Annals of Neurosciences最新文献_第3页

Expressed Emotion in Families of Children with Neurodevelopmental Disorders: A Mixed-Method Approach. 神经发育障碍儿童家庭中的情感表达:一种混合方法

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-04-01 Epub Date: 2023-08-09 DOI: 10.1177/09727531231181014

Krishna Priya Balachandran, Mohanraj Bhuvaneswari

Background: Family interaction plays a pivotal role in the overall well-being of each member of a family unit. It is foreseeable that a family caring for an individual with a mental or physical health condition could experience negative family interactions for various reasons. Expressed emotion refers to the family environment based on the relatives' interaction with the individual diagnosed with a specific illness. Expressed emotion in the families of a person with any form of mental condition could pose potential psychological distress and burden to family members, notably the primary caregivers.

Purpose: The current study intends to explore the expressed emotion of the primary caregivers toward children with neurodevelopmental disorders (NDDs). The association between expressed emotion, stress experienced by the caregiver, and the self-sufficiency of the child diagnosed with neurodevelopmental disorders was examined.

Methods: The Five-Minute Speech Sample (FMSS), Kingston Caregivers' Stress Scale (KCSS), and Waisman Activities of Daily Living (WADL) were used to assess expressed emotion, stress, and a child's self-sufficiency, respectively. The snowball sampling technique was adopted, and data were collected from 35 primary caregivers through telephonic interviews. A mixed-method research design was adopted, and the data were analyzed qualitatively and quantitatively.

Results: The findings reveal that there is a significant association between expressed emotion and caregivers' stress, expressed emotion, and the child's self-sufficiency and a significant relationship between the caregivers' stress and the child's self-sufficiency. The qualitative analysis suggests the influence of factors such as future concerns, family factors, and relationship strains contribute to expressed emotion.

Conclusion: It can be concluded that those primary caregivers who reported extreme caregivers' stress and low self-sufficiency in their child exhibited high negative expressed emotion and diverse individual and systemic factors influenced the display of high expressed emotion within the family.

家庭互动在家庭每个成员的整体福祉中起着关键作用。可以预见，照顾有精神或身体健康问题的个人的家庭可能由于各种原因而经历负面的家庭互动。表达的情感是指基于亲属与被诊断患有特定疾病的个体的互动而产生的家庭环境。在任何形式的精神疾病患者的家庭中表达情感都可能给家庭成员，特别是主要照顾者带来潜在的心理困扰和负担。本研究旨在探讨主要照顾者对神经发育障碍(ndd)儿童的情绪表达。对被诊断为神经发育障碍的儿童所表达的情绪、照顾者所经历的压力和其自我满足能力之间的联系进行了研究。采用五分钟语音样本(FMSS)、金斯顿照顾者压力量表(KCSS)和Waisman日常生活活动量表(WADL)分别评估儿童的情绪表达、压力和自立能力。采用滚雪球抽样法，对35名主要护理人员进行电话访谈。采用混合法研究设计，对数据进行定性和定量分析。研究发现，情绪表达与照顾者压力、情绪表达与儿童的自我满足存在显著相关，照顾者压力与儿童的自我满足存在显著相关。定性分析表明，未来担忧、家庭因素和关系紧张等因素对情绪表达有影响。结果表明，报告极端照顾者压力和低自立的主要照顾者表现出较高的负性情绪表达，个体和系统因素的多样性影响了家庭内部高表达情绪的表现。

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引用次数: 0

A Pilot Study of Urine Oxytocin as an Objective Biomarker for Chronic Pain 尿催产素作为慢性疼痛客观生物标志物的试点研究

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-03-22 DOI: 10.1177/09727531231224141

