Pub Date : 2026-02-04DOI: 10.1007/s40520-026-03333-3
Carmen Arroyo-Quiroz, Silvestre Alavez
Background: Older adults were among the most affected by the COVID-19 pandemic, facing greater vulnerability to infection, hospitalization, and post-infection sequelae. However, evidence on its multidimensional impact on healthy aging remains limited, particularly in Latin America. This study examined the association of COVID-19 infection, hospitalization, and vaccination with healthy aging and functional impairment among older Mexican adults.
Methods: We analyzed longitudinal data from the Mexican Health and Aging Study (MHAS), comparing pre-pandemic (2018) and post-pandemic (2021) waves. Two outcomes were assessed: the Healthy Aging Score (HAS), a composite indicator of physical, mental, and social functioning (mean = 50, SD = 10), and functional impairment, defined as any limitation in basic or multiple instrumental activities of daily living. Random-effects regression models estimated associations with self-reported COVID-19 infection, hospitalization, and vaccination, adjusting for sociodemographic and health covariates.
Results: The sample included 8,239 participants (mean age = 72.5 years; 55.9% women). Those reporting prior infection were younger and had higher BMI. COVID-19-related hospitalization was significantly associated with lower HAS (β = -1.96; 95% CI - 3.65 to - 0.26). Infection and vaccination were not significantly associated with HAS. However, vaccination was linked to a reduced likelihood of functional impairment (OR = 0.75; 95% CI 0.53 to 0.95).
Conclusions: Hospitalization due to COVID-19 was associated with poorer multidimensional aging outcomes, whereas vaccination appeared protective against functional decline. These findings highlight the importance of preventive strategies and sustained vaccination coverage to preserve functionality and promote healthy aging in post-pandemic populations.
背景:老年人是受COVID-19大流行影响最大的人群之一,更容易受到感染、住院治疗和感染后后遗症的影响。然而,关于其对健康老龄化的多方面影响的证据仍然有限,特别是在拉丁美洲。本研究调查了墨西哥老年人中COVID-19感染、住院和疫苗接种与健康老龄化和功能障碍的关系。方法:我们分析了墨西哥健康与老龄化研究(MHAS)的纵向数据,比较了大流行前(2018年)和大流行后(2021年)的波动。评估了两个结果:健康老龄化评分(HAS),一个身体、精神和社会功能的综合指标(平均值= 50,SD = 10),以及功能障碍,定义为日常生活中基本或多种工具活动的任何限制。随机效应回归模型估计了与自我报告的COVID-19感染、住院和疫苗接种的关联,并调整了社会人口统计学和健康协变量。结果:样本包括8,239名参与者(平均年龄= 72.5岁,女性55.9%)。那些报告先前感染的人更年轻,BMI更高。与covid -19相关的住院治疗与较低的HAS显著相关(β = -1.96; 95% CI - 3.65至- 0.26)。感染和疫苗接种与HAS无显著相关性。然而,接种疫苗与降低功能损害的可能性有关(OR = 0.75; 95% CI 0.53至0.95)。结论:因COVID-19住院与较差的多维衰老结果相关,而接种疫苗对功能衰退具有保护作用。这些发现强调了预防战略和持续疫苗接种覆盖率对大流行后人群保持功能和促进健康老龄化的重要性。
{"title":"Impact of the SARS-CoV-2 pandemic on healthy aging and functionality in older Mexican adults: insights from the MHAS cohort.","authors":"Carmen Arroyo-Quiroz, Silvestre Alavez","doi":"10.1007/s40520-026-03333-3","DOIUrl":"https://doi.org/10.1007/s40520-026-03333-3","url":null,"abstract":"<p><strong>Background: </strong>Older adults were among the most affected by the COVID-19 pandemic, facing greater vulnerability to infection, hospitalization, and post-infection sequelae. However, evidence on its multidimensional impact on healthy aging remains limited, particularly in Latin America. This study examined the association of COVID-19 infection, hospitalization, and vaccination with healthy aging and functional impairment among older Mexican adults.</p><p><strong>Methods: </strong>We analyzed longitudinal data from the Mexican Health and Aging Study (MHAS), comparing pre-pandemic (2018) and post-pandemic (2021) waves. Two outcomes were assessed: the Healthy Aging Score (HAS), a composite indicator of physical, mental, and social functioning (mean = 50, SD = 10), and functional impairment, defined as any limitation in basic or multiple instrumental activities of daily living. Random-effects regression models estimated associations with self-reported COVID-19 infection, hospitalization, and vaccination, adjusting for sociodemographic and health covariates.