Pub Date : 2020-01-01DOI: 10.21767/2321-547X.8.1.33
Jyoti Rawat
The blood–brain barrier (BBB) is made out of cerebrum endothelial cells, pericytes, and astrocytes, which assemble a tight cell obstruction. Restorative (macro)molecules can't travel through the BBB in their free structure. This constraint is skirted by apolipoprotein E (ApoE)âÂÂfunctionalized polymeric nanoparticles (NPs) that can move drugs (e.g., dalargin, loperamide, doxorubicin, and nerve development factor) over the BBB by means of low density lipoprotein (LDL) receptorâÂÂmediated transcytosis. Covering with polysorbate 80 or poloxamer 188 encourages ApoE adsorption onto polymeric NPs empowering acknowledgment by LDL receptors of cerebrum endothelial cells. This impact is even upgraded when NPs are legitimately covered with ApoE without surfactant grapple. Also, covalent coupling of ApoE to NPs that bear receptive gatherings on their surface prompts altogether improved cerebrum take-up while keeping away from the utilization of surfactants. In this Progress Report a few in vitro BBB models utilizing mind endothelial cells or cocultures with astrocytes/pericytes/glioma cells are portrayed, which give bits of knowledge in regards to the capacity of a m
{"title":"Functionalization of Polymeric Nanoparticles for Drug Delivery Across the BloodâBrain Barrier","authors":"Jyoti Rawat","doi":"10.21767/2321-547X.8.1.33","DOIUrl":"https://doi.org/10.21767/2321-547X.8.1.33","url":null,"abstract":"The blood–brain barrier (BBB) is made out of cerebrum endothelial cells, pericytes, and astrocytes, which assemble a tight cell obstruction. Restorative (macro)molecules can't travel through the BBB in their free structure. This constraint is skirted by apolipoprotein E (ApoE)âÂÂfunctionalized polymeric nanoparticles (NPs) that can move drugs (e.g., dalargin, loperamide, doxorubicin, and nerve development factor) over the BBB by means of low density lipoprotein (LDL) receptorâÂÂmediated transcytosis. Covering with polysorbate 80 or poloxamer 188 encourages ApoE adsorption onto polymeric NPs empowering acknowledgment by LDL receptors of cerebrum endothelial cells. This impact is even upgraded when NPs are legitimately covered with ApoE without surfactant grapple. Also, covalent coupling of ApoE to NPs that bear receptive gatherings on their surface prompts altogether improved cerebrum take-up while keeping away from the utilization of surfactants. In this Progress Report a few in vitro BBB models utilizing mind endothelial cells or cocultures with astrocytes/pericytes/glioma cells are portrayed, which give bits of knowledge in regards to the capacity of a m","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85819673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.21767/2321-547X.8.1.34
Jyoti Rawat
The A steroid is a sort of natural exacerbate that contains a features plan of four cycloalkane rings that are joined to one another. Steroid biosynthesis is an anabolic metabolic pathway that produces steroids from basic forerunners. Steroid, any of a class of regular or engineered natural mixes portrayed by a sub-atomic structure of 17 carbon particles orchestrated in four rings. Steroids are significant in science, science, and medication
{"title":"Steroidal molecules as swiftly acting therapeutics","authors":"Jyoti Rawat","doi":"10.21767/2321-547X.8.1.34","DOIUrl":"https://doi.org/10.21767/2321-547X.8.1.34","url":null,"abstract":"The A steroid is a sort of natural exacerbate that contains a features plan of four cycloalkane rings that are joined to one another. Steroid biosynthesis is an anabolic metabolic pathway that produces steroids from basic forerunners. Steroid, any of a class of regular or engineered natural mixes portrayed by a sub-atomic structure of 17 carbon particles orchestrated in four rings. Steroids are significant in science, science, and medication","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76605687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.21767/2321-547X.8.1.30
Koffi
{"title":"Development and Evaluation of a Shea Butter Based Cream Containing Essential Oils from the Leaves of Ocimum gratissimum Lamiaceae), a Plant with Antifungal Activity","authors":"Koffi","doi":"10.21767/2321-547X.8.1.30","DOIUrl":"https://doi.org/10.21767/2321-547X.8.1.30","url":null,"abstract":"","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"14 21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80670799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.36648/2321-547X.8.1.31
I. Ali, M. Suhail, Mohd Fazil, B. Ahmad, A. Sayeed, Mohd Farooq Naqshb, A. Azam
All around the world, the percentage of deaths due to cancer is continuously increasing-the greatest devastation of deaths. Among all medications, Unani medicines are boon for human beings to treat cancer with no or least side effects. About 80% rural population use natural products for primary health care. Cuscuta reflexa Roxb. (family Cuscutaceae) is utilized in traditional medicines for curing cancer and other diseases, and it is considered as the most significant plant in the Unani medicinal system. The extracts of Cuscuta reflexa Roxb. were obtained to measure the anticancer activity with H-1299 and MCF-7 cancer cell lines. Soxhlet extraction was utilized for stem and seeds. The anticancer activity of fractions of each extract obtained by using Flash chromatography was also checked. Besides, the antioxidant activity of each fraction was also checked. DNA binding study supported the results obtained during whole process. The cellular death was detected utilizing ELISA. The results indicated that extracts of Cuscuta reflexa Roxb. exhibited strong anticancer activities as compared to the fractions of each extract. Cuscuta reflexa Roxb. extracts indicated noteworthy cytotoxicity against human H-1299 and (lung cancer) MCF-7 cancer cells (breast cancer). The extract of this plant may be given to the patients having lung cancer and breast cancer.
