Pub Date : 1985-12-01DOI: 10.1016/S0307-742X(21)00607-X
Michael D. Lockshin
It should be obvious that our understanding of the problems of SLE pregnancy is just beginning, but that individual problems can be isolated, studied, and controlled. It should also be obvious that casual reassurance about pregnancy is never indicated; even very well patients can have major complications. All patients need to be closely monitored by both primary physician and obstetrician. Under these circumstances healthy, living babies and mothers are possible even in severely adverse circumstances.
{"title":"Lupus Pregnancy","authors":"Michael D. Lockshin","doi":"10.1016/S0307-742X(21)00607-X","DOIUrl":"https://doi.org/10.1016/S0307-742X(21)00607-X","url":null,"abstract":"<div><p>It should be obvious that our understanding of the problems of SLE pregnancy is just beginning, but that individual problems can be isolated, studied, and controlled. It should also be obvious that casual reassurance about pregnancy is never indicated; even very well patients can have major complications. All patients need to be closely monitored by both primary physician and obstetrician. Under these circumstances healthy, living babies and mothers are possible even in severely adverse circumstances.</p></div>","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137404797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Giant cell arteritis and polymyalgia rheumatica.","authors":"G G Hunder, C J Michet","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15023882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-12-01DOI: 10.1016/S0307-742X(21)00605-6
Ralph C. Williams Jr
{"title":"Molecular Mimicry and Rheumatic Fever","authors":"Ralph C. Williams Jr","doi":"10.1016/S0307-742X(21)00605-6","DOIUrl":"https://doi.org/10.1016/S0307-742X(21)00605-6","url":null,"abstract":"","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137404799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-12-01DOI: 10.1016/S0307-742X(21)00600-7
Gene G. Hunder, Clement J. Michet
{"title":"Giant Cell Arteritis and Polymyalgia Rheumatica","authors":"Gene G. Hunder, Clement J. Michet","doi":"10.1016/S0307-742X(21)00600-7","DOIUrl":"https://doi.org/10.1016/S0307-742X(21)00600-7","url":null,"abstract":"","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136403226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S H Lee, T Matsuyama, P Logalbo, J Silver, R J Winchester
Since the first description of human leukocyte agglutination antibodies, knowledge of the MHC, particularly the Ia region, has grown immensely and it is now recognized as a major polymorphic multigene family involved in the regulation of immune response and disease susceptibility. This review examined the hypothesis that there is another level of complexity within the Ia system, beyond multiple loci and allelic series, that involves specific epitopes as the functionally important components of the Ia molecule. Certain of these epitopes are likely to be responsible for the regulation of immune responses and susceptibility to certain autoimmune diseases such as rheumatoid arthritis (RA). Evidence was presented that certain monoclonal antibodies recognize epitopes found in a significantly more positive association with susceptibility to RA than available markers such as DR4. Biochemical characterization of the Ia molecules bearing this epitope revealed that the same epitope was present on two different molecules. The possibility was considered that such epitopes are closely related but not identical to Ia determinants that are primarily involved in producing the abnormal immune state characterizing those with RA.
{"title":"Ia antigens and susceptibility to rheumatoid arthritis.","authors":"S H Lee, T Matsuyama, P Logalbo, J Silver, R J Winchester","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since the first description of human leukocyte agglutination antibodies, knowledge of the MHC, particularly the Ia region, has grown immensely and it is now recognized as a major polymorphic multigene family involved in the regulation of immune response and disease susceptibility. This review examined the hypothesis that there is another level of complexity within the Ia system, beyond multiple loci and allelic series, that involves specific epitopes as the functionally important components of the Ia molecule. Certain of these epitopes are likely to be responsible for the regulation of immune responses and susceptibility to certain autoimmune diseases such as rheumatoid arthritis (RA). Evidence was presented that certain monoclonal antibodies recognize epitopes found in a significantly more positive association with susceptibility to RA than available markers such as DR4. Biochemical characterization of the Ia molecules bearing this epitope revealed that the same epitope was present on two different molecules. The possibility was considered that such epitopes are closely related but not identical to Ia determinants that are primarily involved in producing the abnormal immune state characterizing those with RA.</p>","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13563609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epstein-Barr virus in rheumatoid arthritis.","authors":"R I Fox, M Lotz, G Rhodes, J H Vaughan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-12-01DOI: 10.1016/S0307-742X(21)00604-4
Mart Mannik, Francis A. Nardella
IgG RFs are unique antibodies since they form immune complexes by self-association without the presence of separate antigen molecules. These immune complexes can drive inflammation by complement activation and by interaction with monocytes. Plasma cells in the synovial tissues of patients with RA synthesize IgG RFs and other rheumatoid factors. The reason for the accumulation of these cells in the synovium has not been elucidated.
The detection and quantitation of IgG RFs has been difficult owing to the unique nature of these antibodies. The methods for this purpose, however, have improved. In patients with RA the presence of high levels of IgG RFs in serum is associated with clinical evidence of vasculitis. The quantitation of IgG RFs in serum of patients has not yet been established as a diagnostic or prognostic tool. Available evidence, however, suggests that these antibodies have a significant role in the pathogenesis of rheumatoid arthritis.
{"title":"IgG Rheumatoid Factors and Self-association of These Antibodies","authors":"Mart Mannik, Francis A. Nardella","doi":"10.1016/S0307-742X(21)00604-4","DOIUrl":"10.1016/S0307-742X(21)00604-4","url":null,"abstract":"<div><p>IgG RFs are unique antibodies since they form immune complexes by self-association without the presence of separate antigen molecules. These immune complexes can drive inflammation by complement activation and by interaction with monocytes. Plasma cells in the synovial tissues of patients with RA synthesize IgG RFs and other rheumatoid factors. The reason for the accumulation of these cells in the synovium has not been elucidated.</p><p>The detection and quantitation of IgG RFs has been difficult owing to the unique nature of these antibodies. The methods for this purpose, however, have improved. In patients with RA the presence of high levels of IgG RFs in serum is associated with clinical evidence of vasculitis. The quantitation of IgG RFs in serum of patients has not yet been established as a diagnostic or prognostic tool. Available evidence, however, suggests that these antibodies have a significant role in the pathogenesis of rheumatoid arthritis.</p></div>","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56625009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunological aspects of rheumatic diseases.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77693,"journal":{"name":"Clinics in rheumatic diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14996691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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