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Acute stroke: pathophysiology, diagnosis, and treatment. 急性中风:病理生理学、诊断和治疗。
Pub Date : 2005-10-01 DOI: 10.1097/00044067-200510000-00002
Joan Parker Frizzell

Stroke, a neurologic event due to altered cerebral circulation, is the third leading cause of death in the United States. Risk factors for stroke include hypertension, family history, and diabetes mellitus. The subtypes of stroke are ischemia, infarction, and hemorrhage. Ischemia and infarction are the result of atherosclerotic development of thrombi and emboli. Decreased and/or absent cerebral circulation causes neuronal cellular injury and death. Intracerebral hemorrhage occurs from rupture of cerebral vessels often as the result of hypertension. Patient assessment and diagnosis include the use of computed tomography scans, magnetic resonance imaging, and the National Institute of Health Stroke Scale, and treatment depends on the etiology of the stroke. Thrombolytic therapy is the mainstay of treatment for thrombotic and embolic events. Current recommendations for future stroke care include the development of designated stroke centers. Directions for research in stroke treatment includes examining neuroprotective therapies.

中风是一种由脑循环改变引起的神经系统疾病,是美国第三大死亡原因。中风的危险因素包括高血压、家族史和糖尿病。中风的亚型有缺血、梗死和出血。缺血和梗死是动脉粥样硬化形成血栓和栓子的结果。脑循环减少和/或缺失导致神经元细胞损伤和死亡。脑出血通常由高血压引起的脑血管破裂引起。患者评估和诊断包括使用计算机断层扫描、磁共振成像和美国国立卫生研究院卒中量表,治疗取决于卒中的病因。溶栓治疗是治疗血栓和栓塞事件的主要方法。目前对未来中风护理的建议包括发展指定的中风中心。中风治疗的研究方向包括检查神经保护疗法。
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引用次数: 91
Prevention of secondary brain injury: targeting technology. 预防继发性脑损伤:靶向技术。
Pub Date : 2005-10-01 DOI: 10.1097/00044067-200510000-00007
Linda Littlejohns, Mary Kay Bader

Use of technology in the management of the severely brain-injured patient has increased over the past decade and can be confusing and overwhelming to the critical care nurse clinicians who are new to the field of neurology. This article will describe normal physiology and cerebral dynamics and potential abnormal physiology encountered after brain injury. The technology reviewed will include intracranial pressure monitoring, cerebral blood flow monitoring and autoregulation, cerebral oxygen consumption and tissue oxygen monitoring, metabolism, sedation, and temperature monitoring. Integration of appropriate technology into patient management will be discussed using a case study to explore the utility of information at the bedside. Recognizing the difficult task of trying to control secondary injury in our patients is the first step to better outcomes. Implementing the use of technology to mitigate the situation must be done with careful consideration and a team approach to achieve the greatest benefit for the patient.

在过去的十年中,在严重脑损伤患者的管理中使用技术的情况有所增加,对于神经病学领域的新重症护理护士临床医生来说,这可能是令人困惑和压倒性的。本文将描述脑损伤后的正常生理和脑动力学以及可能遇到的异常生理。回顾的技术将包括颅内压监测、脑血流监测和自动调节、脑氧消耗和组织氧监测、代谢、镇静和温度监测。将适当的技术整合到患者管理中,将使用一个案例研究来探讨床边信息的效用。认识到控制患者继发性损伤的艰巨任务是获得更好结果的第一步。实施使用技术来缓解这种情况必须经过仔细考虑和团队方法,以实现患者的最大利益。
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引用次数: 30
Endovascular coiling for cerebral aneurysms. 脑动脉瘤的血管内盘绕术。
Pub Date : 2005-10-01 DOI: 10.1097/00044067-200510000-00008
Sandra Brettler

Aneurysmal subarachnoid hemorrhage is an increasing problem in the United States, affecting approximately 30,000 people every year. Despite advances in the neurosurgical field, approximately 50% of patients die within the first month after hemorrhage. Traditionally, craniotomy with aneurysmal clipping has been employed to manage these patients, but endovascular embolization is moving to the forefront of treatment, particularly for high grade (IV to V) aneurysms. Patient selection is often based on age, aneurysm size, location, characteristics and presentation, and patient hemodynamics. Postprocedure management relies on skilled observers to determine those potential complications that may occur, including vasospasm, rupture, bleeding, or vessel occlusion. Advanced practice nurses have an obligation to be aware not only of the procedure and its management, but also of the potential complications and ongoing care of the patients and families as well.

