Pub Date : 2023-11-07DOI: 10.1177/09727531231198298
Parameshwar Some, Vijaya Majumdar, Manjunath N. K., Kuldeep Shetty, Atmakur Snigdha
Background Numerous studies have shown that yoga can aid patients with Parkinson’s disease (PD) in managing their motor function, functional mobility, balance, anxiety, and overall quality of life. However, most of the reported research either needed more power or evaluated the results during or after the intervention. Due to the long-standing nature of PD, there are still few longitudinal studies investigating the potential of yoga to decrease the progression of the disease. Purpose We study whether sustained adjunct yoga intervention slows PD progression. Methods Over 18 months, this study will investigate the long-term benefits of yoga-based intervention in Parkinson’s patients. The concept of “intention-to-treat (ITT)” will be employed. From the outpatient clinic of the Swami Vivekananda Yoga Anusandhana Samsthana in India, 160 patients with PD will be chosen. They will then be randomly assigned to either the interventional or control groups (1:1). The adjunct intervention group will participate in 21 daily contact yoga sessions (60 min) at the University Medical Center, followed by continued tele-supervised home practice and at-home self-practice. The effectiveness of the adjunct intervention will be evaluated at four different time points (baseline, 3-, 9-, 12-, and 18-month post-randomization). The primary endpoint will be the difference in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at baseline and after 18 months of intervention. Secondary outcomes will include subscores of MDS-UPDRS I, II, and IV, Parkinson’s Disease Questionnaire (PDQ)-39 scores, treatment adherence, the PDQ-39, the Depression, Anxiety, and Stress Scale-21, and the Scales for Outcomes in PD-Sleep Scale (SCOPA-S). The primary outcome will be analyzed using mixed-effect models for repeated measures, adjusted for covariates as fixed effects. Results The protocol was conceptualized in October 2021 and approved by the Institutional Ethics Committee of SVYASA. Recruitment began in February 2022 and is underway with patient enrollment. Conclusion To our knowledge, this is the first controlled study to examine the long-term effects of yoga as an adjuvant therapy on the progression of PD. Key message This would be the first long-term trial to assess the potential of an adjunct yoga intervention to modulate disease progression in early Parkinson’s patients.
{"title":"A Longitudinal Two-Armed Randomized Controlled Trial Protocol to Evaluate the Efficacy of Yoga on Progression of Disease in Early Parkinson’s Disease","authors":"Parameshwar Some, Vijaya Majumdar, Manjunath N. K., Kuldeep Shetty, Atmakur Snigdha","doi":"10.1177/09727531231198298","DOIUrl":"https://doi.org/10.1177/09727531231198298","url":null,"abstract":"Background Numerous studies have shown that yoga can aid patients with Parkinson’s disease (PD) in managing their motor function, functional mobility, balance, anxiety, and overall quality of life. However, most of the reported research either needed more power or evaluated the results during or after the intervention. Due to the long-standing nature of PD, there are still few longitudinal studies investigating the potential of yoga to decrease the progression of the disease. Purpose We study whether sustained adjunct yoga intervention slows PD progression. Methods Over 18 months, this study will investigate the long-term benefits of yoga-based intervention in Parkinson’s patients. The concept of “intention-to-treat (ITT)” will be employed. From the outpatient clinic of the Swami Vivekananda Yoga Anusandhana Samsthana in India, 160 patients with PD will be chosen. They will then be randomly assigned to either the interventional or control groups (1:1). The adjunct intervention group will participate in 21 daily contact yoga sessions (60 min) at the University Medical Center, followed by continued tele-supervised home practice and at-home self-practice. The effectiveness of the adjunct intervention will be evaluated at four different time points (baseline, 3-, 9-, 12-, and 18-month post-randomization). The primary endpoint will be the difference in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at baseline and after 18 months of intervention. Secondary outcomes will include subscores of MDS-UPDRS I, II, and IV, Parkinson’s Disease Questionnaire (PDQ)-39 scores, treatment