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Humanistic and Holistic Strategies for Combating Mental Health Sequelae in the Elderly During the Post-COVID Era. 后 COVID 时代应对老年人心理健康后遗症的人文和整体战略。
IF 1.8 Q4 NEUROSCIENCES Pub Date : 2024-01-18 DOI: 10.1177/09727531231208292
Kalyan Maity, Parth Lal, Saras Jyoti, Parul Bali, Uttam Kumar Thakur, Gurmeet Singh, Vijaya Majumdar, Sanjib Patra, Jaideep Arya, Akshay Anand

Background: The elderly population is rapidly growing worldwide. By the year 2050, the elderly population will increase up to 2.1 billion. Among them, most of the elderly will be from low- to middle-income countries. India and China are the most populated countries in the world, and also they fall in the category of low- to middle-income countries. The elderly population in these two countries is also growing rapidly and creating an economic burden of geriatric care. On the other hand, the COVID-19 pandemic greatly affected the healthcare system. A higher mortality rate was documented among the elderly due to COVID-19; hence, it was a challenge for them to deal with a high load of the elderly population during the pandemic. These challenges never sublimate even during the post-COVID era. Mental health issues, such as stress, anxiety, and depression, are major drawbacks of COVID-19 among the elderly due to excessive fear of getting reinfection of COVID-19 and fear of social withdrawal. These factors are affecting healthy aging among the elderly. Even though WHO has taken few initiatives for healthy aging, proper interventional strategies are required to prevent mental illness and improve mental health among the elderly during the post-COVID era.

Summary: In this review, we have proposed a few mind-body strategies like Yoga, Exercise, Tai-Chi, and Qigong to improve mental health and holistic patient-centric implementation of those practices in the elderly during the post-COVID era.

Key message: Mind-body interventions can be used in a holistic patient-centric manner to prevent infectious diseases, and post-infection consequences. Further, it enhances immunomodulation along with mental health in the elderly.

背景:全球老年人口正在迅速增长。到 2050 年,老年人口将增至 21 亿。其中,大部分老年人将来自中低收入国家。印度和中国是世界上人口最多的国家,也属于中低收入国家。这两个国家的老年人口也在迅速增长,造成了老年护理的经济负担。另一方面,COVID-19 大流行对医疗保健系统造成了巨大影响。根据记录,COVID-19 造成的老年人死亡率较高;因此,在大流行期间,如何应对老年人口的高负荷是一项挑战。即使在后 COVID 时代,这些挑战也从未缓解。压力、焦虑和抑郁等心理健康问题是 COVID-19 在老年人中造成的主要弊端,因为他们过度害怕再次感染 COVID-19,害怕退出社会。这些因素正在影响老年人的健康老龄化。总结:在这篇综述中,我们提出了一些身心策略,如瑜伽、运动、太极和气功,以改善老年人的心理健康,并在后 COVID 时代以患者为中心在老年人中全面实施这些做法:关键信息:身心干预措施可用于以患者为中心的整体方式,预防感染性疾病和感染后的后果。此外,它还能加强老年人的免疫调节和心理健康。
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引用次数: 0
The Effects of Physical Activity on Experimental Models of Vascular Dementia: A Systematic Review and Meta-Analysis 体育锻炼对血管性痴呆实验模型的影响:系统回顾与元分析
IF 1.5 Q4 NEUROSCIENCES Pub Date : 2024-01-10 DOI: 10.1177/09727531231192759
I. Biose, W. H. Chastain, Rebecca Solch-Ottaiano, Viktoriya S. Grayson, Hanyun Wang, Somdeb Banerjee, Gregory Bix
Background: Physical activity is associated with improved brain health and cognition in humans. However, the validity, range, and quality of evidence for the beneficial outcomes linked to exercise in experimental models of vascular dementia (VaD) have not been evaluated. We performed a systematic review and meta-analysis of studies that assessed the effect of exercise intervention on models of VaD to provide an unbiased and comprehensive determination of the cognitive function and brain morphology benefits of exercise. Summary: A systematic search in three databases as well as study design characteristics and experimental data extraction were completed in December 2021. We investigated the effects of exercise on cognitive function and brain-morphology outcomes in VaD models. Twenty-five studies were included for systematic review, while 21 studies were included in the meta-analysis. These studies included seven models of VaD in rats (60%, 15 studies), mice (36%, 9 studies), and pigs (4%, 1 study). None of the included studies used aged animals, and the majority of studies (80%) used only male animals. Key Message: Exercise improves cognition but increased neuro-inflammation in VaD models. Exercise improved cognitive function as well as some markers of brain morphology in models of VaD. However, exercise increased anxiety and neuro-inflammatory signals in VaD models. Further, we observed increased reporting anomalies such as a lack of blinding to group treatment or data analysis and randomization of animals to groups. Our report could help in the appropriate design of experimental studies seeking to investigate the effects of exercise as a non-pharmacological intervention on VaD models with a high translational impact.
