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Neurodevelopmental burden in young adults undergoing opioid substitution therapy: The role of inattentive and hyperactive/impulsive symptoms. 接受阿片类药物替代治疗的年轻人的神经发育负担：注意力不集中和多动/冲动症状的作用
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-30 DOI: 10.1111/ajad.70103
Maddalena Cesco, Marco Garzitto, Livia Pischiutta, Tiziana Lombardelli, Enrico Moratti, Giuliano Zamparutti, Matteo Balestrieri, Umberto Albert, Marco Colizzi

Background and objectives: Attention-deficit/hyperactivity disorder (ADHD) is recognized as a condition that can persist into adulthood, often with psychiatric comorbidities that worsen the overall prognosis. ADHD has been associated with substance use disorders (SUDs), especially through symptoms like hyperactivity and impulsivity, while the role of inattentive symptoms remains more difficult to judge. This study aimed to estimate the likelihood of ADHD in a sample of young adults with SUDs undergoing opioid agonist treatment, and to evaluate how inattentive and hyperactive/impulsive traits affect their clinical, psychological, and social functioning.

Methods: 57 individuals were evaluated using comprehensive clinical interviews and self-administered questionnaires to assess characteristics of SUDs, current and childhood ADHD symptoms, levels of impulsivity, and psychiatric comorbidities.

Results: Overall, 22.8% of participants were classified as possible ADHD cases (p-ADHD). Compared to the comparison group, p-ADHD patients exhibited more severe SUDs symptomatology and greater impairments in specific domains of adaptive functioning. They also had a higher lifetime prevalence of social anxiety disorder, unspecified Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5) diagnoses, and clinically relevant impulsivity. Further, p-ADHD individuals were more likely to experience limitations and craving, with the inattentive symptoms significantly mediating these associations.

Discussion and conclusions: ADHD frequently co-occurs in SUDs patients in OAT and can worsen the SUDs clinical presentation. Moreover, inattentive symptoms may play a prominent role in SUDs development.

Scientific significance: This study suggests that different ADHD presentations influence SUDs manifestations, challenging the idea that impulsivity is the main contributor in SUDs.

背景和目的：注意力缺陷/多动障碍（ADHD）被认为是一种可以持续到成年的疾病，通常伴有精神合并症，使总体预后恶化。ADHD与物质使用障碍（sud）有关，尤其是多动症和冲动等症状，而注意力不集中症状的作用仍然难以判断。本研究旨在评估接受阿片类激动剂治疗的年轻成年sud患者患ADHD的可能性，并评估注意力不集中和多动/冲动特征如何影响他们的临床、心理和社会功能。方法：采用综合临床访谈和自填问卷对57名个体进行评估，以评估sud的特征、当前和儿童ADHD症状、冲动水平和精神合并症。结果：总体而言，22.8%的参与者被归类为可能的ADHD病例（p-ADHD）。与对照组相比，p-ADHD患者在适应功能的特定领域表现出更严重的sud症状和更大的损伤。他们也有更高的社交焦虑症的终生患病率，未明确的精神障碍诊断和统计手册第五版（DSM-5）的诊断，以及临床相关的冲动。此外，p-ADHD个体更有可能经历限制和渴望，注意力不集中的症状显著地介导了这些关联。讨论与结论：ADHD经常在OAT的sud患者中同时发生，并可使sud的临床表现恶化。此外，注意力不集中症状可能在sud的发展中起重要作用。科学意义：本研究表明，不同的ADHD表现会影响sud的表现，挑战了冲动是sud主要诱因的观点。
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引用次数: 0
The mediating role of impulsivity in the relationship between childhood maltreatment and depression in methamphetamine patients. 冲动在甲基苯丙胺患者童年虐待与抑郁关系中的中介作用。
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-30 DOI: 10.1111/ajad.70102
Saad Ullah, Yang Tian, Jia-Jing Chen, Arsalan Haider, Abdur Rab Tariq Kiyani, Han Chen, Ren Huang, Dong-Mei Wang, Xiang-Yang Zhang

Background and objectives: Childhood maltreatment (CM) significantly increases the risk of depression in patients with methamphetamine use disorder (MAUD). However, the underlying psychological mechanism remains unclear. The purpose of this study was to explore whether impulsivity mediates the relationship between CM and depression in patients with MAUD.

