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Protective effects of a zinc-hydroxyapatite toothpaste on enamel erosion: SEM study. 锌-羟基磷灰石牙膏对釉质侵蚀的保护作用:扫描电镜研究。
Pub Date : 2016-07-01 DOI: 10.11138/ads/2016.7.3.038
Marco Colombo, Riccardo Beltrami, Davide Rattalino, M. Mirando, M. Chiesa, C. Poggio
AIMThe aim of the present in vitro study was to evaluate the protective effects of a zinc-hydroxyapatite toothpaste against an erosive challenge produced by a soft drink (Coca-Cola) using Scanning Electron Microscopy (SEM).METHODSForty specimens were assigned to 4 groups of 10 specimens each (group 1: no erosive challenge, no toothpaste treatment, group 2: erosive challenge, no toothpaste treatment, group 3: erosive challenge, fluoride toothpaste treatment, group 4: erosive challenge, zinc-hydroxyapatite toothpaste treatment). The surface of each specimen was imaged by SEM. A visual rating system was used to evaluate the condition of the enamel surface; results were analyzed by nonparametric statistical methods.RESULTSStatistically significant differences were found between the samples untreated and those immersed in Coca-Cola (group 1, 2); the highest grade of damage was found in group 2, while the lowest grade was recorded in the samples of group 4. Comparing the groups, the two analyzed toothpaste tended to protect in different extend.CONCLUSIONSIn this study treatment of erosively challenged enamel with Zn-Hap toothpaste showed a clear protective effect. This was greater than the effect observed for a normal fluoride toothpaste and confirmed the potential benefit the Zn-HAP technology can provide in protecting enamel from erosive acid challenges.
目的:本体外研究的目的是利用扫描电子显微镜(SEM)评估锌-羟基磷灰石牙膏对软饮料(可口可乐)产生的侵蚀挑战的保护作用。方法将40例标本分为4组,每组10例(第1组:无侵蚀侵蚀、无牙膏处理;第2组:侵蚀侵蚀、无牙膏处理;第3组:侵蚀侵蚀、含氟牙膏处理;第4组:侵蚀侵蚀、锌羟基磷灰石牙膏处理)。通过扫描电镜对每个试样的表面进行成像。采用目视评定法对牙釉质表面状况进行评价;结果采用非参数统计方法进行分析。结果未处理的样品与浸泡在可口可乐中的样品(1、2组)差异有统计学意义;第2组的损伤程度最高,第4组的损伤程度最低。两组比较,两种牙膏的保护程度不同。结论锌- hap牙膏对侵蚀性牙釉质有明显的保护作用。这比普通含氟牙膏的效果更好,证实了锌羟基磷灰石技术在保护牙釉质免受酸性侵蚀方面的潜在好处。
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引用次数: 17
Childhood overweight-obesity and periodontal diseases: is there a real correlation? 儿童超重肥胖和牙周病:真的有关联吗?
Pub Date : 2016-07-01 DOI: 10.11138/ads/2016.7.3.065
G. Sfasciotti, R. Marini, A. Pacifici, G. Ierardo, L. Pacifici, A. Polimeni
OBJECTIVEThe association between obesity and periodontitis has been extensively investigated in adults but not in young people. The aim of this study was to examine the association between overweight-obesity and periodontal disease in pediatric subjects.METHODSControlled cross-sectional study involving 100 school children of both gender (50 M and 50 F) between 7 and 12 years of age (mean age 9,19±1,57). Two groups were formed based on Body Mass Index value: test group with BMI ≥ 25 Kg/m2 and control group with BMI ≤ 24 Kg/m2. Diet intake and oral hygiene habits were recorded by a specific questionnaire and the periodontal clinical parameters were evaluated.RESULTSThe periodontal examination in the control group revealed a full-mouth plaque score (FMPS) value equal to 21.86% against 50.08% in the group of patients overweight/obese; the full-mouth bleeding score (FMBS) in the control group amounted to 12.7% against 26.24% of test group. No patient in either group included in the study presented a probing pocket depth (PPD) ≥3, so a significant difference regarding this value was not found. Regarding the frequency and quantity of food consumption, the number of obese patients who did not follow a balanced diet largely exceeded the number of normal-weight patients (70 versus 20%).CONCLUSIONSThese results focus the attention on the negative impact of obesity on gingival health in young subjects, probably due to a combination of metabolic and inflammatory profiles and the result of a careless attitude towards prevention diseases of the oral cavity.