adherence, the PDQ-39, the Depression, Anxiety, and Stress Scale-21, and the Scales for Outcomes in PD-Sleep Scale (SCOPA-S). The primary outcome will be analyzed using mixed-effect models for repeated measures, adjusted for covariates as fixed effects. Results The protocol was conceptualized in October 2021 and approved by the Institutional Ethics Committee of SVYASA. Recruitment began in February 2022 and is underway with patient enrollment. Conclusion To our knowledge, this is the first controlled study to examine the long-term effects of yoga as an adjuvant therapy on the progression of PD. Key message This would be the first long-term trial to assess the potential of an adjunct yoga intervention to modulate disease progression in early Parkinson’s patients.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"68 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135479886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-07DOI: 10.1177/09727531231198964
Kalyani Biswal, Kailash B. L. Srivastava, Sayed Firoj Alli
Background Employees are the real capital of any organisation, and to keep the employees productive and functional, employers need to focus on the psychological capital and social relationship of the employees to keep them engaged in their work. This study examined the emerging field of constructs of psychological and social capital to examine Indian employee’s behaviour. Purpose The purpose of this study is to examine a comprehensive model of the relationship between employees’ psychological capital and work engagement. Furthermore, it examines the moderating effect of social relationships between them. Methods This is a primary survey conducted mainly on the manufacturing industry. A sample of 375 mid- and senior-level executives of different age groups was considered in the study from India’s public and private manufacturing sectors administering a questionnaire survey. A random sampling technique was used for data collection. This study applied SPSS and Amos software to validate the measurement model. Results The results indicate a significant correlation among PsyCap, work engagement, and social relationships. PsyCap and social relationships are positively connected to work engagement. Thus, these results provide preliminary support for our hypotheses. The finding suggests that psychological capital and social relationships positively influence work engagement, and social relationships moderate the association between positive psychological capital and work engagement. It helps employees get better engaged at work. Conclusion Organisations must develop psychological capital to provide resources to employees and share a supportive relationship. Developing and maintaining a supportive relationship for employees and employers is important. In the future, both qualitative research methods and longitudinal data from other sectors can be used to understand the interplay between social and psychological capital for enhancing work engagement. Developing and cultivating positive social relations can help employees utilise their psychological strength to better engage in work.
{"title":"Psychological Capital and Work Engagement: Moderating Role of Social Relationships","authors":"Kalyani Biswal, Kailash B. L. Srivastava, Sayed Firoj Alli","doi":"10.1177/09727531231198964","DOIUrl":"https://doi.org/10.1177/09727531231198964","url":null,"abstract":"Background Employees are the real capital of any organisation, and to keep the employees productive and functional, employers need to focus on the psychological capital and social relationship of the employees to keep them engaged in their work. This study examined the emerging field of constructs of psychological and social capital to examine Indian employee’s behaviour. Purpose The purpose of this study is to examine a comprehensive model of the relationship between employees’ psychological capital and work engagement. Furthermore, it examines the moderating effect of social relationships between them. Methods This is a primary survey conducted mainly on the manufacturing industry. A sample of 375 mid- and senior-level executives of different age groups was considered in the study from India’s public and private manufacturing sectors administering a questionnaire survey. A random sampling technique was used for data collection. This study applied SPSS and Amos software to validate the measurement model. Results The results indicate a significant