Onengiyeofori Ibama, D. Onwuli, A. Ben-Chioma, F. E. Konne, E. O. Nwachuku
{"title":"Comparative Effects of Sildenafil Citrate and Revive Capsule on Some Liver and Kidney Parameters in Male Albino Rats","authors":"Onengiyeofori Ibama, D. Onwuli, A. Ben-Chioma, F. E. Konne, E. O. Nwachuku","doi":"10.5099/aj210400148","DOIUrl":"https://doi.org/10.5099/aj210400148","url":null,"abstract":"","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81465407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. K. Ajeigbe, Tewogbade Adeoye Adedeji, O. Ajose, O. Jeje, O. S. Smith, Medinat B. Bello, Oluwabori E. Olukoyejo, O. J. Jokanola, R. Makinde, Ifeoluwa H. Ojelabi, Olufunke O. Odun-Afolabi, Ogra V. Ogra
{"title":"Pattern and Sero-prevalence of Covid-19 Screening among Patients in a Tertiary Hospital, South-western Nigeria","authors":"A. K. Ajeigbe, Tewogbade Adeoye Adedeji, O. Ajose, O. Jeje, O. S. Smith, Medinat B. Bello, Oluwabori E. Olukoyejo, O. J. Jokanola, R. Makinde, Ifeoluwa H. Ojelabi, Olufunke O. Odun-Afolabi, Ogra V. Ogra","doi":"10.5099/aj210400184","DOIUrl":"https://doi.org/10.5099/aj210400184","url":null,"abstract":"","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90902998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Delta Plus variant of COVID-19: Will it be the worst nightmare in the SARS-CoV-2 pandemic?","authors":"B. Roy, Harekrishna Roy","doi":"10.3126/JBS.V8I1.38449","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38449","url":null,"abstract":"No abstract available.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87903080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: SARS-CoV-2 is an RNA virus that undergoes mutation producing a variety of strains. Mutagens include UV radiation, metals, and endogenous components of organisms. Each strain is specific in terms of virulence, immune response in the body and efficacy of the vaccines. Conclusion: Researchers need to gather data and collaborate with global organizations to learn about the newly evolving strains. Information about the mutations and variants are inevitable in understanding virus transmission and developing vaccines to end the COVID-19 pandemic.
{"title":"Global variants of COVID-19: Current understanding","authors":"B. Roy, J. Dhillon, N. Habib, B. Pugazhandhi","doi":"10.3126/JBS.V8I1.38453","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38453","url":null,"abstract":"Background: SARS-CoV-2 is an RNA virus that undergoes mutation producing a variety of strains. Mutagens include UV radiation, metals, and endogenous components of organisms. Each strain is specific in terms of virulence, immune response in the body and efficacy of the vaccines. \u0000Conclusion: Researchers need to gather data and collaborate with global organizations to learn about the newly evolving strains. Information about the mutations and variants are inevitable in understanding virus transmission and developing vaccines to end the COVID-19 pandemic.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78968434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Viral infections and saliva as a potential diagnostic tool","authors":"O. Osadolor, A. Osadolor, O. Osadolor","doi":"10.3126/JBS.V8I1.38451","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38451","url":null,"abstract":"No abstract available.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79062813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The international situation surrounding the COVID-19 pandemic is seeing multiple countries battle various waves of the SARS-CoV-2 virus infections, with millions of individuals being infected globally. COVID-19 cases initially involved the immuno-compromised and elderly. As the virus has infected millions globally, the demographic profile of cases has shifted with more children being infected; this increase in younger individuals contracting the infection has resulted in new symptoms with altered manifestations and presentations of the disease in the young. In comparison to the severe symptoms of COVID-19 in adults children present with a more trivial group of symptoms. The majority of children develop mild symptoms or remain asymptomatic. This is in stark contrast to adults who have a higher admission rate with severe symptoms. A sign of great importance and now incidence in pediatric cases with COVID-19 is that of the gastrointestinal tract. The virus has a tropism for the GIT due to the presence of ACE2 receptors, which facilitate the entry of the virus into the cell. Conclusion: It is now established that the GIT symptoms form part of a newly recognized multisystem inflammatory syndrome (MIS-C) which occurs as a result and or manifestation of the COVID-19 infection. The innate difficulty in correctly and accurately diagnosing such a case is that the symptoms very close mimic gastroenteritis and acute abdominal pathologies. Therefore, physicians need to be aware of the various manners in which the COVID-19 infection manifests itself in children to diagnose better and isolate the cases.
