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Cardiac pacing device therapy for atrial dysrhythmias: how does it work? 心脏起搏器治疗心房心律失常:它是如何工作的?
Pub Date : 2004-07-01 DOI: 10.1097/00044067-200407000-00006
Marleen E Irwin

Atrial fibrillation (AF) is the most common dysrhythmia in North America. Paroxysmal or persistent AF affects an estimated 2.8 million individuals, causes significant morbidity, and is associated with 1 billion dollars in healthcare costs each year in the United States. An aging population, the prevalence of hypertension, and the emergence of heart failure as the final common pathway of heart disease finds us in an age where the incidence of AF is ever increasing and the management challenges are indeed an expanding clinical problem. Although guidelines for selection of the appropriate pacing mode have been published, device therapy for the control of AF and paroxysmal AF is an emerging clinical management strategy. In 2001 The American College of Cardiology (ACC)/American Heart Association (AHA) published a document to revise the 1998 guidelines for device therapy, and even now these guidelines require elucidation and inclusion for the use of cardiac pacing device therapy for the control of atrial dysrhythmia. Choosing a complex system, in particular for the patient with persistent and symptomatic atrial dysrhythmia, is a most intricate challenge for the healthcare professional and the healthcare system. Rate dependent effects on refractoriness, reduction of ectopy, remodeling of the substrate, and prevention of pauses have been described as the potential mechanisms responsible for the rhythmic control effect attributed to atrial pacing. However, while permanent cardiac pacing is required for patients with symptomatic bradycardia with atrioventricular block and AF, the concept of pacing for the primary prevention of AF is novel. Pacing algorithms, single site, biatrial, and dual-site atrial pacing and site-specific pacing have all been studied as substrate modulators to prevent recurrent atrial dysrhythmia.A dilemma exists surrounding the primary approach for the control of symptomatic AF with rapid ventricular response. The question remains: should it be to maintain the sinus rhythm or to control the ventricular response rate to the AF and anticoagulate? Variations in the population studied, differences in the pacing algorithms and protocols, and a lack of definitive end points account for the variable results of the studies completed thus far. With the current data available, it appears that for individuals with sinus node dysfunction and paroxysmal AF in combination with a bradyarrhythmia indication for pacing, suppression algorithms may play an additive role with full atrial pacing in the management and reduction of episodes and burden of paroxysmal AF. The goal of these therapies is to reduce the symptoms and hopefully decrease the healthcare costs associated with paroxysmal and persistent AF with uncontrolled ventricular response.

心房颤动(AF)是北美最常见的心律失常。阵发性或持续性房颤影响约280万人,导致显著的发病率,在美国每年与10亿美元的医疗费用相关。人口老龄化,高血压的流行,以及心衰作为心脏病的最后共同途径的出现,使我们处于一个AF发病率不断增加的时代,管理挑战确实是一个不断扩大的临床问题。虽然选择合适的起搏模式的指南已经发表,但控制房颤和阵发性房颤的装置治疗是一种新兴的临床管理策略。2001年,美国心脏病学会(ACC)/美国心脏协会(AHA)发布了一份文件,修订了1998年的器械治疗指南,即使是现在,这些指南也需要阐明和纳入心脏起搏器治疗控制心房心律失常的使用。选择一个复杂的系统,特别是对于持续性和症状性心房心律失常患者,是医疗保健专业人员和医疗保健系统最复杂的挑战。心房起搏的节律性控制作用的潜在机制包括:难阻性、异位减少、底物重塑和防止暂停。然而,虽然对于伴有房室传导阻滞和房颤的症状性心动过缓患者需要永久性心脏起搏,但起搏用于房颤一级预防的概念是新颖的。起搏算法、单站点、双站点和双站点心房起搏以及站点特异性起搏都被研究作为底物调节剂来预防复发性心房心律失常。围绕控制症状性房颤伴快速心室反应的主要方法存在一个困境。问题仍然存在:是维持窦性心律还是控制心室对房颤和抗凝的反应率?研究人群的差异,起搏算法和方案的差异,以及缺乏明确的终点,导致迄今为止完成的研究结果不一。根据现有数据,对于窦房结功能障碍和阵发性房颤合并心律失常适应症起搏的个体,抑制算法可能与全心房起搏一起在管理和减少阵发性房颤发作和负担方面发挥附加作用。这些治疗的目标是减轻症状,并希望降低与阵发性和持续性房颤相关的医疗费用。
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引用次数: 4
Dysrhythmias and the athlete. 心律失常和运动员。
Pub Date : 2004-07-01 DOI: 10.1097/00044067-200407000-00010
Jane M Trusty, Douglas S Beinborn, Arshad Jahangir