Daisuke Ono, T. Matsusaki, Yoshikazu Matsuoka, R. Kaku, Hiroshi Morimatsu

Background: Measuring pain objectively or quantitatively is difficult. Since urine oxytocin (OXT) concentration has been reported to be potentially associated with chronic pain. Purpose: We conducted a pilot study to evaluate the relationship between changes in numerical rating scale (NRS) score following nerve block and urine OXT concentration in patients with chronic pain. Methods: We investigated 19 chronic pain patients who were admitted to our hospital for nerve intervention. NRS score and urine OXT concentration were assessed before and after the nerve block. Results: NRS scores were 7 [6, 9] and 2 [1, 4] (median [interquartile range]) before and after the treatment intervention, respectively. Urinary OXT levels were 523 [293, 743] and 531 [308, 887] pg/mL (median [interquartile range]) before and after the treatment, respectively. We compared the group with greater improvement in NRS after the treatment intervention and those with less improvement. The group with greater improvement in NRS after the treatment intervention showed a greater increase in OXT level. However, baseline urine OXT concentrations were highly variable in patients with chronic pain and the changes in urinary OXT concentrations were also variable. Conclusion: Based on this pilot study, the utility of urine OXT concentration as an objective biomarker of chronic pain needs further investigation.

背景：对疼痛进行客观或定量的测量非常困难。据报道，尿液催产素（OXT）浓度可能与慢性疼痛有关。目的：我们进行了一项试验性研究，以评估慢性疼痛患者神经阻滞后的数字评分量表（NRS）评分变化与尿液催产素浓度之间的关系。方法：我们对 19 名慢性疼痛患者进行了调查：我们调查了 19 名在我院接受神经介入治疗的慢性疼痛患者。评估神经阻滞前后的 NRS 评分和尿液 OXT 浓度。结果：NRS治疗干预前后的 NRS 评分分别为 7 [6, 9]和 2 [1, 4]（中位数[四分位数间距]）。治疗前后尿液中的 OXT 水平分别为 523 [293, 743] pg/mL 和 531 [308, 887] pg/mL（中位数[四分位数间距]）。我们比较了治疗干预后 NRS 改善较大的组别和改善较小的组别。治疗干预后 NRS 改善幅度较大的一组患者的 OXT 水平上升幅度较大。然而，慢性疼痛患者尿液中 OXT 的基线浓度差异很大，尿液中 OXT 浓度的变化也不尽相同。结论：基于这项试点研究，尿液中 OXT 浓度作为慢性疼痛客观生物标志物的实用性有待进一步研究。

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引用次数: 0

Adversity Quotient as Determining Factor of Mental Health and Professional Quality of Life Among Healthcare Professionals: A Systematic Review 逆境商数是决定医护人员心理健康和职业生活质量的因素：系统回顾

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-03-11 DOI: 10.1177/09727531241231055

Swati Saxena, Bhanupriya Rathore

Background: Adversity quotient (AQ) is an individual’s ability to persist during the phase of constant alteration within one’s context, privation and response is measured by assessing AQ. It is a measure of resilience including four components which are ‘control’, ‘ownership’, ‘reach’ and ‘endurance’. Healthcare professionals face regularly changing adversities and new challenges, yet perform with optimal functioning. This also sometimes results in anxiety, depression, burnout and poor professional quality of life (ProQOL). Summary: The current systematic review’s aim is to explore the existing literature on AQ and the ProQOL of doctors, counsellors, psychologists, nurses, nursing students, psychiatric social workers and other healthcare professionals. Electronic databases of PubMed, NIH and Scopus were searched and authors conducted a systematic review of 23 published, unpublished studies and dissertations on the impact of workplace adversities on AQ and ProQOL of healthcare professionals, medical students and other helping professionals, up to 2024. Key Message: Showed a significant relationship between AQ, ProQOL, anxiety, depression and burnout among healthcare professionals and other helping professions. It was also observed that healthcare professionals with high AQ were able to experience a better ProQOL and improved well-being at the workplace.