{"title":"Anti-cancer and Anti-oxidant Potencies of Cuscuta reflexa Roxb. Plant Extracts","authors":"I. Ali, M. Suhail, Mohd Fazil, B. Ahmad, A. Sayeed, Mohd Farooq Naqshb, A. Azam","doi":"10.36648/2321-547X.8.1.31","DOIUrl":"https://doi.org/10.36648/2321-547X.8.1.31","url":null,"abstract":"All around the world, the percentage of deaths due to cancer is continuously increasing-the greatest devastation of deaths. Among all medications, Unani medicines are boon for human beings to treat cancer with no or least side effects. About 80% rural population use natural products for primary health care. Cuscuta reflexa Roxb. (family Cuscutaceae) is utilized in traditional medicines for curing cancer and other diseases, and it is considered as the most significant plant in the Unani medicinal system. The extracts of Cuscuta reflexa Roxb. were obtained to measure the anticancer activity with H-1299 and MCF-7 cancer cell lines. Soxhlet extraction was utilized for stem and seeds. The anticancer activity of fractions of each extract obtained by using Flash chromatography was also checked. Besides, the antioxidant activity of each fraction was also checked. DNA binding study supported the results obtained during whole process. The cellular death was detected utilizing ELISA. The results indicated that extracts of Cuscuta reflexa Roxb. exhibited strong anticancer activities as compared to the fractions of each extract. Cuscuta reflexa Roxb. extracts indicated noteworthy cytotoxicity against human H-1299 and (lung cancer) MCF-7 cancer cells (breast cancer). The extract of this plant may be given to the patients having lung cancer and breast cancer.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87387679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2321-547X.1000021
L. Hendricks, R. Ashmore, Samuel K. Bore
Flakka, a new designer drug, is surging in popularity. The name comes from la flaca, a Spanish club-slang term for a beautiful skinny girl. This latest illegal substance of abuse is likened to other synthetic cathinone drugs popularly called “bath salts” and takes the form of a pink or white foul-smelling crystal that can be eaten, mixed in drinks, snorted, injected, vaporized, and some have even used it like a suppository. The khat plant found in the Middle East and Somalia is the source of natural cathinones; there, leaves are chewed on to gain a sense of euphoria2,3. Vaporization is also a craze, using the fairly new e-cigarettes, where inhalation increases the immediacy to the blood stream. The U.S. National Institute on Drug Abuse has warned that smoking Flakka not only sends the drug very quickly into the bloodstream, it makes it particularly easy to overdose4. Poison control centers in states including Florida, Alabama, Mississippi, and Texas are responding to an increasing number of incidents involving it5. The lone active ingredient, alpha-PVP, is a stimulant that was developed in the 60s.