Young competitive athletes are perceived by the general population to be the healthiest members of society. The possibility that highly trained high school and college athletes may have a potentially serious cardiac condition that can predispose to life-threatening dysrhythmias or sudden cardiac death (SCD) seems paradoxical. The occurrence of SCD in young athletes from dysrhythmias is an uncommon but highly visible event. Media reports of sudden death in athletes have intensified the public and medical interest in medical, ethical, and legal issues related to cardiac disorders in the athlete. Developing screening strategies to identify conditions associated with sudden death has been the focus of attention of experts in the fields of arrhythmology and sports medicine and has resulted in Consensus Statements and Guidelines for evaluation of athletes. These guidelines provide information and recommendations for detection, evaluation, and management of athletes with cardiovascular disorders and criteria for eligibility and disqualification from participation in high-intensity and competitive sports. Differentiating normal exercise-induced physiologic changes in the heart from pathological conditions associated with sudden death is critical for developing screening strategies to identify athletes at high risk. This article discusses a case report of sudden cardiac death in an athlete followed by a brief review of various causes of cardiac dysrhythmias in young athletes and recommendations for screening and management of athletes with cardiovascular diseases.

年轻的竞技运动员被大众认为是社会中最健康的成员。训练有素的高中和大学运动员可能有潜在的严重心脏疾病,可能导致危及生命的心律失常或心源性猝死(SCD),这种可能性似乎是矛盾的。发生SCD的年轻运动员心律失常是一个不常见的,但高度明显的事件。媒体对运动员猝死的报道,加强了公众和医学界对与运动员心脏疾病相关的医学、伦理和法律问题的兴趣。制定筛查策略以确定与猝死相关的条件一直是心律失常学和运动医学领域专家关注的焦点,并产生了运动员评估的共识声明和指南。这些指南为心血管疾病运动员的检测、评估和管理以及参加高强度竞技体育的资格和取消资格标准提供了信息和建议。区分正常的运动引起的心脏生理变化与与猝死相关的病理状况对于制定筛查策略以识别高风险运动员至关重要。本文讨论了一例运动员心源性猝死的病例报告,随后简要回顾了年轻运动员心律失常的各种原因,并提出了筛查和管理心血管疾病运动员的建议。
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引用次数: 19
Cardiac defibrillation and resynchronization therapies: principles, therapies, and management implications. 心脏除颤和再同步化治疗:原理、治疗和管理意义。
Pub Date : 2004-07-01 DOI: 10.1097/00044067-200407000-00004
Rosemary S Bubien, Elizabeth A Ching, G Neal Kay

Patients with heart failure remain at high risk for sudden cardiac death (SCD) and death due to heart failure progression, despite the incorporation of pharmacologic agents into clinical practice that have been shown to decrease mortality in clinical trials. Most patients experience SCD as their first dysrrhythmic event. The implantable cardioverter defibrillator (ICD) effectively terminates ventricular tachycardia/fibrillation (VT/VF) aborting SCD. Cardiac resynchronization therapy (CRT) complements pharmacologic therapy improving cardiac performance, quality of life, functional status, and exercise capacity in patients with systolic dysfunction despite optimal medical therapy who have a prolonged QRS duration; furthermore, it decreases mortality when compared with optimal medical therapy alone. Implantation of a combination CRT and ICD device, a CRT-D, reduces mortality by aborting SCD and providing the functional benefits of CRT. This article discusses the evolution of CRT-D therapy, the mechanism of operation of a CRT-D device, and nursing implications.

