Pub Date : 2025-12-17DOI: 10.1097/MJT.0000000000002046
Inbal Kestenbom, Shaked Bar-Moshe, Gidon Test, Or Kaplan, Tal Grupel, Michael Shilo, Natalya Bilenko, Michael Friger, Michal S Maimon, Dennis Scolnik, Miguel Glatstein
Background: Scorpion envenomation is a significant public health concern in specific regions and can have severe consequences in pediatric patients. The efficacy of antivenom treatment remains controversial.
Objective: To compare the clinical course and outcomes of pediatric scorpion envenomation in patients receiving SCORPIFAV antivenom versus supportive care alone.
Methods: We conducted a retrospective study of children aged 0-18 years presenting with grade ≥2 scorpion envenomation to the pediatric emergency department at Soroka University Medical Center, Israel, between 2014 and 2020. Clinical outcomes were compared between patients who received SCORPIFAV and those treated with supportive care alone.
Results: A total of 194 children were included (median age: 3 years, interquartile range: 2-8 years); 125 received SCORPIFAV and 69 received supportive care only. Patients treated with SCORPIFAV required less sedation (10.3% vs. 23.4%, P = 0.02), less analgesia (53.3% vs. 81.3%, P < 0.001), and fewer antihypertensive medications (0% vs. 17.2%, P < 0.001). SCORPIFAV administration was associated with higher odds of requiring minimal additional treatment (OR = 2.568, 95% CI, 1.168-5.646, P = 0.019). No significant differences were found in pediatric intensive care unit admission rates or length of stay.
Conclusions: In pediatric patients with grade ≥2 scorpion envenomation, SCORPIFAV use was associated with reduced need for sedatives, analgesics, and antihypertensive medications. These findings suggest that early administration of SCORPIFAV in the emergency setting may help attenuate the sympathetic response and reduce overall treatment intensity.
{"title":"Scropifav Antivenom Versus Supportive Care Alone in the Treatment of Pediatric Scorpion Envenomation.","authors":"Inbal Kestenbom, Shaked Bar-Moshe, Gidon Test, Or Kaplan, Tal Grupel, Michael Shilo, Natalya Bilenko, Michael Friger, Michal S Maimon, Dennis Scolnik, Miguel Glatstein","doi":"10.1097/MJT.0000000000002046","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002046","url":null,"abstract":"<p><strong>Background: </strong>Scorpion envenomation is a significant public health concern in specific regions and can have severe consequences in pediatric patients. The efficacy of antivenom treatment remains controversial.</p><p><strong>Objective: </strong>To compare the clinical course and outcomes of pediatric scorpion envenomation in patients receiving SCORPIFAV antivenom versus supportive care alone.</p><p><strong>Methods: </strong>We conducted a retrospective study of children aged 0-18 years presenting with grade ≥2 scorpion envenomation to the pediatric emergency department at Soroka University Medical Center, Israel, between 2014 and 2020. Clinical outcomes were compared between patients who received SCORPIFAV and those treated with supportive care alone.</p><p><strong>Results: </strong>A total of 194 children were included (median age: 3 years, interquartile range: 2-8 years); 125 received SCORPIFAV and 69 received supportive care only. Patients treated with SCORPIFAV required less sedation (10.3% vs. 23.4%, P = 0.02), less analgesia (53.3% vs. 81.3%, P < 0.001), and fewer antihypertensive medications (0% vs. 17.2%, P < 0.001). SCORPIFAV administration was associated with higher odds of requiring minimal additional treatment (OR = 2.568, 95% CI, 1.168-5.646, P = 0.019). No significant differences were found in pediatric intensive care unit admission rates or length of stay.</p><p><strong>Conclusions: </strong>In pediatric patients with grade ≥2 scorpion envenomation, SCORPIFAV use was associated with reduced need for sedatives, analgesics, and antihypertensive medications. These findings suggest that early administration of SCORPIFAV in the emergency setting may help attenuate the sympathetic response and reduce overall treatment intensity.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1097/MJT.0000000000002090
