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Time of day of cardiac surgery and postoperative outcomes in the UK : a secondary analysis of linked national datasets 英国心脏手术的时间和术后结果:对相关国家数据集的二次分析
IF 10.7 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2026-01-09 DOI: 10.1111/anae.70125
Gareth Kitchen, Karen Thomas, Tim Felton, Hannah Durrington, John Blaikley, Stuart W. Grant, David Harrison, Peter McGuigan, Kathryn Rowan, Anthony Wilson, Danny McAuley, Paul Dark
Summary Introduction Uncertainty remains regarding whether the time of day that cardiac surgery is performed affects postoperative outcomes or if the observed variation can be explained by patient or surgical factors. Methods A secondary analysis of prospectively collected data was conducted to examine the association between time of cardiac surgery and clinical outcomes. Data were derived from four linked UK datasets: the National Adult Cardiac Surgery Audit; the Case Mix Programme; Hospital Episode Statistics; and Office for National Statistics mortality records. The primary outcomes were hazard of death due to cardiovascular disease and time to hospital readmission for myocardial infarction or acute heart failure. Secondary outcomes included duration of postoperative hospital stay; occurrence of major cardiovascular events; and all‐cause mortality. Results Linked data for 24,068 patients were identified. Surgeries performed in late morning (10:00 to 11:59) had the highest mean (SD) predicted risk of death (3.7% (4.6)), compared with 3.2% (3.7) for early morning (07:00 to 09:59), 2.8% (3.4) for early afternoon (12:00 to 13:59) and 3.1% (3.6) for late afternoon (14:00 to 19:59) surgeries, respectively. The primary outcome measures showed an increased hazard of death from cardiovascular disease in the late morning (adjusted hazard ratio 1.18, 95%CI 1.00–1.39), with no difference in hazard of readmission for myocardial infarction or acute heart failure (adjusted hazard ratio 0.97, 95%CI 0.85–1.11). There were no differences in the secondary outcome measures. Discussion Time‐of‐day variation in postoperative death due to cardiovascular disease following cardiac surgery was observed, with the highest risk seen in late morning procedures. These findings suggest that intra‐operative or organisational factors specific to this period may influence outcomes. Future research should explore whether individual circadian phenotypes or chronotypes contribute to this variation, supporting a move towards precision and personalised scheduling of cardiac surgery to optimise patient outcomes.
关于心脏手术的时间是否会影响术后结果,或者观察到的变化是否可以由患者或手术因素来解释,仍然存在不确定性。方法对前瞻性收集的资料进行二次分析,以检验心脏手术时间与临床结果之间的关系。数据来源于四个相关的英国数据集:国家成人心脏手术审计;混合病例规划;医院事件统计;以及国家统计局的死亡率记录。主要结局为心血管疾病死亡风险和因心肌梗死或急性心力衰竭再入院的时间。次要结局包括术后住院时间;主要心血管事件的发生;以及全因死亡率。结果确定了24,068例患者的关联数据。上午晚些时候(10:00至11:59)进行手术的平均(SD)预测死亡风险最高(3.7%(4.6)),而清晨(07:00至09:59)的平均(SD)预测死亡风险为3.2%(3.7),下午早些时候(12:00至13:59)的平均(SD)预测死亡风险为2.8%(3.4),下午晚些时候(14:00至19:59)的平均(SD)预测死亡风险为3.1%(3.6)。主要结局指标显示,上午晚些时候心血管疾病死亡风险增加(校正风险比1.18,95%CI 1.00-1.39),心肌梗死或急性心力衰竭再入院风险无差异(校正风险比0.97,95%CI 0.85-1.11)。次要结局指标没有差异。观察到心脏手术后心血管疾病导致的术后死亡在一天中的时间变化,上午晚些时候的手术风险最高。这些发现表明,这一时期的手术内或组织因素可能会影响结果。未来的研究应该探索个体昼夜节律表型或时间型是否会导致这种差异,以支持心脏手术的精确和个性化安排,以优化患者的预后。
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引用次数: 0
Clinical effectiveness of procalcitonin‐ or C‐reactive protein‐guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta‐analysis 降钙素原或C反应蛋白引导下的成人重症脓毒症患者停药方案的临床效果:一项快速系统回顾和荟萃分析