{"title":"Gastrointestinal manifestations as early symptoms to diagnose COVID-19 paediatric cases","authors":"J. Robinson, I. Banerjee, Alexandra Leclézio","doi":"10.3126/JBS.V8I1.38452","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38452","url":null,"abstract":"Background: The international situation surrounding the COVID-19 pandemic is seeing multiple countries battle various waves of the SARS-CoV-2 virus infections, with millions of individuals being infected globally. COVID-19 cases initially involved the immuno-compromised and elderly. As the virus has infected millions globally, the demographic profile of cases has shifted with more children being infected; this increase in younger individuals contracting the infection has resulted in new symptoms with altered manifestations and presentations of the disease in the young. In comparison to the severe symptoms of COVID-19 in adults children present with a more trivial group of symptoms. The majority of children develop mild symptoms or remain asymptomatic. This is in stark contrast to adults who have a higher admission rate with severe symptoms. A sign of great importance and now incidence in pediatric cases with COVID-19 is that of the gastrointestinal tract. The virus has a tropism for the GIT due to the presence of ACE2 receptors, which facilitate the entry of the virus into the cell. \u0000Conclusion: It is now established that the GIT symptoms form part of a newly recognized multisystem inflammatory syndrome (MIS-C) which occurs as a result and or manifestation of the COVID-19 infection. The innate difficulty in correctly and accurately diagnosing such a case is that the symptoms very close mimic gastroenteritis and acute abdominal pathologies. Therefore, physicians need to be aware of the various manners in which the COVID-19 infection manifests itself in children to diagnose better and isolate the cases. ","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87779536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Various medical subjects pose a daunting task to students. Chief amongst which the subject’s students grapple with is pharmacology. The study’s primary objective was to find out the second professional medical student’s preferences, feedback, and attitude towards pharmacology textbooks at SSR Medical College, Mauritius. Methods: This cross-sectional questionnaire-based observational survey was conducted from May 2018- June 2018 at Seewoosagur Ramgoolam Medical College, Mauritius. A Chi-square test was performed to find out correlations between variables. p < 0.05 was considered as statistically significant. Results: A total of 192 medical students participated in the study out of 210 students, giving an overall response rate of 91.42%. 103 (35.6%) students chosen Essentials of Medical Pharmacology- K.D. Tripathi as a first preference, followed by 59 (30.7%) students selected Pharmacology for Medical Students- Tara V Shanbhag and Smita Shenoy as a second preference, and 22 (11.5%) chosen Medical Pharmacology- Padmaja Udaykumar as a third preference. Conclusion: The textbook Essentials of Medical Pharmacology by K.D. Tripathi is the most popular and most preferred textbook, closely seconded by Pharmacology for Medical Students by Tara V Shanbhag and Smita Shenoy and followed by Medical Pharmacology by Padmaja Udaykumar, the third in the list of the most preferred textbook. The shortcomings of textbooks, such as the innate lack of the ability to cultivate interest in common diseases which are prevalent in the home country of the students, as well as the lack to inspire students to do further reading into research articles and studies, clearly showcases the disconnect that exists between publishers, authors and users.
