Alcohol最新文献_第7页

Circulating microRNAs and alcohol consumption in the multiethnic cohort study 多种族队列研究中的循环microrna与酒精消耗

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2025-01-27 DOI: 10.1016/j.alcohol.2025.01.007

Nicholas Acuna , Song-Yi Park , David V. Conti , Mariana C. Stern , Anna H. Wu , Iona Cheng , Lynne R. Wilkens , Xiao-Ou Shu , Veronica Wendy Setiawan

Excessive alcohol consumption is a significant public health concern and contributes to liver diseases and cancer. Modifiable lifestyle factors including alcohol consumption can influence circulating microRNAs (miRNAs), which are increasingly used as biomarkers for early disease detection. Yet limited studies have identified miRNAs associated with alcohol intake, particularly in multiethnic populations. We aimed to assess the association of alcohol consumption and circulating miRNAs in the Multiethnic Cohort Study. Participants (N = 917) had alcohol consumption data collected at baseline and miRNA data collected at follow-up. Negative binomial models were used to assess the association between alcohol consumption (continuous and categorical [nondrinkers: 0 g of ethanol/day; light drinkers: <28 g of ethanol/day for men and <14 g of ethanol/day for women; and heavy drinkers: ≥28 g of ethanol/day for men and ≥14 g of ethanol/day for women]) and miRNAs. Stratified analyses also examined categories by sex, race/ethnicity, smoking status, and body mass index. Overall, there were 52% non-drinkers, 37 % light drinkers, and 11 % were heavy drinkers. We did not detect an association of miRNAs with alcohol intake in continuous models after correcting for multiple comparisons. However, we did find an inverse association for light drinkers [incidence rate ratio (IRR) = 0.59, p = 8.21E-04] and heavy drinkers (IRR = 0.44, p = 1.47E-03) compared to nondrinkers for miR-451a. Additionally, miR-320e (IRR = 0.63, p = 1.61E-03) had an inverse association with alcohol intake for light drinkers compared to nondrinkers. Subgroup analysis also suggested there were differences by subgroups, underscoring that miRNAs used to detect chronic diseases may be subgroup specific. When stratified by case-control status, we found that among controls both light and heavy drinkers were associated with miR-451a. We identified an association for light and heavy drinkers with miR-451a and mir-320e, miRNAs associated with cancers and liver diseases, in comparison to nondrinkers.

过度饮酒是一个重大的公共卫生问题，会导致肝脏疾病和癌症。包括饮酒在内的可改变的生活方式因素可以影响循环中的microrna (mirna)，而microrna越来越多地被用作早期疾病检测的生物标志物。然而，有限的研究已经确定了与酒精摄入相关的mirna，特别是在多种族人群中。我们的目的是在多种族队列研究中评估饮酒与循环mirna的关系。参与者（N = 917）在基线时收集酒精消耗数据，在随访时收集miRNA数据。使用负二项模型来评估酒精消耗（连续和分类）之间的关系[不饮酒者：0 g乙醇/天；光喝酒:

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引用次数: 0

Associations between sleep health, negative reinforcement learning, and alcohol use among South Florida college students with elevated internalizing symptoms 南佛罗里达州内化症状加重的大学生睡眠健康、负强化学习和饮酒之间的关系。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2024-04-27 DOI: 10.1016/j.alcohol.2024.04.006

Nathan A. Sollenberger, Logan R. Cummings, Josefina Freitag, Elisa M. Trucco, Sthefany Gomez, Melanie Giraldo, Gabriela Muse, Aaron T. Mattfeld, Dana L. McMakin