IF 10.7 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2026-01-08 DOI: 10.1111/anae.70109
Sonya Rafiq, Chunhu Shi, Shraboni Ghosal, Paul Dark, Tim Felton, Evangelos Kontopantelis, Jo Dumville
Summary Introduction Antibiotics are a first‐line treatment for sepsis, with guidelines recommending a 7‐ to 10‐day course. Prolonged antibiotic use carries significant risks, prompting growing interest in using inflammatory biomarkers, such as procalcitonin or C‐reactive protein, to guide clinical decision‐making on the duration of antibiotic therapy in patients who are critically ill. This rapid systematic review aims to assess the effectiveness and safety of using procalcitonin‐ or C‐reactive protein‐guided protocols for antibiotic discontinuation in patients who are critically ill with sepsis. Methods We conducted systematic searches for articles published after January 2005 in relevant databases. Eligible studies included randomised controlled trials comparing procalcitonin‐ or C‐reactive protein‐guided protocols for antibiotic discontinuation with standard care, or with each other. Primary outcomes were duration of antibiotic therapy and mortality. Secondary outcomes included infection recurrences; secondary infections or superinfections; and the duration of intensive care and hospital stays. Results We identified 21 eligible studies. Moderate certainty evidence from 19 trials, involving 6382 patients, indicated that procalcitonin‐guided protocols probably reduced antibiotic therapy by, on average, 2.0 days (95%CI ‐2.6 to ‐1.4) compared with standard care. Moderate certainty evidence from 18 trials, involving 6228 patients, suggested an average 5% reduction in mortality risk when using procalcitonin‐guided protocols compared with standard care (risk ratio 0.95, 95%CI 0.83–1.07). The evidence regarding C‐reactive protein‐guided protocols versus standard care approaches remained unclear, with very low to low certainty evidence available. Discussion Combining relevant trials suggests that procalcitonin‐guided discontinuation protocols may be both safe and effective for patients who are critically ill with sepsis, with no increased risk in mortality. In contrast, the evidence supporting C‐reactive protein‐guided protocols is limited. These findings underscore the potential importance of utilising procalcitonin to inform antimicrobial stewardship practices, particularly in critical care settings.
抗生素是败血症的一线治疗方法,指南推荐7 - 10天疗程。长期使用抗生素具有显著的风险,促使人们越来越关注使用炎症生物标志物,如降钙素原或C反应蛋白,来指导危重患者抗生素治疗时间的临床决策。本快速系统综述旨在评估使用降钙素原或C反应蛋白指导方案治疗危重脓毒症患者停药的有效性和安全性。方法系统检索2005年1月以后发表的相关文献。符合条件的研究包括随机对照试验,比较降钙素原或C反应蛋白指导下的抗生素停药方案与标准治疗方案,或两者之间的差异。主要结局是抗生素治疗的持续时间和死亡率。次要结局包括感染复发;继发感染或重复感染;以及重症监护和住院的时间。结果我们确定了21项符合条件的研究。来自19项试验的中等确定性证据,涉及6382例患者,表明与标准治疗相比,降钙素原引导的方案可能平均减少2.0天的抗生素治疗(95%CI‐2.6至‐1.4)。来自18项试验的中等确定性证据,涉及6228例患者,表明与标准治疗相比,使用降钙素原指导方案的死亡风险平均降低5%(风险比0.95,95%CI 0.83-1.07)。关于C反应蛋白指导方案与标准护理方法的证据仍然不清楚,证据的确定性非常低。综合相关试验表明,降钙素原引导下的停药方案对于危重脓毒症患者可能是安全有效的,且不会增加死亡风险。相比之下,支持C反应蛋白引导方案的证据有限。这些发现强调了利用降钙素原为抗菌药物管理实践提供信息的潜在重要性,特别是在重症监护环境中。
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引用次数: 0
Patient-reported outcomes, postoperative pain and pain relief after day-case surgery (POPPY): baseline data from day surgery practice in the UK. 患者报告的结果、术后疼痛和日间手术后疼痛缓解(POPPY):来自英国日间手术实践的基线数据。
IF 6.9 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2026-01-07 DOI: 10.1111/anae.70055
Martha Belete, Adam B Brayne, Harriet Daykin, Matthew Everson, William M Hare, Anna Ratcliffe, Lexy Sorrell, Mark Rockett