背景：逆境商数（AQ）是通过评估逆境商数来衡量一个人在其所处环境不断变化的阶段中坚持下去的能力。逆境商数是对抗逆能力的衡量，包括 "控制"、"自主"、"到达 "和 "耐力 "四个部分。医疗保健专业人员经常面临不断变化的逆境和新挑战，但仍能以最佳状态开展工作。这有时也会导致焦虑、抑郁、职业倦怠和较差的职业生活质量（ProQOL）。摘要：本系统性综述旨在探讨有关 AQ 和医生、辅导员、心理学家、护士、护理专业学生、精神科社会工作者及其他医疗保健专业人员的 ProQOL 的现有文献。作者检索了PubMed、NIH和Scopus等电子数据库，并对23篇已发表、未发表的研究和论文进行了系统综述，内容涉及工作场所逆境对截至2024年医护专业人员、医科学生和其他帮助专业人员的AQ和ProQOL的影响。关键信息：研究显示，在医护专业人员和其他助人专业人员中，工作环境逆境与工作质量、焦虑、抑郁和职业倦怠之间存在重要关系。研究还发现，AQ 高的医护专业人员在工作场所能够体验到更好的 ProQOL 和更高的幸福感。

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引用次数: 0

Superparamagnetic Iron Oxide Nanoparticle Implantation and Magnetic Field Exposure Modulate Bone Microarchitecture Following Spinal Cord Injury in Adult Male Rats 超顺磁性氧化铁纳米粒子植入和磁场暴露可调节成年雄性大鼠脊髓损伤后的骨微结构

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-02-23 DOI: 10.1177/09727531231223569

Arpita Chakraborty, Konica Porwal, Srishty Raman, Subhash Chandra Yadav, S. Vishnubhatla, K. Kochhar, Suman Jain

Background: Osteoporosis is one of the detrimental effects of spinal cord injury (SCI), leading to bone loss. It has already been established that superparamagnetic nanoparticles when exposed to an external magnetic field (MF) show strong magnetisation and promote locomotor recovery. Purpose: The aim of the present study is to explore the role of magnetised nanoparticles in ameliorating SCI-induced osteoporosis. Methods: The rats were divided into Sham, SCI, SCI+MF, SCI+V, SCI+NP and SCI+NP+MF groups. A complete transection was performed at the T13 level, followed by iron oxide nanoparticle implantation along with MF exposure for 7 or 14 days. Results: A significant increase in locomotor score was evident at day 5 in all groups except in the SCI+V group, and at day 7, all groups showed a significant increase in Basso, Beattie and Bresnahan score as compared to the pre-surgery score at week 1 of the study period. A significant decrease in bone volume/total volume ratio and trabecular thickness and increase in trabecular separation were observed in all groups as compared to Sham. A significant increase in trabecular thickness in the SCI+NP+MF group as compared to the SCI+MF group was observed after one week. After two weeks, the SCI+MF group showed a significant increase in locomotor scores at days 5 and 13 as compared to the SCI, SCI+V and SCI+NP groups. Bone loss was significantly observed in all groups except SCI+MF, as compared to Sham. Cortical bone showed no significant change at both time points. On histopathological examination of the spinal cord, we observed significant improvement in lesion volume in SCI+MF and SCI+NP+MF groups after one week, whereas only the SCI+NP+MF group showed a significant decrease after two weeks. Conclusion: Electromagnetic field stimulation partially restored bone architecture after superparamagnetic nanoparticle implantation, which may be due to reduced lesion volume and improved locomotor behaviour.

