Pub Date : 2026-02-04DOI: 10.1097/MJT.0000000000002100
Andrew Xanthopoulos, Grigorios Giamouzis, Michail Papamichalis, Ioannis Leventis, Alexandros Briasoulis, Dimitrios E Magouliotis, Filippos Triposkiadis, Randall C Starling, Frederik H Verbrugge, John Skoularigis
{"title":"Pulmonary Arterial Pressure Monitoring of the Pulmonary Hemodynamics With Vericiguat in Heart Failure With Reduced Ejection Fraction.","authors":"Andrew Xanthopoulos, Grigorios Giamouzis, Michail Papamichalis, Ioannis Leventis, Alexandros Briasoulis, Dimitrios E Magouliotis, Filippos Triposkiadis, Randall C Starling, Frederik H Verbrugge, John Skoularigis","doi":"10.1097/MJT.0000000000002100","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002100","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1097/MJT.0000000000002116
Vidhya Parameswaran, Sheldon Wang, JoAnn Clair
{"title":"Comment on \"Risk of Pericarditis Recurrence Associated With Rilonacept and NSAID/Colchicine Therapy After Initial Pericarditis Presentation: A Retrospective Real-World Comparative Risk Analysis With TriNetX\".","authors":"Vidhya Parameswaran, Sheldon Wang, JoAnn Clair","doi":"10.1097/MJT.0000000000002116","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002116","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1097/MJT.0000000000002103
Kannan Sridharan, Gowri Sivaramakrishnan
{"title":"Comparative Microbiome Analysis in Ventilator-Associated Pneumonia Across Oral Care Interventions in Intubated Patients: A Systematic Review and Meta-Analysis.","authors":"Kannan Sridharan, Gowri Sivaramakrishnan","doi":"10.1097/MJT.0000000000002103","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002103","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146002816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1097/MJT.0000000000002095
Ahmed Naguy, Hessah H Abul, Bibi Alamiri
{"title":"Long-Acting Injectable Antipsychotics in Child and Adolescent Psychiatry.","authors":"Ahmed Naguy, Hessah H Abul, Bibi Alamiri","doi":"10.1097/MJT.0000000000002095","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002095","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1097/MJT.0000000000002025
Radu Filipescu, Sean P Collins, Razvan I Radu, Tuvia Ben Gal, Laura Antohi, Magdy Abdelhamid, Oliviana Geavlete, Maria Pana, Dimitrios Farmakis, Diana C Matei, Gianluigi Savarese, Cornelia Margineanu, Marija Polovina, Òscar Miró, Dragos Guz, Alberto Palazzuoli, Josep Masip, Marianna Adamo, Andrew P Ambrosy, Ovidiu Chioncel
Background: Despite the use of vasoactive therapies, invasive monitoring, revascularization, and/or mechanical circulatory support (MCS), cardiogenic shock (CS) continues to be associated with very high mortality. This narrative review aims to describe the therapeutic advances in the management of this syndrome.
Areas of uncertainty: In clinical practice, many uncertainties about CS management remain, particularly regarding management in pre-CS phase, risk stratification algorithms, optimal ventilation mode, local CS protocols, appropriate selection and threshold for MCS initiation, or approach to MCS-related complications. Patients with CS without acute myocardial infarction (AMI) are substantially underrepresented in randomized controlled trials (RCTs), and future research, including new RCTs and high-quality observational studies, is imperiously needed.
Data sources: Evidence-based information on CS is limited, as management recommendations and therapies are mostly extrapolated from large multicentric CS registries or RCTs in patients with AMI occurring at tertiary medical centers. In recent years, numerous studies have been published or are ongoing, emphasizing the unresolved issues in CS management.
Results: The results from the literature showcased the benefits of early revascularization of the culprit vessel in AMI-CS or use of pulmonary artery catheter for better overall monitoring. Despite almost universal administration of inotropes and vasopressors in patients with CS, they lack RCT evidence for increasing the survival rate. The same applies for temporary MCS, except for micro axial flow pumps which have been associated with lower 6-month mortality in a selected CS population. Large tertiary CS centers could develop regional or national networks through hub-and-spoke systems based on multidisciplinary teams and CS protocols.
Conclusions: Although the current general approach to treating patients with CS has improved the prognosis, additional research is needed to overcome the key knowledge gaps and advance individualized CS treatment.
{"title":"Therapeutic Advances in the Management of Cardiogenic Shock.","authors":"Radu Filipescu, Sean P Collins, Razvan I Radu, Tuvia Ben Gal, Laura Antohi, Magdy Abdelhamid, Oliviana Geavlete, Maria Pana, Dimitrios Farmakis, Diana C Matei, Gianluigi Savarese, Cornelia Margineanu, Marija Polovina, Òscar Miró, Dragos Guz, Alberto Palazzuoli, Josep Masip, Marianna Adamo, Andrew P Ambrosy, Ovidiu Chioncel","doi":"10.1097/MJT.0000000000002025","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002025","url":null,"abstract":"<p><strong>Background: </strong>Despite the use of vasoactive therapies, invasive monitoring, revascularization, and/or mechanical circulatory support (MCS), cardiogenic shock (CS) continues to be associated with very high mortality. This narrative review aims to describe the therapeutic advances in the management of this syndrome.</p><p><strong>Areas of uncertainty: </strong>In clinical practice, many uncertainties about CS management remain, particularly regarding management in pre-CS phase, risk stratification algorithms, optimal ventilation mode, local CS protocols, appropriate selection and threshold for MCS initiation, or approach to MCS-related complications. Patients with CS without acute myocardial infarction (AMI) are substantially underrepresented in randomized controlled trials (RCTs), and future research, including new RCTs and high-quality observational studies, is imperiously needed.</p><p><strong>Data sources: </strong>Evidence-based information on CS is limited, as management recommendations and therapies are mostly extrapolated from large multicentric CS registries or RCTs in patients with AMI occurring at tertiary medical centers. In recent years, numerous studies have been published or are ongoing, emphasizing the unresolved issues in CS management.</p><p><strong>Results: </strong>The results from the literature showcased the benefits of early revascularization of the culprit vessel in AMI-CS or use of pulmonary artery catheter for better overall monitoring. Despite almost universal administration of inotropes and vasopressors in patients with CS, they lack RCT evidence for increasing the survival rate. The same applies for temporary MCS, except for micro axial flow pumps which have been associated with lower 6-month mortality in a selected CS population. Large tertiary CS centers could develop regional or national networks through hub-and-spoke systems based on multidisciplinary teams and CS protocols.</p><p><strong>Conclusions: </strong>Although the current general approach to treating patients with CS has improved the prognosis, additional research is needed to overcome the key knowledge gaps and advance individualized CS treatment.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1097/MJT.0000000000002104
Ahmed Naguy
{"title":"Leucovorin for Autism.","authors":"Ahmed Naguy","doi":"10.1097/MJT.0000000000002104","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002104","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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