背景:各种各样的医学科目对学生来说是一项艰巨的任务。这门课的学生们最纠结的是药理学。本研究的主要目的是了解毛里求斯SSR医学院第二名医学生对药理学教科书的偏好、反馈和态度。方法:这项基于横断面问卷的观察性调查于2018年5月至2018年6月在毛里求斯Seewoosagur Ramgoolam医学院进行。进行卡方检验以找出变量之间的相关性。P < 0.05为差异有统计学意义。结果:210名医学生中，共有192名医学生参与研究，总回复率为91.42%。103名(35.6%)学生选择《医学药理学基础——K.D. Tripathi》作为第一选择，其次是59名(30.7%)学生选择《医学生药理学——Tara V Shanbhag和Smita Shenoy》作为第二选择，22名(11.5%)学生选择《医学药理学——Padmaja Udaykumar》作为第三选择。结论:K.D. Tripathi的《医学药理学要领》是最受欢迎和最受欢迎的教科书，Tara V Shanbhag和Smita Shenoy的《医学生药理学》紧随其后，Padmaja Udaykumar的《医学药理学》在最受欢迎的教科书中排名第三。教科书的缺点，例如天生缺乏培养学生对本国普遍存在的常见病的兴趣的能力，以及缺乏激励学生进一步阅读研究文章和研究的能力，清楚地显示了出版商、作者和用户之间存在的脱节。
{"title":"An insight of medical student’s preference and opinions to Pharmacology textbooks","authors":"I. Banerjee, J. Robinson, A. Annavarapu, R. Gupta","doi":"10.3126/JBS.V8I1.38458","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38458","url":null,"abstract":"Background: Various medical subjects pose a daunting task to students. Chief amongst which the subject’s students grapple with is pharmacology. The study’s primary objective was to find out the second professional medical student’s preferences, feedback, and attitude towards pharmacology textbooks at SSR Medical College, Mauritius. \u0000Methods: This cross-sectional questionnaire-based observational survey was conducted from May 2018- June 2018 at Seewoosagur Ramgoolam Medical College, Mauritius. A Chi-square test was performed to find out correlations between variables. p < 0.05 was considered as statistically significant. \u0000Results: A total of 192 medical students participated in the study out of 210 students, giving an overall response rate of 91.42%. 103 (35.6%) students chosen Essentials of Medical Pharmacology- K.D. Tripathi as a first preference, followed by 59 (30.7%) students selected Pharmacology for Medical Students- Tara V Shanbhag and Smita Shenoy as a second preference, and 22 (11.5%) chosen Medical Pharmacology- Padmaja Udaykumar as a third preference. \u0000Conclusion: The textbook Essentials of Medical Pharmacology by K.D. Tripathi is the most popular and most preferred textbook, closely seconded by Pharmacology for Medical Students by Tara V Shanbhag and Smita Shenoy and followed by Medical Pharmacology by Padmaja Udaykumar, the third in the list of the most preferred textbook. The shortcomings of textbooks, such as the innate lack of the ability to cultivate interest in common diseases which are prevalent in the home country of the students, as well as the lack to inspire students to do further reading into research articles and studies, clearly showcases the disconnect that exists between publishers, authors and users.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76714507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Pandey, D. Panday, P. Pyakurel, S. Marahatta, SP Rimal, M. Dali, R. Gyawali, Rambha Sigdel, N. Bhattarai, N. Limbu, G. Rauniar
Background: COVID-19, a global health crisis of the 21st century, has threatened possibly every aspect of human life. Since the pandemic is not yet over, this study was carried out among undergraduate students of a medical institute in Nepal to assess and boost their KAP status on the disease. Material and methods: It was an online cross-sectional census survey performed among consenting undergraduate healthcare students of BPKIHS. A self-made and validated questionnaire assessing KAP on COVID-19 was prepared in Google form and distributed online among target students. The study population was 745. Both descriptive and inferential analysis of the data was performed. Student’s T-Test and one-way ANOVA were applied for which level of statistical significance was kept at p<0.05. Results: Ninety-six students participated in a pilot-study (Cronbach α= 0.792). The response rate was 76.27%. Most participants (76.76%) were from Nepal. The male/female ratio was 0.76. Most (59.2%) had not participated in such studies before. For 93.54%, the source of information was the internet. Assessed by questionnaire, right Knowledge (n=16) was 85.06% ± 8.81%; right Attitude (n=6) was 65.00% ± 16.16 and right Practice (n=6) was 82.88%± 8.50%. Male were more knowledgeable about the disease (p=0.011). However, females secured higher in practical aspects (p=0.000). Indian students possessed better knowledge (p=0.005) and a better attitude (p=0.033). MBBS students had better knowledge (p=0.000), but Nursing students secured higher in Practice (p=0.012). Attitude is better in the earlier years (p=0.045). Conclusion: We assessed KAP related to COVID-19 via score among healthcare undergraduate students. Different co-factors do impact students’ overall KAP status.