背景：骨质疏松症是脊髓损伤（SCI）的有害影响之一，会导致骨质流失。已有研究证实，超顺磁性纳米粒子暴露于外部磁场（MF）时会显示出很强的磁性，并促进运动机能的恢复。目的：本研究旨在探索磁化纳米粒子在改善 SCI 引起的骨质疏松症中的作用。研究方法将大鼠分为 Sham 组、SCI 组、SCI+MF 组、SCI+V 组、SCI+NP 组和 SCI+NP+MF 组。在 T13 水平进行完全横断，然后植入氧化铁纳米粒子并暴露于 MF 7 或 14 天。结果在第 5 天，除 SCI+V 组外，其他各组的运动评分均有明显提高；在第 7 天，与研究期间第 1 周的手术前评分相比，各组的巴索评分、比提评分和布雷斯纳罕评分均有明显提高。与 Sham 组相比，所有组的骨量/总骨量比和骨小梁厚度都明显减少，骨小梁分离度增加。一周后，与 SCI+MF 组相比，SCI+NP+MF 组的骨小梁厚度明显增加。两周后，与 SCI 组、SCI+V 组和 SCI+NP 组相比，SCI+MF 组在第 5 天和第 13 天的运动评分有明显增加。与 Sham 组相比，除 SCI+MF 组外，其他各组均出现明显的骨质流失。皮质骨在两个时间点均无明显变化。在脊髓组织病理学检查中，我们观察到 SCI+MF 组和 SCI+NP+MF 组的病变体积在一周后有明显改善，而只有 SCI+NP+MF 组在两周后有明显减少。结论超顺磁性纳米粒子植入后，电磁场刺激可部分恢复骨结构，这可能是病变体积缩小和运动行为改善的原因。

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引用次数: 0

The Yoga Brain Connection: A Neuroscientific Approach to Chronic Back Pain Management 瑜伽与大脑的联系治疗慢性背痛的神经科学方法

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-02-18 DOI: 10.1177/09727531241232243

Rajni Sharma, Babita Ghai

引用次数: 0

Empowering Minds and Bodies: The Impact of Exercise on Multiple Sclerosis and Cognitive Health 增强身心能力：运动对多发性硬化症和认知健康的影响

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-02-12 DOI: 10.1177/09727531241227674

Ushna Zameer, Amna Tariq, Fatima Asif, Ateeba Kamran

Multiple sclerosis (MS) is a global health concern affecting around 2.6 million people. It is characterised by neural inflammation, myelin breakdown and cognitive decline. Cognitive impairment, especially reduced cognitive processing speed (CPS), which affects up to 67% of MS patients and frequently manifests before mobility concerns, is one of the disease’s most serious side effects. Effective adaptation and the application of cognitive rehabilitation treatments depend on the early diagnosis of cognitive impairment. Although pharmaceutical therapies have some drawbacks, endurance training has become a promising alternative. Intensity-controlled endurance exercise has the ability to delay the onset of MS symptoms and enhance cognitive function. Exercise has also been shown to have neuroprotective effects in a number of neurological disorders, including MS, Parkinson’s disease and stroke. This includes both aerobic and resistance training. A mix of aerobic exercise and weight training has shown promise, especially for people with mild cognitive impairment, but according to recent studies any amount of physical activity is beneficial to cognitive performance. In conclusion, this in-depth analysis highlights the crucial part endurance exercise plays in treating MS-related cognitive impairment. It improves not only neurological health in general but also cognitive performance. Exercise can help control MS in a way that dramatically improves quality of life and well-being.

多发性硬化症（MS）是一个全球性的健康问题，影响着约 260 万人。其特征是神经炎症、髓鞘破坏和认知能力下降。认知障碍，尤其是认知处理速度下降（CPS）是该疾病最严重的副作用之一，多达 67% 的多发性硬化症患者会受到影响，并且经常在行动不便之前表现出来。认知康复治疗的有效适应和应用取决于认知障碍的早期诊断。虽然药物疗法存在一些缺陷，但耐力训练已成为一种很有前景的替代疗法。强度可控的耐力锻炼能够延缓多发性硬化症症状的出现并增强认知功能。运动还被证明对包括多发性硬化症、帕金森病和中风在内的多种神经系统疾病具有神经保护作用。这包括有氧运动和阻力训练。有氧运动和负重训练的混合使用已显示出良好的前景，尤其是对轻度认知障碍患者而言，但根据最近的研究，任何运动量都有益于认知能力的提高。总之，这项深入分析强调了耐力锻炼在治疗多发性硬化症相关认知障碍中的关键作用。它不仅能改善神经系统的总体健康状况，还能改善认知能力。运动有助于控制多发性硬化症，从而显著提高生活质量和幸福感。

