Science China Chemistry最新文献

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with increasing global prevalence. Conventional therapeutic strategies are limited by suboptimal efficacy, systemic side effects, and poor patient compliance, while current diagnostic approaches lack sufficient sensitivity and specificity. The advent of nanotechnology, particularly poly(lactic-co-glycolic acid) (PLGA)-based nanomedicine, offers promising avenues for both the diagnosis and treatment of IBD. PLGA nanomedicine exhibits excellent biocompatibility, biodegradability, and controlled drug release properties, enabling targeted and efficient therapeutic delivery. This review comprehensively summarizes recent advances in PLGA-based nanocarriers for IBD management, focusing on innovative design strategies including core-shell architectures, multi-targeting approaches, immune modulation, stimuli-responsive systems, and combination therapies. We also discuss mechanisms to overcome gastrointestinal barriers, enhance mucosal penetration, and modulate the gut immune microenvironment. Furthermore, the integration of diagnostic imaging with therapeutic modalities improves precision in IBD diagnosis. Despite challenges related to long-term safety, large-scale manufacturing, and clinical translation, PLGA nanomedicine holds significant potential for personalized, multidisciplinary IBD treatment, positioning itself as a transformative solution in the field.

Organic fluorescent materials with multistimuli-responsive behaviors have attracted much attention because of their promising applications in diverse fields. Most chromophores exhibit bright emission in either dilute solutions or aggregation states, which inevitably suffer from the aggregation-caused quenching (ACQ) problem or encounter serious energy loss at low concentration. To overcome these limitations, dual-state emissive (DSE) materials with bright emission in both solution and solid states have been developed. However, most DSE materials only involve one or two stimulus-responsive behaviors. Herein, through combining characteristics of imidazopyridine N1 as well as manipulation of electronic structure and intermolecular interaction, DSE molecule TPA-IPBA with four multistimuli-responsive behaviors has been rationally and accurately prepared, which could be easily converted to ACQ (TPA-IPB) and AIE (aggregation-induced emission) (TPA-IPBCN) molecules. Under external stimuli, four types of multistimuli-responsive behaviors have been successfully achieved, including solvatochromism (redshift of 124 nm), mechanofluorochromism (redshift of 6 or 30 nm), reversible tricolor acidichromism (redshift of 148 nm) and solid-phase polymorphism with solvent-dependent solid emission (from B-state to G-state, redshift of 52 nm). We explained four types of multistimuli-responsive behaviors in detail through nuclear magnetic resonance spectroscopies, theoretical calculations, single crystal analysis, and PXRD characterization. In addition, on the basis of our biological research on imidazo[1,2-α]-pyridines, we found that TPA-IPBA serves as a fluorescent probe to dynamically detect biological lipid droplets with high co-localization ability (PC = 0.95). These results provide new insight into developing DSE materials via a delicate manipulation of molecular structure with acceptor-dependent tunable multistimuli-responsive properties and bioimaging applications.

Electronic textile represents the future of wearable electronics, offering unparalleled permeability and comfort, and holding immense promise for next-generation sensing, communication and smart functionalities. A critical enabler of these capabilities is the integration of stretchable, stable and customizable circuits. However, achieving high-resolution, seamlessly integrated circuits with robust electrical and mechanical performance directly on textiles remains a formidable challenge. Here, we introduce a novel photopatterning strategy for high-resolution, stretchable textile circuits based on surface-modified liquid metal nanoparticles. Our approach uniquely leverages coordination bonding between photopolymerizable monomers and the native oxide layer of liquid metal, enabling the nanoparticles to actively participate in photopolymerization. The process forms a crosslinked polymer network that not only allows for precise microscale patterning but also significantly enhances the electromechanical stability of the circuits. The resulting textile circuits exhibit a resolution of 100 µm, stretchability of up to 200% with minimal resistance change (ΔR < 0.1), and durability against repeated mechanical deformations including stretching, bending, and twisting. Moreover, they demonstrate environmental robustness, maintaining stable performance across varying humidity and temperatures, and even enduring practical scenarios such as washing, pressing, wrinkling and ironing. With this integrated strategy, a stretchable textile sensing system is developed as a breathable healthcare wristband for prolonged and irritation-free healthcare monitoring. By combining chemical design with photopatterning precision, this work establishes a versatile and scalable platform for the fabrication of advanced textile electronics.

Asymmetric synthesis of N-N array heterocycles via palladium-catalyzed rapid construction of C(sp³)–N and C(sp³)–C(sp²) remains a formidable challenge. Herein, we demonstrate the β,γ-unsaturated hydrazones with aryl or alkenyl halides leading to a series of dihydropyrazoles in good yields with excellent enantioselectivities. This robust catalyst system is responsible for excellent reactivity and avoiding the N-Ts-hydrazones decomposition. The salient of this transformation include mild reaction conditions, broad substrate scopes, well functional group tolerance. Density functional theory (DFT) calculations disclose the effective coordination mode of palladium/Xu-Phos in asymmetric coupling and shed some light on the reaction mechanism and the origin of the enantioselectivity. Moreover, mechanistic experiments and DFT calculations demonstrate that syn- and anti-additions occur almost simultaneously in the enantiodetermining olefin insertion step.

Investigation of luminescent materials with efficient photoluminescence (PL) and mechanoluminescence (ML) is significant for the development of both basic theories and industrial applications for new light sources, pressure sensors, and information security. In this study, we obtain a pair of isomorphic europium(Eu)³⁺-containing coordination polymers (CPs), namely, [Eu(tfpd)₃(phen)]_n (1) and [Eu(tfpd)₃(bipy)]_n (2) (tfpd = 4,4,4-trifluoro-4-pyridyl-1,3-diketonate, phen = 1,10-phenanthroline, bipy = 2,2′-bipyridine), which exhibit novel helical chain-like structures that can be extended to 3D supramolecular networks through moderate interchain interactions. The thermostable CPs simultaneously exhibit strong photoluminescence (PL) emissions with high quantum yields and excellent mechanoluminescence (ML) activity with an unusual anti-thermal quenching effect. Careful analyses of the CP crystal structures and optical performances, coupled with theoretical calculations, demonstrate that the PL emission depends on the asymmetric Eu³⁺ coordination spheres, whereas the ML activity is significantly correlated with molecular packing derived from appropriate interchain H-bonding interactions. As these CPs have highly efficient optical activities, they have promising potential applications in pressure sensing, anti-counterfeiting, and fingerprint recognition technologies.