Zeitschrift fur Urologie und Nephrologie最新文献

In 3 out of 133 patients suffering from prostatic cancer and treated with depot estrogens a porphyria cutanea tarda was found after a follow-up ranging from few months to 10 years. Therefore, a defect of the uroporphyrinogen decarboxylase has been postulated. The therapy could be continued under small doses of chlorochin diphosphate.

In 236 own patients suffering from malignant testicular tumors a maldescensus testis was evaluated in childhood. Because of increased risk of cancer in maldescended testis attention should be paid also after successful orchiopexy.

In a prospective randomized study the efficiacy of physical therapy in female stress incontinence could be verified. The greatest success rate was achieved by medical gymnastics, whereas the perineal electrical stimulation should be used as supporting measure like a biofeedback mechanism because of its low effective intensity. Despite of the good therapeutic success (51.5%) with lasting effects no objective criteria to the use of physical therapy in female stress incontinence were found.

In nephrology in the GDR there are three data processing systems on 16-bit basis either in preparation or in use. 1. Data system nephrology - outpatient service 2. Individual dialysis/urea kinetics 3. Data system nephrology/dialysis (DSND). The latter system was developed in Schwerin and is available to all dialysis units. Data administration of constant patient groups and for complicated documentation methods can be rationalized by enlisting computer technology. This is also true for organisation and scientific studies, especially in cases where more than 50 dialysis patients are concerned. DSND offers a variable menue, which is prepared in dialogue and reveals over screen or printer clinical, dialysis-specific or Labdata and contains testprogrammes, warning and results. The requirements for kidney transplantation and EDTA reports are also taken into consideration.

It is reported on 7 patients after mumps orchitis. In 7 out of 9 affected testes an atrophy was found. Because of this high atrophy rate the current therapeutic measures are discussed and a systemic immunoglobulin prophylaxis and corticosteroid therapy is emphasized. As an orchitis prophylaxis the application of mumps immunoglobulin in males aged from 12 to 20 years with mumps exposition is postulated.

The Na-K-ATPase is the enzymatic basis of a energy-dependent transport of sodium and potassium through the cell membrane and is therefore of importance to the survival of organs during periods of decreased energy supply. In the present paper the influence of various preservation solutions on the activity of this enzyme was examined. It was shown that Na-K-ATPase activity in rat kidneys did remain unchanged after 48 hour preservation in various preservation solutions (Bretschneider, Ross, Collins, Sacks, Belzer). Therefore, its estimation is no valuable for evaluation of preservation solutions.

Application of OKT-3 as rescue therapy in steroid-resistant rejection was effective in 7 out of 9 patients early after cadaveric kidney transplantation. Under attention of instructions for use of OKT-3 the adverse first-dose reactions are rare. The problem of OKT-3 therapy is early use and its reuse.

The shortage of donor kidneys is the main cause of the even insufficient supply of patients suffering from end stage renal disease. In 1987 a transplant coordinator to the districts Berlin, Frankfurt and Potsdam with 3.1 Mio inhabitants was introduced. The functions of the coordinator and the approach to organ procurement are described in detail. In comparison with 1986 the number of explanted kidneys could doubled in 1988 (68 vs 143). The number of 46.3 explanted kidneys per million inhabitants is comparable with other areas or countries with excellent organ procurement system.

In a retrospective study two patient groups suffering from recurrent calcium oxalate lithiasis are compared before and after antirheumatic therapy using Diclofenac-Natrium alone or in combination with xanthine oxidase inhibitors and/or hydrochlorothiazides. The examination of concentration and excretion of lithogenic important parameters show a partly significant reduction of the concentration mean values of calcium, oxalic acid and uric acid. The influence of non-steroidal antiphlogistics (NSAP) on calculus recurrence rate in calcium oxalate lithiasis is recognized.