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引用次数: 0

Empowering Minds and Bodies: The Impact of Exercise on Multiple Sclerosis and Cognitive Health 增强身心能力：运动对多发性硬化症和认知健康的影响

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-02-12 DOI: 10.1177/09727531241227674

Ushna Zameer, Amna Tariq, Fatima Asif, Ateeba Kamran

Multiple sclerosis (MS) is a global health concern affecting around 2.6 million people. It is characterised by neural inflammation, myelin breakdown and cognitive decline. Cognitive impairment, especially reduced cognitive processing speed (CPS), which affects up to 67% of MS patients and frequently manifests before mobility concerns, is one of the disease’s most serious side effects. Effective adaptation and the application of cognitive rehabilitation treatments depend on the early diagnosis of cognitive impairment. Although pharmaceutical therapies have some drawbacks, endurance training has become a promising alternative. Intensity-controlled endurance exercise has the ability to delay the onset of MS symptoms and enhance cognitive function. Exercise has also been shown to have neuroprotective effects in a number of neurological disorders, including MS, Parkinson’s disease and stroke. This includes both aerobic and resistance training. A mix of aerobic exercise and weight training has shown promise, especially for people with mild cognitive impairment, but according to recent studies any amount of physical activity is beneficial to cognitive performance. In conclusion, this in-depth analysis highlights the crucial part endurance exercise plays in treating MS-related cognitive impairment. It improves not only neurological health in general but also cognitive performance. Exercise can help control MS in a way that dramatically improves quality of life and well-being.

多发性硬化症（MS）是一个全球性的健康问题，影响着约 260 万人。其特征是神经炎症、髓鞘破坏和认知能力下降。认知障碍，尤其是认知处理速度下降（CPS）是该疾病最严重的副作用之一，多达 67% 的多发性硬化症患者会受到影响，并且经常在行动不便之前表现出来。认知康复治疗的有效适应和应用取决于认知障碍的早期诊断。虽然药物疗法存在一些缺陷，但耐力训练已成为一种很有前景的替代疗法。强度可控的耐力锻炼能够延缓多发性硬化症症状的出现并增强认知功能。运动还被证明对包括多发性硬化症、帕金森病和中风在内的多种神经系统疾病具有神经保护作用。这包括有氧运动和阻力训练。有氧运动和负重训练的混合使用已显示出良好的前景，尤其是对轻度认知障碍患者而言，但根据最近的研究，任何运动量都有益于认知能力的提高。总之，这项深入分析强调了耐力锻炼在治疗多发性硬化症相关认知障碍中的关键作用。它不仅能改善神经系统的总体健康状况，还能改善认知能力。运动有助于控制多发性硬化症，从而显著提高生活质量和幸福感。

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引用次数: 0

Low Dose Amantadine and Escitalopram in Progressive Supranuclear Palsy and Multiple System Atrophy 小剂量金刚烷胺和艾司西酞普兰在进行性核上性麻痹和多系统萎缩中的应用

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-02-07 DOI: 10.1177/09727531231222700

P. Chutia, S. Tripathi

Background: Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are less responsive to usual antiparkinsonian drugs. Purpose: To assess the treatment outcome of the combination of low-dose amantadine and escitalopram in the study population. Methods: A retrospective study of PSP and MSA patients from June 2021 to December 2022 treated with the dose of amantadine 100 mg and escitalopram 5 mg per day with a follow-up of 2 months at a tertiary care centre in India. The primary outcome measure was a change in the PSP and MSA severity rating scale scores, while cognition, neuropsychiatric symptoms and functionality scale scores were secondary outcomes on follow-up visits. Repeated measures ANOVA and Friedman rank test were used to analyse the data. Results: A total of 21 patients (8 PSP and 13 MSA), including 19 males, with a mean age of 72.84 years, were included. The mean total PSP rating scale score had a significant decline from baseline to week 2 and 8 ( p < .001), along with the scores for limb symptoms ( p < .001), ocular ( p = .001), history ( p = .003), gait ( p = .007), mentation ( p = .014) and bulbar ( p = .018) symptoms. Similarly, the mean score of the MSA rating scale significantly decreased on follow-up visits ( p < .001). The cognition, functional disability and behavioural symptoms scores also had significant improvement with p < .01. Conclusion: The PSP and MSA patients had clinically significant improvement with the combination treatment in both motor and non-motor domains. Further prospective trials for longer durations are needed to establish the effect size and stability of response.