</p><p><strong>Results: </strong>The sample included 8,239 participants (mean age = 72.5 years; 55.9% women). Those reporting prior infection were younger and had higher BMI. COVID-19-related hospitalization was significantly associated with lower HAS (β = -1.96; 95% CI - 3.65 to - 0.26). Infection and vaccination were not significantly associated with HAS. However, vaccination was linked to a reduced likelihood of functional impairment (OR = 0.75; 95% CI 0.53 to 0.95).</p><p><strong>Conclusions: </strong>Hospitalization due to COVID-19 was associated with poorer multidimensional aging outcomes, whereas vaccination appeared protective against functional decline. These findings highlight the importance of preventive strategies and sustained vaccination coverage to preserve functionality and promote healthy aging in post-pandemic populations.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1007/s40520-025-03309-9
Astrid Sawicki, Emmanuel Gonzalez-Bautista, Alberta Peluso, Gabor Abellan van Kan, Sandrine Sourdet, Maria Soto
{"title":"Mild behavioral impairment is longitudinally associated with frailty in very old adults with MCI: insights from COGFRAIL.","authors":"Astrid Sawicki, Emmanuel Gonzalez-Bautista, Alberta Peluso, Gabor Abellan van Kan, Sandrine Sourdet, Maria Soto","doi":"10.1007/s40520-025-03309-9","DOIUrl":"10.1007/s40520-025-03309-9","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":"64"},"PeriodicalIF":3.4,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Despite established health benefits of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet in older populations, its relationship with muscle health remains largely unexplored. This study investigated associations between adherence to a Chinese-modified MIND diet and both low muscle mass (LMM) and physical performance among community-dwelling older Chinese adults.
Methods: Data were drawn from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), including 13,422 older adults. Muscle mass was assessed using a validated appendicular skeletal muscle mass (ASM) prediction formula. Physical performance was evaluated using a four-item functional assessment scale in reference to SARC-F. The associations between Chinese version of the MIND (cMIND) diet adherence and outcomes were examined using multivariable logistic regression for LMM and linear regression for physical performance. Comprehensive subgroup and sensitivity analyses were conducted to assess effect modification and result robustness.
Results: The prevalence of LMM was 45.2% among participants. Higher cMIND diet scores demonstrated significant inverse associations with LMM probability across all analytical models. After full adjustment for sociodemographic, lifestyle, and health-related confounders, participants in the highest tertile of cMIND adherence showed substantially lower odds of LMM compared to those in the lowest tertile (odds ratio [OR]: 0.79; 95% confidence intervals [CI]: 0.69-0.90). Similarly, better cMIND diet adherence was positively associated with higher physical performance score in multivariable models. These findings remained consistent across sensitivity analyses.
Conclusion: Greater adherence to the cMIND dietary pattern is independently associated with lower probability of LMM and better physical performance among older Chinese adults. These findings suggest potential benefits of promoting MIND diet principles for maintaining musculoskeletal health in aging populations.