{"title":"Flakka: A Designer Drug with Deadly Consequences","authors":"L. Hendricks, R. Ashmore, Samuel K. Bore","doi":"10.21767/2321-547X.1000021","DOIUrl":"https://doi.org/10.21767/2321-547X.1000021","url":null,"abstract":"Flakka, a new designer drug, is surging in popularity. The name comes from la flaca, a Spanish club-slang term for a beautiful skinny girl. This latest illegal substance of abuse is likened to other synthetic cathinone drugs popularly called “bath salts” and takes the form of a pink or white foul-smelling crystal that can be eaten, mixed in drinks, snorted, injected, vaporized, and some have even used it like a suppository. The khat plant found in the Middle East and Somalia is the source of natural cathinones; there, leaves are chewed on to gain a sense of euphoria2,3. Vaporization is also a craze, using the fairly new e-cigarettes, where inhalation increases the immediacy to the blood stream. The U.S. National Institute on Drug Abuse has warned that smoking Flakka not only sends the drug very quickly into the bloodstream, it makes it particularly easy to overdose4. Poison control centers in states including Florida, Alabama, Mississippi, and Texas are responding to an increasing number of incidents involving it5. The lone active ingredient, alpha-PVP, is a stimulant that was developed in the 60s.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88018654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2321-547X.1000029
Lana Alsharkas, Vijayaraj Kumar Palanirajan, Y. Wei
Clostridium difficile is a species of gram-positive bacteria thought to infect patients with weakened immune response resulting in colitis. Oral vancomycin hydrochloride is given four times a day to treat Clostridium difficile colitis and is commercially available in the form of capsule and solution. Patient’s compliance is the main issue in this treatment due to the multiple dosing frequencies. Accordingly, replacement of such dose regimen with a once daily dosage will enhance patient compliance. In this study, mucoadhesive vancomycin hydrochloride tablets were prepared with the use of chitosan to exert a local effect in the colon. Sustained release property was also imparted by chitosan. Enteric coating with Eudragit® S 100 was applied to prevent the sticking of chitosan tablets in the stomach and small intestine and deliver the tablets intact to the colon. The prepared tablets were evaluated for In vitro drug release for 24 hours and compared with the marketed formulation. The formulation was found to release in a sustained manner in pH 7.4 buffer allowing the colon delivered oral vancomycin hydrochloride to be a promising formulation in the development of a once daily treatment for Clostridium difficile colitis.
{"title":"Preparation and In vitro Evaluation of Enteric Coated Oral Vancomycin Hydrochloride Sustained Release Formulation with Mucoadhesive Properties","authors":"Lana Alsharkas, Vijayaraj Kumar Palanirajan, Y. Wei","doi":"10.21767/2321-547X.1000029","DOIUrl":"https://doi.org/10.21767/2321-547X.1000029","url":null,"abstract":"Clostridium difficile is a species of gram-positive bacteria thought to infect patients with weakened immune response resulting in colitis. Oral vancomycin hydrochloride is given four times a day to treat Clostridium difficile colitis and is commercially available in the form of capsule and solution. Patient’s compliance is the main issue in this treatment due to the multiple dosing frequencies. Accordingly, replacement of such dose regimen with a once daily dosage will enhance patient compliance. In this study, mucoadhesive vancomycin hydrochloride tablets were prepared with the use of chitosan to exert a local effect in the colon. Sustained release property was also imparted by chitosan. Enteric coating with Eudragit® S 100 was applied to prevent the sticking of chitosan tablets in the stomach and small intestine and deliver the tablets intact to the colon. The prepared tablets were evaluated for In vitro drug release for 24 hours and compared with the marketed formulation. The formulation was found to release in a sustained manner in pH 7.4 buffer allowing the colon delivered oral vancomycin hydrochloride to be a promising formulation in the development of a once daily treatment for Clostridium difficile colitis.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73560763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2321-547X.1000027
Akriti Nepala, Sufia Yasmeenb, Fahad Akhtarc, Nirmala Kojua, Qu Aina, Cao Teng-Lia, Zhang Xiu-Xiua, Li Qinga, Chen Ding-Dinga
Heart failure (HF) is the ultimate trail anteceded by different genetics and categorized by impaired cardiac remodeling where heart chambers gradually expand and contractile function declines. Apoptosis is a well-thought-out system that gestures cells to self-destruct for cell renewal or to switch abnormal cell growth. The stability of cardiomyocytes is acknowledged using an essential method for the advancement of HF. Apoptosis possibly will remain in control on behalf of a substantial quantity of cardiomyocytes death in the sequence of acute myocardial infarction (MI) as well as advanced damage of persisting cells among the failing hearts. Indicating that distinctive apoptosis and the prospective ability knows how to remain lured in cardiomyocytes next to the investigational circumstances of beneficial mediation to inhibit apoptosis remnants as notorious. Promisingly apoptosis shows a starring protagonist in the reperfusion of tissue impairment, which has prophylactic, pathological and useful inferences. Numerous studies concluded that the progression of HF along with the apoptotic inhibitor is cardio protective and can prevent HF. This review article aims to deliberate lessons mainly to identify potential therapeutic targets in the cardiac muscles, as well as mechanisms of apoptosis in MI which is primarily intended for the upcoming treatment and inhibition of HF.