Abdallfatah Abdallfatah, Ahmed Hamdy G Ali, Samaa Daoud, Douglas G Adler
{"title":"A Head-To-Head Comparison of Diclofenac Versus Indomethacin for the Prophylaxis of Post-ERCP Pancreatitis: A Systematic Review and Meta-Analysis.","authors":"Abdallfatah Abdallfatah, Ahmed Hamdy G Ali, Samaa Daoud, Douglas G Adler","doi":"10.1097/MJT.0000000000002090","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002090","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1097/MJT.0000000000002096
Ahmad Al-Abdouh, Ahmad Jabri, Mohammed Mhanna, Laith Alhuneafat, Deya Alkhatib, Ibrahim Mortada, Shareef Mansour, Wissam Khalife
{"title":"The Use of Beta-Blockers After Myocardial Infarction in Patients With Left Ventricular Ejection Fraction of More Than 40%: A Meta-Analysis.","authors":"Ahmad Al-Abdouh, Ahmad Jabri, Mohammed Mhanna, Laith Alhuneafat, Deya Alkhatib, Ibrahim Mortada, Shareef Mansour, Wissam Khalife","doi":"10.1097/MJT.0000000000002096","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002096","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1097/MJT.0000000000002087
Dhouha Sahnoun, Myriam Agrebi, Chayma Ladhari, Hajer Bouraoui, Nejla El Amri, Elyes Bouajina, Chaker Ben Salem
{"title":"A Case of Acute Pancreatitis Related to Therapeutic Dosing With Colchicine and Review of the Literature.","authors":"Dhouha Sahnoun, Myriam Agrebi, Chayma Ladhari, Hajer Bouraoui, Nejla El Amri, Elyes Bouajina, Chaker Ben Salem","doi":"10.1097/MJT.0000000000002087","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002087","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145720415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-09DOI: 10.1097/MJT.0000000000002068
Cara Mohammed, Muhammad Waqi Qamar, Basanta Pathak, Madiha Shareef, Rimsha Saeed Ahmed, Anas Shihab, Umair Khalid, Gagandeep Singh, Areehah Zafar Masood, Rai Dilawar Shahjehan, Sarah MacKenzie Picker, Raheel Ahmed, Mushood Ahmed, Muhammad Ehsan
{"title":"Impact of Discontinuing Renin-Angiotensin-Aldosterone System Inhibitors With or Without Calcium Channel Blockers on Cardiovascular Outcomes in Noncardiac Surgery: A Meta-Analysis of Randomized Controlled Trials.","authors":"Cara Mohammed, Muhammad Waqi Qamar, Basanta Pathak, Madiha Shareef, Rimsha Saeed Ahmed, Anas Shihab, Umair Khalid, Gagandeep Singh, Areehah Zafar Masood, Rai Dilawar Shahjehan, Sarah MacKenzie Picker, Raheel Ahmed, Mushood Ahmed, Muhammad Ehsan","doi":"10.1097/MJT.0000000000002068","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002068","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1097/MJT.0000000000002066
Yasuyuki Inoue, Shigeki Kosugi
{"title":"Successful Treatment of Evans Syndrome With efgartigimod: A Case Report.","authors":"Yasuyuki Inoue, Shigeki Kosugi","doi":"10.1097/MJT.0000000000002066","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002066","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1097/MJT.0000000000002063
Shigeki Kosugi, Yasuyuki Inoue
{"title":"Successful Treatment of Relapsed Transformed Aggressive B-Cell Lymphoma After Autologous Hematopoietic Stem Cell Transplantation With Polatuzumab Vedotin Combined With Bendamustine and Rituximab Followed by Nonmyeloablative Related HLA-Identical Stem Cell Transplantation.","authors":"Shigeki Kosugi, Yasuyuki Inoue","doi":"10.1097/MJT.0000000000002063","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002063","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1097/MJT.0000000000001771
Sheng Li, Bing-Jun Shi
{"title":"A Case of an Elderly Bullous Pemphigoid Patient With Enterostomy Was Effectively Treated With Dupilumab.","authors":"Sheng Li, Bing-Jun Shi","doi":"10.1097/MJT.0000000000001771","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001771","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tofacitinib for the Treatment of Refractory Severe Acute Urticaria: A Retrospective Case Series.","authors":"Anqi Chen, Xianjie Yang, Xuewei Huang, Shifei Li, Huan Wang, Sisi Deng, Zhiqiang Song, Qiquan Chen","doi":"10.1097/MJT.0000000000002076","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002076","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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