{"title":"Associations of chinese-modified MIND diet with low muscle mass and physical performance among old adults in china: findings from the CLHLS 2018 national survey.","authors":"Zhisen Dai, Yanlin Wu, Yan Chen, Junheng Chen, Hui Jiang, Huaqing Huang, Huizhe Zheng","doi":"10.1007/s40520-026-03325-3","DOIUrl":"10.1007/s40520-026-03325-3","url":null,"abstract":"<p><strong>Background: </strong>Despite established health benefits of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet in older populations, its relationship with muscle health remains largely unexplored. This study investigated associations between adherence to a Chinese-modified MIND diet and both low muscle mass (LMM) and physical performance among community-dwelling older Chinese adults.</p><p><strong>Methods: </strong>Data were drawn from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), including 13,422 older adults. Muscle mass was assessed using a validated appendicular skeletal muscle mass (ASM) prediction formula. Physical performance was evaluated using a four-item functional assessment scale in reference to SARC-F. The associations between Chinese version of the MIND (cMIND) diet adherence and outcomes were examined using multivariable logistic regression for LMM and linear regression for physical performance. Comprehensive subgroup and sensitivity analyses were conducted to assess effect modification and result robustness.</p><p><strong>Results: </strong>The prevalence of LMM was 45.2% among participants. Higher cMIND diet scores demonstrated significant inverse associations with LMM probability across all analytical models. After full adjustment for sociodemographic, lifestyle, and health-related confounders, participants in the highest tertile of cMIND adherence showed substantially lower odds of LMM compared to those in the lowest tertile (odds ratio [OR]: 0.79; 95% confidence intervals [CI]: 0.69-0.90). Similarly, better cMIND diet adherence was positively associated with higher physical performance score in multivariable models. These findings remained consistent across sensitivity analyses.</p><p><strong>Conclusion: </strong>Greater adherence to the cMIND dietary pattern is independently associated with lower probability of LMM and better physical performance among older Chinese adults. These findings suggest potential benefits of promoting MIND diet principles for maintaining musculoskeletal health in aging populations.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":"75"},"PeriodicalIF":3.4,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1007/s40520-025-03307-x
Jialu Zhuo, Ting Han, Ning Yang, Zhihua Qu, Zixiang Li, Fangjing Hong
Objective: To investigate the effects of prebiotics combined with β-hydroxy-β-methylbutyrate (HMB) on muscle function, intestinal barrier integrity, and inflammation in elderly patients with sarcopenia.
Methods: A randomized controlled trial was conducted on 78 elderly sarcopenic patients recruited from Tongji University Affiliated Tenth People's Hospital and Baoshan District Geriatric Care Hospital (Jan 2023 - Jan 2025). Participants were randomly assigned Group A (n = 32, standard diet + HMB-supplement), Group B (n = 31, standard diet + HMB + fructooligosaccharides), or Group C (n = 15, standard diet alone) for 30 days. Outcomes included muscle function (skeletal muscle mass index, grip strength, calf circumference), intestinal barrier markers (serum diamine oxidase, D-lactic acid, endotoxin), and inflammatory and nutritional markers (CRP, neutrophil/lymphocyte ratio, systemic immune inflammation index, albumin, prealbumin).
Results: Baseline indicators did not differ among groups (P > 0.05). After intervention, skeletal muscle mass index and grip strength improved significantly in Groups A and B (P < 0.05), with higher grip strengths to Group B than C (adj. P = 0.017). Calf circumference decreased in all groups (P < 0.05), most in Group C (t = 4.461, P = 0.001). Group B exhibited lower diamine oxidase, D-lactic acid, and endotoxin levels than Groups A and C (P < 0.05) and the greatest reductions in CRP, NLR, and SII (P < 0.001). Albumin or prealbumin showed no significant changes (P > 0.05).
Conclusion: HMB improves muscle function in sarcopenic elderly, prebiotics combined with HMB further enhance intestinal barrier repair and reduce inflammation, offering a promising gut-muscle-targeted nutritional strategy.
{"title":"Preliminary clinical study on the synergistic effects of prebiotics and β-hydroxy-β-methylbutyrate in improving muscle function and intestinal barrier function in elderly patients with sarcopenia.","authors":"Jialu Zhuo, Ting Han, Ning Yang, Zhihua Qu, Zixiang Li, Fangjing Hong","doi":"10.1007/s40520-025-03307-x","DOIUrl":"10.1007/s40520-025-03307-x","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of prebiotics combined with β-hydroxy-β-methylbutyrate (HMB) on muscle function, intestinal barrier integrity, and inflammation in elderly patients with sarcopenia.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted on 78 elderly sarcopenic patients recruited from Tongji University Affiliated Tenth People's Hospital and Baoshan District Geriatric Care Hospital (Jan 2023 - Jan 2025). Participants were randomly assigned Group A (n = 32, standard diet + HMB-supplement), Group B (n = 31, standard diet + HMB + fructooligosaccharides), or Group C (n = 15, standard diet alone) for 30 days. Outcomes included muscle function (skeletal muscle mass index, grip strength, calf circumference), intestinal barrier markers (serum diamine oxidase, D-lactic acid, endotoxin), and inflammatory and nutritional markers (CRP, neutrophil/lymphocyte ratio, systemic immune inflammation index, albumin, prealbumin).</p><p><strong>Results: </strong>Baseline indicators did not differ among groups (P > 0.05). After intervention, skeletal muscle mass index and grip strength improved significantly in Groups A and B (P < 0.05), with higher grip strengths to Group B than C (adj. P = 0.017). Calf circumference decreased in all groups (P < 0.05), most in Group C (t = 4.461, P = 0.001). Group B exhibited lower diamine oxidase, D-lactic acid, and endotoxin levels than Groups A and C (P < 0.05) and the greatest reductions in CRP, NLR, and SII (P < 0.001). Albumin or prealbumin showed no significant changes (P > 0.05).</p><p><strong>Conclusion: </strong>HMB improves muscle function in sarcopenic elderly, prebiotics combined with HMB further enhance intestinal barrier repair and reduce inflammation, offering a promising gut-muscle-targeted nutritional strategy.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":"63"},"PeriodicalIF":3.4,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Age-related circulating factors are recognized as major contributors to the progression of sarcopenia. This network meta-analysis (NMA) aimed to compare the effects of various interventions on circulating factor responses among individuals with sarcopenia.
