方面包括角色和责任、职业发展、培训和发展、高质量职业和数据分析。
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引用次数: 0
Balancing Diet Quality and Environmental Impact in Self-Selected Diets of Older Adults in Ireland 平衡饮食质量和环境对爱尔兰老年人自选饮食的影响
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.201
Clarissa Leydon, Eithne Sexton, Janas Harrington
Background Shifting toward sustainable diets is a key strategy for addressing both climate change and public health challenges. However, many proposed sustainable diets rely on theoretical models that differ markedly from current eating habits and may overlook important trade-offs. This study aimed to identify self-selected eating patterns in older adults in Ireland that are both nutritionally adequate and environmentally favorable. Methods Dietary data were analysed from 1,860 free-living, older adults from a population-based cohort in the southwest of Ireland (2010–2011). Diet quality was assessed using the Mean Adequacy Ratio (MAR) and Mean Excess Ratio (MER). Environmental impact was estimated for each diet using greenhouse gas emissions (GHGE) and blue water use (BWU) indicators, based on life cycle assessment data from UK studies. Energy-adjusted multiple factor analysis, followed by hierarchical clustering identified dietary patterns with lower environmental impacts and higher nutritional quality. Results Four distinct dietary clusters were identified. One cluster, comprising 31% of the sample, had the highest micronutrient adequacy and moderate daily GHGE (6.3 kg CO₂-equivalent) and BWU (344 litres), making it the most nutritionally and environmentally balanced pattern. The cluster with the lowest environmental impact had the lowest nutritional quality. In contrast, the cluster with the highest GHGE (9.63 kg CO₂-equivalent/day) had the highest protein intake, with a greater proportion of participants meeting proposed higher protein targets important for preserving muscle mass and function. Conclusion One cluster had the highest nutritional quality and moderate environmental impacts, offering a promising compromise. While not the lowest in environmental burden, it highlights the potential to identify healthier, more sustainable diets grounded in existing eating behaviours. For older adults, dietary shifts that promote healthy ageing and advance environmental goals are more likely to succeed when grounded in realistic, culturally acceptable changes rather than idealised or prescriptive models that diverge from current practices.
向可持续饮食转变是应对气候变化和公共卫生挑战的一项关键战略。然而,许多提出的可持续饮食依赖于与当前饮食习惯明显不同的理论模型,可能忽略了重要的权衡。这项研究旨在确定爱尔兰老年人自我选择的饮食模式,既营养充足又有利于环境。方法对爱尔兰西南部(2010-2011年)1860名自由生活的老年人的饮食数据进行分析。采用平均充足比(MAR)和平均过剩比(MER)评价饲粮质量。根据英国研究的生命周期评估数据,使用温室气体排放(GHGE)和蓝水利用(BWU)指标估计每种饮食对环境的影响。通过能量调整后的多因素分析,确定了环境影响较小、营养质量较高的膳食模式。结果鉴定出4种不同的膳食群。其中一个集群(占样本的31%)具有最高的微量营养素充足性和中等的每日温室气体排放量(6.3 kg CO₂当量)和BWU(344升),使其成为营养和环境最平衡的模式。环境影响最小的群集营养质量最低。相比之下,温室气体排放量最高的群体(9.63 kg CO₂当量/天)的蛋白质摄入量最高,更大比例的参与者达到了对保持肌肉质量和功能重要的更高蛋白质目标。结论其中一个群体的营养质量最高,对环境的影响较小,是一个有希望的折衷方案。虽然不是环境负担最低的,但它强调了在现有饮食行为基础上确定更健康、更可持续饮食的潜力。对于老年人来说,促进健康老龄化和推进环境目标的饮食转变,如果以现实的、文化上可接受的变化为基础,而不是以偏离当前做法的理想化或规定性模式为基础,就更有可能取得成功。
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引用次数: 0
Proton pump inhibitors independently associated with an increased risk of falls in older Irish adults 质子泵抑制剂与爱尔兰老年人跌倒风险增加独立相关
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.035
Finlay Brennan, Aisling Carroll, Donal Fitzpatrick, Eamon Laird, Leanne Hoey, Catherine Hughes, JJ Strain, Anne Molloy, Helene McNulty, Conal Cunningham, Rosaleen Lannon, Kevin McCarroll
Background Recent studies have shown an association between PPI use and increased risk of falls. A meta-analysis of eight studies (n=367,068) identified a 27% increased falls risk in PPI users. Potential mechanisms include reduced gut absorption of calcium, magnesium and other nutrients, altered gut microbiome and possible effects on muscle function. We aimed to explore the association between PPI use and falls risk in older adults. Methods Participants were adults aged &gt;60 yrs from the TUDA study. Exclusion criteria were MMSE &lt;24, history of stroke and current or long-term steroid use. The relationship between PPI use and self- reported falls in the last year was explored in multinomial regression adjusting for age, sex, BMI, timed up and go (TUG), diabetes, vitamin D, serum B12, parathyroid hormone, depression, dizziness on standing, ischemic heart disease, MMSE, medications (antihypertensives, loop diuretics, NSAIDs, benzodiazepines, opioids, Z drugs). We also explored for an association in those with normal TUG (&lt;10 seconds) and in high dose PPI users versus non-users. Results 3701 participants, mean age 73.1, 68.8% female, 32.6% fallen in last year, 35.3% PPI users. PPI use was associated with an increased risk of falls before and after multivariate adjustment (OR 1.29 CI 1.11-1.50, P&lt;0.001). In a subsample (n=3059), high dose PPI users versus non-users had a greater risk of falls (OR 1.43, CI 1.17-1.75, p=0.0003). In those with normal TUG, the overall relationship remained significant (OR 1.34, CI 1.07-1.69, p=0.011) and also in high dose PPI users versus non-users (OR 1.89, CI 1.39-2.58, p&lt;0.0001). Conclusion Overall, PPI users had a 29% increased risk of falls independent of numerous factors and this remained significant in those without physical frailty. Furthermore, risk was greater risk in high dose PPI users. Future studies are needed to further explore this and the potential mechanisms.