{"title":"A Critical Therapeutic Target to Inhibit Apoptosisin Relevant Heart Failure: An Overview","authors":"Akriti Nepala, Sufia Yasmeenb, Fahad Akhtarc, Nirmala Kojua, Qu Aina, Cao Teng-Lia, Zhang Xiu-Xiua, Li Qinga, Chen Ding-Dinga","doi":"10.21767/2321-547X.1000027","DOIUrl":"https://doi.org/10.21767/2321-547X.1000027","url":null,"abstract":"Heart failure (HF) is the ultimate trail anteceded by different genetics and categorized by impaired cardiac remodeling where heart chambers gradually expand and contractile function declines. Apoptosis is a well-thought-out system that gestures cells to self-destruct for cell renewal or to switch abnormal cell growth. The stability of cardiomyocytes is acknowledged using an essential method for the advancement of HF. Apoptosis possibly will remain in control on behalf of a substantial quantity of cardiomyocytes death in the sequence of acute myocardial infarction (MI) as well as advanced damage of persisting cells among the failing hearts. Indicating that distinctive apoptosis and the prospective ability knows how to remain lured in cardiomyocytes next to the investigational circumstances of beneficial mediation to inhibit apoptosis remnants as notorious. Promisingly apoptosis shows a starring protagonist in the reperfusion of tissue impairment, which has prophylactic, pathological and useful inferences. Numerous studies concluded that the progression of HF along with the apoptotic inhibitor is cardio protective and can prevent HF. This review article aims to deliberate lessons mainly to identify potential therapeutic targets in the cardiac muscles, as well as mechanisms of apoptosis in MI which is primarily intended for the upcoming treatment and inhibition of HF.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89373242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite recent breakthroughs in melanoma treatment with anti-PD-1 immunotherapy, innovative approaches are needed to improve off-target effects. In this study, we report a T cell mimetic microparticle delivery of soluble PD1 aiming at providing a carrier substrate for future combinatorial and targeting efforts. Microparticles of sizes varying from (5 μm to-7 μm) were conjugated with soluble mouse or human PD-1 through nearly irreversible binding between streptavidin and biotin. PD-1 conjugated microparticles (PDMPs) suppressed 3-dimensional tumor growth of human A375 and mouse B16-F10 melanoma cells compared to control microparticles conjugated with the Fc portion of human IgG1 (IgG1MPs). This can be attributed to competitive inhibition by PDMPs on a melanoma cell-intrinsic PD-1/PD-L1 pathway. A single, local administration of mPDMPs in a B16-F10 mouse melanoma model inhibited tumor growth significantly compared to control IgMPs at the same dose. CD45+ immune cells were found to infiltrate tumors treated with mPDMPs as a mechanism for tumor control. These results collectively suggest that PDMPs can target the melanoma cell-intrinsic PD-1/PD-L1 pathway and that these artificial T cell mimetics can be the scaffold for further improvements in anti-tumor immunotherapy.
{"title":"Artificial T Cell Mimetics to Combat Melanoma Tumor Growth.","authors":"Shilpaa Mukundan, Dongli Guan, Amy Singleton, Yunlong Yang, Matthew Li, Biju Parekkadan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite recent breakthroughs in melanoma treatment with anti-PD-1 immunotherapy, innovative approaches are needed to improve off-target effects. In this study, we report a T cell mimetic microparticle delivery of soluble PD1 aiming at providing a carrier substrate for future combinatorial and targeting efforts. Microparticles of sizes varying from (5 μm to-7 μm) were conjugated with soluble mouse or human PD-1 through nearly irreversible binding between streptavidin and biotin. PD-1 conjugated microparticles (PDMPs) suppressed 3-dimensional tumor growth of human A375 and mouse B16-F10 melanoma cells compared to control microparticles conjugated with the Fc portion of human IgG1 (IgG1MPs). This can be attributed to competitive inhibition by PDMPs on a melanoma cell-intrinsic PD-1/PD-L1 pathway. A single, local administration of mPDMPs in a B16-F10 mouse melanoma model inhibited tumor growth significantly compared to control IgMPs at the same dose. CD45+ immune cells were found to infiltrate tumors treated with mPDMPs as a mechanism for tumor control. These results collectively suggest that PDMPs can target the melanoma cell-intrinsic PD-1/PD-L1 pathway and that these artificial T cell mimetics can be the scaffold for further improvements in anti-tumor immunotherapy.</p>","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"6 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126372/pdf/nihms-983472.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36476270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2321-547X.1000022
N. L. Patil, H. Mahajan
The main objective of the study was to utilize potential of nanostructured lipid carriers of the quercetin for direct nose to brain delivery of drug as tool for the targeted delivery. The aim of this study was to prepare and characterize quercetin loaded NLC and to study its brain distribution. Novel QUE-NLCs were formulated. NLC Formulation was evaluated for various physicochemical properties such as particle size, zeta potential, drug loading, percent entrapment efficiency, morphology, in vitro drug release, and histopathology. The size of the QUE-NLC was about 118.2nm with poly dispersity index of 0.220 and zeta potential of -20.1 mV. Nose to brain distribution studies were performed using wistar rats.QUE-NLC exhibited sustained delivery of drug. Significant targeting to brain was achieved when compare to quercetin.The result showed that NLCs might be the promising approach for the nose to brain delivery of quercetin.