Methods: PubMed, Web of Science, MEDLINE, Cochrane Central Register of Controlled Trials, Scopus, and Chinese National Knowledge Infrastructure (CNKI) were searched from inception through April 2025 and updated in October 2025. Randomized clinical trials (RCTs) involving healthy individuals with sarcopenia were included if they reported circulating factors related to exercise, nutrition, or a combination of both interventions. Effect sizes were calculated as standardized mean difference (SMD) with 95% confidence interval (CI) using a frequentist NMA framework. The rank order of competing interventions was determined using the surface under the cumulative ranking curve (SUCRA). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework was employed to evaluate the quality of evidence supporting each network estimate.
Results: A total of 24 RCTs involving 1,779 sarcopenia individuals were included. Seven distinct intervention strategies and control group were involved in this study. The C-reactive protein (CRP) network included 12 direct comparisons, while the insulin-like growth factor-1 (IGF-1) network encompassed 9 studies (n = 996 participants). Combined exercise (SMD = -2.24, 95%CI: -3.67 to -0.81) and Nutrition (SMD = 0.45, 95%CI: 0.04 to 0.86) were the most effective interventions for reducing CRP and improving the IGF-1 response in patients with sarcopenia, respectively. The certainty of evidence, on average, ranged from low to moderate in this study.
Conclusion: The findings suggest that Combined exercise may be optimal for CRP reduction in patients with sarcopenia, whereas Nutrition appears to be effective in improving IGF-1 response. These findings need to be validated and addressed in future large-scale, high-quality RCTs.
背景:年龄相关的循环因子被认为是肌肉减少症进展的主要因素。该网络荟萃分析(NMA)旨在比较各种干预措施对肌肉减少症患者循环因子反应的影响。方法:检索PubMed、Web of Science、MEDLINE、Cochrane Central Register of Controlled Trials、Scopus、Chinese National Knowledge Infrastructure (CNKI),检索时间为2025年4月至2025年10月。随机临床试验(rct)纳入健康的肌肉减少症患者,如果他们报告了与运动、营养或两者结合相关的循环因素。效应量以95%置信区间(CI)的标准化平均差(SMD)计算,采用频率主义NMA框架。采用累积排名曲线(SUCRA)下曲面确定竞争干预措施的排名顺序。采用建议分级评估、发展和评价(GRADE)框架来评估支持每个网络评估的证据质量。结果:共纳入24项随机对照试验,涉及1779例肌肉减少症患者。本研究涉及七种不同的干预策略和对照组。c反应蛋白(CRP)网络包括12个直接比较,而胰岛素样生长因子-1 (IGF-1)网络包括9个研究(n = 996名参与者)。联合运动(SMD = -2.24, 95%CI: -3.67至-0.81)和营养(SMD = 0.45, 95%CI: 0.04至0.86)分别是降低肌肉减少症患者CRP和改善IGF-1反应的最有效干预措施。在这项研究中,证据的确定性平均从低到中等不等。结论:研究结果表明,联合运动可能是降低肌肉减少症患者CRP的最佳方法,而营养似乎在改善IGF-1反应方面有效。这些发现需要在未来大规模、高质量的随机对照试验中得到验证和解决。
{"title":"Comparative efficacy of different interventions on circulating factors in sarcopenia individuals: a systematic review and network meta-analysis.","authors":"Chengwei Yang, Qing Yi, Xingxing Lv, Wuyue Hu, Xiaohe Guo, Jia Zhang","doi":"10.1007/s40520-025-03295-y","DOIUrl":"10.1007/s40520-025-03295-y","url":null,"abstract":"<p><strong>Background: </strong>Age-related circulating factors are recognized as major contributors to the progression of sarcopenia. This network meta-analysis (NMA) aimed to compare the effects of various interventions on circulating factor responses among individuals with sarcopenia.</p><p><strong>Methods: </strong>PubMed, Web of Science, MEDLINE, Cochrane Central Register of Controlled Trials, Scopus, and Chinese National Knowledge Infrastructure (CNKI) were searched from inception through April 2025 and updated in October 2025. Randomized clinical trials (RCTs) involving healthy individuals with sarcopenia were included if they reported circulating factors related to exercise, nutrition, or a combination of both interventions. Effect sizes were calculated as standardized mean difference (SMD) with 95% confidence interval (CI) using a frequentist NMA framework. The rank order of competing interventions was determined using the surface under the cumulative ranking curve (SUCRA). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework was employed to evaluate the quality of evidence supporting each network estimate.