肥胖和牙周炎之间的关系已经在成年人中进行了广泛的研究,但在年轻人中还没有。本研究的目的是研究超重、肥胖和儿童牙周病之间的关系。方法采用横断面对照研究方法,对100名年龄在7 ~ 12岁(平均9岁,19±1.57岁)的男女学生(男50名,女50名)进行研究。根据体重指数分为两组:试验组BMI≥25 Kg/m2,对照组BMI≤24 Kg/m2。通过问卷调查记录饮食摄入和口腔卫生习惯,并评估牙周临床参数。结果对照组牙周检查全口菌斑评分(FMPS)为21.86%,超重/肥胖组为50.08%;对照组全口出血评分(FMBS)为12.7%,实验组为26.24%。两组患者均未出现探查袋深度(PPD)≥3,故未发现该值有显著差异。在食物摄入的频率和数量方面,不遵循均衡饮食的肥胖患者的数量大大超过正常体重患者的数量(70% vs 20%)。结论肥胖对年轻受试者牙龈健康的负面影响,可能是由于代谢和炎症特征的结合,以及对口腔疾病预防的粗心态度的结果。
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引用次数: 16
F360 and F6 Skytaper: SEM evaluation of cleaning efficiency. F360和F6 sky锥:清洗效率的SEM评价。
Pub Date : 2016-02-12 DOI: 10.11138/ads/2015.6.3.069
A. Dagna, G. Gastaldo, Riccardo Beltrami, M. Chiesa, C. Poggio
AIMRoot canal preparation may produce a large quantity of smear layer that covers canal walls. Single-file systems have recently appeared, with the aim of reducing the number of steps and files to reach a correct endodontic treatment. The purpose of this study was to evaluate by SEM the root canal walls after instrumentation with F360 (Komet, Brasseler GmbH & Co., Lemgo, Germany) and F6 Skytaper (Komet, Brasseler GmbH & Co., Lemgo, Germany), in order to evaluate the presence/absence of smear layer and the presence/absence of open tubules on the root canal walls at coronal, middle, and apical third of each sample.METHODSTwenty single-rooted freshly extracted teeth were selected and divided into 2 groups. For each group root canals were shaped with F360 (Komet, Brasseler GmbH & Co., Lemgo, Germany) and F6 Skytaper (Komet, Brasseler GmbH & Co., Lemgo, Germany) instruments under irrigation with 5,25% NaOCl and 17% EDTA. Specimens were fractured longitudinally and analyzed by SEM at standard magnification of 5000x. The presence/absence of smear layer and the presence/absence of open tubules at the coronal, middle, and apical third of each canal were evaluated using a 5-step scale for scores. Numeric data were analyzed using Kruskall-Wallis and Mann-Whitney U statistical tests and significance was predetermined at P <0.05.RESULTSThis study did not reveal differences among two groups at the coronal and apical third. The apical third showed the highest values of scores for all Ni-Ti systems used. Significant differences in smear layer scores were recorded among the Ni-Ti systems at middle canal level (P < 0.05), where F6 Skytaper showed significantly lower scores than F360.CONCLUSIONSWithin the limitation of this study, F360 and F6 Skytaper rotary instruments seem to be effective in shaping root canals with good debridement from canal walls, without significant differences between the two systems as it regards the coronal third and the apical third, the area where more debris is still visible. Instead, in the middle third F6 Skytaper seems to be more effective than F360, with statistically significative differences between the two systems.
aimm根管预备可产生大量覆盖根管壁的涂片层。单文件系统最近出现,目的是减少步骤和文件的数量,以达到正确的根管治疗。本研究的目的是通过扫描电镜评估F360 (Komet, Brasseler GmbH & Co., Lemgo,德国)和F6 sky锥度(Komet, Brasseler GmbH & Co., Lemgo,德国)预备后的根管壁,以评估每个样本冠状、中间和根尖三分之一的根管壁上有无涂抹层和开放小管的存在/缺失。方法选择20颗刚拔除的单根牙,分为2组。每组用F360 (Komet, Brasseler GmbH & Co, Lemgo, Germany)和F6 sky锥度(Komet, Brasseler GmbH & Co, Lemgo, Germany)器械在5.25% NaOCl和17% EDTA的灌溉下形成根管。试样纵向断裂,在标准放大倍数5000x下进行扫描电镜分析。采用5步评分法评估每根管冠状、中间和根尖三分之一处涂片层的存在/不存在以及开放小管的存在/不存在。数值数据采用Kruskall-Wallis和Mann-Whitney U统计检验进行分析,P <0.05为显著性。结果本研究未发现两组在冠状和根尖三分之一处的差异。顶端的三分之一显示了所有使用的Ni-Ti系统的最高分。不同镍钛系统在中管水平的涂片层评分差异有统计学意义(P < 0.05),其中F6 sky锥评分显著低于F360。结论在本研究的限制范围内,F360和F6 sky锥旋转器械似乎可以有效地塑造根管,并良好地清除根管壁,对于冠状三分之一和根尖三分之一,两种系统之间没有显着差异,冠状三分之一和根尖三分之一仍然可见更多碎片。相反,在中间三分之一的F6天空锥似乎比F360更有效,两种系统之间有统计学上的显着差异。