correlation among PsyCap, work engagement, and social relationships. PsyCap and social relationships are positively connected to work engagement. Thus, these results provide preliminary support for our hypotheses. The finding suggests that psychological capital and social relationships positively influence work engagement, and social relationships moderate the association between positive psychological capital and work engagement. It helps employees get better engaged at work. Conclusion Organisations must develop psychological capital to provide resources to employees and share a supportive relationship. Developing and maintaining a supportive relationship for employees and employers is important. In the future, both qualitative research methods and longitudinal data from other sectors can be used to understand the interplay between social and psychological capital for enhancing work engagement. Developing and cultivating positive social relations can help employees utilise their psychological strength to better engage in work.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135480558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-03DOI: 10.1177/09727531231191880
Burhanuddin Sohail Rangwala, Areej Shakil, Muhammad Saqlain Mustafa, Hussain Sohail Rangwala, Hareer Fatima, Mohammad Arham Siddiq
{"title":"Losartan and Immune Checkpoint Inhibitors in Glioblastoma: An Appropriate Substitute for Steroids","authors":"Burhanuddin Sohail Rangwala, Areej Shakil, Muhammad Saqlain Mustafa, Hussain Sohail Rangwala, Hareer Fatima, Mohammad Arham Siddiq","doi":"10.1177/09727531231191880","DOIUrl":"https://doi.org/10.1177/09727531231191880","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"28 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135868768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Compound 350: A New Hope for Individuals with Drug-resistant Epilepsy","authors":"Hareer Fatima, Faiza Riaz, Muhammad Saqlain Mustafa, Burhanuddin Sohail Rangwala, Syed Raza Abbas, Hussain Sohail Rangwala","doi":"10.1177/09727531231192758","DOIUrl":"https://doi.org/10.1177/09727531231192758","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"29 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135868933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-02DOI: 10.1177/09727531231193242
Alok Singh, Madhusudan Prasad Singh, Nitin R. Gaikwad, and Pankaj Kumar Kannauje
Background A number of clinical trials have compared tenecteplase (TNK) and alteplase for the management of acute ischemic stroke (AIS) and the results are inconsistent. Purpose Present systematic review and meta-analysis is undertaken to analyse the efficacy and safety of TNK in AIS compared to alteplase. Summary A thorough literature search was performed through the databases Embase, Cochrane Library, PubMed, and clinicaltrials.gov, for a period from inception to September 2022, with the keywords i.e., “tenecteplase” and “alteplase” and “acute ischemic stroke.” Clinical trials published in English that compared the efficacy and safety of TNK to alteplase in AIS were included. The major outcomes of this meta-analysis were proportion of patients free from disability and functional independence at 90 days, early neurological improvement at 24 hours, all-cause mortality at 90 days, patients with intra cranial hemorrhage (ICH), and patients with severe disability at 90 days. A total of nine studies with 3,573 patients were included in the analysis. The proportion of patients with freedom from disability was comparable in both groups (relative risk [RR] = 1.04, 95 per cent CI = 0.92–1.17; p = .53). Similarly, proportion of patients with functional independence was comparable (RR = 1.12, 95 per cent CI = 0.96–1.31; p = .14). TNK group had a higher rate of early neurological recovery (RR = 1.56, 95 per cent CI = 0.96–2.54; p = .07). All-cause mortality at 90 days was comparable in both groups (RR = 0.97; 95 per cent CI = 0.72–1.29; p = .82). The proportion of patients with ICH was higher in TNK group (RR = 1.14, 95 per cent CI = 0.77–1.68; p = .52). The proportion of patients with severe disability was less in TNK group (RR =0.84, 95 per cent CI = 0.53–1.32; p = .44). Key Message TNK was similar to alteplase in terms of efficacy and safety. The patients in TNK group showed early neurological improvement but were simultaneously at higher risk of ICH. The TNK can be an alternative to alteplase if the benefits outweigh the risks.