动脉瘤性蛛网膜下腔出血在美国是一个日益严重的问题,每年影响大约3万人。尽管神经外科领域取得了进步,但大约50%的患者在出血后的第一个月内死亡。传统上,动脉瘤夹闭的开颅术已被用于治疗这些患者,但血管内栓塞正在成为治疗的前沿,特别是对于高级别(IV到V级)动脉瘤。患者的选择通常基于年龄、动脉瘤大小、位置、特征和表现以及患者的血流动力学。术后管理依赖于熟练的观察者来确定可能发生的潜在并发症,包括血管痉挛、破裂、出血或血管闭塞。高级执业护士不仅有义务了解手术过程及其管理,而且有义务了解潜在的并发症以及对患者和家属的持续护理。
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引用次数: 8
The endogenous opioid system and clinical pain management. 内源性阿片系统与临床疼痛管理。
Pub Date : 2005-07-01 DOI: 10.1097/00044067-200507000-00003
Janean E Holden, Younhee Jeong, Jeannine M Forrest

The endogenous opioid system is one of the most studied innate pain-relieving systems. This system consists of widely scattered neurons that produce three opioids: beta-endorphin, the met- and leu-enkephalins, and the dynorphins. These opioids act as neurotransmitters and neuromodulators at three major classes of receptors, termed mu, delta, and kappa, and produce analgesia. Like their endogenous counterparts, the opioid drugs, or opiates, act at these same receptors to produce both analgesia and undesirable side effects. This article examines some of the recent findings about the opioid system, including interactions with other neurotransmitters, the location and existence of receptor subtypes, and how this information drives the search for better analgesics. We also consider how an understanding of the opioid system affects clinical responses to opiate administration and what the future may hold for improved pain relief. The goal of this article is to assist clinicians to develop pharmacological interventions that better meet their patient's analgesic needs.

内源性阿片系统是研究最多的先天性镇痛系统之一。该系统由广泛分布的神经元组成,产生三种阿片类物质:-内啡肽,蛋氨酸和左脑啡肽,以及啡肽。这些阿片类物质作为神经递质和神经调节剂作用于三大类受体,称为mu, delta和kappa,并产生镇痛作用。像它们的内源性对应物一样,阿片类药物或阿片类药物作用于这些相同的受体,产生镇痛和不良副作用。本文研究了阿片系统的一些最新发现,包括与其他神经递质的相互作用,受体亚型的位置和存在,以及这些信息如何推动寻找更好的镇痛药。我们还考虑了对阿片类药物系统的理解如何影响阿片类药物管理的临床反应,以及未来可能会改善疼痛缓解。这篇文章的目的是帮助临床医生开发药物干预,更好地满足他们的病人的镇痛需求。
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引用次数: 149
Nurse practitioners in pediatric critical care: results of a national survey. 儿科重症护理的护士从业人员:一项全国性调查的结果。
Pub Date : 2005-07-01 DOI: 10.1097/00044067-200507000-00012
Judy T Verger, Kelly Keefe Marcoux, Maureen A Madden, Tom Bojko, Jane H Barnsteiner

The nurse practitioner in pediatric critical care is a distinct advanced practice nursing role that has seen a tremendous increase in development and implementation over the past 10 years. There is a paucity of literature on this unique and valuable role. A total of 74 nurse practitioners practicing in pediatric critical care were surveyed. Part I of the survey solicited descriptive information of the nurse practitioner including background, work environment, reporting structure, and salary. The respondents also identified their role responsibilities that included direct patient management, nursing and medical education, coordination of care, research, and consultation. Part II of the questionnaire addressed skill level and need for supervision for technical procedures and leadership activities. These respondents described expert or proficient skill levels for the majority of technical procedures (ie, lumbar puncture, central line placement) and leadership activities (ie, discharge planning, participation in medical rounds). This is the first published report to delineate the role of the nurse practitioner in pediatric critical care based on responses from a national survey.

儿科重症护理的执业护士是一个独特的高级护理实践角色,在过去的10年里,在发展和实施方面有了巨大的增长。关于这一独特而有价值的角色的文献很少。对74名儿科重症护理执业护士进行调查。调查的第一部分收集了执业护士的描述信息,包括背景、工作环境、报告结构和薪水。受访者还确定了他们的角色责任,包括直接患者管理、护理和医学教育、护理协调、研究和咨询。调查问卷的第二部分涉及技术水平和对技术程序和领导活动的监督需求。这些答复者描述了大多数技术程序(如腰椎穿刺、中央静脉置管)和领导活动(如出院计划、参加查房)的专家或熟练技能水平。这是第一份发表的报告,根据一项全国调查的反应,描述了护士在儿科重症护理中的作用。
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引用次数: 34
Orofacial Pain--Part II: Assessment and management of vascular, neurovascular, idiopathic, secondary, and psychogenic causes. 口面部疼痛——第二部分:血管、神经血管、特发性、继发性和心理原因的评估和管理。
Pub Date : 2005-07-01 DOI: 10.1097/00044067-200507000-00008
Eleni Sarlani, Birute A Balciunas, Edward G Grace