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引用次数: 21
A tooth preparation technique in fixed prosthodontics for students and neophyte dentists. 面向学生和牙医新手的固定义齿预备技术。
Pub Date : 2016-02-12 DOI: 10.11138/ads/2015.6.3.104
D. Rosella, Giancarlo Rosella, E. Brauner, P. Papi, L. Piccoli, G. Pompa
PURPOSEThe aim of this study was to evaluate a novel technique of tooth preparation in fixed prosthodontics suitable for dental students and neophyte dentists.MATERIALS AND METHODSTwenty-four dental students of the sixth-year class were recruited to verify the predicibility of this technique. Each student prepared two mandibular second premolars on a typodont for a dental crown with a 90° shoulder finishing line. One tooth was prepared using standard procedures taught in the prosthodontic dental course; the other tooth was prepared with the new technique. Three Professors of Prosthodontics of the same University evaluated the result on the basis of 10 criteria.RESULTSA statistically significant difference between the two techniques was found in 8 out of 10 criteria. The new technique showed higher values (p<0.05) in 7 criteria, while the conventional technique had better results in just 1 criterion. Moreover, the total sum of values was higher for the new technique (total 41.2±3.98, p<0.05) compared to the conventional technique (total 38.12±5.18, p<0.05).CONCLUSIONSThis study showed that the results were less dependent on manual abilities and personal experience with the novel technique. It could helps dental students and neophyte dentists in their learning curve.
目的探讨一种适合牙科学生和牙科新手的固定修复牙体预备新技术。材料与方法选取24名六年级牙科学生,验证该技术的可预测性。每个学生都准备了两个下颌第二前磨牙,用于90°肩线的牙冠。其中一颗牙齿是按照口腔修复课程的标准程序准备的;另一颗牙齿是用新技术制作的。同一所大学的3名口腔修复学教授根据10项标准对结果进行了评价。结果两种方法在10项标准中有8项差异有统计学意义。新技术在7项指标上有较高的评价值(p<0.05),而传统技术仅在1项指标上有较好的评价值。新技术的总数值(41.2±3.98,p<0.05)高于传统技术(38.12±5.18,p<0.05)。结论本研究表明,该方法对人工操作能力和个人经验的依赖程度较低。它可以帮助牙科学生和牙医新手在他们的学习曲线。
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引用次数: 18
Italian recommendations on dental support in the treatment of adult obstructive sleep apnea syndrome (OSAS). 意大利关于牙科支持治疗成人阻塞性睡眠呼吸暂停综合征(OSAS)的建议。
Pub Date : 2016-02-12 DOI: 10.11138/ads/2015.6.3.081
L. Levrini, F. Sacchi, F. Milano, A. Polimeni, P. Cozza, E. Bernkopf, M. Segù, M. Zucconi, C. Vicini, Enrico Brunello
BACKGROUNDThe aim of the present article is to present a set of proposed clinical recommendations aimed at Italian dentists involved in the management of patients with obstructive sleep apnea syndrome or snoring.METHODSWith the purpose of creating a study group, some of the most important Italian scientific societies operating in fields relevant to the issue of sleep medicine in dentistry were asked to appoint a representative. Each member of the study group was required to answer questions regarding the clinical management of OSAS and snoring.RESULTSOral appliances can be used to treat: - simple snoring, in patients who do not respond to, or do not appear to be suitable candidates for behavioral measures such as weight loss or positional therapy; - mild or moderate OSAS, in patients who prefer OAs to continuous positive airway pressure (CPAP) or who are not suitable candidates for CPAP, because of its failure or failure of behavioral approaches like weight loss or positional therapy; - severe OSAS, in patients who do not respond to or do not tolerate CPAP and in whom no indication for either maxillofacial or ENT surgery appears applicable.CONCLUSIONSThe application of oral appliances is highly desirable in cases of simple snoring or mild to moderate OSAS, whereas considerable caution is warranted when treating severe OSAS. It is fundamental to ensure that the patient understands his problem and, at the same time, to present all the various treatment options.