心衰患者发生心源性猝死(SCD)和因心衰进展而死亡的风险仍然很高,尽管在临床试验中已证明将药物纳入临床实践可降低死亡率。大多数患者的第一个心律失常事件是SCD。植入式心律转复除颤器(ICD)有效终止室性心动过速/颤动(VT/VF)流产SCD。心脏再同步化治疗(CRT)补充药物治疗,改善心脏功能、生活质量、功能状态和运动能力,尽管最佳药物治疗有延长的QRS持续时间;此外,与单独的最佳药物治疗相比,它降低了死亡率。CRT和ICD的联合植入,即CRT- d,通过终止SCD和提供CRT的功能优势来降低死亡率。本文讨论了CRT-D治疗的发展,CRT-D装置的操作机制,以及护理意义。
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引用次数: 5
Electromagnetic interference in cardiac rhythm management devices. 心律管理装置中的电磁干扰。
Pub Date : 2004-07-01 DOI: 10.1097/00044067-200407000-00007
Mark W Sweesy, James L Holland, Kerry W Smith

Clinicians caring for cardiac device patients with implanted pacemakers or cardioverter defibrillators (ICDs) are frequently asked questions by their patients concerning electromagnetic interference (EMI) sources and the devices. EMI may be radiated or conducted and may be present in many different forms including (but not limited to) radiofrequency waves, microwaves, ionizing radiation, acoustic radiation, static and pulsed magnetic fields, and electric currents. Manufacturers have done an exemplary job of interference protection with device features such as titanium casing, signal filtering, interference rejection circuits, feedthrough capacitors, noise reversion function, and programmable parameters. Nevertheless, EMI remains a real concern and a potential danger. Many factors influence EMI including those which the patient can regulate (eg, distance from and duration of exposure) and some the patient cannot control (eg, intensity of the EMI field, signal frequency). Potential device responses are many and range from simple temporary oversensing to permanent device damage Several of the more common EMI-generating devices and their likely effects on cardiac devices are considered in the medical, home, and daily living and work environments.

临床医生照顾植入心脏起搏器或心脏转复除颤器(ICDs)的心脏设备患者经常被患者问及有关电磁干扰(EMI)来源和设备的问题。电磁干扰可以被辐射或传导,并可能以许多不同的形式存在,包括(但不限于)射频波、微波、电离辐射、声辐射、静态和脉冲磁场以及电流。制造商通过钛外壳、信号滤波、干扰抑制电路、馈通电容器、噪声恢复功能和可编程参数等设备功能,完成了干扰保护的示范工作。尽管如此,百代仍是一个真正的问题和潜在的危险。影响电磁干扰的因素很多,包括患者可以调节的因素(例如,接触的距离和持续时间)和一些患者无法控制的因素(例如,电磁干扰场的强度,信号频率)。潜在的设备反应有很多,范围从简单的暂时性过感到永久性设备损坏。在医疗、家庭和日常生活和工作环境中,考虑了几种更常见的产生emi的设备及其对心脏设备的可能影响。
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引用次数: 46
Atrial fibrillation: treatment options and caveats. 心房颤动:治疗选择和注意事项。
Pub Date : 2004-07-01 DOI: 10.1097/00044067-200407000-00005
Esther M Weiss, Traci Buescher

Atrial fibrillation is the most common clinically significant dysrhythmia. It has great impact on quality of life especially related to complications such as stroke and heart failure as well as functional status and the cost of chronic treatment. Pharmacologic treatment strategies are now better defined and more efficacious. Side effects of drugs are better understood. Recent clinical studies have contributed recommended treatment guidelines. The identification of atrial ectopic foci in cardiac venous sites has defined targets for isolation ablations. Novel catheter ablation techniques are offering improved prognosis for patients with atrial fibrillation.

心房颤动是临床上最常见的心律失常。它对生活质量有很大的影响,特别是与中风和心力衰竭等并发症以及功能状态和慢性治疗费用有关。药物治疗策略现在更明确,更有效。人们对药物的副作用有了更好的了解。最近的临床研究提供了推荐的治疗指南。心房异位灶在心脏静脉部位的识别确定了隔离消融的目标。新型导管消融技术改善了房颤患者的预后。
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引用次数: 4
Risk stratification and primary prevention of sudden cardiac death: sudden death prevention. 心源性猝死的风险分层和一级预防:猝死预防。
Pub Date : 2004-07-01 DOI: 10.1097/00044067-200407000-00008
Dulce Obias-Manno, Mevan Wijetunga

The initial challenge in primary prevention of sudden cardiac death (SCD) lies in identifying those at greatest risk, before the index event. Ventricular fibrillation is the leading cause of SCD; however, many clinical conditions predispose fatal ventricular dysrhythmias. In patients with structural heart disease, left ventricular dysfunction is the strongest predictor of SCD. Noninvasive markers such as nonsustained ventricular tachycardia, delayed potentials, decreased heart rate variability and baroreflex sensitivity, and repolarization alternans are further observed to assess risk in ischemic cardiomyopathy; however, most of these markers have poor positive predictive value and lack specificity. The electrophysiologic study has strong positive predictive value, but remains a costly and invasive method for risk stratification. In patients with normal hearts, genetic predisposition may identify patients at risk but clinical markers are not readily recognized. The implantable loop recorder is a useful tool in detecting dysrhythmic causes of syncope and identifying patients at risk for SCD.