Negative reinforcement is proposed to mediate associations between sleep and alcohol use, especially among people with depression and/or anxiety symptoms. Worse sleep (e.g., shorter duration, less efficiency, more irregular timing) exacerbates negative emotions, which alcohol may temporarily relieve. Not yet examined, we propose sleep indirectly impacts early stages of alcohol use via differences in negative reinforcement learning (NRL), since sleep impacts emotion, reward response, and learning. The current study aimed to replicate associations between sleep and alcohol use, test associations with NRL, and examine indirect associations between sleep health and alcohol use via NRL among 60 underage college students (ages 18–20 years, 77% female) varying in depression and anxiety symptoms. Participants wore Fitbit smartwatches and completed daily diaries measuring sleep and substance use for ∼14 days before completing two computer tasks assessing social (SNRL) and monetary (MNRL) negative reinforcement learning. Robust generalized linear models tested direct associations within the proposed model. SNRL performance was positively associated with alcohol use, but no other associations were observed. Statistical mediation models failed to indicate indirect effects of sleep on alcohol use via SNRL or MNRL performance. Post-hoc exploratory models examining depression and anxiety symptoms as moderators of direct associations indicated several interactions. Positive associations between sleep timing variability and alcohol use were weakened at higher anxiety symptom severity and stronger at higher depression symptom severity. The positive association between SNRL performance and alcohol use was also stronger at higher depression symptom severity. Among students with elevated depression symptoms, variable sleep timing and stronger SNRL performance were independently associated with more alcohol use, but indirect effects were not supported. Future research should replicate findings, confirm causality of interactions, and examine sleep timing and behavioral responses to negative social stimuli as targets for improving alcohol-related outcomes among underage college students with elevated depressive symptoms.

负强化被认为是睡眠与饮酒之间的中介作用，尤其是在有抑郁和/或焦虑症状的人群中。较差的睡眠（如持续时间较短、效率较低、时间较不规律）会加剧负面情绪，而酒精可能会暂时缓解负面情绪。由于睡眠会影响情绪、奖赏反应和学习，因此我们认为睡眠会通过负强化学习（NRL）的差异间接影响饮酒的早期阶段。目前的研究旨在复制睡眠与饮酒之间的关联，测试与 NRL 的关联，并通过 NRL 检验睡眠健康与饮酒之间的间接关联，研究对象为 60 名未成年大学生（18-20 岁，77% 为女性），他们的抑郁和焦虑症状各不相同。参与者佩戴 Fitbit 智能手表，在完成两项评估社交（SNRL）和金钱（MNRL）负强化学习的计算机任务之前，每天填写睡眠和药物使用日记，为期 14 天。稳健的广义线性模型检验了拟议模型中的直接关联。SNRL成绩与饮酒呈正相关，但未观察到其他关联。统计中介模型未能显示睡眠通过SNRL或MNRL表现对饮酒的间接影响。事后探索性模型将抑郁和焦虑症状作为直接关联的调节因素进行了研究，结果表明两者之间存在若干相互作用。焦虑症状严重程度越高，睡眠时间变异性与饮酒之间的正相关就越弱，而抑郁症状严重程度越高，两者之间的正相关就越强。在抑郁症状严重程度较高的情况下，SNRL 表现与饮酒之间的正相关也较强。在抑郁症状较重的学生中，睡眠时间不稳定和SNRL表现较强与饮酒较多独立相关，但间接效应不成立。未来的研究应复制研究结果，确认相互作用的因果关系，并研究睡眠时间和对负面社会刺激的行为反应，以此作为改善抑郁症状加重的未成年大学生与酒精相关的结果的目标。

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引用次数: 0

Associations between sleep medication use and alcohol consumption over 36 years in Finnish twins 芬兰双胞胎在 36 年中使用睡眠药物与饮酒之间的关系

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2023-12-14 DOI: 10.1016/j.alcohol.2023.12.004

Viola Helaakoski , Stephanie Zellers , Christer Hublin , Hanna M. Ollila , Antti Latvala

Background

Sleep medication use is an indicator of underlying sleep problems that might be induced by various factors such as alcohol use. However, the longitudinal relationship between drinking and sleep problems remains poorly understood. We investigated associations between sleep medication and alcohol use throughout adulthood, and examined the role of familial and potential confounding factors contributing to these associations.

Methods

We used information of zygosity and self-report questionnaire data over a follow-up period of 36 years from the Older Finnish Twin Cohort (N = 13 851).

Results

Logistic regression analyses suggested consistent associations between sleep medication use and heavy/binge drinking at all four time points (OR range = 1.36–3.18, P < 0.05), implying that increased drinking is associated with increased sleep medication use over time. Cross-lagged path analyses suggested that moderate/heavy and binge drinking predict sleep medication use at most time points (OR range = 1.15–1.94, P < 0.05), whilst sleep medication use predicts subsequent abstaining from alcohol (OR range = 2.26–2.47, P < 0.05). Within-pair analyses implied that familial factors play a role, and quantitative genetic modelling estimated genetic factors to explain approximately 80 % of the lifetime association of sleep medication use with moderate/heavy and binge drinking.