</p><p><strong>Results: </strong>A total of 24 RCTs involving 1,779 sarcopenia individuals were included. Seven distinct intervention strategies and control group were involved in this study. The C-reactive protein (CRP) network included 12 direct comparisons, while the insulin-like growth factor-1 (IGF-1) network encompassed 9 studies (n = 996 participants). Combined exercise (SMD = -2.24, 95%CI: -3.67 to -0.81) and Nutrition (SMD = 0.45, 95%CI: 0.04 to 0.86) were the most effective interventions for reducing CRP and improving the IGF-1 response in patients with sarcopenia, respectively. The certainty of evidence, on average, ranged from low to moderate in this study.</p><p><strong>Conclusion: </strong>The findings suggest that Combined exercise may be optimal for CRP reduction in patients with sarcopenia, whereas Nutrition appears to be effective in improving IGF-1 response. These findings need to be validated and addressed in future large-scale, high-quality RCTs.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":"61"},"PeriodicalIF":3.4,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1007/s40520-026-03327-1
Maddalena Beccherle, Stefania Amato, Elena Facci, Georgeta Stefanescu, Sara Bertagnoli, Vincenzo Di Francesco, Giorgia Fontana, Giuseppe Gambina, Valentina Moro
{"title":"Patterns of cognitive and motor decline in Alzheimer's Disease (AD) and ageing in healthy populations.","authors":"Maddalena Beccherle, Stefania Amato, Elena Facci, Georgeta Stefanescu, Sara Bertagnoli, Vincenzo Di Francesco, Giorgia Fontana, Giuseppe Gambina, Valentina Moro","doi":"10.1007/s40520-026-03327-1","DOIUrl":"10.1007/s40520-026-03327-1","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":"74"},"PeriodicalIF":3.4,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1007/s40520-026-03330-6
Clara Burgo-Beiro, David Facal, Carlos Dosil-Díaz, Alba Felpete, Jhilenia Villamide-Gesto, María Campos-Magdaleno
{"title":"Cognitive, functional and affective effects of a multi-task training in nursing home residents: results from a randomized pilot study.","authors":"Clara Burgo-Beiro, David Facal, Carlos Dosil-Díaz, Alba Felpete, Jhilenia Villamide-Gesto, María Campos-Magdaleno","doi":"10.1007/s40520-026-03330-6","DOIUrl":"https://doi.org/10.1007/s40520-026-03330-6","url":null,"abstract":"","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1007/s40520-025-03278-z
Rachael Patusco, King Gyasi, Allyn Kaufmann
Aging is characterized by a progressive decline in physiological resilience and functional capacity, often accompanied by chronic, low-grade systemic inflammation, a phenomenon termed "inflammaging". This persistent inflammatory milieu contributes significantly to musculoskeletal degeneration, impaired neuromotor coordination, and reduced mobility, collectively diminishing quality of life, particularly among older adults. Key biological drivers of inflammaging include cellular senescence, immune system dysregulation, and mitochondrial dysfunction, which are orchestrated through complex molecular signaling pathways such as NF-κB, mTOR, JAK/STAT, MAPK, and NLRP3. These pathways facilitate the development of the senescence-associated secretory phenotype (SASP), thereby perpetuating tissue damage and systemic inflammation. Mobility decline, frequently manifesting as sarcopenia, osteoarthritis (OA), and gait instability, is closely associated with these inflammatory processes. Early identification of individuals at risk for mobility decline using biomarkers and functional assessments enables timely and targeted interventions that can help extend 'mobility span'. Foundational strategies such as lifestyle modification remain critical in mitigating the effects of inflammaging however, emerging therapeutic modalities including nutraceuticals and pharmacological agents offer promising avenues for intervention. This review synthesizes current evidence on the interplay between inflammaging and mobility decline, emphasizing mechanistic insights, therapeutic approaches, and future research directions. Addressing these interconnected biological processes is essential for promoting healthy aging, preserving functional independence, and extending health span.