心源性猝死(SCD)一级预防的最初挑战在于在指标事件发生之前识别出风险最大的人群。心室颤动是SCD的主要原因;然而,许多临床条件易致死性室性心律失常。在结构性心脏病患者中,左心室功能障碍是SCD的最强预测因子。进一步观察非持续性室性心动过速、延迟电位、心率变异性和压力反射敏感性降低以及复极化交替等非侵入性标志物,以评估缺血性心肌病的风险;然而,这些标志物大多阳性预测价值较差,缺乏特异性。电生理研究具有很强的阳性预测价值,但仍然是一种昂贵且侵入性的风险分层方法。在心脏正常的患者中,遗传易感性可以识别有危险的患者,但临床标志物不易识别。植入式循环记录仪是一种有用的工具,用于检测晕厥的心律失常原因和识别有SCD风险的患者。
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引用次数: 10
The effects of drugs on thermoregulation. 药物对体温调节的影响。
Pub Date : 2004-04-01 DOI: 10.1097/00044067-200404000-00010
Mary Linda Stotter Cuddy

Body temperature is a balance of the hypothalamic set point, neurotransmitter action, generation of body heat, and dissipation of heat. Drugs affect body temperature by different mechanisms. Antipyretics lower body temperature when the body's thermoregulatory set point has been raised by endogenous or exogenous pyrogens. The use of antipyretics may be unnecessary or may interfere with the body's resistance to infection, mask an important sign of illness, or cause adverse drug effects. Drugs may cause increased body temperature in five ways: altered thermoregulatory mechanisms, drug administration-related fever, fever from the pharmacologic action of the drug, idiosyncratic reactions, and hypersensitivity reactions. Certain drugs cause hypothermia by depression of the thermoregulatory set point or prevention of heat conservation. By affecting the balance of thermoregulatory neurotransmitters, drugs may prevent the signs and symptoms of hot flashes.

体温是下丘脑设定点、神经递质作用、体热产生和散热之间的平衡。药物通过不同的机制影响体温。当机体的体温调节设定点被内源性或外源性热原升高时,退烧药可降低体温。使用退烧药可能是不必要的,或可能干扰身体对感染的抵抗力,掩盖疾病的重要迹象,或引起药物不良反应。药物可通过五种方式引起体温升高:体温调节机制改变、药物给药相关发热、药物药理作用引起的发热、特异性反应和超敏反应。某些药物通过降低体温调节设定值或防止热保存而引起体温过低。通过影响热调节神经递质的平衡,药物可以预防潮热的症状和体征。
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引用次数: 50
Heat stroke: a comprehensive review. 中暑:全面回顾。
Pub Date : 2004-04-01 DOI: 10.1097/00044067-200404000-00013
Theresa Pluth Yeo

Heat stroke (HS) is a serious and potentially life-threatening condition defined as a core body temperature >40.6 degrees C. Two forms of HS are recognized, classic heat stroke, usually occurring in very young or elderly persons, and exertional heat stroke, more common in physically active individuals. An elevated body temperature and neurologic dysfunction are necessary but not sufficient to diagnose HS. Associated clinical manifestations such as extreme fatigue; hot dry skin or heavy perspiration; nausea; vomiting; diarrhea; disorientation to person, place, or time; dizziness; uncoordinated movements; and reddened face are frequently observed. Potential complications related to severe HS are acute renal failure, disseminated intravascular coagulation, rhabdomyolysis, acute respiratory distress syndrome, acid-base disorders, and electrolyte disturbances. Long-term neurologic sequelae (varying degrees of irreversible brain injury) occur in approximately 20% of patients. The prognosis is optimal when HS is diagnosed early and management with cooling measures and fluid resuscitation and electrolyte replacement begins promptly. The prognosis is poorest when treatment is delayed >2 hours.

