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From spermatogonia to spermatozoa: Filling gaps in andrology at the 16th Network of Young Researchers in Andrology meeting 从精原细胞到精子:在第 16 届男性学青年研究人员网络会议上填补男性学空白
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-20 DOI: 10.1111/andr.13763
Emily Delgouffe, Juan Manuel Paturlanne, Andjela Kovacevic, Isidora Keselj, Omar Ammar, Avinash S. Gaikwad, Gülizar Saritas, Dorte Egeberg, Daniel Marcu, Alberto de la Iglesia
The 16th Network of Young Researchers in Andrology meeting, hosted at the Sleepwell Hostel in Brussels, Belgium, was the first Network of Young Researchers in Andrology meeting as the young arm of the European Academy of Andrology. Over three days, this vibrant event provided a valuable platform for early-career researchers in andrology to present and discuss their research. With 41 attendees from 12 different countries, the meeting featured a diverse scientific program including keynote lectures from six world-leading experts, covering a broad range of topics in andrology. The 16th Network of Young Researchers in Andrology meeting showcased advancements in fertility preservation, single-cell applications, in vitro testis modeling, and epigenetics. Networking opportunities were a key highlight, featuring a scientific speed-dating session and a networking dinner designed to foster meaningful connections and collaborations among participants. The meeting concluded with a workshop on the science of sleep, offering attendees practical strategies to enhance their rest and well-being. Overall, the 16th Network of Young Researchers in Andrology meeting significantly advanced the audience's knowledge, strengthened the network of young researchers, and underlined Network of Young Researchers in Andrology's commitment to supporting and collaborating with emerging scientists in the andrology community.
第 16 届青年 Andrology 研究人员网络会议在比利时布鲁塞尔的 Sleepwell 旅馆举行,这是作为欧洲 Andrology 学院青年分支的第一届青年 Andrology 研究人员网络会议。在为期三天的时间里,这一充满活力的活动为早期从事雄性学研究的人员提供了一个展示和讨论其研究成果的宝贵平台。来自 12 个不同国家的 41 名与会者参加了会议,会议的科学议程丰富多彩,包括六位世界领先专家的主题演讲,涵盖了广泛的雄性学主题。第 16 届青年 Andrology 研究人员网络会议展示了生育力保存、单细胞应用、体外睾丸建模和表观遗传学方面的进展。交流机会是一大亮点,包括科学速配环节和交流晚宴,旨在促进与会者之间建立有意义的联系与合作。会议最后举行了睡眠科学研讨会,为与会者提供了加强休息和提高健康水平的实用策略。总之,第 16 届青年 Andrology 研究人员网络会议极大地提高了与会者的知识水平,加强了青年研究人员网络,并彰显了青年 Andrology 研究人员网络对支持 Andrology 界新兴科学家并与之合作的承诺。
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引用次数: 0
Male contraceptive acceptability versus male acceptance of contraceptive responsibility 男性对避孕药具的接受程度与男性对避孕责任的接受程度
IF 3.2 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-20 DOI: 10.1111/andr.13719
Brian T. Nguyen

Despite the projected impact of new male contraceptives, resources and investments directed at their development remain limited in part due to concerns that men would not actually use them. Now, more than 30 studies have been conducted over the last 30 years—regionally and internationally, within clinical trials, and across populations—examining men and women's attitudes towards new male contraceptive methods, all consistently demonstrating interest in and willingness to use new methods. Yet even these studies, inclusive of competitive contraceptive market projections, seem not to be convincing enough.

Rather than study whether men would be willing to use male contraceptives, more resources should be devoted to developing the infrastructure and supporting the cultural changes needed to ensure that when new male contraceptives inevitably emerge, that they will be disseminated quickly and made readily accessible.

Men's views on what their roles are in society, families, relationships, and pregnancy prevention are changing in ways that may impact what they consider to be acceptable contraceptive risks. As society moves toward more gender equitable beliefs, men's positive involvement in contraception might organically develop into an expected behavior. Interventions aimed at sensitizing men toward gender equitable beliefs may pay dividends in improving male contraceptive acceptability.