最近的研究显示PPI的使用与跌倒风险增加之间存在关联。8项研究(n=367,068)的荟萃分析发现,PPI使用者的跌倒风险增加27%。潜在的机制包括肠道对钙、镁和其他营养物质的吸收减少,肠道微生物群的改变以及对肌肉功能的可能影响。我们的目的是探讨老年人使用PPI与跌倒风险之间的关系。方法参与者为年龄为&;gt;从TUDA研究开始的60年。排除标准为MMSE &;lt;24、中风史和目前或长期使用类固醇。使用PPI与去年自我报告跌倒之间的关系通过多项回归调整年龄、性别、BMI、timed up and go (TUG)、糖尿病、维生素D、血清B12、甲状旁腺激素、抑郁、站立头晕、缺血性心脏病、MMSE、药物(降压药、利尿剂、非甾体抗炎药、苯二氮平类药物、阿片类药物、Z类药物)进行了探讨。我们还探讨了正常TUG (<;10秒)和高剂量PPI使用者与非使用者之间的关联。结果3701名参与者,平均年龄73.1岁,女性68.8%,去年下降32.6%,PPI使用者占35.3%。多因素调整前后,PPI使用与跌倒风险增加相关(OR 1.29 CI 1.11-1.50, P<0.001)。在一个子样本(n=3059)中,高剂量PPI使用者与非使用者相比有更大的跌倒风险(OR 1.43, CI 1.17-1.75, p=0.0003)。在TUG正常的患者中,总体关系仍然显著(OR 1.34, CI 1.07-1.69, p=0.011),高剂量PPI使用者与非PPI使用者之间的关系也是如此(OR 1.89, CI 1.39-2.58, p amp;lt;0.0001)。总体而言,PPI使用者跌倒的风险增加了29%,独立于许多因素,这在那些没有身体虚弱的人中仍然很明显。此外,高剂量PPI使用者的风险更大。未来的研究需要进一步探讨这一点和潜在的机制。
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引用次数: 0
Healthcare Professional Perspectives of a Health Communication Passport for Stroke: An International UK and Ireland Survey 医疗保健专业人士对中风的健康沟通护照的看法:一项国际英国和爱尔兰调查
IF 6.7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-05 DOI: 10.1093/ageing/afaf318.041
Norma O' Leary, Helen Kelly
Background The Irish National Stroke Strategy 2022-2027 (HSE, 2022) has recommended the introduction of a patient held resource such as a ‘Stroke Passport’ to allow patients to keep clear and current records of health treatment and support throughout their rehabilitation. Given that a Stroke Passport can be categorised as a complex intervention, characterised by multiple interacting components and the need to modify established practices, it is crucial to explore current practices related to information provision across the stroke care continuum. Methods An online survey explored the opinions of healthcare professionals based in Ireland and the UK who worked in stroke care. Numerical data was analysed using descriptive and inferential statistics. Opinions and comments made by participants were analysed using Thematic Content Analysis based on the Theoretical Domains Framework. Results A total of 111 (64% Ireland; 36% United Kingdom (UK)) healthcare professionals completed the survey. The survey respondents identified the most common methods that stroke information was provided to patients across settings were verbal discussions, booklets, leaflets, and telephone calls. There was consensus that information should be provided at multiple care pathway timepoints. UK respondents indicated a significantly greater perceived satisfaction by patients and family/caregiver with current information provision compared to their Irish counterparts (p&lt;.001). Most participants stated that a Stroke Passport should ideally be provided in both digital and paper formats. Conclusion This survey provides important insights into current information provision practices of healthcare professionals working in the area of stroke. There was agreement about the importance of the provision of a standardised information resource, such as a Stroke Passport, to enhance stroke patient care. This ultimately has the potential to equip stroke patients in the active management of their healthcare.
爱尔兰国家中风战略2022-2027 (HSE, 2022)建议引入患者持有的资源,如“中风护照”,使患者在整个康复过程中保持清晰和最新的健康治疗和支持记录。鉴于卒中护照可归类为一种复杂的干预措施,其特点是具有多个相互作用的组成部分,并且需要修改现有的做法,因此探索与卒中护理连续体中信息提供相关的当前做法至关重要。方法一项在线调查探讨了在爱尔兰和英国从事中风护理的医疗保健专业人员的意见。数值数据采用描述统计和推理统计进行分析。使用基于理论领域框架的主题内容分析对参与者提出的意见和评论进行分析。结果共有111名卫生保健专业人员(爱尔兰占64%,英国占36%)完成了调查。调查对象确定,向患者提供中风信息的最常见方法是口头讨论、小册子、传单和电话。共识是,信息应在多个护理路径时间点提供。英国受访者表示,与爱尔兰同行相比,患者和家属/护理人员对当前信息提供的满意度明显更高(p<.001)。大多数与会者表示,笔划护照最好以数码和纸张两种格式提供。结论:本调查对当前卒中医疗专业人员的信息提供实践提供了重要的见解。与会者一致认为,提供标准化信息资源(如卒中护照)对于加强卒中患者护理的重要性。这最终有可能使中风患者积极管理他们的医疗保健。
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Age and ageing
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