Conclusions

Drinking is associated with sleep medication use throughout adulthood. Further, our results suggest that drinking is likely to predict sleep medication use, thereby potentially constituting a risk factor for sleep problems, and that genetic factors contribute to the association. These findings are important in terms of better understanding the development of sleep and alcohol use disorders.

背景睡眠药物的使用是潜在睡眠问题的一个指标，而睡眠问题可能是由饮酒等各种因素诱发的。然而，人们对饮酒与睡眠问题之间的纵向关系仍然知之甚少。我们调查了整个成年期睡眠用药与饮酒之间的关系，并研究了家族因素和潜在混杂因素在这些关系中的作用。方法我们使用了芬兰老年双胞胎队列（N=13851）中随访 36 年的遗传信息和自我报告问卷数据。结果逻辑回归分析表明，在所有四个时间点上，睡眠药物的使用与大量/酗酒之间存在一致的关联（OR 范围 =1.36-3.18，P <0.05），这意味着随着时间的推移，酗酒的增加与睡眠药物使用的增加有关。交叉滞后路径分析表明，中度/重度饮酒和暴饮可预测大多数时间点的睡眠药物使用情况（OR 范围 = 1.15-1.94，P <0.05），而睡眠药物使用可预测随后的戒酒情况（OR 范围 = 2.26-2.47，P <0.05）。对内分析表明，家族因素在其中发挥了作用，而定量遗传建模估计，遗传因素可解释睡眠药物使用与中度/重度饮酒和暴饮暴食的终生关联的大约 80%。此外，我们的研究结果表明，饮酒有可能预测睡眠药物的使用，从而有可能构成睡眠问题的一个风险因素，而遗传因素则促成了这种关联。这些发现对于更好地了解睡眠和饮酒障碍的发展具有重要意义。

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引用次数: 0

The mediating role of impulsivity on suicidal behaviour among higher education students with depression and substance abuse disorders 冲动性对抑郁症和药物滥用障碍大学生自杀行为的中介作用。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2025-01-16 DOI: 10.1016/j.alcohol.2025.01.002

Rachel McHugh , Margaret McLafferty , Natasha Brown , Caoimhe Ward , Colum P. Walsh , Anthony J. Bjourson , Louise McBride , John Brady , Siobhan O'Neill , Elaine K. Murray

Background

Alcohol and drug dependent individuals have consistently exhibited elevated impulsivity and some studies have indicated that impulsivity recorded in young adults predicts future alcohol abuse. Research also indicates that depressed individuals with higher impulsivity are more likely to report suicidal ideation even when they are less depressed, which may indicate that impulsivity could more strongly predict suicidality than severity of depressive symptoms.

Objective

The aim of this study was to investigate the mediating role of impulsivity on suicidal behaviour and self-harm among students with depression, alcohol and substance abuse disorders.

Materials and methods

Participants were first-year undergraduate students (n = 1829) across Ulster University (NI) and Letterkenny Institute of Technology - now known as Atlantic Technological University Donegal (ROI), who were recruited as part of the World Mental Health International College Student Initiative. Participants completed an online survey utilising the WMH-Composite International Diagnostic Interview Screening Scales (CIDI-SC). Mediation analyses were conducted in three different stages.

Results

A high prevalence of depression and substance use disorders, suicidal ideation, plans, attempts and self-harm were observed. Impulsivity was found to partially mediate the association between depression and suicidal behaviours and substance use disorders and suicidal behaviours. Impulsivity was significantly associated with suicide ideation, attempts and self-harm, but not suicide plans. Males were more likely to be impulsive, and higher levels of depression and substance use disorders were related to higher impulsivity.

Conclusions

The main findings of this study reinforce the role of impulsivity in mediating the relationship between depression and suicidality and substance use and suicidality. College wellbeing services may consider whether screening for impulsivity, rather than for example substance abuse, could be more beneficial and less prone to under-reporting, when assessing for suicide risk among vulnerable students.