背景:体育锻炼与人类大脑健康和认知能力的改善有关。然而,在血管性痴呆(VaD)的实验模型中,与运动相关的有益结果的有效性、范围和证据质量尚未得到评估。我们对评估运动干预对血管性痴呆模型影响的研究进行了系统回顾和荟萃分析,以便对运动对认知功能和大脑形态学的益处做出公正、全面的判断。摘要:我们于 2021 年 12 月完成了对三个数据库的系统检索以及研究设计特征和实验数据提取。我们研究了运动对 VaD 模型认知功能和脑形态结果的影响。系统回顾纳入了 25 项研究,荟萃分析纳入了 21 项研究。这些研究包括大鼠(60%,15 项研究)、小鼠(36%,9 项研究)和猪(4%,1 项研究)的七种 VaD 模型。所有纳入的研究均未使用老年动物,且大多数研究(80%)仅使用雄性动物。关键信息:运动可改善 VaD 模型的认知能力,但会增加神经炎症。运动能改善VaD模型的认知功能以及大脑形态的一些标志物。然而,运动增加了VaD模型的焦虑和神经炎症信号。此外,我们还观察到了更多的报告异常,如缺乏对分组治疗或数据分析的盲法以及将动物随机分组。我们的报告有助于适当设计实验研究,以探究运动作为一种非药物干预措施对VaD模型的影响,并具有较高的转化影响。
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引用次数: 0
Neuro Receptor Signal Detecting and Monitoring Smart Devices for Biological Changes in Cognitive Health Conditions 神经受体信号检测和监控智能设备,了解认知健康状况下的生物变化
IF 1.5 Q4 NEUROSCIENCES Pub Date : 2024-01-10 DOI: 10.1177/09727531231206888
Vivek Reddy M, Ganesh Gnk, Rudhresh D, Vaishnavi Parimala T, Gaddam Narasimha Rao
Currently, wearable sensors significantly impact health care through continuous monitoring and event prediction. The types and clinical applications of wearable technology for the prevention of mental illnesses, as well as associated health authority rules, are covered in the current review. The technologies behind wearable ECG monitors, biosensors, electronic skin patches, neural interfaces, retinal prosthesis, and smart contact lenses were discussed. We described how sensors will examine neuronal impulses using verified machine-learning algorithms running in real-time. These sensors will closely monitor body signals and demonstrate continuous sensing with wireless functionality. The wearable applications in the following medical fields were covered in our review: sleep, neurology, mental health, anxiety, depression, Parkinson’s disease, epilepsy, seizures, and schizophrenia. These mental health conditions can cause serious issues, even death. Inflammation brought on by mental health problems can worsen hypothalamic-pituitary-adrenal axis dysfunction and interfere with certain neuroregulatory systems such as the neural peptide Y, serotonergic, and cholinergic systems. Severe depressive disorder symptoms are correlated with elevated Interleukin (IL-6) levels. On the basis of previous and present data collected utilizing a variety of sensory modalities, researchers are currently investigating ways to identify or detect the current mental state. This review explores the potential of various mental health monitoring technologies. The types and clinical uses of wearable technology, such as ECG monitors, biosensors, electronic skin patches, brain interfaces, retinal prostheses, and smart contact lenses, were covered in the current review will be beneficial for patients with mental health problems like Alzheimer, epilepsy, dementia. The sensors will closely monitor bodily signals with wireless functionality while using machine learning algorithms to analyse neural impulses in real time.