The current lack of a reversible male contraceptive method prevents us from collecting data that might disprove presumptions that men would be unwilling to take on responsibility for pregnancy prevention. However, studies of men's involvement in (1) over-the-counter emergency contraception, (2) vasectomy, and (3) abortion offer case studies for men's increasing consciousness of opportunities for shared contraceptive responsibility, the structural and sociopolitical barriers that men face when trying to participate in family planning, and how these might translate into new male contraceptive interest and development.

尽管新的男性避孕药具预计会产生影响,但用于开发这些药具的资源和投资仍然有限,部分原因是担心男性不会实际使用这些药具。在过去的 30 年中,已经进行了 30 多项研究--在地区和国际范围内、在临床试验中、在不同人群中--调查了男性和女性对新型男性避孕方法的态度,所有研究都一致表明,男性和女性对新型避孕方法感兴趣并愿意使用。然而,即使是这些研究,包括竞争性避孕药具市场预测,似乎也不足以令人信服。
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引用次数: 0
Relevance, strategies, and added value of mouse models in androgenetics 雄激素遗传学小鼠模型的相关性、策略和附加值
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-19 DOI: 10.1111/andr.13761
Vertika Singh, John C. Schimenti
Male Infertility is a prevalent condition worldwide, and a substantial fraction of cases are thought to have a genetic basis. Investigations into the responsible genes is limited experimentally, so mice have been used extensively to identify genes required for fertility and to understand their functions.
男性不育症在全世界都很普遍,其中相当一部分病例被认为与遗传有关。对致病基因的研究仅限于实验,因此人们广泛使用小鼠来确定生育所需的基因并了解其功能。
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引用次数: 0
Utility of exome sequencing in primary spermatogenic disorders: From research to diagnostics 外显子组测序在原发性精子生成障碍中的应用:从研究到诊断
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-19 DOI: 10.1111/andr.13753
Antoni Riera-Escamilla, Liina Nagirnaja
Primary spermatogenic disorders represent a severe form of male infertility whereby sperm production is impaired due to testicular dysfunction, leading to reduced quality or quantity of spermatozoa. Gene-centered research has certainly demonstrated the importance of the genetic factor in the etiology of both poor sperm morphology or motility and reduced sperm count. In the last decade, next-generation sequencing has expanded the research to whole exome which has transformed our understanding of male infertility genetics, but uncertainty persists in its diagnostic yield, especially in large unrelated populations.
原发性生精障碍是一种严重的男性不育症,由于睾丸功能障碍,精子生成受到影响,导致精子质量或数量下降。以基因为中心的研究无疑证明了遗传因素在精子形态或活力低下以及精子数量减少的病因中的重要性。近十年来,下一代测序技术将研究扩展到了全外显子组,这改变了我们对男性不育遗传学的认识,但其诊断结果仍存在不确定性,尤其是在大量非相关人群中。
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引用次数: 0
Can the male germline offer insight into mammalian brain size expansion? 雄性生殖系能否揭示哺乳动物脑容量扩张的奥秘?
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-18 DOI: 10.1111/andr.13766
Stephen J. Bush, Anne Goriely
Recent advances in single‐cell transcriptomic data have greatly expanded our understanding of both spermatogenesis and the molecular mechanisms of male infertility. However, this growing wealth of data could also shed light on a seemingly unrelated biological problem: the genetic basis of mammalian brain size expansion throughout evolution. It is now increasingly recognized that the testis and brain share many cellular and molecular similarities including pivotal roles for the RAS/MAPK and PI3K/AKT/mTOR pathways, mutations in which are known to have a pronounced impact on cell proliferation. Most notably, in the stem cell lineages of both organs, new mutations have been shown to increase cellular output over time. These include ‘selfish’ mutations in spermatogonial stem cells, which disproportionately increase the proportion of mutant sperm, and—to draw a parallel—human‐specific mutations in neural stem cells which, by increasing the number of neurons, have been implicated in neocortical expansion. Here we speculate that the origin for many ‘expansion’‐associated mutations is the male germline and that as such, a deeper understanding of the mechanisms controlling testicular turnover may yield fresh insight into the biology and evolution of the brain.