背景：进行性核上性麻痹（PSP）和多系统萎缩（MSA）对普通抗帕金森病药物的反应较差。目的：在研究人群中评估小剂量金刚烷胺和艾司西酞普兰联合用药的治疗效果。方法：对帕金森病患者进行回顾性研究：回顾性研究：2021年6月至2022年12月期间，在印度的一家三级医疗中心接受金刚烷胺100毫克/天和艾司西酞普兰5毫克/天治疗的PSP和MSA患者，随访2个月。主要研究结果是PSP和MSA严重程度量表评分的变化，认知、神经精神症状和功能量表评分是随访的次要结果。采用重复测量方差分析和弗里德曼秩检验分析数据。结果共纳入 21 名患者（8 名 PSP 和 13 名 MSA），包括 19 名男性，平均年龄为 72.84 岁。从基线到第2周和第8周，PSP评分量表的平均总分显著下降（p < .001），肢体症状（p < .001）、眼部（p = .001）、病史（p = .003）、步态（p = .007）、精神（p = .014）和球部（p = .018）症状的评分也显著下降。同样，随访时 MSA 评定量表的平均得分也明显下降（p < .001）。认知、功能性残疾和行为症状评分也有明显改善，p < .01。结论通过联合治疗，PSP 和 MSA 患者在运动和非运动领域均有明显的临床改善。需要进一步开展持续时间更长的前瞻性试验，以确定疗效大小和反应的稳定性。

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引用次数: 0

Low Dose Amantadine and Escitalopram in Progressive Supranuclear Palsy and Multiple System Atrophy 小剂量金刚烷胺和艾司西酞普兰在进行性核上性麻痹和多系统萎缩中的应用

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-02-07 DOI: 10.1177/09727531231222700

P. Chutia, S. Tripathi

Background: Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are less responsive to usual antiparkinsonian drugs. Purpose: To assess the treatment outcome of the combination of low-dose amantadine and escitalopram in the study population. Methods: A retrospective study of PSP and MSA patients from June 2021 to December 2022 treated with the dose of amantadine 100 mg and escitalopram 5 mg per day with a follow-up of 2 months at a tertiary care centre in India. The primary outcome measure was a change in the PSP and MSA severity rating scale scores, while cognition, neuropsychiatric symptoms and functionality scale scores were secondary outcomes on follow-up visits. Repeated measures ANOVA and Friedman rank test were used to analyse the data. Results: A total of 21 patients (8 PSP and 13 MSA), including 19 males, with a mean age of 72.84 years, were included. The mean total PSP rating scale score had a significant decline from baseline to week 2 and 8 ( p < .001), along with the scores for limb symptoms ( p < .001), ocular ( p = .001), history ( p = .003), gait ( p = .007), mentation ( p = .014) and bulbar ( p = .018) symptoms. Similarly, the mean score of the MSA rating scale significantly decreased on follow-up visits ( p < .001). The cognition, functional disability and behavioural symptoms scores also had significant improvement with p < .01. Conclusion: The PSP and MSA patients had clinically significant improvement with the combination treatment in both motor and non-motor domains. Further prospective trials for longer durations are needed to establish the effect size and stability of response.