目前,可穿戴传感器通过持续监测和事件预测对医疗保健产生了重大影响。本综述介绍了可穿戴技术在预防精神疾病方面的类型和临床应用,以及相关的卫生部门规定。我们讨论了可穿戴心电图监测仪、生物传感器、电子皮肤贴片、神经接口、视网膜假体和智能隐形眼镜背后的技术。我们介绍了传感器如何利用实时运行的经过验证的机器学习算法来检查神经元冲动。这些传感器将密切监测身体信号,并展示具有无线功能的连续传感。我们的综述涵盖了可穿戴设备在以下医疗领域的应用:睡眠、神经学、心理健康、焦虑、抑郁、帕金森病、癫痫、癫痫发作和精神分裂症。这些精神疾病会导致严重的问题,甚至死亡。精神健康问题引起的炎症会加重下丘脑-垂体-肾上腺轴功能紊乱,并干扰某些神经调节系统,如神经肽 Y、血清素能和胆碱能系统。严重的抑郁症状与白细胞介素(IL-6)水平升高有关。根据以前和现在利用各种感官模式收集的数据,研究人员目前正在研究识别或检测当前精神状态的方法。本综述探讨了各种心理健康监测技术的潜力。本综述涵盖了可穿戴技术的类型和临床用途,如心电图监测器、生物传感器、电子皮肤贴片、大脑接口、视网膜义肢和智能隐形眼镜等,这些技术将对阿尔茨海默症、癫痫、痴呆症等精神疾病患者有益。这些传感器将利用无线功能密切监测身体信号,同时利用机器学习算法实时分析神经冲动。
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引用次数: 0
Citrus Odour Produces Resilient Response to Cognitive Load and Enhances Performance in the N-Back Task 柑橘气味能产生对认知负荷的弹性反应并提高 N-Back 任务的成绩
IF 1.5 Q4 NEUROSCIENCES Pub Date : 2024-01-04 DOI: 10.1177/09727531231215556
Deep Shikha, P. Ojha, Kamla Kant Shukla, Om Lata Bhagat, A. Dixit
Background: Olfactory pathway and limbic system demonstrate a close nexus, which paves common ground for investigating the effects of smell on emotions, cognitive load and autonomic functions. Notably, olfactory stimulation during the administration of cognitive load may interfere with the performance. Purpose: The study is planned to investigate the effect of citrus inhalation on cognitive performance, through psychophysiological assessments. Methods: Thirty male participants were subjected to the cognitive load with the 2-back task in control and experimental sessions. Olfactory stimulation was administered with a pure citrus odour through an aroma diffuser. Electrocardiogram (ECG) for heart rate variability (HRV); photoplethysmography (PPG), and electrodermal activity (EDA) were recorded in experimental and control sessions. Results: Citrus odour significantly improved the performance in 2-back task. A paired t-test revealed that the target correct response numbers and target accuracy were significantly increased with the citrus odour inhalation. The EDA showed a rise in the skin conductance level with the 2-back task that was suppressed with the citrus odour administration. The HRV measures, pNN50, RMSSD, and HF power demonstrated a significant increase in the citrus smell. Conclusion: Importantly, citrus odour produced resilience to cognitive stress due to the cognitive task and it was reflected in the EDA. Olfactory stimulation with citrus improved the scores in the 2-back task performance. Though there was no alteration in the overall variability of cardiac oscillation but there was a conspicuous shift of autonomic balance towards the parasympathetic system with the citrus inhalation. The observed finding advocates the use of citrus odour as a cognitive stress-suppressing measure for cognitive enhancement.
背景:嗅觉通路和边缘系统有着密切的联系,这为研究嗅觉对情绪、认知负荷和自律神经功能的影响奠定了基础。值得注意的是,在进行认知负荷时,嗅觉刺激可能会干扰认知表现。目的:本研究计划通过心理生理学评估,调查柑橘吸入对认知能力的影响。研究方法30 名男性参与者分别在对照组和实验组接受了 2 回任务的认知负荷。通过芳香扩散器对参与者进行纯柑橘气味的嗅觉刺激。实验组和对照组分别记录了心电图(ECG)以检测心率变异性(HRV)、光电血压计(PPG)和皮下电活动(EDA)。结果柑橘气味明显改善了 2 回任务的表现。配对 t 检验显示,吸入柑橘气味后,目标正确反应数和目标准确率都有明显提高。EDA显示,在进行2-back任务时,皮肤电导水平上升,而在吸入柑橘气味后,皮肤电导水平被抑制。心率变异测量、pNN50、RMSSD 和高频功率在柑橘气味的作用下均有显著增加。结论重要的是,柑橘气味能产生对认知任务造成的认知压力的恢复力,这一点在 EDA 中得到了反映。柑橘的嗅觉刺激提高了 "2-back "任务的得分。虽然心脏振荡的总体变异性没有改变,但吸入柑橘后,自律神经平衡明显向副交感神经系统转移。这一观察结果主张使用柑橘气味作为认知压力抑制措施,以提高认知能力。
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引用次数: 0
Need for E-module-based Validated Yoga Protocol 需要基于电子模块的经过验证的瑜伽协议
IF 1.5 Q4 NEUROSCIENCES Pub Date : 2023-12-26 DOI: 10.1177/09727531231213471