Methods: We recruited 577 Chinese male inpatients with MAUD. CM, depression, and impulsivity were assessed using standardized questionnaires.

Results: A total of 321 of 577 (55.63%) patients with MAUD had experienced at least one form of CM. Maltreated patients exhibited elevated impulsivity and severe depression compared to nonmaltreated patients (both p < .001). CM, impulsivity, and depression were significantly interrelated (all p < .01). In addition, impulsivity partially mediated the CM-depression link in patients with MAUD (β = .015, 95% CI [0.007, 0.026]).

Discussion and conclusions: Our findings indicate that CM has a long-term effect on depression, and impulsivity is an essential contributor to depressive symptoms in patients with MAUD who have experienced CM. Future research should investigate these associations using multimodal approaches and assess focused interventions that may reduce impulsivity and mitigate the psychological impact of adverse childhood experiences (ACEs) in patients with MAUD.

Scientific significance: We identified impulsivity as a key mechanism in the CM-depression link, offering a novel intervention target. Our findings advance the understanding of the psychological mechanisms in addiction psychiatry and suggest that interventions targeting impulsivity may help mitigate depression in this population.

背景和目的：儿童虐待（CM）显著增加甲基苯丙胺使用障碍（MAUD）患者抑郁的风险。然而，潜在的心理机制尚不清楚。本研究的目的是探讨冲动性是否介导MAUD患者CM与抑郁之间的关系。方法：我们招募577例中国男性住院MAUD患者。CM、抑郁和冲动采用标准化问卷进行评估。结果：577例MAUD患者中有321例（55.63%）经历过至少一种形式的CM。与未受虐待的患者相比，受虐待的患者表现出更高的冲动性和严重的抑郁症(p讨论和结论：我们的研究结果表明，CM对抑郁症有长期影响，而冲动性是经历过CM的MAUD患者抑郁症状的重要因素。未来的研究应该使用多模式方法来调查这些关联，并评估可能减少冲动和减轻MAUD患者不良童年经历（ace）心理影响的重点干预措施。科学意义：我们发现冲动性是cm -抑郁联系的关键机制，提供了一个新的干预目标。我们的发现促进了对成瘾精神病学心理机制的理解，并表明针对冲动的干预可能有助于减轻这一人群的抑郁症。
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引用次数: 0
Opioid Recover Network - ORN: Recruiting qualified consultants for the ORN 阿片类药物恢复网络- ORN：为ORN招聘合格的顾问
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70095

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引用次数: 0
Call for Review Papers 2025 2025年征稿
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70094

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引用次数: 0
Call for Special Issue Papers 2025 征集2025年特刊论文
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70093

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引用次数: 0
STILL TIME TO REGISTER: Don't miss out on the chance to attend this year's AAAP Annual Meeting, Nov. 6 – 9, 2025 仍有时间报名：不要错过参加2025年11月6日至9日举行的今年AAAP年会的机会
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70098

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引用次数: 0
FREE WEBINAR: Cultural Considerations in Tribal Behavioral Health Practice, December 10, 2025 免费网络研讨会：部落行为健康实践中的文化考虑，2025年12月10日
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70097

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AAAP NEWSLETTER: What do your colleagues have to say about the latest updates in Addiction Psychiatry? AAAP通讯：你的同事对成瘾精神病学的最新进展有什么看法？
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70096

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引用次数: 0
AAAP MEMBERSHIP: Reap the benefits of belonging to AAAP AAAP会员资格：获得属于AAAP的好处
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70099

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Updated OUD PIP: Take this free, updated PIP activity on treating opioid use disorder 更新的OUD PIP：使用这个免费的，更新的PIP活动来治疗阿片类药物使用障碍
IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
American Journal on Addictions
Pub Date : 2025-10-27 DOI: 10.1111/ajad.70100

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引用次数: 0
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