{"title":"Knowledge, attitude, and practice on COVID-19 among undergraduate students of B. P. Koirala Institute of Health Sciences, Dharan, Nepal: An online cross-sectional survey","authors":"K. Pandey, D. Panday, P. Pyakurel, S. Marahatta, SP Rimal, M. Dali, R. Gyawali, Rambha Sigdel, N. Bhattarai, N. Limbu, G. Rauniar","doi":"10.3126/JBS.V8I1.38457","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38457","url":null,"abstract":"Background: COVID-19, a global health crisis of the 21st century, has threatened possibly every aspect of human life. Since the pandemic is not yet over, this study was carried out among undergraduate students of a medical institute in Nepal to assess and boost their KAP status on the disease. \u0000Material and methods: It was an online cross-sectional census survey performed among consenting undergraduate healthcare students of BPKIHS. A self-made and validated questionnaire assessing KAP on COVID-19 was prepared in Google form and distributed online among target students. The study population was 745. Both descriptive and inferential analysis of the data was performed. Student’s T-Test and one-way ANOVA were applied for which level of statistical significance was kept at p<0.05. \u0000Results: Ninety-six students participated in a pilot-study (Cronbach α= 0.792). The response rate was 76.27%. Most participants (76.76%) were from Nepal. The male/female ratio was 0.76. Most (59.2%) had not participated in such studies before. For 93.54%, the source of information was the internet. Assessed by questionnaire, right Knowledge (n=16) was 85.06% ± 8.81%; right Attitude (n=6) was 65.00% ± 16.16 and right Practice (n=6) was 82.88%± 8.50%. Male were more knowledgeable about the disease (p=0.011). However, females secured higher in practical aspects (p=0.000). Indian students possessed better knowledge (p=0.005) and a better attitude (p=0.033). MBBS students had better knowledge (p=0.000), but Nursing students secured higher in Practice (p=0.012). Attitude is better in the earlier years (p=0.045). \u0000Conclusion: We assessed KAP related to COVID-19 via score among healthcare undergraduate students. Different co-factors do impact students’ overall KAP status.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75059151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Global emergence of SARS-CoV-2 surfaced neurological complications amongst the patients. COVID-19 resembles with other coronavirus strains follows a trend of neurological complication, damage and encephalopathy, which entails considerable risks, requires attention for the neurologists. This is, to our knowledge, the first systematic review of the literature to investigate solely to elucidate the seizure spectrum by unfolding epileptogenicity of the SARS CoV-2 and potential pathways of neuroinvasion. Methods: A systematic literature search was performed in PubMed and Embase database following standard guidelines, using specific keywords based on epileptic seizure onset described from December 01, 2019, to July 17, 2020 Results: A total of 17 studies were included ranging from case reports, series of cases, multicentre cross-sectional study with the first-time onset of seizure associated with an epileptic origin. We excavated causes of complex COVID-19 related neurological manifestations, e.g., cerebrovascular diseases, encephalitis, demyelinating lesions, cytokine storm and proposed routes of SARS-CoV-2 entry into the nervous system to understand the mechanism of an epileptic seizure. Conclusion: COVID-19 is a potent neuropathogen which causes the new onset of epileptic seizures should get diagnostic recognition to evade possible deterioration of neurological conditions. However, more shreds of evidence from the future will further elucidate the epileptogenic potential of the pandemic.