背景:本文的目的是提出一套针对意大利牙医参与管理阻塞性睡眠呼吸暂停综合征或打鼾患者的临床建议。方法:为了建立一个研究小组,要求在与牙科睡眠医学问题有关的领域开展活动的一些最重要的意大利科学学会任命一名代表。研究小组的每个成员都被要求回答有关睡眠呼吸暂停症和打鼾的临床管理问题。结果口腔矫治器可用于治疗:单纯性打鼾,患者对减肥或体位治疗等行为措施无反应或似乎不适合;-轻度或中度阻塞性睡眠呼吸暂停(OSAS),发生在选择OAs而不是持续气道正压通气(CPAP)或由于CPAP失败或行为方法(如减肥或体位疗法)失败而不适合CPAP的患者;-严重OSAS,对CPAP无反应或不能耐受,且没有颌面或耳鼻喉外科手术指征的患者。结论单纯打鼾或轻至中度阻塞性睡眠呼吸暂停(OSAS)患者应用口腔矫治器是非常可取的,而严重阻塞性睡眠呼吸暂停(OSAS)患者则需要相当谨慎。确保病人了解他的问题是至关重要的,同时,提供所有不同的治疗方案。
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引用次数: 14
Management and treatment of sinonasal inverted papilloma. 鼻窦内翻性乳头状瘤的处理与治疗。
Pub Date : 2016-02-12 DOI: 10.11138/ads/2015.6.3.087
C. Ungari, E. Riccardi, G. Reale, A. Agrillo, C. Rinna, V. Mitro, F. Filiaci
AIMSThe aim of this paper is to describe the surgical experience of 35 patients with Inverted Papilloma (IP) of paranasal sinuses and its recurrence rate after a year of follow-up.MATERIALSA retrospective chart review was performed on patients presenting with IP of paranasal sinuses. Thirty-five patients comprised the focus of this study. For all patients was performed a pre-surgery TC, and for more 5 patients it was necessary to perform a Magnetic Resonance (MR) with gadolinium.RESULTSAmong 35 patients selected, 18 patients underwent to open surgery, 4 patients had a combined approach with endoscopy and open surgery, while 13 patients were managed only with an endoscopic approach, with a minimum of 1 year of follow-up. Our results highlighted that the global percentage of success 12 months after the treatment was 93% and it not vary according to the tipology of the approach used if a radical excision of the lesion is achieved. More in depth, among 35 cases, only 2 patients were found to have recurrences and were treated with coronal and endoscopic approach.CONCLUSIONIt is fundamental to underline that surgery must be carried on in a radical manner to treat these tend to recur. A complete removal of the lesion and bone peripheral border filing are essential to perform a correct and definitive treatment. Also, endoscopic approach can be taken into account when tumors are localized median to a sagittal plan crossing the orbit median wall and when they did not massively compromised paranasal sinus walls.
目的总结35例鼻窦内翻性乳头状瘤(IP)的手术治疗经验及随访1年后的复发率。资料:对以鼻窦炎为表现的患者进行回顾性图表回顾。35例患者是本研究的重点。所有患者术前均行TC, 5例以上患者需行钆磁共振(MR)。结果入选的35例患者中,18例患者行开放手术,4例患者行内镜和开放手术联合入路,13例患者仅行内镜入路,随访时间至少1年。我们的研究结果强调,治疗后12个月的全球成功率为93%,并且如果实现了病灶的根治性切除,则该成功率不会因所使用的方法的形态学而变化。更深入地说,在35例病例中,只有2例发现复发,并采取冠状和内镜入路治疗。结论对易复发的顽固性鼻咽癌必须进行根治性手术治疗。完全切除病变和骨周围边界锉是进行正确和明确治疗的必要条件。此外,当肿瘤位于横过眶中壁的矢状平面的中间位置,并且没有严重损害鼻窦壁时,可以考虑内镜入路。
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引用次数: 17
Carcinoma of the lip five years after bone marrow transplantation. 骨髓移植后五年的唇癌。
Pub Date : 2015-12-01 eCollection Date: 2015-04-01
M Ardore, M Berrone, G Marchitto, S Gandolfo, M Pentenero
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引用次数: 0
Craniofacial growth and respiration: a study on an animal model. 颅面生长与呼吸:动物模型的研究。
Pub Date : 2015-07-28 eCollection Date: 2015-04-01
Luca Levrini, Alessandro Mangano, Alessandro Ambrosoli, Paola Merlo, Carlo Mangano, Alberto Caprioglio