Introduction: Most patients undergoing elective surgery in the UK are discharged from hospital on the same day. Despite this, there is a lack of UK patient-centred outcome measures relating to quality of recovery, pain and analgesic use. The POPPY study was a UK-wide prospective, observational study measuring short- and longer-term patient-reported outcomes following day-case surgery. This article is the second in a series and describes baseline characteristics to contextualise successive articles which explore outcome data.

Methods: Baseline data were collected from eligible consenting adults undergoing day-case surgery. Data included patient characteristics; pre-operative analgesic use; pre-existing pain surgical and anaesthetic details; and quality of life scores. Descriptive analysis was performed to provide baseline characteristics of the study cohort.

Results: A total of 9618 patients were eligible on screening from 199 sites, with 7839 eligible following exclusions. Unplanned admission following surgery was the most common reason for exclusion, affecting 1131/9618 (11.8%) patients. Unplanned admission was more likely with increasing surgical magnitude, frailty and higher ASA physical status. Some common operations had admission rates of > 50%. Pain at the site of proposed surgery was reported by 3060/7839 (39%) patients and this was chronic pain in 2387/7839 (30.5%). Opioids were taken at least daily by 885/7839 (11.3%) patients, 1109/7839 (14.1%) were receiving treatment for depression and 1039/7839 (13.3%) were receiving treatment for anxiety. Anxiety or depression was rated as moderate or worse in 1002/7839 (12.8%) patients.

Discussion: In the UK, over a third of patients presenting for day-case surgery are in pain, which is mostly chronic in duration. One in four have access to opioid medications and a little over one in 10 are using opioids daily. More than one in 10 do not receive their planned surgery as a day-case and readmission rates for day-case surgery do not meet suggested targets.

简介:在英国,大多数接受择期手术的患者在同一天出院。尽管如此,英国缺乏与康复质量、疼痛和止痛药使用有关的以患者为中心的结果测量。POPPY研究是一项全英国范围的前瞻性观察性研究,测量患者报告的日间手术后的短期和长期结果。本文是该系列的第二篇,描述了基线特征,以便将探索结果数据的后续文章置于背景中。方法:基线数据收集自接受日间手术的符合条件的成年人。数据包括患者特征;术前镇痛药的使用;先前存在的疼痛、手术和麻醉细节;生活质量得分。进行描述性分析以提供研究队列的基线特征。结果:来自199个站点的9618例患者在筛查中符合条件,其中7839例患者在排除后符合条件。术后意外入院是最常见的排除原因,影响1131/9618例(11.8%)患者。随着手术规模的增加、虚弱和ASA身体状况的提高,意外入院的可能性更大。一些常见手术的住院率为50%。3060/7839例(39%)患者报告手术部位疼痛,其中2387/7839例(30.5%)为慢性疼痛。885/7839例(11.3%)患者每天至少服用阿片类药物,1109/7839例(14.1%)患者接受抑郁症治疗,1039/7839例(13.3%)患者接受焦虑症治疗。在1002/7839例(12.8%)患者中,焦虑或抑郁被评为中度或更严重。讨论:在英国,超过三分之一的病人来做日间手术时都感到疼痛,而且大多是慢性的。四分之一的人可以获得阿片类药物,超过十分之一的人每天使用阿片类药物。超过十分之一的人没有接受他们计划的日间手术,日间手术的再入院率没有达到建议的目标。
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引用次数: 0
Chronic pain after day-case surgery: the next challenge in the prevention of chronic post-surgical pain. 日间手术后慢性疼痛:预防慢性术后疼痛的下一个挑战。
IF 6.9 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2026-01-07 DOI: 10.1111/anae.70101
Laura Gérard, Patricia M Lavand'homme
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引用次数: 0
Patient-reported outcomes, postoperative pain and pain relief after day-case surgery (POPPY): chronic post-surgical pain prevalence and associations. 患者报告的结果、术后疼痛和术后疼痛缓解(POPPY):慢性术后疼痛患病率及其相关性
IF 6.9 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2026-01-07 DOI: 10.1111/anae.70092
Adam B Brayne, Martha Belete, Harriet Daykin, Matthew Everson, William M Hare, Anna Ratcliffe, Lexy Sorrell, Mark Rockett