单细胞转录组数据的最新进展极大地扩展了我们对精子发生和男性不育分子机制的了解。然而,这些日益丰富的数据还可以揭示一个看似无关的生物学问题:哺乳动物大脑体积在整个进化过程中不断扩大的遗传基础。现在越来越多的人认识到,睾丸和大脑在细胞和分子方面有许多相似之处,包括RAS/MAPK和PI3K/AKT/mTOR通路的关键作用,而这些通路的突变已知会对细胞增殖产生明显影响。最值得注意的是,在这两个器官的干细胞系中,新的突变已被证明会随着时间的推移增加细胞的产量。这包括精原干细胞中的 "自私 "突变,它不成比例地增加了突变精子的比例;与此类似,神经干细胞中的人类特异性突变,通过增加神经元的数量,被认为与新皮质扩展有关。在此,我们推测许多与 "扩张 "相关的突变起源于男性生殖细胞,因此,更深入地了解控制睾丸更替的机制可能会对大脑的生物学和进化产生新的见解。
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引用次数: 0
Israeli men's attitudes toward posthumous reproduction and prior consent amid ongoing armed conflict 以色列男性在武装冲突中对死后生育和事先同意的态度
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-17 DOI: 10.1111/andr.13757
Bella Savitsky, Talia Eldar‐Geva, Rachel Shvartsur
BackgroundFrom October 7, 2023, until August 28, 2024, 187 posthumous sperm retrieval (PSR) procedures have been conducted on deceased men, 171 of whom are soldiers. PSR was predominantly initiated by parents to cope with their profound loss. However, the attitudes of Israeli men toward this procedure are unknown.ObjectiveThis study aims to investigate the attitudes of Israeli men toward prior consent to PSR and posthumous‐assisted reproduction (PAR) initiated by partner or parents.MethodsA cross‐sectional study of 600 Israeli men aged 18–49 years who were questioned in February–April 2024 amid the ongoing armed conflict. The questionnaire included demographic details, role in the conflict, and attitudes toward PSR/PAR. Multivariable logistic regression analysis was used to assess agreement for PSR/PAR after adjustment for possible confounders.ResultsThe average age of participants was 32 years, with 52% married or in a committed relationship and 6.5% self‐identified as having same‐sex relationships. The majority were secular (63%), 21% were traditional (21%), and 16% were religious. In terms of involvement in the ongoing conflict, 35% served in combat, 21% in non‐combat roles, and 44% did not participate. Most men (71%) prefer pre‐documenting their PSR preferences, with 70% advocating for consent during recruitment for regular military service and 78% before reserve service. Regarding PAR, 37% opposed it at their partner's request, while 47% opposed it at their parents’ request. In a multivariable model, the odds of approval of PAR following parental request were four‐ and three‐fold higher among traditional and secular versus religious men (odds ratio, OR = 4.1, 95% CI: 2.0–8.1 and OR = 3.3, 95% CI: 1.8–6.2, respectively) and following the request of a partner, twice higher among traditional and secular versus religious (OR = 2.0, 95% CI: 1.1–4.2 and OR = 2.0, 95% CI: 1.1–3.6, respectively).ConclusionWhile it is understandable that grieving parents seek solace through PSR, consent should be obtained from the men themselves, as a considerable proportion do not support the process as it is currently performed.