Aims: The aim of this study was to analyse the effects of nasal obliteration with regards to the linear dimensions of dissected hemimandibles of a homogeneous sample of young rats.

Methods: 68 pure breed male Sprague-Dawley rats, aged four weeks, were divided into four groups of 17: two control groups and two test groups. The first control group was sacrificed at the beginning of the observation period and the other one at the end. The test groups, one of which had the right nostril occluded by silicon material while the other had the left occluded, were sacrificed after eight weeks, at twelve weeks. After isolating the hemi-mandibles, four vertical and four sagittal measurements were taken; comparison was then made between the control groups and the experimental groups. The sagittal measurements are articular surface of the condyle-neck incisor (SARCIN), articular surface of the condyle-mental foramen (SARFORO), articular surface of the condyle-margo incisalis (SARMI), articular surface of the condyle-surface mesial of the first molar (SARSMM). The vertical measurements are superior condyle surface-base (SCOSUB), mesial surface of the first molar-base (SUMESM), maximum inferior arched concavity-base, (XCOARIB), maximum sigmoid notch concavity-base (XCOINSB).

Results: The sagittal and vertical measurements showed an increase in the values of the experimental group when compared to the controls.

Conclusion: An altered nasal respiration is able to influence the patterns of facial growth and in particular to induce an increase in the growth of the mandible.

目的:本研究的目的是分析鼻塞术对同龄大鼠半下颌骨解剖线性尺寸的影响。方法:68只4周龄纯种雄性Sprague-Dawley大鼠,随机分为4组,每组17只:2个对照组和2个试验组。第一组在观察期开始时处死,另一组在观察期结束时处死。实验组,一组右鼻孔被硅材料堵塞,另一组左鼻孔被硅材料堵塞,8周后,12周时被处死。分离半下颌骨后,进行4次垂直测量和4次矢状测量;然后将对照组与实验组进行比较。矢状面测量为:髁颈切牙关节面(SARCIN)、髁颏孔关节面(SARFORO)、切牙髁弓关节面(SARMI)、第一磨牙髁近内侧关节面(SARSMM)。垂直测量为上髁面基(SCOSUB)、第一磨牙基近中面(SUMESM)、最大下弓凹度基(XCOARIB)、最大s形切口凹度基(XCOINSB)。结果:与对照组相比,实验组的矢状面和垂直面测量值均有所增加。结论:鼻呼吸的改变能够影响面部生长的模式,特别是诱导下颌骨生长的增加。
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引用次数: 0
Treatment timing and multidisciplinary approach in Apert syndrome. Apert综合征的治疗时机及多学科方法。
Pub Date : 2015-07-28 eCollection Date: 2015-04-01
Maria Teresa Fadda, Gaetano Ierardo, Barbara Ladniak, Gianni Di Giorgio, Alessandro Caporlingua, Ingrid Raponi, Alessandro Silvestri

Apert syndrome is a rare congenital disorder characterized by craniosynostosis, midface hypoplasia and symmetric syndactyly of hands and feet. Abnormalities associated with Apert syndrome include premature fusion of coronal sutures system (coronal sutures and less frequently lambdoid suture) resulting in brachiturricephalic dismorphism and impaired skull base growth. After this brief explanation it is clear that these anatomical abnormalities may have a negative impact on the ability to perform essential functions. Due to the complexity of the syndrome a multidisciplinary (respiratory, cerebral, maxillo-mandibular, dental, ophthalmic and orthopaedic) approach is necessary in treating the psychological, aesthetic and functional issues. The aim of this paper is to analyse the different functional issues and surgical methods trying to enhance results through a treatment plan which includes different specialities involved in Apert syndrome treatment. Reduced intellectual capacity is associated to the high number of general anaesthesia the small patients are subject to. Therefore the diagnostic and therapeutic treatment plan in these patients has established integrated and tailored surgical procedures based on the patients' age in order to reduce the number of general anaesthesia, thus simplifying therapy for both Apert patients and their family members.