Introduction: Day-case surgical activity is increasing in the UK yet there is a lack of data on the prevalence of chronic post-surgical pain in this population. This study uses data from the POPPY study to estimate the prevalence of chronic post-surgical pain after day-case surgery, its relationship with quality of life and also explores associated factors.

Methods: Data were collected from eligible consenting adults having day-case surgery in 199 sites across the UK. Baseline data were collected on the day of surgery, and patients were followed up by short message service-delivered questionnaires on day 1, day 3, day 7 and day 97. Chronic post-surgical pain was defined using pain severity scores at day 97. Multivariable logistic regression models were used to explore associations with chronic post-surgical pain.

Results: At day 97, 3442 patients had responded from a total of 7839 recruited. The estimated prevalence of chronic post-surgical pain was 7.2% (95%CI 6.4-8.1%). We found the following were associated with chronic post-surgical pain: week 1 pain scores; orthopaedic, breast and plastic surgical specialities; non-surgical site chronic pain at baseline; deprivation; and ethnicity. Patients with chronic post-surgical pain had a mean (SD) decrease of 0.137 (0.205) in health-related quality of life score compared with baseline.

Discussion: This is the first large UK multicentre, prospective observational study exploring chronic post-surgical pain after day-case surgery. Multivariable modelling highlighted several associated factors. Chronic post-surgical pain is common after day-case surgery and is associated with reduced quality of life.