许多临床试验比较了替奈普酶(TNK)和阿替普酶治疗急性缺血性卒中(AIS)的疗效，结果不一致。目的:通过系统回顾和荟萃分析，分析TNK与阿替普酶治疗AIS的疗效和安全性。通过Embase、Cochrane Library、PubMed和clinicaltrials.gov数据库进行了全面的文献检索，检索时间从成立到2022年9月，关键词为“tenecteplase”、“alteplase”和“急性缺血性卒中”。英文发表的临床试验比较了TNK和阿替普酶在AIS中的疗效和安全性。该荟萃分析的主要结果是90天无残疾和功能独立患者的比例、24小时早期神经系统改善、90天全因死亡率、90天颅内出血(ICH)患者和严重残疾患者。共有9项研究，共3573名患者被纳入分析。两组患者无残疾的比例具有可比性(相对危险度[RR] = 1.04, 95% CI = 0.92-1.17;P = .53)。同样，功能独立患者的比例也具有可比性(RR = 1.12, 95% CI = 0.96-1.31;P = .14)。TNK组早期神经系统恢复率较高(RR = 1.56, 95% CI = 0.96-2.54;P = .07)。两组90天全因死亡率具有可比性(RR = 0.97;95% CI = 0.72-1.29;P = .82)。TNK组脑出血患者比例较高(RR = 1.14, 95% CI = 0.77-1.68;P = .52)。TNK组重度残疾患者比例较低(RR =0.84, 95% CI = 0.53-1.32;P = .44)。TNK在疗效和安全性方面与阿替普酶相似。TNK组患者早期神经功能改善，但同时脑出血风险较高。如果益处大于风险，TNK可以作为阿替普酶的替代品。
{"title":"Tenecteplase versus Alteplase in Acute Ischemic Stroke: A Systematic Review and Meta-analysis","authors":"Alok Singh, Madhusudan Prasad Singh, Nitin R. Gaikwad, and Pankaj Kumar Kannauje","doi":"10.1177/09727531231193242","DOIUrl":"https://doi.org/10.1177/09727531231193242","url":null,"abstract":"Background A number of clinical trials have compared tenecteplase (TNK) and alteplase for the management of acute ischemic stroke (AIS) and the results are inconsistent. Purpose Present systematic review and meta-analysis is undertaken to analyse the efficacy and safety of TNK in AIS compared to alteplase. Summary A thorough literature search was performed through the databases Embase, Cochrane Library, PubMed, and clinicaltrials.gov, for a period from inception to September 2022, with the keywords i.e., “tenecteplase” and “alteplase” and “acute ischemic stroke.” Clinical trials published in English that compared the efficacy and safety of TNK to alteplase in AIS were included. The major outcomes of this meta-analysis were proportion of patients free from disability and functional independence at 90 days, early neurological improvement at 24 hours, all-cause mortality at 90 days, patients with intra cranial hemorrhage (ICH), and patients with severe disability at 90 days. A total of nine studies with 3,573 patients were included in the analysis. The proportion of patients with freedom from disability was comparable in both groups (relative risk [RR] = 1.04, 95 per cent CI = 0.92–1.17; p = .53). Similarly, proportion of patients with functional independence was comparable (RR = 1.12, 95 per cent CI = 0.96–1.31; p = .14). TNK group had a higher rate of early neurological recovery (RR = 1.56, 95 per cent CI = 0.96–2.54; p = .07). All-cause mortality at 90 days was comparable in both groups (RR = 0.97; 95 per cent CI = 0.72–1.29; p = .82). The proportion of patients with ICH was higher in TNK group (RR = 1.14, 95 per cent CI = 0.77–1.68; p = .52). The proportion of patients with severe disability was less in TNK group (RR =0.84, 95 per cent CI = 0.53–1.32; p = .44). Key Message TNK was similar to alteplase in terms of efficacy and safety. The patients in TNK group showed early neurological improvement but were simultaneously at higher risk of ICH. The TNK can be an alternative to alteplase if the benefits outweigh the risks.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"10 24","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135973675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Naegleria fowleri, a “brain-eating” amoeba, is the cause of primary amoebic meningoencephalitis. It spreads through the nasal route via contaminated water sources and invades the central nervous system. Purpose The objective of our study was to assess the knowledge, attitude, and practices about N. fowleri among the general population of Karachi, Pakistan. Methods This study was conducted on the general population in Karachi to assess their knowledge, attitudes, and practices regarding N. fowleri. Data was collected using a questionnaire with four parts, covering demographics, N. fowleri knowledge, attitudes, and preventive practices. The sample size of 400 was determined using the Raosoft Survey Tool. Data analysis was performed using SPSS 25.0, including descriptive analysis and the Pearson chi-square test. Non-probability convenience sampling was used. The study period was June–December 2022. Results This study showed that around 80% of people had never heard about N. fowleri. Conclusion This study revealed the level of awareness of N. fowleri and measures to avoid its infection in Karachi is very low, where N. fowleri infections are reported every year. Hence, appropriate measures should be taken to increase knowledge and awareness to avoid the spread of N. fowleri infection among the population.