Chronic orofacial pain is a common health complaint faced by health practitioners today and constitutes a challenging diagnostic problem that often requires a multidisciplinary approach to diagnosis and treatment. The previous article by the same authors in this issue discussed the major clinical characteristics and the treatment of various musculoskeletal and neuropathic orofacial pain conditions. This second article presents aspects of vascular, neurovascular, and idiopathic orofacial pain, as well as orofacial pain due to various local, distant, or systemic diseases and psychogenic orofacial pain. The emphasis in this article is on the general differential diagnosis and various therapeutic regimens of each of these conditions. An accurate diagnosis is the key to successful treatment of chronic orofacial pain. Given that for many of the entities discussed in this article no curative treatment is available, current standards of management are emphasized. A comprehensive reference section has been included for those who wish to gain further information on a particular entity.

慢性口面部疼痛是当今健康从业者面临的一种常见健康投诉,并且构成了一个具有挑战性的诊断问题,通常需要多学科方法来诊断和治疗。同一作者在本期杂志上的前一篇文章讨论了各种肌肉骨骼和神经性口面部疼痛的主要临床特征和治疗方法。第二篇文章介绍了血管、神经血管和特发性口面部疼痛,以及由于各种局部、远处或全身性疾病和心因性口面部疼痛引起的口面部疼痛。在这篇文章的重点是一般的鉴别诊断和各种治疗方案的每一个这些条件。准确的诊断是成功治疗慢性口面部疼痛的关键。鉴于本文中讨论的许多实体没有治愈治疗,强调当前的管理标准。为那些希望获得关于某一实体的进一步信息的人提供了一个全面的参考部分。
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引用次数: 23
Skin-to-skin contact (Kangaroo Care) analgesia for preterm infant heel stick. 皮肤与皮肤接触(袋鼠式护理)用于早产儿脚跟贴镇痛。
Pub Date : 2005-07-01 DOI: 10.1097/00044067-200507000-00010
Susan M Ludington-Hoe, Robert Hosseini, Deborah L Torowicz

The purpose of the study was to compare a heel stick conducted during Kangaroo Care (skin-to-skin contact) with the mother to a heel stick in a warmer in reducing premature infant physiologic and behavioral pain responses. Twenty-four premature infants in a university-based neonatal intensive care unit were recruited and randomized to 2 sequences: sequence A group received 3 hours of Kangaroo Care (with a heel stick in Kangaroo Care) followed by 3 hours in a warmer (with a heel stick in the warmer). Sequence B group had warmer care and a heel stick (in the warmer) before Kangaroo Care and a heel stick (in Kangaroo Care). Heart rate, respiratory rate, oxygen saturation, crying time, and behavioral state were measured before, during, and after heel stick. Repeated measures ANOVA and Mann Whitney U statistics were performed. Heart rate and length of crying in response to pain were significantly reduced during Kangaroo Care and the Kangaroo Care heel stick as compared to when infants were in the warmer and had a heel stick in the warmer. Three infants did not cry at all during the Kangaroo Care heel stick; infants slept more during Kangaroo Care than in the warmer. Kangaroo Care positioning before and during heel stick is a simple and inexpensive analgesic intervention to ameliorate pain in stable premature infants.

该研究的目的是比较在袋鼠护理(皮肤对皮肤接触)期间与母亲进行的脚跟贴与在加热器中进行的脚跟贴在减少早产儿生理和行为疼痛反应方面的效果。本研究招募了24名来自某大学新生儿重症监护病房的早产儿,并将其随机分为两组:第一组接受3小时的袋鼠式护理(袋鼠式护理中使用鞋跟棒),第二组接受3小时的保温器(鞋跟棒在保温器中)。序列B组在袋鼠式护理和袋鼠式护理之前进行了温暖护理和脚跟贴(在温暖中)。分别在贴足前、贴足中、贴足后测量心率、呼吸频率、血氧饱和度、哭闹时间及行为状态。采用重复测量方差分析和Mann Whitney U统计。在袋鼠式护理和袋鼠式护理中,婴儿对疼痛的反应的心率和哭泣时间明显减少,与婴儿在加热器中使用后跟棒时相比。三个婴儿在袋鼠护理鞋跟贴期间根本没有哭;在袋鼠式护理中,婴儿比在温暖的环境中睡得更多。袋鼠式护理是一种简单和廉价的镇痛干预措施,可以改善稳定早产儿的疼痛。
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引用次数: 163
Surgery-induced immunosuppression and postoperative pain management. 手术诱导的免疫抑制和术后疼痛处理。
Pub Date : 2005-07-01 DOI: 10.1097/00044067-200507000-00004
Gayle Giboney Page