简介:在英国,日病例手术活动正在增加,但缺乏关于这一人群中慢性术后疼痛患病率的数据。本研究使用POPPY研究的数据来估计日例手术后慢性术后疼痛的患病率及其与生活质量的关系,并探讨相关因素。方法:数据收集自英国199个地点接受日间手术的符合条件的成年人。在手术当天收集基线数据,并在第1天、第3天、第7天和第97天通过短信服务发送问卷对患者进行随访。术后慢性疼痛的定义采用疼痛严重程度评分在第97天。采用多变量logistic回归模型探讨与慢性术后疼痛的关系。结果:在第97天,总共7839名患者中有3442名患者有反应。术后慢性疼痛的发生率估计为7.2% (95%CI 6.4-8.1%)。我们发现以下与慢性术后疼痛相关:第1周疼痛评分;骨科、乳房和整形外科专科;非手术部位慢性疼痛基线;剥夺;和种族。与基线相比,慢性术后疼痛患者的健康相关生活质量评分平均(SD)下降0.137(0.205)。讨论:这是英国首个大型多中心前瞻性观察性研究,探讨了日间手术后的慢性术后疼痛。多变量模型突出了几个相关因素。慢性术后疼痛在日间手术后很常见,并与生活质量下降有关。
{"title":"Patient-reported outcomes, postoperative pain and pain relief after day-case surgery (POPPY): chronic post-surgical pain prevalence and associations.","authors":"Adam B Brayne, Martha Belete, Harriet Daykin, Matthew Everson, William M Hare, Anna Ratcliffe, Lexy Sorrell, Mark Rockett","doi":"10.1111/anae.70092","DOIUrl":"10.1111/anae.70092","url":null,"abstract":"<p><strong>Introduction: </strong>Day-case surgical activity is increasing in the UK yet there is a lack of data on the prevalence of chronic post-surgical pain in this population. This study uses data from the POPPY study to estimate the prevalence of chronic post-surgical pain after day-case surgery, its relationship with quality of life and also explores associated factors.</p><p><strong>Methods: </strong>Data were collected from eligible consenting adults having day-case surgery in 199 sites across the UK. Baseline data were collected on the day of surgery, and patients were followed up by short message service-delivered questionnaires on day 1, day 3, day 7 and day 97. Chronic post-surgical pain was defined using pain severity scores at day 97. Multivariable logistic regression models were used to explore associations with chronic post-surgical pain.</p><p><strong>Results: </strong>At day 97, 3442 patients had responded from a total of 7839 recruited. The estimated prevalence of chronic post-surgical pain was 7.2% (95%CI 6.4-8.1%). We found the following were associated with chronic post-surgical pain: week 1 pain scores; orthopaedic, breast and plastic surgical specialities; non-surgical site chronic pain at baseline; deprivation; and ethnicity. Patients with chronic post-surgical pain had a mean (SD) decrease of 0.137 (0.205) in health-related quality of life score compared with baseline.</p><p><strong>Discussion: </strong>This is the first large UK multicentre, prospective observational study exploring chronic post-surgical pain after day-case surgery. Multivariable modelling highlighted several associated factors. Chronic post-surgical pain is common after day-case surgery and is associated with reduced quality of life.</p>","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid‐free vs. opioid‐inclusive anaesthesia with or without regional anaesthesia for postoperative pain: a systematic review with network meta‐analysis of randomised controlled trials 无阿片类药物麻醉与含阿片类药物麻醉加或不加区域麻醉治疗术后疼痛:随机对照试验网络meta分析的系统综述
IF 10.7 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2026-01-05 DOI: 10.1111/anae.70121
Clístenes C. de Carvalho, Kariem El‐Boghdadly, Idrys H. L. Guedes, Maria Vitória M. Dantas, Danusa P. B. Tomé, Isabella B. Ramos, Clarissa S. H. Gomes, Guilherme K. P. A. Alves, Arthur P. Bezerra, Jayme M. Santos Neto, Jaideep J. Pandit, Leandro G. Braz
Summary Introduction Concerns about opioid‐related adverse effects have increased interest in opioid‐free anaesthesia, but the benefits compared with opioid‐inclusive techniques, especially in the presence of regional anaesthesia, remain uncertain. Methods We undertook a systematic review with a network meta‐analysis of randomised controlled trials comparing six strategies in adults: opioid‐free anaesthesia and opioid‐inclusive anaesthesia using remifentanil alone or other opioids, each with or without regional anaesthesia. Primary outcome was postoperative pain. Secondary outcomes were: postoperative opioid use; post‐anaesthesia care unit discharge time; hospital duration of stay; and incidence of complications. Results We included 885 trials from 59 countries. Techniques incorporating regional anaesthesia consistently ranked highest for postoperative pain. Regional anaesthesia combined with an opioid‐free intra‐operative strategy achieved some of the highest surface under the cumulative ranking curve values for pain at 2 h, 12 h and 48 h (93%, 85% and 75%, all low certainty). When regional anaesthesia was used, differences between opioid‐free and opioid‐inclusive techniques were minimal (moderate certainty). For opioid consumption, regional anaesthesia with an opioid‐free strategy ranked best at 2 h (moderate certainty), 12 h (low certainty) and 48 h (low certainty), with surface under the cumulative ranking curve values > 98%. Techniques without regional anaesthesia were associated with higher pain scores and greater