背景：酒精和药物依赖个体一直表现出较高的冲动性，一些研究表明，记录在年轻人中的冲动性预示着未来的酒精滥用。研究还表明，冲动性较高的抑郁个体即使在抑郁程度较轻的情况下也更有可能报告自杀念头，这可能表明冲动性比抑郁症状的严重程度更能预测自杀行为。目的：探讨冲动性对抑郁、酒精和药物滥用障碍学生自杀和自残行为的中介作用。材料和方法：参与者是阿尔斯特大学（NI）和莱特肯尼理工学院（ROI）的一年级本科生（n=1829），他们是作为世界心理健康国际大学生倡议的一部分招募的。参与者使用wmh复合国际诊断访谈筛选量表（CIDI-SC）完成了一项在线调查。中介分析分三个阶段进行。结果：抑郁症、药物使用障碍、自杀意念、自杀计划、自杀企图和自残的发生率较高。冲动性在抑郁与自杀行为、物质使用障碍与自杀行为之间起部分中介作用。冲动与自杀意念、自杀企图和自残显著相关，但与自杀计划无关。男性更容易冲动，更高程度的抑郁和物质使用障碍与更高的冲动有关。结论：本研究的主要发现强化了冲动性在抑郁与自杀、物质使用与自杀之间的中介作用。在评估弱势学生的自杀风险时，大学福利服务部门可能会考虑是否筛查冲动，而不是药物滥用，可能更有益，更不容易漏报。

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引用次数: 0

Maternal, paternal, and dual-parental alcohol exposures result in both overlapping and distinct impacts on behavior in adolescent offspring 母亲、父亲和双亲酒精暴露对青少年后代的行为既有重叠的影响，又有不同的影响。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2025-01-22 DOI: 10.1016/j.alcohol.2025.01.004

Kara N. Thomas , Alison Basel , Hayden Reitz , Rachel Toler , Kelly R. Thomas , Luke J. Dotson , Tyler Brown , Alan Nguyen Pham , Siara K. Rouzer , Rajesh C. Miranda , Michael C. Golding

Emerging research reveals that alcohol use by fathers before conception can affect the growth and development of their offspring. Here, we used a C57BL/6J mouse model to study the effects of alcohol exposure on the behavior of the first-generation (F1) offspring, comparing the impacts of alcohol exposure by mothers, fathers, and both parents. Our goal was to determine how alcohol exposure by each parent or both parents influences the behavior of the offspring. We found that adolescent male offspring of alcohol-exposed fathers showed reduced anxiety-like behaviors as they spent more time in the center of the testing arena during the open field test. Both maternal and paternal alcohol exposure caused sex-specific increases in the nestlet shredding test while decreasing the number of buried marbles in the marble burying test. Interestingly, dual-parental alcohol exposure did not produce any significant changes in these same tests. However, during novel object recognition testing, we found that dual-parental male and female offspring exhibit an increased preference for novel objects, suggesting an increased risk preference. Finally, at sixteen weeks, male offspring of dual-exposed parents exhibited decreased voluntary physical activity on running wheels during the active phase, suggesting alterations in their circadian rhythms. Although differences in parental exposure histories between treatment groups make interpretation challenging, our findings suggest that exposure to alcohol by both parents may have unique effects on behavior and that studying both maternal and paternal alcohol use is essential for understanding the full range of factors influencing the penetrance and severity of alcohol-related phenotypes.

最新研究表明，父亲在怀孕前饮酒会影响后代的生长发育。在这里，我们使用C57BL/6J小鼠模型来研究酒精暴露对第一代（F1）后代行为的影响，比较了母亲、父亲和父母双方酒精暴露的影响。我们的目标是确定父母一方或双方的酒精暴露如何影响后代的行为。我们发现，酗酒父亲的青春期男性后代在开放场地测试中，当他们花更多的时间在测试场地的中心时，他们的焦虑行为就会减少。母亲和父亲的酒精暴露均引起雏鸟粉碎试验的性别特异性增加，而大理岩掩埋试验中掩埋大理岩的数量减少。有趣的是，双亲酒精暴露在这些相同的测试中没有产生任何显著的变化。然而，在新物体识别测试中，我们发现双亲双亲的雄性和雌性后代对新物体的偏好增加，这表明风险偏好增加。最后，在16周时，双暴露父母的雄性后代在活动阶段在跑步轮上的自愿体力活动减少，这表明他们的昼夜节律发生了变化。尽管治疗组之间父母接触史的差异使得解释具有挑战性，但我们的研究结果表明，父母双方都接触酒精可能对行为有独特的影响，研究母亲和父亲的酒精使用对于理解影响酒精相关表型外显率和严重程度的所有因素至关重要。