Surgery is well-known to result in the suppression of some immune functions; however, the role of perioperative pain has only recently been studied. Pain-relieving anesthesia techniques and perioperative analgesia provide some protection against surgery-induced immune suppression and infectious surgical sequelae, although few studies also assess postoperative pain. Attributing a biological consequence to the observed immune alterations remains an issue in human studies, and the use of immune sensitive tumor models in animals enables the linking of immune changes with disease and a means by which to explore causal relationships among surgery-related pain, immune function, and metastatic development. There is strong evidence in animals that pain-relieving interventions significantly reduce the tumor-enhancing effects of undergoing and recovering from surgery. It cannot be assumed that animal findings are directly applicable to the human condition; however, if such relationships hold in humans, perioperative pain management becomes an important strategy for reducing postoperative sequelae.

众所周知,手术会导致某些免疫功能的抑制;然而,围手术期疼痛的作用直到最近才被研究。镇痛麻醉技术和围手术期镇痛对手术引起的免疫抑制和感染性手术后遗症提供了一定的保护,尽管很少有研究也评估术后疼痛。将观察到的免疫改变归因于生物学后果仍然是人类研究中的一个问题,在动物中使用免疫敏感肿瘤模型可以将免疫变化与疾病联系起来,并通过这种方法探索手术相关疼痛、免疫功能和转移性发展之间的因果关系。在动物实验中有强有力的证据表明,缓解疼痛的干预措施显著降低了手术和术后恢复对肿瘤的增强作用。不能假定在动物身上的发现直接适用于人类的情况;然而,如果这种关系在人类中成立,围手术期疼痛管理成为减少术后后遗症的重要策略。
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引用次数: 68
Complex pain consultations in the pediatric intensive care unit. 儿科重症监护室的复杂疼痛咨询。
Pub Date : 2005-07-01 DOI: 10.1097/00044067-200507000-00011
Helen N Turner

The assessment and management of pain in children is not always easy and it is clearly more difficult in the critical care setting. Pain management is further complicated in this vulnerable population by the nature of their critical condition, the complexity and multidimensionality of their illness or injuries, and the intensity of emotions in this environment. A variety of pain syndromes are encountered in the pediatric intensive care unit, and the staff there may not be familiar with or comfortable managing these cases. Pain assessment and treatment can be more appropriately managed when guided by the experts of a multidisciplinary pediatric pain service.

评估和管理儿童疼痛并不总是容易的,在重症监护环境中显然更加困难。由于这些弱势群体的危急状况、疾病或伤害的复杂性和多维性,以及在这种环境中情绪的强度,疼痛管理进一步复杂化。在儿科重症监护室遇到各种各样的疼痛综合征,那里的工作人员可能不熟悉或不适应处理这些病例。在多学科儿科疼痛服务专家的指导下,疼痛评估和治疗可以得到更适当的管理。
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引用次数: 23
Decision making for the patient who presents with acute dental pain. 为出现急性牙痛的病人做决定。
Pub Date : 2005-07-01 DOI: 10.1097/00044067-200507000-00009
Deborah S Rodriguez, Eleni Sarlani

Patients who require dental emergency care for pain or trauma may not be able to see a dental practitioner for treatment. The patients often seek care in alternative medical facilities when the symptoms are too severe to be managed by over-the-counter medications. Nurses, physicians, and allied medical staff may be required to triage these patients and provide palliative treatment until the patient is able to seek definitive dental treatment. By using criteria to assess the etiology of the dental pain and implementing possible alternative treatments, these patients can receive palliative care until dental treatment becomes accessible. With the potential for development of resistant forms of microorganisms, the indiscriminate use of antibiotics for dental pain is to be avoided. Occasionally, dental patients presenting to medical settings exhibit symptoms and signs of dental-related problems that are potentially life threatening. Identification of signs of impending life-threatening complications is of paramount importance, since prompt treatment will significantly affect the prognosis.

因疼痛或创伤而需要牙科急救的病人可能无法去看牙医治疗。当症状严重到无法用非处方药物治疗时,患者通常会到其他医疗机构寻求治疗。护士、医生和相关医务人员可能需要对这些患者进行分类,并提供姑息治疗,直到患者能够寻求最终的牙科治疗。通过使用标准来评估牙痛的病因,并实施可能的替代治疗,这些患者可以接受姑息治疗,直到牙科治疗成为可能。由于可能产生耐药形式的微生物,应避免滥用抗生素治疗牙痛。偶尔,到医疗机构就诊的牙科患者会表现出与牙齿有关的问题的症状和迹象,这些问题可能危及生命。确定即将发生的危及生命的并发症的迹象至关重要,因为及时治疗将显著影响预后。
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引用次数: 7
期刊
AACN clinical issues
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