opioid requirements. Opioid‐free approaches, especially when combined with regional techniques, were associated with lower rates of postoperative nausea and vomiting. Discussion Regional anaesthesia was the key determinant of improved postoperative pain control, and intra‐operative opioids added little additional benefit when regional techniques provided adequate coverage. Without regional anaesthesia, neither opioid‐free nor opioid‐inclusive strategies showed consistent analgesic superiority. However, opioid‐free techniques reduced postoperative nausea and vomiting. These findings support preferential use of regional anaesthesia where feasible and suggest that avoiding intra‐operative opioids may facilitate recovery, particularly when regional techniques are employed effectively.
对阿片类药物相关不良反应的关注增加了人们对无阿片类药物麻醉的兴趣,但与含阿片类药物麻醉相比,特别是在区域麻醉下,其益处仍不确定。方法:我们进行了一项系统综述,对随机对照试验进行了网络meta分析,比较了六种成人策略:无阿片类药物麻醉和单独使用瑞芬太尼或其他阿片类药物的阿片类药物麻醉,每种麻醉都有或没有区域麻醉。主要结局为术后疼痛。次要结局是:术后阿片类药物使用;麻醉后护理病房出院时间;住院时间;以及并发症的发生率。我们纳入了来自59个国家的885项试验。结合区域麻醉的技术在术后疼痛方面一直排名最高。区域麻醉联合无阿片类药物术中策略在2小时、12小时和48小时的累积排序曲线值下获得了一些最高的表面(93%、85%和75%,均为低确定性)。当使用区域麻醉时,无阿片类药物和含阿片类药物技术之间的差异很小(中等确定性)。对于阿片类药物的消耗,无阿片类药物策略的区域麻醉在2小时(中等确定性)、12小时(低确定性)和48小时(低确定性)时排名最佳,其累积排名曲线下的表面值为98%。无区域麻醉的技术与更高的疼痛评分和更大的阿片类药物需求相关。无阿片类药物入路,特别是与局部技术相结合时,可降低术后恶心和呕吐的发生率。区域麻醉是改善术后疼痛控制的关键决定因素,当区域技术提供足够的覆盖范围时,术中阿片类药物增加的额外益处很少。在没有区域麻醉的情况下,无阿片类药物和含阿片类药物的策略都没有显示出一致的镇痛优势。然而,不含阿片类药物的技术减少了术后恶心和呕吐。这些发现支持在可行的情况下优先使用区域麻醉,并建议避免术中使用阿片类药物可能有助于恢复,特别是当有效使用区域技术时。
{"title":"Opioid‐free vs. opioid‐inclusive anaesthesia with or without regional anaesthesia for postoperative pain: a systematic review with network meta‐analysis of randomised controlled trials","authors":"Clístenes C. de Carvalho, Kariem El‐Boghdadly, Idrys H. L. Guedes, Maria Vitória M. Dantas, Danusa P. B. Tomé, Isabella B. Ramos, Clarissa S. H. Gomes, Guilherme K. P. A. Alves, Arthur P. Bezerra, Jayme M. Santos Neto, Jaideep J. Pandit, Leandro G. Braz","doi":"10.1111/anae.70121","DOIUrl":"https://doi.org/10.1111/anae.70121","url":null,"abstract":"Summary Introduction Concerns about opioid‐related adverse effects have increased interest in opioid‐free anaesthesia, but the benefits compared with opioid‐inclusive techniques, especially in the presence of regional anaesthesia, remain uncertain. Methods We undertook a systematic review with a network meta‐analysis of randomised controlled trials comparing six strategies in adults: opioid‐free anaesthesia and opioid‐inclusive anaesthesia using remifentanil alone or other opioids, each with or without regional anaesthesia. Primary outcome was postoperative pain. Secondary outcomes were: postoperative opioid use; post‐anaesthesia care unit discharge time; hospital duration of stay; and incidence of complications. Results We included 885 trials from 59 countries. Techniques incorporating regional anaesthesia consistently ranked highest for postoperative pain. Regional anaesthesia combined with an opioid‐free intra‐operative strategy achieved some of the highest surface under the cumulative ranking curve values for pain at 2 h, 12 h and 48 h (93%, 85% and 75%, all low certainty). When regional anaesthesia was used, differences between opioid‐free and opioid‐inclusive techniques were minimal (moderate certainty). For opioid consumption, regional anaesthesia with an opioid‐free strategy ranked best at 2 h (moderate certainty), 12 h (low certainty) and 48 h (low certainty), with surface under the cumulative ranking curve values &gt; 98%. Techniques without regional anaesthesia were associated with higher pain scores and greater opioid requirements. Opioid‐free approaches, especially when combined with regional techniques, were associated with lower rates of postoperative nausea and vomiting. Discussion Regional anaesthesia was the key determinant of improved postoperative pain control, and intra‐operative opioids added little additional benefit when regional techniques provided adequate coverage. Without regional anaesthesia, neither opioid‐free nor opioid‐inclusive strategies showed consistent analgesic superiority. However, opioid‐free techniques reduced postoperative nausea and vomiting. These findings support preferential use of regional anaesthesia where feasible and suggest that avoiding intra‐operative opioids may facilitate recovery, particularly when regional techniques are employed effectively.","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"29 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to advance gender equity in anaesthesia leadership: a state-of-the-art review. 促进麻醉领导性别平等的战略:最新的审查。
IF 6.9 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2026-01-01 DOI: 10.1111/anae.70120
Kara J Allen, Anjalee Brahmbhatt, Kathryn Rough, Juliana Caicedo Salazar, Phyllis Phukubye-Johnson, Fiona Desmond