{"title":"Knowledge, Attitude, and Practices related to <i>Naegleria fowleri</i> Among General Population of Karachi, Pakistan: A Cross-Sectional Study","authors":"Shaheera Younus, Hareer Fatima, Burhanuddin Sohail Rangwala, Ashna Munir, Syed Muhammad Ahsan, Wania Naeem, Syed Raza Abbas, Hussain Sohail Rangwala","doi":"10.1177/09727531231196996","DOIUrl":"https://doi.org/10.1177/09727531231196996","url":null,"abstract":"Background Naegleria fowleri, a “brain-eating” amoeba, is the cause of primary amoebic meningoencephalitis. It spreads through the nasal route via contaminated water sources and invades the central nervous system. Purpose The objective of our study was to assess the knowledge, attitude, and practices about N. fowleri among the general population of Karachi, Pakistan. Methods This study was conducted on the general population in Karachi to assess their knowledge, attitudes, and practices regarding N. fowleri. Data was collected using a questionnaire with four parts, covering demographics, N. fowleri knowledge, attitudes, and preventive practices. The sample size of 400 was determined using the Raosoft Survey Tool. Data analysis was performed using SPSS 25.0, including descriptive analysis and the Pearson chi-square test. Non-probability convenience sampling was used. The study period was June–December 2022. Results This study showed that around 80% of people had never heard about N. fowleri. Conclusion This study revealed the level of awareness of N. fowleri and measures to avoid its infection in Karachi is very low, where N. fowleri infections are reported every year. Hence, appropriate measures should be taken to increase knowledge and awareness to avoid the spread of N. fowleri infection among the population.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"24 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons, resulting in motor symptoms. Ongoing research shows promise for long-term solutions. Summary Studies highlight the dysregulation of Syt11 and α-synuclein (α-syn) in PD. Disrupted α-syn homeostasis due to palmitoylation of Syt11 contributes to its aggregation, potentially playing a role in PD pathology. α-synuclein aggregates in stool samples show promise as an early diagnostic biomarker. Vocal impairments in PD may be linked to α-syn-induced neuropathology. Irisin, produced after exercise, promotes the degradation of pathologic α-syn. Progress has been made in identifying PD biomarkers. Retinal thinning and abnormal protein aggregates in skin biopsies provide noninvasive diagnostic indicators. Blood-based biomarkers like α-syn, DJ-1, and LRRK2 hold promise but face limitations. Artificial intelligence (AI) models enhance mitophagy, detect PD through sleep-breathing signals, and improve survival. AI analysis aids noninvasive assessment and risk prediction. Further understanding of PD involves studying pathological seeds and genetic mutations. Adenosine receptor regulation relates to early-onset PD, and specific gene mutations impact patient survival. Differentiated-induced pluripotent stem cells offer the potential for cell replacement therapy. Autoimmune features and T-cell involvement suggest intervention targets. Stem cell-based therapies and neurostimulation strategies show promise for improving motor function. Imaging reveals increased central inflammation in PD, suggesting an inflammatory role. Machine learning algorithms and home gait speed monitoring aid in diagnosis and disease progression tracking. Abnormal putamen gradients reflect dopaminergic loss and motor dysfunction. Antiepileptic drug prescriptions are associated with an increased PD risk. Personalized medicine, gut–brain axis involvement, and vestibular stimulation therapy offer potential PD treatment avenues. Genetic engineering techniques and deep brain stimulation show promise for alleviating PD symptoms. Key Message Ongoing research and technological advancements promise to improve PD screening, diagnosis, and treatment, bringing hope to affected individuals.