{"title":"Epileptic seizures in patients with COVID-19: A systematic review of early evidences","authors":"B. Roy, I. Banerjee","doi":"10.3126/JBS.V8I1.38459","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38459","url":null,"abstract":"Background: Global emergence of SARS-CoV-2 surfaced neurological complications amongst the patients. COVID-19 resembles with other coronavirus strains follows a trend of neurological complication, damage and encephalopathy, which entails considerable risks, requires attention for the neurologists. This is, to our knowledge, the first systematic review of the literature to investigate solely to elucidate the seizure spectrum by unfolding epileptogenicity of the SARS CoV-2 and potential pathways of neuroinvasion. \u0000Methods: A systematic literature search was performed in PubMed and Embase database following standard guidelines, using specific keywords based on epileptic seizure onset described from December 01, 2019, to July 17, 2020 \u0000Results: A total of 17 studies were included ranging from case reports, series of cases, multicentre cross-sectional study with the first-time onset of seizure associated with an epileptic origin. We excavated causes of complex COVID-19 related neurological manifestations, e.g., cerebrovascular diseases, encephalitis, demyelinating lesions, cytokine storm and proposed routes of SARS-CoV-2 entry into the nervous system to understand the mechanism of an epileptic seizure. \u0000Conclusion: COVID-19 is a potent neuropathogen which causes the new onset of epileptic seizures should get diagnostic recognition to evade possible deterioration of neurological conditions. However, more shreds of evidence from the future will further elucidate the epileptogenic potential of the pandemic.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76464622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Robinson, I. Banerjee, B. Roy, Alexandra Leclézio
Background: Pegylated Interferon Alpha-2b is synthesized via the use of PEG (polyethylene glycol). It is formulated via attaching a 12kDa mono methoxy polyethylene glycol moiety to the recombinant human Interferon Alpha-2b protein. Pegylated Interferon Alpha-2b acts via binding to the (JAK/STAT) Janus kinase signal transducer and activator of the transcription interferon receptor. The Pegylated Interferon Alpha-2b /Virafin binds to the (IFNAR1/2) alpha interferon receptor 1 and 2. Pegylated Interferon Alpha-2b better known as Virafin has been approved by the Drugs Controller General of India. This therapeutic agent is currently under a multicentric phase 3 trial with very promising results being reported. A single subcutaneous dose of Virafin has been shown to decrease the need for oxygen therapy in patients. This reduction in the need for oxygen therapy is a vital factor needed to provide relief to the Indian medical system in light of the recent oxygen shortages faced due to India’s worst wave of COVID-19 cases since the onset of the global pandemic. Pegylated Interferon Alpha-2b/ Virafin confers enhanced viral clearance and bolsters the immune response to induce a quicker recovery in patients with mild to moderate symptoms. Conclusion: It is of paramount importance that further research on Virafin is undertaken as it can hinder the progression of COVID-19, reduce pressure on the inundated health systems, and save countless lives.
{"title":"Novel drug for COVID-19: Virafin a therapeutic breakthrough","authors":"J. Robinson, I. Banerjee, B. Roy, Alexandra Leclézio","doi":"10.3126/JBS.V8I1.38456","DOIUrl":"https://doi.org/10.3126/JBS.V8I1.38456","url":null,"abstract":"Background: Pegylated Interferon Alpha-2b is synthesized via the use of PEG (polyethylene glycol). It is formulated via attaching a 12kDa mono methoxy polyethylene glycol moiety to the recombinant human Interferon Alpha-2b protein. Pegylated Interferon Alpha-2b acts via binding to the (JAK/STAT) Janus kinase signal transducer and activator of the transcription interferon receptor. The Pegylated Interferon Alpha-2b /Virafin binds to the (IFNAR1/2) alpha interferon receptor 1 and 2. Pegylated Interferon Alpha-2b better known as Virafin has been approved by the Drugs Controller General of India. This therapeutic agent is currently under a multicentric phase 3 trial with very promising results being reported. A single subcutaneous dose of Virafin has been shown to decrease the need for oxygen therapy in patients. This reduction in the need for oxygen therapy is a vital factor needed to provide relief to the Indian medical system in light of the recent oxygen shortages faced due to India’s worst wave of COVID-19 cases since the onset of the global pandemic. Pegylated Interferon Alpha-2b/ Virafin confers enhanced viral clearance and bolsters the immune response to induce a quicker recovery in patients with mild to moderate symptoms. \u0000Conclusion: It is of paramount importance that further research on Virafin is undertaken as it can hinder the progression of COVID-19, reduce pressure on the inundated health systems, and save countless lives.","PeriodicalId":7690,"journal":{"name":"American Journal of Biomedical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79875730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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