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引用次数: 0

Effects of alcohol and its prevention strategies on adolescent school students 酒精对青少年学生的影响及其预防策略。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2024-03-26 DOI: 10.1016/j.alcohol.2024.03.009

Emmanuel Janagan Johnson , Jessica Evangelin Emmanuel Janagan

Substance use continues to be recognized as one of the major health and social issues in the Caribbean. This study focusses on the risks and consequences of adolescent school student's exposure to alcohol and prevention strategies. Participants were selected from the age group of 13–19 years old, who are attending Secondary School. Five schools were chosen according to the prevalence of alcohol. Students were purposively selected from each school based on the recommendations from the school social workers. Students completed the Adolescent Drug Involvement Scale (ADIS) to understand the extent of involvement in alcohol use. The study recommends that there is a need for effective parenting where training in awareness, skills, and techniques around engaging young adolescent students with age-appropriate information on alcohol abuse can be disbursed and reinforced as they enter various stages of their development.

在加勒比地区，使用药物仍然被认为是主要的健康和社会问题之一。本研究的重点是青少年学生接触酒精的风险和后果以及预防策略。研究对象选自 13 至 19 岁的中学生。根据酗酒的普遍程度选择了五所学校。根据学校社工的推荐，有目的地从每所学校挑选学生。学生们填写了青少年毒品参与量表（ADIS），以了解参与饮酒的程度。研究建议，有必要开展有效的亲职教育，在青少年学生进入不同的成长阶段时，对他们进行有关酗酒的意识、技能和技巧培训，让他们了解适合其年龄的信息。

引用次数: 0

Association between 5-HTRs gene polymorphism and alcohol use disorder in Han males from Yunnan, China 中国云南汉族男性 5-HTRs 基因多态性与酒精使用障碍的关系

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2025-01-29 DOI: 10.1016/j.alcohol.2025.01.008

Kuan Li , Wei Wei , Yue Wang , Ning Zhang , Jianjun Bao , Xulan Zhang , Xinjian Zheng , Fei Zhao , Xiaopei Yang , Jiahui Peng , Changqing Gao , Shurong Zhong

Alcohol use disorder (AUD) has become a very serious medical and social problem. It is found that genetic polymorphisms of the 5-hydroxytryptamine receptors (5-HTRs) genes were associated with the risk of AUD. However, the results are controversial among different ethnic groups. At present, the correlation between 5-HTRs gene polymorphism and AUD in Han population from Yunnan Province remains unclear. In this study, 13 single nucleotide polymorphisms (SNPs) of HTR1B, HTR2A, HTR3A, HTR3B and HTR7 were detected by universal fluorescent probe technique. The CT genotype frequency of HTR3A rs1062613 was significantly higher in AUD case group than that in control group (P = 0.037, OR = 2.193, 95% CI: 1.048–4.366). The study indicated that the genetic polymorphisms of 5-HTRs were significantly associated with risk of AUD in Han male from Yunnan, China. In addition, this study further demonstrated the impact of alcohol on human health, especially liver damage, by analyzing the blood biochemical indicators of patients with AUD and combining them with their medical history.

酒精使用障碍（AUD）已经成为一个非常严重的医学和社会问题。发现5-羟色胺受体（5-HTRs）基因的遗传多态性与AUD的风险相关。然而，这一结果在不同的种族群体中存在争议。目前，云南汉族人群5-HTRs基因多态性与AUD的相关性尚不清楚。本研究采用通用荧光探针技术检测了HTR1B、HTR2A、HTR3A、HTR3B和HTR7的13个单核苷酸多态性（snp）。AUD病例组HTR3A rs1062613的CT基因型频率显著高于对照组（P = 0.037, OR = 2.193, 95% CI: 1.048 ~ 4.366）。研究表明，5-HTRs基因多态性与中国云南汉族男性患AUD的风险显著相关。此外，本研究通过分析AUD患者的血液生化指标，并结合患者的病史，进一步论证了酒精对人体健康的影响，尤其是对肝脏的损害。

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引用次数: 0

Pain predicts past-month co-use of alcohol and cannabis among emerging adults: Results from the Population Assessment of Tobacco and Health (PATH) Study 疼痛预测过去一个月初成人酒精和大麻的共同使用：烟草和健康人口评估（PATH）研究的结果。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2025-02-25 DOI: 10.1016/j.alcohol.2025.02.003