中暑(HS)是一种严重且可能危及生命的疾病,定义为核心体温>40.6摄氏度。HS有两种形式,典型中暑,通常发生在非常年轻或老年人中,以及用力性中暑,更常见于体力活动的个体。体温升高和神经功能障碍是诊断HS的必要条件,但不是充分条件。相关临床表现如极度疲劳;皮肤干热或大量出汗;恶心;呕吐;腹泻;迷失方向:对人、地点或时间的迷失;头晕;不协调的动作;经常观察到脸变红。与严重HS相关的潜在并发症有急性肾功能衰竭、弥散性血管内凝血、横纹肌溶解、急性呼吸窘迫综合征、酸碱失调和电解质紊乱。大约20%的患者会出现长期的神经系统后遗症(不同程度的不可逆脑损伤)。如果早期诊断出HS,并及时采取降温措施、液体复苏和电解质补充治疗,预后最佳。当治疗延迟>2小时时,预后最差。
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引用次数: 119
Using mediation techniques to manage conflict and create healthy work environments. 运用调解技巧管理冲突,创造健康的工作环境。
Pub Date : 2004-04-01 DOI: 10.1097/00044067-200404000-00003
Debra Gerardi

Healthcare organizations must find ways for managing conflict and developing effective working relationships to create healthy work environments. The effects of unresolved conflict on clinical outcomes, staff retention, and the financial health of the organization lead to many unnecessary costs that divert resources from clinical care. The complexity of delivering critical care services makes conflict resolution difficult. Developing collaborative working relationships helps to manage conflict in complex environments. Working relationships are based on the ability to deal with differences. Dealing with differences requires skill development and techniques for balancing interests and communicating effectively. Techniques used by mediators are effective for resolving disputes and developing working relationships. With practice, these techniques are easily transferable to the clinical setting. Listening for understanding, reframing, elevating the definition of the problem, and forming clear agreements can foster working relationships, decrease the level of conflict, and create healthy work environments that benefit patients and professionals.

医疗保健组织必须找到管理冲突和发展有效工作关系的方法,以创造健康的工作环境。未解决的冲突对临床结果、员工保留和组织财务健康的影响导致许多不必要的成本,从而转移了临床护理的资源。提供重症监护服务的复杂性使解决冲突变得困难。发展协作工作关系有助于管理复杂环境中的冲突。工作关系是建立在处理分歧的能力之上的。处理差异需要技巧的发展,以及平衡利益和有效沟通的技巧。调解员使用的技巧对解决纠纷和发展工作关系是有效的。通过实践,这些技术很容易转移到临床环境。倾听理解,重新定义,提升问题的定义,形成明确的协议,可以促进工作关系,减少冲突的程度,并创造有利于患者和专业人员的健康工作环境。
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引用次数: 67
Power: an application to the nursing image and advanced practice. 力量:护理形象与先进实践的应用。
Pub Date : 2004-04-01 DOI: 10.1097/00044067-200404000-00004
Darryl W Roberts, Elias Vasquez

When asked to put a mental picture to the word nurse, the image people see is often far removed from the image nurses wish to project. Many see nurses as the handmaidens to physicians, wearing white caps and stockings, and surrendering their chairs to physicians. Others see unflattering images from the media. Nursing's tarnished image is partially responsible for a perception of oppression in nursing. Much of nursing's image problem relates to how nurses perceive and use power. Regardless of how nurses perceive power, it is through power that advanced practice nurses (APNs) will be acknowledged as members of a profession versus an occupation. With a better understanding of power, APNs may be able to improve their use of power to advance the profession. This article presents and discusses power through a review of the literature in order to better understand the term as it applies to advanced practice nursing.

当被要求在脑海中描绘护士这个词时,人们看到的形象往往与护士希望投射的形象相去甚远。许多人认为护士是医生的侍女,头戴白帽,脚穿长筒袜,把椅子让给医生。另一些人则从媒体上看到了不讨人喜欢的形象。护理的暗淡形象部分地导致了人们对护理的压迫感。护士的形象问题与护士如何看待和使用权力有关。无论护士如何看待权力,通过权力,高级执业护士(apn)将被承认为一个专业的成员,而不是一个职业。随着对权力的更好理解,apn可能能够改善他们对权力的使用,以促进职业发展。本文通过对文献的回顾来介绍和讨论权力,以便更好地理解这个术语,因为它适用于高级护理实践。
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引用次数: 32
期刊
AACN clinical issues
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