Introduction: Gender equity for anaesthetists remains elusive, despite patient and clinician benefits. Many strategies have been proposed to promote gender equity, yet women remain under-represented in anaesthesia leadership compared with men. This review identifies contemporary implemented strategies to improve gender equity in anaesthesia leadership.

Methods: We searched databases for studies published from January 2019 to March 2024, including reports of implementation. We employed state-of-the-art review methodology to provide a current understanding of this complex sociocultural problem, using Cook's and Stufflebeam frameworks for categorisation and deductive data extraction and analysis based on context, inputs, processes and outcomes.

Results: We screened 257 abstracts and identified 18 studies for analysis; 14 were conducted in the USA. The most prominent individual interventions were mentorship and sponsorship. These were supported by organisational interventions including professional development curricula; policies; and leadership roles supporting diversity. Two studies reported how programmes were iteratively developed. Reported success metrics included quantitative (increased diversity in leadership, achieving promotion) and qualitative outcomes (networks and wellbeing).

Discussion: Evidence for best practices to address gender equity in anaesthesia leadership is emerging. Prospective determination of key outcomes enables monitoring of success, including representation and wellbeing. Organisational support, in the form of policies and leadership roles linked to diversity outcomes, amplifies the benefits of mentorship and sponsorship. Future interventions should report the context in which the interventions were mobilised, associated costs and details of the iterative programme delivery and development process.

导言:尽管患者和临床医生受益,麻醉师的性别平等仍然难以捉摸。已经提出了许多促进性别平等的战略,但与男性相比,女性在麻醉领导中的代表性仍然不足。本综述确定了当代实施的战略,以改善麻醉领导中的性别平等。方法:我们检索了数据库中2019年1月至2024年3月发表的研究,包括实施报告。我们采用了最先进的审查方法来提供对这一复杂社会文化问题的当前理解,使用Cook和Stufflebeam框架进行分类和演绎数据提取,并基于上下文、输入、过程和结果进行分析。结果:我们筛选了257篇摘要,筛选出18篇研究进行分析;14例在美国进行。最突出的个人干预是指导和赞助。这些都得到了包括专业发展课程在内的组织干预措施的支持;政策;领导角色支持多元化。两项研究报告了如何迭代地制定方案。报告的成功指标包括定量(领导层的多样性增加、获得晋升)和定性结果(人际关系和幸福感)。讨论:解决麻醉领导中性别平等问题的最佳实践的证据正在出现。对关键结果的前瞻性确定能够监测成功,包括代表性和福祉。组织的支持,以政策和领导角色的形式与多样性成果相联系,放大了指导和赞助的好处。今后的干预措施应报告动员这些干预措施的背景、相关费用以及迭代方案执行和发展过程的细节。
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引用次数: 0
Issue Information – Editorial Board 发行信息-编辑委员会
IF 6.9 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-29 DOI: 10.1111/anae.70106
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引用次数: 0
Population characteristics of individual enhanced facilities in the UK compared with critical care 与重症监护相比,英国个体强化设施的人口特征
IF 10.7 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-26 DOI: 10.1111/anae.70113
Christopher Oddy
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引用次数: 0
Neurocognitive outcomes: too much data, not enough clarity 神经认知结果:数据太多,不够清晰
IF 10.7 1区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-26 DOI: 10.1111/anae.70117
Tuhin Mistry, Abhijit Sukumaran Nair
{"title":"Neurocognitive outcomes: too much data, not enough clarity","authors":"Tuhin Mistry, Abhijit Sukumaran Nair","doi":"10.1111/anae.70117","DOIUrl":"https://doi.org/10.1111/anae.70117","url":null,"abstract":"","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"2 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145830257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Anaesthesia
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