Callon M. Williams , Nadine R. Mastroleo , Mark F. Lenzenweger , Emily L. Zale

Alcohol use, cannabis use, and pain are public health concerns among emerging adults (18–24 years old). Co-use of alcohol and cannabis is of particular concern since individuals who co-use alcohol and cannabis use more of each substance and experience greater substance-related harm. Pain and substance use frequently co-occur, and a growing body of literature indicates pain is unique risk factor for substance use. The goal of the current study was to examine moderate/severe pain (vs. no/low pain) as a prospective predictor of engaging in co-use of alcohol and cannabis among emerging adults, and to test sex as a moderator of this hypothesized relationship. Data were drawn from Waves 1–5 of the Population Assessment of Tobacco and Health Study (n = 3544). Unadjusted logistic regression revealed that those with moderate/severe pain at baseline were 1.4 times more likely to engage in past-month co-use of alcohol and cannabis over the next four years (p = .046). The effects of pain on co-use were no longer significant after inclusion of covariates and a pain∗sex interaction term, which was also nonsignificant (ps > .05). These findings provide initial support for pain as a risk factor for engaging in co-use of alcohol and cannabis during emerging adulthood. Future research should continue investigating how pain may motivate co-use of alcohol and cannabis, exploring how pain is associated with other measures of co-use, and determining how providers can incorporate pain-substance use psychoeducation for emerging adults in clinical settings.

酒精使用、大麻使用和疼痛是新兴成人（18-24岁）的公共卫生问题。同时使用酒精和大麻是一个特别令人关切的问题，因为同时使用酒精和大麻的个人使用的每种物质更多，受到的与物质有关的伤害也更大。疼痛和药物使用经常同时发生，越来越多的文献表明疼痛是药物使用的独特风险因素。当前研究的目的是检查中度/重度疼痛（与无/轻度疼痛相比）作为新兴成年人共同使用酒精和大麻的前瞻性预测因素，并测试性别作为这种假设关系的调节因素。数据来自烟草与健康研究人口评估的第1-5波（n = 3,544）。未经调整的逻辑回归显示，那些在基线时有中度/重度疼痛的人在过去一个月里同时使用酒精和大麻的可能性是未来四年的1.4倍（p = 0.046）。在纳入协变量和疼痛*性别相互作用项后，疼痛对共同使用的影响不再显著，也不显著（ps >.05）。这些发现初步支持了疼痛是初成年期酒精和大麻共同使用的风险因素。未来的研究应该继续调查疼痛如何激励酒精和大麻的共同使用，探索疼痛如何与其他共同使用的措施相关联，并确定提供者如何在临床环境中为新成年患者提供疼痛物质使用心理教育。

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引用次数: 0

KCa2 channel positive modulation reduces alcohol drinking in female C57BL/6J mice KCa2通道正向调节减少雌性C57BL/6J小鼠的饮酒。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2025-01-27 DOI: 10.1016/j.alcohol.2025.01.005

Kathy L. Lindquist, Audrey E. Padula, Natalie S. Katzenmeyer, Hannah N. Potts, Jennifer A. Rinker, Patrick J. Mulholland

Although men have historically exhibited higher levels of alcohol use disorder (AUD) diagnosis, the gap between men and women has been diminishing quickly. Preclinical screening for pharmacological treatments for AUD has typically focused solely on males, ignoring the possibility that males and females may differ mechanistically for the same behavioral phenotype. To ensure the efficacy of treatment targets across the sexes, it is crucial to study the pharmacological effects of AUD treatments in males and females. While positive K_Ca2 channel modulation can reduce ethanol consumption and seeking behaviors, withdrawal-induced hyperexcitability, and negative affective behaviors in male rodents, the effect of K_Ca2 channel modulation on female ethanol consumption has not been reported. To determine the efficacy of K_Ca2 channel positive modulation in female C57BL/6J mice, we assessed the ability of the K_Ca2 channel positive modulator 1-EBIO to affect locomotor activity, voluntary home cage ethanol intake prior to and following chronic intermittent ethanol (CIE) exposure, and voluntary home cage sucrose drinking. There were no significant changes to distance traveled in an open field apparatus following administration of 1-EBIO in our locomotor assay. In ethanol drinking mice, 1-EBIO significantly reduced ethanol consumption in air controls and CIE exposed mice, without altering water consumption. While administration of 1-EBIO did not affect consumption of sucrose in male mice, 1-EBIO significantly increased sucrose intake in females. Together, these data provide further evidence that K_Ca2 channel positive modulation is a promising therapeutic target to reduce ethanol drinking in males and females alike.