{"title":"From Diagnosis to Treatment: A Comprehensive Review of Biomarkers and Therapeutic Advances in Parkinson’s Disease","authors":"Hussain Sohail Rangwala, Hareer Fatima, Aina Marzia Syed, Syed Raza Abbas, Burhanuddin Sohail Rangwala","doi":"10.1177/09727531231200733","DOIUrl":"https://doi.org/10.1177/09727531231200733","url":null,"abstract":"Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons, resulting in motor symptoms. Ongoing research shows promise for long-term solutions. Summary Studies highlight the dysregulation of Syt11 and α-synuclein (α-syn) in PD. Disrupted α-syn homeostasis due to palmitoylation of Syt11 contributes to its aggregation, potentially playing a role in PD pathology. α-synuclein aggregates in stool samples show promise as an early diagnostic biomarker. Vocal impairments in PD may be linked to α-syn-induced neuropathology. Irisin, produced after exercise, promotes the degradation of pathologic α-syn. Progress has been made in identifying PD biomarkers. Retinal thinning and abnormal protein aggregates in skin biopsies provide noninvasive diagnostic indicators. Blood-based biomarkers like α-syn, DJ-1, and LRRK2 hold promise but face limitations. Artificial intelligence (AI) models enhance mitophagy, detect PD through sleep-breathing signals, and improve survival. AI analysis aids noninvasive assessment and risk prediction. Further understanding of PD involves studying pathological seeds and genetic mutations. Adenosine receptor regulation relates to early-onset PD, and specific gene mutations impact patient survival. Differentiated-induced pluripotent stem cells offer the potential for cell replacement therapy. Autoimmune features and T-cell involvement suggest intervention targets. Stem cell-based therapies and neurostimulation strategies show promise for improving motor function. Imaging reveals increased central inflammation in PD, suggesting an inflammatory role. Machine learning algorithms and home gait speed monitoring aid in diagnosis and disease progression tracking. Abnormal putamen gradients reflect dopaminergic loss and motor dysfunction. Antiepileptic drug prescriptions are associated with an increased PD risk. Personalized medicine, gut–brain axis involvement, and vestibular stimulation therapy offer potential PD treatment avenues. Genetic engineering techniques and deep brain stimulation show promise for alleviating PD symptoms. Key Message Ongoing research and technological advancements promise to improve PD screening, diagnosis, and treatment, bringing hope to affected individuals.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"61 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135221534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.1177/09727531231203453
Maliha Edhi, Mishal Abid, Zoya Khemane, Maham Asif, Muhammad Saqlain Mustafa, Hussain Sohail Rangwala, Mohammad Arham Siddiq
{"title":"Postpartum Depression: Role of Therapy and Associated Stigmas in Developing Countries","authors":"Maliha Edhi, Mishal Abid, Zoya Khemane, Maham Asif, Muhammad Saqlain Mustafa, Hussain Sohail Rangwala, Mohammad Arham Siddiq","doi":"10.1177/09727531231203453","DOIUrl":"https://doi.org/10.1177/09727531231203453","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"5 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135367505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.1177/09727531231203452
Syeda Mahrukh Fatima Zaidi, Faizan ur Rehman
{"title":"Malaria-induced Coagulopathy: Complexities and Treatment Challenges in Intracranial Hemorrhage","authors":"Syeda Mahrukh Fatima Zaidi, Faizan ur Rehman","doi":"10.1177/09727531231203452","DOIUrl":"https://doi.org/10.1177/09727531231203452","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"321 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135405354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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