背景从2023年10月7日到2024年8月28日,已经对187名男性死者进行了遗体取精(PSR)手术,其中171人是军人。PSR主要是由父母发起的,以应对他们的巨大损失。本研究旨在调查以色列男性对事先同意由伴侣或父母发起的 PSR 和死后辅助生殖(PAR)的态度。方法对 600 名年龄在 18-49 岁之间的以色列男性进行了横断面研究,这些男性于 2024 年 2-4 月在持续的武装冲突中接受了问卷调查。问卷内容包括人口统计学细节、在冲突中的角色以及对 PSR/PAR 的态度。结果参与者的平均年龄为 32 岁,52% 已婚或有固定关系,6.5% 自认有同性关系。大多数人是世俗的(63%),21%是传统的(21%),16%是宗教的。在参与当前冲突方面,35% 的人参加过战斗,21% 的人担任过非战斗性角色,44% 的人没有参与。大多数男性(71%)倾向于事先记录他们的 PSR 偏好,70% 的人主张在正规军招募时征得同意,78% 的人主张在预备役服役前征得同意。关于 PAR,37% 的人应伴侣的要求反对,47% 的人应父母的要求反对。在多变量模型中,应父母要求同意 PAR 的几率在传统男性和世俗男性中分别是宗教男性的四倍和三倍(几率比,OR = 4.1,95% CI:2.0-8.1 和 OR = 3.3,95% CI:1.8-6.2),应伴侣要求同意 PAR 的几率在传统男性和世俗男性中是宗教男性的两倍(OR = 2.结论虽然悲伤的父母通过 PSR 寻求慰藉是可以理解的,但应征得男性本人的同意,因为相当一部分人并不支持目前的做法。
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引用次数: 0
Genital gender‐affirming surgery trends in Germany: Total population data with 19,600 cases from 2006 to 2022 德国生殖器性别确认手术趋势:2006 年至 2022 年 19,600 个病例的总人口数据
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-17 DOI: 10.1111/andr.13762
Cem Aksoy, Sascha Wellenbrock, Philipp Reimold, Philipp Karschuck, Mahmut Ozturk, Tobias Hirsch, Michael Sohn, Nicole Eisenmenger, Sabine Kliesch, Saskia Morgenstern, Aristeidis Zacharis, Johannes Huber, Luka Flegar
PurposeTo delineate the current trends regarding gender‐affirming surgeries (GAS) in Germany.MethodsAnalysis of German hospital quality reports from 2006 to 2022 was conducted using the reimbursement.info tool. The German procedure classification (OPS) codes 5‐646.0 for masculinizing‐ and 5‐646.1 for feminizing surgery were assessed to identify GAS. Linear regression models were utilized for the analysis and depiction of current trends.ResultsA total of 19,632 gender‐affirming procedures were performed during the study period with an exponential increase over the years. Masculinizing surgeries increased from 246 in 2006 to 1291 cases in 2022 (increase by 424%; p < 0.001). The highest annual increase of 37.2% in numbers was from 2018 to 2019 (from 1235 to 1694 cases). Feminizing surgeries increased from 180 cases in 2006 to 799 procedures in 2022 (increase by 343%; p < 0.001). The cases increased most between 2015 and 2016 from 277 to 502 cases (81.2%). The number of hospitals offering these surgeries expanded from 24 in 2006 to 29 in 2022 (21% increase; p < 0.001).ConclusionThis study demonstrates an exponential growth in numbers feminizing and masculinizing of GAS performed each year in Germany. Furthermore, a discernible trend emerges with a propensity for concentration of procedures within selected high‐caseload centers across Germany.
方法使用 reimbursement.info 工具对 2006 年至 2022 年的德国医院质量报告进行分析。对德国手术分类(OPS)代码 5-646.0 (男性化手术)和 5-646.1 (女性化手术)进行评估,以确定 GAS。研究期间共进行了 19,632 例性别确认手术,手术数量呈指数级增长。男性化手术从 2006 年的 246 例增加到 2022 年的 1291 例(增加了 424%;p < 0.001)。2018年至2019年(从1235例增至1694例)的数量年增幅最高,达37.2%。女性化手术从 2006 年的 180 例增加到 2022 年的 799 例(增加了 343%;p <;0.001)。2015年至2016年间,病例数增幅最大,从277例增至502例(81.2%)。提供此类手术的医院数量从 2006 年的 24 家增至 2022 年的 29 家(增长 21%;p <;0.001)。此外,还发现了一个明显的趋势,即手术集中在全德国选定的高手术量中心。
{"title":"Genital gender‐affirming surgery trends in Germany: Total population data with 19,600 cases from 2006 to 2022","authors":"Cem Aksoy, Sascha Wellenbrock, Philipp Reimold, Philipp Karschuck, Mahmut Ozturk, Tobias Hirsch, Michael Sohn, Nicole Eisenmenger, Sabine Kliesch, Saskia Morgenstern, Aristeidis Zacharis, Johannes Huber, Luka Flegar","doi":"10.1111/andr.13762","DOIUrl":"https://doi.org/10.1111/andr.13762","url":null,"abstract":"PurposeTo delineate the current trends regarding gender‐affirming surgeries (GAS) in Germany.MethodsAnalysis of German hospital quality reports from 2006 to 2022 was conducted using the reimbursement.info tool. The