{"title":"Quercetin Loaded Nanostructured Lipid Carriers for Nose to Brain Delivery: In Vitro and In Vivo Studies","authors":"N. L. Patil, H. Mahajan","doi":"10.21767/2321-547X.1000022","DOIUrl":"https://doi.org/10.21767/2321-547X.1000022","url":null,"abstract":"The main objective of the study was to utilize potential of nanostructured lipid carriers of the quercetin for direct nose to brain delivery of drug as tool for the targeted delivery. The aim of this study was to prepare and characterize quercetin loaded NLC and to study its brain distribution. Novel QUE-NLCs were formulated. NLC Formulation was evaluated for various physicochemical properties such as particle size, zeta potential, drug loading, percent entrapment efficiency, morphology, in vitro drug release, and histopathology. The size of the QUE-NLC was about 118.2nm with poly dispersity index of 0.220 and zeta potential of -20.1 mV. Nose to brain distribution studies were performed using wistar rats.QUE-NLC exhibited sustained delivery of drug. Significant targeting to brain was achieved when compare to quercetin.The result showed that NLCs might be the promising approach for the nose to brain delivery of quercetin.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76145303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2321-547X.1000028
A. Salem, H. A. Hussein, Y. Gomaa, F. Allam
Progesterone (P4) and vitamin E (Vitamin E) are important in early stage of pregnancy especially in young does. The goal was to investigate effect of injection of P4, Vitamin E and their integration on pregnancy enhancement, embryo dimensions and P4 concentration in young does. 24 animals were divided into 4 equal groups: control group, P4 group (each doe was injected i.m with single dose of 1.0 mg long-acting P4 two days post-mating), Vitamin E group (each doe was injected i.m with 20 IU Vitamin E/kg BW every 3 days from mating to mid-pregnancy and P4+Vitamin E group. All does were ultrasono-graphically examined at days 7,10,12,14,16,18,20 and 22 of pregnancy. Results revealed that P4 and P4+Vitamin E treatment facilitated establishment of pregnancy on day 7 of pregnancy more than the control and Vitamin E alone. Amniotic vesicles diameters on day 12 and fetal length on days 14 and 16 were greater (P<0.05) in P4 and P4+Vitamin E groups. On days 18-22, fetus length was significantly larger in P4 group. P4 concentrations at first week and mid-pregnancy were significantly greater in P4 group followed by P4+Vitamin E. Conclusion: P4 and P4+Vitamin E enhanced the early stage of pregnancy during the first parity of rabbit does.
{"title":"Effect of Progesterone with Vitamin E on Pregnancy in Young Rabbit Does","authors":"A. Salem, H. A. Hussein, Y. Gomaa, F. Allam","doi":"10.21767/2321-547X.1000028","DOIUrl":"https://doi.org/10.21767/2321-547X.1000028","url":null,"abstract":"Progesterone (P4) and vitamin E (Vitamin E) are important in early stage of pregnancy especially in young does. The goal was to investigate effect of injection of P4, Vitamin E and their integration on pregnancy enhancement, embryo dimensions and P4 concentration in young does. 24 animals were divided into 4 equal groups: control group, P4 group (each doe was injected i.m with single dose of 1.0 mg long-acting P4 two days post-mating), Vitamin E group (each doe was injected i.m with 20 IU Vitamin E/kg BW every 3 days from mating to mid-pregnancy and P4+Vitamin E group. All does were ultrasono-graphically examined at days 7,10,12,14,16,18,20 and 22 of pregnancy. Results revealed that P4 and P4+Vitamin E treatment facilitated establishment of pregnancy on day 7 of pregnancy more than the control and Vitamin E alone. Amniotic vesicles diameters on day 12 and fetal length on days 14 and 16 were greater (P<0.05) in P4 and P4+Vitamin E groups. On days 18-22, fetus length was significantly larger in P4 group. P4 concentrations at first week and mid-pregnancy were significantly greater in P4 group followed by P4+Vitamin E. Conclusion: P4 and P4+Vitamin E enhanced the early stage of pregnancy during the first parity of rabbit does.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87972629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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