R. Padmavathi, K. S. Dhamodhini, K. Maheshkumar, Kantipudi Suvarna Jyothi, Silambanan Santhi
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引用次数: 0
Prognostic Accuracy of Common Mortality Prognostic Scales in Very Old Patients with Intracerebral Haemorrhage 高龄脑出血患者常见死亡率预后量表的预后准确性
IF 1.5 Q4 NEUROSCIENCES Pub Date : 2023-12-23 DOI: 10.1177/09727531231185200
Rafael Batista, Marta Pereira, Deise Catamo Vaz, Helena Buque, H. Nzwalo, A. Marreiros
Spontaneous intracerebral haemorrhage (SICH) is the most severe form of all stroke types. Stratification of SICH severity is important for group comparisons and treatment decisions. The existing prognostic scores for clinical prediction in SICH have not been specifically validated in the very old (≥75 years). Therefore, we aimed to evaluate the accuracy of different SICH vital prognostic scores in the very old. To compare the short-term accuracy of three vital prognostic scores: Functional Outcome in Patients with Primary Intracerebral Haemorrhage (FUNC), Modified Emergency Department Intracerebral Haemorrhage (mEDICH) and the Intracerebral Haemorrhage Score (‘ICH score’) in patients aged 75 or older. Comparison of the discriminative performance of three SICH prognostic scores in a consecutive case series of patients ≥75 years. The prognostic discrimination was assessed using the area under the receiver operating characteristic curve (AUROC). Additionally, a binary logistic regression was conducted to determine independent prognostic factors associated with mortality. The case-fatality was 40.6%. The AUROC and Younden index for the three scores was as it follows: ‘ICH score’ 0.882 and 0.648; mEDICH 0.867 and 0.571; FUNC 0.802 and 0.519. The main independent risk factors of death were presence of intraventricular extension (OR = 4.000,95% CI= 1.933–8.276), INR value (OR = 2.173, 95% CI = 1.146–4.117), haemorrhage volume (OR = 1.881, 95% CI = 1.029–3.440) and GCS (OR = 0.119, 95% CI = 0.060–0.236) for mEDICH. Haemorrhage volume (OR = 3.020, 95% CI = 1.806–5.050) and GCS (OR = 0.043, 95% CI = 0.013–0.151) for FUNC. Haemorrhage volume (OR = 4.950, 95% CI = 2.249–10.897) and intraventricular haemorrhage (OR = 3.811, 95% CI = 1.833–7.924) for ‘ICH score’. The three scores (‘ICH score’, FUNC and mEDICH) showed an excellent capability of discriminating the group of elderly patients at risk of short-term death. Age per se may not be crucial for accurate discrimination of death in the group of elderly. Instead, the inclusion of available physiological markers of fragility would be more scientifically meaningful than age.
自发性脑出血(SICH)是所有中风类型中最严重的一种。对 SICH 严重程度进行分层对于分组比较和治疗决策非常重要。现有的用于 SICH 临床预测的预后评分尚未专门针对高龄老人(≥75 岁)进行验证。因此,我们旨在评估不同的 SICH 生命预后评分在高龄老人中的准确性。比较三种生命预后评分的短期准确性:比较三种生命预后评分:原发性脑出血患者功能预后评分(FUNC)、改良急诊科脑出血评分(mEDICH)和脑出血评分("ICH 评分")在 75 岁或以上患者中的短期准确性。在≥75岁患者的连续病例系列中比较三种SICH预后评分的鉴别性能。使用接收者操作特征曲线下面积(AUROC)评估预后判别能力。此外,还进行了二元逻辑回归,以确定与死亡率相关的独立预后因素。病死率为 40.6%。三种评分的 AUROC 和 Younden 指数如下:ICH评分 "为0.882和0.648;mEDICH为0.867和0.571;FUNC为0.802和0.519。死亡的主要独立危险因素是脑室内扩展(OR = 4.000,95% CI = 1.933-8.276)、INR 值(OR = 2.173,95% CI = 1.146-4.117)、出血量(OR = 1.881,95% CI = 1.029-3.440)和 mEDICH 的 GCS(OR = 0.119,95% CI = 0.060-0.236)。FUNC的出血量(OR = 3.020,95% CI = 1.806-5.050)和GCS(OR = 0.043,95% CI = 0.013-0.151)。出血量(OR = 4.950,95% CI = 2.249-10.897)和脑室内出血(OR = 3.811,95% CI = 1.833-7.924)表示 "ICH 评分"。这三种评分("ICH 评分"、FUNC 和 mEDICH)在区分有短期死亡风险的老年患者群体方面显示出卓越的能力。年龄本身可能并不是准确判别老年患者死亡的关键。相反,与年龄相比,纳入现有的脆性生理指标更具有科学意义。
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引用次数: 0