尽管男性在历史上表现出更高的酒精使用障碍（AUD）诊断水平，但男性和女性之间的差距正在迅速缩小。AUD的临床前药物治疗筛查通常只针对男性，而忽略了男性和女性在相同行为表型下可能存在机制差异的可能性。为了确保治疗靶点在性别上的有效性，研究AUD治疗在男性和女性中的药理作用至关重要。虽然正向的KCa2通道调节可以减少雄性啮齿动物的乙醇消耗和寻找行为、戒断诱导的超兴奋性和负面情感行为，但KCa2通道调节对雌性乙醇消耗的影响尚未报道。为了确定雌性C57BL/6J小鼠KCa2通道正向调节的功效，我们评估了KCa2通道正向调节剂1-EBIO对运动活动、慢性间歇性乙醇暴露（CIE）之前和之后自愿在家笼中乙醇摄入以及自愿在家笼中蔗糖饮用的影响。在我们的运动试验中，使用1-EBIO后，在开放场地装置中行走的距离没有明显变化。在饮用乙醇的小鼠中，1-EBIO显著减少了空气对照组和CIE暴露小鼠的乙醇消耗，而不改变水消耗。虽然给药1-EBIO不影响雄性小鼠的蔗糖摄入量，但1-EBIO显著增加了雌性小鼠的蔗糖摄入量。总之，这些数据提供了进一步的证据，证明KCa2通道正调节是一个有希望的治疗靶点，以减少男性和女性的乙醇饮酒。

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引用次数: 0

Coping-strategies as a mediator between emotional disorders and problematic alcohol use 应对策略是情绪失调与酗酒问题之间的中介。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-05-01 Epub Date: 2024-07-27 DOI: 10.1016/j.alcohol.2024.07.008

Celia Antuña-Camblor , Gabriel Esteller-Collado , Joel Juarros-Basterretxea , Roger Muñoz-Navarro , Francisco Javier Rodríguez-Díaz

Background

Epidemiological studies reveal a high prevalence of alcohol use and comorbidity rates with emotional disorders. This study aims to explore the possible mediational effect of stress-coping strategies on the relationship between symptoms of emotional disorders and problematic alcohol use.

Methods

The sample included 1014 participants (33.82% male, 66.17% female) aged 18–75 years (M = 33.0, SD = 15.15). Three mediation analyzes were carried out, for depressive, anxious and somatization symptomatology measured with the LSB-50 in which they acted as an independent variable, the coping strategies of the CSQ as a mediating variable and the problematic alcohol use, measured with AUDIT, as a dependent variable. Additionally, sex, age, educational level, and socioeconomic status were entered as covariates.

Results

In all the models, problematic alcohol use was mediated by Problem-Solving Focus and Open Emotional Expression. However, while in depressive symptoms was a fully mediation, in anxious and somatization symptomatology was partially mediated.

Conclusions

The similarities found may be due to shared variance between emotional disorders. Interventions focused on Problem-Solving Focus could improve the emotional symptoms and the problematic alcohol use.

背景：流行病学研究显示，酒精使用的流行率很高，而且与情绪障碍的合并率也很高。本研究旨在探讨压力应对策略对情绪障碍症状与问题性饮酒之间关系的可能中介效应：样本包括 1014 名参与者（33.82% 为男性，66.17% 为女性），年龄在 18 岁至 75 岁之间（M = 33.0，SD = 15.15）。对以 LSB-50 测量的抑郁、焦虑和躯体化症状进行了三项中介分析，其中抑郁、焦虑和躯体化症状作为自变量，CSQ 的应对策略作为中介变量，以 AUDIT 测量的问题性饮酒作为因变量。此外，还将性别、年龄、教育程度和社会经济地位作为协变量：结果：在所有模型中，问题性饮酒都受到问题解决焦点和开放式情感表达的调节。然而，虽然抑郁症状是完全中介，但焦虑和躯体化症状却是部分中介：结论：所发现的相似性可能是由于情绪障碍之间存在共同的变异。结论：所发现的相似性可能是由于情绪障碍之间存在共同的变异。以 "关注问题解决 "为重点的干预措施可以改善情绪症状和酗酒问题。

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