背景：进行性核上性麻痹（PSP）和多系统萎缩（MSA）对普通抗帕金森病药物的反应较差。目的：在研究人群中评估小剂量金刚烷胺和艾司西酞普兰联合用药的治疗效果。方法：对帕金森病患者进行回顾性研究：回顾性研究：2021年6月至2022年12月期间，在印度的一家三级医疗中心接受金刚烷胺100毫克/天和艾司西酞普兰5毫克/天治疗的PSP和MSA患者，随访2个月。主要研究结果是PSP和MSA严重程度量表评分的变化，认知、神经精神症状和功能量表评分是随访的次要结果。采用重复测量方差分析和弗里德曼秩检验分析数据。结果共纳入 21 名患者（8 名 PSP 和 13 名 MSA），包括 19 名男性，平均年龄为 72.84 岁。从基线到第2周和第8周，PSP评分量表的平均总分显著下降（p < .001），肢体症状（p < .001）、眼部（p = .001）、病史（p = .003）、步态（p = .007）、精神（p = .014）和球部（p = .018）症状的评分也显著下降。同样，随访时 MSA 评定量表的平均得分也明显下降（p < .001）。认知、功能性残疾和行为症状评分也有明显改善，p < .01。结论通过联合治疗，PSP 和 MSA 患者在运动和非运动领域均有明显的临床改善。需要进一步开展持续时间更长的前瞻性试验，以确定疗效大小和反应的稳定性。

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引用次数: 0

Characteristics of Auditory Brainstem Response in Night-shift Health Workers 夜班医护人员的听觉脑干反应特征

IF 1.5 Q3 Neuroscience

Annals of Neurosciences

Pub Date : 2024-01-24 DOI: 10.1177/09727531231214345

Samir Kumar Singh, Poonam Jyoti Rana, Anita Gupta, Dibyodyuti Samaddar, Hanjabam Barun Sharma

Background: With technological advancement and economic competitiveness there is an exponential rise in the number of shift workers. Worldwide, healthcare workers constitute the single largest proportion of workers who work on shift duty in order to provide round-the-clock healthcare services to patients. Various studies have demonstrated an association between circadian cycle disturbance due to shift work and adverse health impacts. Purpose: The purpose of the study was to investigate the impact of night shift work on the brainstem-evoked auditory potentials in nursing interns who had been assigned to their first night shift after working day shifts. Methods: A longitudinal, self-case-control study was designed with a sample of 67 nursing interns. Brainstem evoked response audiometry (BERA) had been done after completion of their first posting in Day-shift and then after completion of Night-shift. The paired t-test was used for data analysis. Results: The findings of the study showed significant changes in latencies of wave II ( p < .0001), wave IV ( p < .0001), wave V ( p = .012 & .30), interpeak latency III-V ( p = .009 & .003) and V/I ratio ( p < .0001) for both ears. Conclusions: BERA is an objective non-invasive test to evaluate hearing ability by measuring increased latency and interaural latency difference. After night shift, there were significant changes in auditory acuity which was highly suggestive of delayed transmission in auditory pathway. Hearing impairment has a cascading effect on cognition which may affect night-shift workers’ daily activities and may lead to medical error and risk to patient safety.

背景：随着技术进步和经济竞争力的提高，轮班工人的数量呈指数级增长。在全球范围内，医护人员是轮班工作人数最多的群体，他们需要为病人提供全天候的医疗服务。多项研究表明，轮班工作导致的昼夜节律紊乱与不良健康影响之间存在关联。目的：本研究旨在调查夜班工作对护理实习生脑干诱发听觉电位的影响，这些实习生是在白班工作后被分配到第一个夜班的。研究方法以 67 名护理实习生为样本，设计了一项纵向自我病例对照研究。脑干诱发反应测听（BERA）是在实习生完成首次白班工作后和夜班工作后进行的。数据分析采用配对 t 检验。结果研究结果显示，双耳的第二波潜伏期（p < .0001）、第四波潜伏期（p < .0001）、第五波潜伏期（p = .012 & .30）、第三至第五波峰间潜伏期（p = .009 & .003）和 V/I 比值（p < .0001）均有明显变化。结论：BERA 是一种客观的非侵入性测试，可通过测量增大的潜伏期和耳间潜伏期差来评估听力能力。夜班后，听觉敏锐度发生了显著变化，这高度提示听觉通路的延迟传输。听力障碍会对认知能力产生连带影响，可能会影响夜班工人的日常活动，并可能导致医疗失误和危及患者安全。

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