{"title":"Exploring the nexus between inflammation and mobility through the lens of healthy aging: current scenario and future perspectives.","authors":"Rachael Patusco, King Gyasi, Allyn Kaufmann","doi":"10.1007/s40520-025-03278-z","DOIUrl":"10.1007/s40520-025-03278-z","url":null,"abstract":"<p><p>Aging is characterized by a progressive decline in physiological resilience and functional capacity, often accompanied by chronic, low-grade systemic inflammation, a phenomenon termed \"inflammaging\". This persistent inflammatory milieu contributes significantly to musculoskeletal degeneration, impaired neuromotor coordination, and reduced mobility, collectively diminishing quality of life, particularly among older adults. Key biological drivers of inflammaging include cellular senescence, immune system dysregulation, and mitochondrial dysfunction, which are orchestrated through complex molecular signaling pathways such as NF-κB, mTOR, JAK/STAT, MAPK, and NLRP3. These pathways facilitate the development of the senescence-associated secretory phenotype (SASP), thereby perpetuating tissue damage and systemic inflammation. Mobility decline, frequently manifesting as sarcopenia, osteoarthritis (OA), and gait instability, is closely associated with these inflammatory processes. Early identification of individuals at risk for mobility decline using biomarkers and functional assessments enables timely and targeted interventions that can help extend 'mobility span'. Foundational strategies such as lifestyle modification remain critical in mitigating the effects of inflammaging however, emerging therapeutic modalities including nutraceuticals and pharmacological agents offer promising avenues for intervention. This review synthesizes current evidence on the interplay between inflammaging and mobility decline, emphasizing mechanistic insights, therapeutic approaches, and future research directions. Addressing these interconnected biological processes is essential for promoting healthy aging, preserving functional independence, and extending health span.</p>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":" ","pages":"60"},"PeriodicalIF":3.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-25DOI: 10.1007/s40520-026-03321-7
André Hajek, Dong Keon Yon, Pinar Soysal, Karl Peltzer, Supa Pengpid, Hans-Helmut König
Background: There is limited knowledge regarding the association of loneliness or social exclusion with donation behavior.
Aims: Our aim was to investigate the association of loneliness and perceived social exclusion with donation behavior based on a longitudinal approach.
Methods: Longitudinal data were taken from wave 5 (year 2014) to wave 8 (year 2023) of the German Ageing Survey encompassing community-dwelling individuals aged 40 years and over. Established tools were used to quantify loneliness and perceived social exclusion. The willingness to donate and the total amount (in euros) of all donations (in the last 12 months) served as outcome measures. Fixed effects (FE) regressions with cluster-robust standard errors were used.
Results: FE regressions showed that increases in loneliness were significantly associated with lower odds of donation after adjusting for socioeconomic factors, but became insignificant when accounting for lifestyle and health-related covariates. Conversely, a significant association was found between increases in perceived social exclusion and lower odds of donation across all models. However, neither changes in loneliness nor perceived social exclusion were significantly associated with changes in log amount of donations. Sociodemographic factors (i.e., age, sex, and education) did not moderate the identified associations.
Discussion: Even after adjusting for a wide array of covariates, our longitudinal study showed a significant and robust association between increases in social exclusion and lower odds of donation.
Conclusions: Avoiding increases in perceived social exclusion could encourage the decision to donate, an important prosocial behavior, pending further longitudinal evidence. Cross-country comparisons are recommended.
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