German procedure classification (OPS) codes 5‐646.0 for masculinizing‐ and 5‐646.1 for feminizing surgery were assessed to identify GAS. Linear regression models were utilized for the analysis and depiction of current trends.ResultsA total of 19,632 gender‐affirming procedures were performed during the study period with an exponential increase over the years. Masculinizing surgeries increased from 246 in 2006 to 1291 cases in 2022 (increase by 424%; <jats:italic>p</jats:italic> &lt; 0.001). The highest annual increase of 37.2% in numbers was from 2018 to 2019 (from 1235 to 1694 cases). Feminizing surgeries increased from 180 cases in 2006 to 799 procedures in 2022 (increase by 343%; <jats:italic>p</jats:italic> &lt; 0.001). The cases increased most between 2015 and 2016 from 277 to 502 cases (81.2%). The number of hospitals offering these surgeries expanded from 24 in 2006 to 29 in 2022 (21% increase; <jats:italic>p</jats:italic> &lt; 0.001).ConclusionThis study demonstrates an exponential growth in numbers feminizing and masculinizing of GAS performed each year in Germany. Furthermore, a discernible trend emerges with a propensity for concentration of procedures within selected high‐caseload centers across Germany.","PeriodicalId":7898,"journal":{"name":"Andrology","volume":"106 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning classification method for boar sperm morphology analysis 用于公猪精子形态分析的深度学习分类方法
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-17 DOI: 10.1111/andr.13758
Alexandra Keller, McKenna Maus, Emma Keller, Karl Kerns
BackgroundBoar semen quality emphasizes three major criteria: sperm concentration, motility, and morphology. Methods to analyze concentration and motility quickly and objectively readily exist, but few exist for analyzing morphology outside of subjective manual counting. Other vital factors for fertilization, like acrosome health, lack efficient detection methods due to limitations in detection by the human eye and costly biomarker analysis, which is rarely used in semen diagnostics.ObjectiveTo overcome these challenges, we propose a novel approach integrating deep‐learning technology with high‐throughput image‐based flow cytometry (IBFC) for objective and accurate analysis of both morphology and label‐free acrosome health of thousands of individual spermatozoa at once, as opposed to manually counting on a microscope slide.Materials and methodsImages of 10,000 spermatozoa were captured using an IBFC and manually annotated based on the primary morphological defect or acrosome health status for the training of the convolutional neural network (CNN). The CNN used these images to train and then applied that training to unannotated images to predict the model accuracy.ResultsUsing the CNNs, high F1 scores of 96.73%, 98.55%, and 99.31% for 20x, 40x, and 60x magnifications, respectively, for morphological classification were attained. Additionally, the model demonstrates an F1 score of 99.8% in detecting subtle acrosome health variations at the 60x magnification.Discussion and conclusionsWe have established an integrated approach to rapidly collect and classify morphological defects and acrosome health status, without the use of manual counting or biomarker labeling. Our study underscores the potential of artificial intelligence in semen diagnostics, reducing technician variability, streamlining assays, and facilitating the development of additional label‐free detection methods. This innovative approach addresses the barriers hindering biomarker adoption in semen analysis, offering a promising avenue for enhancing reproductive health assessments.