Apert综合征是一种罕见的先天性疾病,其特征是颅缝闭合,面中部发育不全和手脚对称并指。与Apert综合征相关的异常包括冠状缝合线系统(冠状缝合线和较少出现的小绵羊状缝合线)的过早融合,导致肱二头畸形和颅底生长受损。在这简短的解释之后,很明显,这些解剖异常可能对执行基本功能的能力产生负面影响。由于该综合征的复杂性,在治疗心理、美学和功能问题时,需要多学科(呼吸、大脑、上颌-下颌、牙科、眼科和骨科)的方法。本文的目的是分析不同的功能问题和手术方法,试图通过包括不同专业参与Apert综合征治疗的治疗计划来提高结果。智力下降与小病人接受大量全身麻醉有关。因此,这些患者的诊断和治疗计划根据患者的年龄建立了综合和量身定制的手术程序,以减少全身麻醉的次数,从而简化了Apert患者及其家属的治疗。
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引用次数: 0
Disseminated necrotic mediastinitis spread from odontogenic abscess: our experience. 弥散性坏死性纵隔炎由牙源性脓肿扩散:我们的经验。
Pub Date : 2015-07-28 eCollection Date: 2015-04-01
Fabio Filiaci, Emiliano Riccardi, Valeria Mitro, Pasquale Piombino, Claudio Rinna, Alessandro Agrillo, Claudio Ungari

Aims: Deep neck infections are rare but potentially fatal complication of pulpal abscess of the teeth. If an infection can progress rapidly from a toothache to a life threatening infection, then it is critical that dentists be able to recognize the danger signs and identify the patients who are at risk. Mediastinitis is a severe inflammatory process involving the connective tissues that fills the intracellular spaces and surrounds the organs in the middle of the chest. This pathology has both an acute and a chronic form and, in most cases, it has an infectious etiology. This study want to expose the experience acquired in the Oral and Maxillo-facial Sciences Department, Policlinico Umberto I, "Sapienza" University of Rome, regarding two clinical cases of disseminated necrotizing mediastinitis starting from an odontogenic abscess.

Methods: We report two clinical cases of disseminated necrotic mediastinitis with two different medical and surgical approaches. The radiographic and photographic documentation of the patients was collected in the pre-and post-operatively. All patients underwent a CT scan and MRI.

Results: Mediastinitis can result from a serious odontogenic abscess, and the extent of its inflammation process must be never underestimated. Dental surgeons play a key role as a correct diagnosis can prevent further increasing of the inflammation process.

Conclusions: A late diagnosis and an inadequate draining represent the major causes of the elevated mortality rate of disseminated necrotizing mediastinitis.

目的:深颈部感染是牙髓脓肿的罕见并发症,但可能致命。如果感染可以从牙痛迅速发展为危及生命的感染,那么牙医能够识别危险迹象并识别处于危险中的患者是至关重要的。纵隔炎是一种严重的炎症过程,涉及填充细胞内间隙的结缔组织,并包围胸腔中部的器官。这种病理有急性和慢性两种形式,在大多数情况下,它具有感染性病因。本研究旨在揭示罗马“Sapienza”大学polilinico Umberto I口腔颌面科学系关于两例从牙源性脓肿开始的弥散性坏死性纵隔炎的临床经验。方法:我们报告2例弥散性坏死性纵隔炎的临床病例,采用两种不同的内科和外科方法。术前和术后收集患者的影像学和摄影资料。所有患者均行CT扫描和MRI检查。结果:纵隔炎可由严重的牙源性脓肿引起,其炎症过程的程度不可低估。牙科医生扮演着关键的角色,因为正确的诊断可以防止炎症的进一步加剧。结论:弥散性坏死性纵隔炎的晚期诊断和引流不当是死亡率升高的主要原因。
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引用次数: 0
期刊
Annali di stomatologia
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