Changing Horizon in Teaching Profession in India: Issues and Challenges 印度教师职业不断变化的前景:问题与挑战
IF 1.5 Q4 NEUROSCIENCES Pub Date : 2023-12-21 DOI: 10.1177/09727531231208290
Shikha Verma, Mitima Sachdeva, Amita Bajpai
Background: The education system is the lifeline of a nation. If the education system is strong and free from issues, the nation will, certainly, progress. Teachers have a key role in nation-building. Their opinions for overcoming the issues and challenges of education in the changing horizon can work as a roadmap to quality education. Purpose: The researcher has surveyed 450 teaching professionals to explore the issues and challenges of the changing horizon for teaching professionals in India. Methods: The researcher has developed a five-point rating scale, after an extensive literature review of regulations and reports of commissions and regulatory bodies. MS Excel 2016 version is used and analysis has been done by finding the frequency of respondents on each point of the rating scale. Then, the results have been interpreted and concluded. Results: The recommendations to overcome the issues and challenges for teaching professionals are also given in the changing horizon in India. Conclusion: Concerned professionals must consider factors including adequate infrastructure, up-to-date curricula, qualified faculty, suitable class sizes, learning materials, financial support and well-planned guidelines for quality education in order to improve education quality. A new teacher education program named as Integrated Teacher Education Programme (ITEP)1 and a reform in educational policy as New Education Policy (2020)2 have begun. All the teaching professionals are hopefully waiting for their implementation. A great future for everyone will undoubtedly result from our work.
背景:教育系统是一个国家的生命线。如果教育系统强大,没有问题,国家就一定会进步。教师在国家建设中起着关键作用。在不断变化的世界中,他们对克服教育问题和挑战的意见可以作为优质教育的路线图。目的:研究人员对 450 名教学专业人员进行了调查,以探讨印度教学专业人员在不断变化的地平线上所面临的问题和挑战。调查方法研究人员在对委员会和监管机构的法规和报告进行广泛的文献查阅后,制定了一个五点评级量表。使用 MS Excel 2016 版本,通过查找受访者在评分表各点上的频率进行分析。然后,对结果进行解释和总结。结果:在印度不断变化的地平线上,还提出了克服教学专业人员面临的问题和挑战的建议。结论:为了提高教育质量,相关专业人员必须考虑各种因素,包括充足的基础设施、最新的课程、合格的师资、合适的班级规模、学习材料、财政支持以及计划周密的优质教育指导方针。一项名为 "综合教师教育计划(ITEP)"1 的新教师教育计划和一项名为 "新教育政策(2020)"2 的教育政策改革已经启动。所有教学专业人员都在满怀希望地等待着它们的实施。我们的工作无疑将为每个人带来美好的未来。
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引用次数: 0
Disruption in Sleep and Circadian Rhythm: A Potential Accelerator in Alzheimer’s Disease Progression 睡眠和昼夜节律中断:阿尔茨海默病进展的潜在加速器
Q4 NEUROSCIENCES Pub Date : 2023-11-09 DOI: 10.1177/09727531231200958
Abdul Hadi Khan, Ali Abdullah, Muhammad Saqlain Mustafa, Muhammad Abdul Qadeer
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引用次数: 0
Targeting Beta-Amyloid Protein with Monoclonal Antibodies: A New Hope for Alzheimer’s Treatment 靶向β -淀粉样蛋白单克隆抗体:阿尔茨海默病治疗的新希望
Q4 NEUROSCIENCES Pub Date : 2023-11-09 DOI: 10.1177/09727531231190989
Farheen Ashraf, Fatimah Kashif Rasool, Muhammad Musab Nafees Uddin, Mohammad Arham Siddiq, Muhammad Saqlain Mustafa
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引用次数: 0
Recent Advances in Prenatal Management of Spina Bifida 脊柱裂产前处理的最新进展
Q4 NEUROSCIENCES Pub Date : 2023-11-08 DOI: 10.1177/09727531231189939
Areej Shakil, Burhanuddin Sohail Rangwala, Tooba Noor, Aimen Waqar Khan, Hussain Sohail Rangwala
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引用次数: 0
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Annals of Neurosciences
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