背景公猪精液质量强调三个主要标准:精子浓度、活力和形态。目前已有快速客观地分析精子浓度和活力的方法,但除了主观的人工计数外,很少有分析形态的方法。为了克服这些挑战,我们提出了一种将深度学习技术与高通量图像流式细胞术(IBFC)相结合的新方法,可一次性客观准确地分析数千个精子的形态和无标记顶体健康状况,而无需在显微镜载玻片上手动计数。材料与方法使用 IBFC 采集 10,000 个精子的图像,并根据主要形态缺陷或顶体健康状况进行人工标注,用于训练卷积神经网络(CNN)。结果使用卷积神经网络,在 20 倍、40 倍和 60 倍放大率下,形态分类的 F1 分数分别达到 96.73%、98.55% 和 99.31%。此外,该模型在 60x 放大倍率下检测细微顶体健康变化的 F1 得分为 99.8%。讨论与结论我们建立了一种综合方法,可快速收集形态缺陷和顶体健康状况并进行分类,而无需使用人工计数或生物标记标记。我们的研究强调了人工智能在精液诊断中的潜力,它可以减少技术人员的变异性,简化检测过程,促进更多无标记检测方法的开发。这种创新方法解决了精液分析中采用生物标记物的障碍,为加强生殖健康评估提供了一条前景广阔的途径。
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引用次数: 0
Effect of chronic periodontitis on the endothelial glycocalyx of rat penile corpus cavernosum 慢性牙周炎对大鼠阴茎海绵体内皮糖萼的影响
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-17 DOI: 10.1111/andr.13765
Yuanhang Xia, Yang Zeng, Rui Jiang
BackgroundChronic periodontitis may induce erectile dysfunction (ED), however, the specific mechanism involved is unclear. The endothelial glycocalyx (eGlx) is a structure that can regulate endothelial nitric oxide synthase (eNOS) phosphorylation on the cavity surface of vessels.AimTo investigate whether chronic periodontitis leads to ED by affecting the eGlx.MethodsTwenty‐four 4‐week‐old male Sprague‒Dawley rats were randomly divided into four groups (n = 6): the control group, chronic periodontitis group, chronic periodontitis + heparin group (subcutaneous heparin 200 U/kg/day, 7 days), and control + heparin group. Four weeks after the induction of periodontitis in the rats, the maximum intra‐cavernous pressure/mean arterial pressure (ICPmax/MAP), serum C‐reactive protein (CRP), tumor necrosis factor alpha (TNF‐α), interleukin‐6 (IL‐6), nitric oxide (NO), heparin sulfate (HS), syndecan‐1 (SDC‐1), heparanase (HPSE), eNOS, and phosphor‐eNOS (p‐eNOS) concentration were measured, and the eGlx of the penile corpus cavernosum was observed by transmission electron microscopy (TEM).OutcomesChronic periodontitis can degrade eGlx on the rat penile corpus cavernosum by increasing serum CRP, TNF‐α, and IL‐6 levels, reducing the p‐eNOS/eNOS ratio and the NO concentration in the penile corpus cavernosum, and resulting in the inhibition of the erectile function.ResultsSerum CRP, TNF‐α, and IL‐6 levels and HPSE expression in penile cavernous tissue were significantly greater in the chronic periodontitis group than in the control group and the chronic periodontitis + heparin group (P < 0.05). The average thickness of the eGlx muscle in the penile corpus cavernosum in the chronic periodontitis group was significantly lower than those in the control group and chronic periodontitis + heparin group (P < 0.05). The HS concentration, SDC‐1 expression, p‐eNOS/eNOS, NO concentration, and ICPmax/MAP in the chronic periodontitis group were significantly lower than those in the control group and chronic periodontitis+ heparin group (P < 0.01).Clinical implicationsThe eGlx on penile cavernosum vessels may be a new therapeutic target for the treatment of ED.Strengths and limitationsThis study revealed that chronic periodontitis promotes the decomposition of vascular eGlx in the rat penile corpus cavernosum, however, it is not clear whether chronic periodontitis inhibits the synthesis of eGlx.ConclusionChronic periodontitis can degrade eGlx on the rat penile corpus cavernosum by increasing serum CRP, TNF‐α, and IL‐6 levels, reducing the p‐eNOS/eNOS ratio and the NO concentration in penile cavernous tissue, and resulting in the inhibition of the erectile function. Heparin inhibited eGlx decomposition and improved erectile function in rats with chronic periodontitis.
背景慢性牙周炎可能诱发勃起功能障碍(ED),但其具体机制尚不清楚。目的研究慢性牙周炎是否会通过影响内皮糖萼(eGlx)而导致勃起功能障碍。方法将24只4周龄雄性Sprague-Dawley大鼠随机分为4组(n = 6):对照组、慢性牙周炎组、慢性牙周炎+肝素组(皮下注射肝素200 U/kg/天,7天)和对照+肝素组。诱导大鼠患牙周炎四周后,大鼠的最大龈腔内压/平均动脉压(ICPmax/MAP)、血清 C 反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)一氧化氮 (NO)、硫酸肝素 (HS)、辛迪加-1 (SDC-1)、肝素酶 (HPSE)、eNOS 和磷-eNOS (p-eNOS) 的浓度,并用透射电子显微镜 (TEM) 观察阴茎海绵体的 eGlx。结果 慢性牙周炎可通过增加血清CRP、TNF-α和IL-6水平,降低p-eNOS/eNOS比值和阴茎海绵体内NO浓度,使大鼠阴茎海绵体的eGlx退化,导致勃起功能受抑制。结果慢性牙周炎组血清 CRP、TNF-α、IL-6 水平和阴茎海绵体组织中 HPSE 表达明显高于对照组和慢性牙周炎 + 肝素组(P < 0.05)。慢性牙周炎组阴茎海绵体 eGlx 肌肉的平均厚度明显低于对照组和慢性牙周炎 + 肝素组(P < 0.05)。慢性牙周炎组的 HS 浓度、SDC-1 表达、p-eNOS/eNOS、NO 浓度和 ICPmax/MAP 均明显低于对照组和慢性牙周炎+肝素组(P < 0.01)。优点和局限性本研究发现,慢性牙周炎会促进大鼠阴茎海绵体血管 eGlx 的分解,但尚不清楚慢性牙周炎是否会抑制 eGlx 的合成。结论 慢性牙周炎可通过增加血清CRP、TNF-α和IL-6水平,降低阴茎海绵体组织中p-eNOS/eNOS比值和NO浓度,从而降解大鼠阴茎海绵体上的eGlx,导致勃起功能受抑制。肝素能抑制慢性牙周炎大鼠体内 eGlx 的分解,改善其勃起功能。
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引用次数: 0
A comprehensive review on p38MAPK signaling as a potent radioprotector in testis 全面回顾 p38MAPK 信号在睾丸中的强效辐射保护作用
IF 4.5 2区 医学 Q1 ANDROLOGY Pub Date : 2024-09-17 DOI: 10.1111/andr.13760
Juan Yang, Xiangying Ou, Huihong Zeng, Lijian Shao
BackgroundPrevious studies have shown that the activation of p38MAPK signaling plays a crucial role in regulating gonadal cell fate decisions in both mouse and human. Excessive activation of p38MAPK by radiation significantly causes testicular damage and negatively affects the male reproductive function. Therefore, fine‐tuned regulation of p38MAPK signaling is critical in both physiological and pathological conditions.ResultThis review summarizes the impact of p38MAPK signaling on testicular germ cells and microenvironment under normal condition. The relationship between radiation, reactive oxygen species (ROS), and p38MAPK is summarized. In conclusion, radiation exposure triggers the overactivation of p38MAPK, which is regulated by ROS, resulting in testicular damage. Various p38MAPK‐targeting agents are discussed, providing guidance for developing new strategies.
背景以前的研究表明,p38MAPK 信号的激活在调节小鼠和人类性腺细胞命运决定方面起着至关重要的作用。辐射对 p38MAPK 的过度激活会导致睾丸损伤,并对男性生殖功能产生负面影响。本综述总结了正常情况下 p38MAPK 信号转导对睾丸生殖细胞和微环境的影响。综述了辐射、活性氧(ROS)和p38MAPK之间的关系。总之,辐照会引发 p38MAPK 的过度激活,而 p38MAPK 又受 ROS 的调控,从而导致睾丸损伤。本文讨论了各种 p38MAPK 靶向药物,为制定新策略提供了指导。
{"title":"A comprehensive review on p38MAPK signaling as a potent radioprotector in testis","authors":"Juan Yang, Xiangying Ou, Huihong Zeng, Lijian Shao","doi":"10.1111/andr.13760","DOIUrl":"https://doi.org/10.1111/andr.13760","url":null,"abstract":"BackgroundPrevious studies have shown that the activation of p38MAPK signaling plays a crucial role in regulating gonadal cell fate decisions in both mouse and human. Excessive activation of p38MAPK by radiation significantly causes testicular damage and negatively affects the male reproductive function. Therefore, fine‐tuned regulation of p38MAPK signaling is critical in both physiological and pathological conditions.ResultThis review summarizes the impact of p38MAPK signaling on testicular germ cells and microenvironment under normal condition. The relationship between radiation, reactive oxygen species (ROS), and p38MAPK is summarized. In conclusion, radiation exposure triggers the overactivation of p38MAPK, which is regulated by ROS, resulting in testicular damage. Various p38MAPK‐targeting agents are discussed, providing guidance for developing new strategies.","PeriodicalId":7898,"journal":{"name":"Andrology","volume":"1 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Andrology
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