A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factorbeta (T GF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. T his agent also inhibits vascular endothelial growth factor (VEGF)and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04) Qeios · Definition, February 7, 2020
{"title":"Suramin.","authors":"M. Eisenberger, V. Sinibaldi, L. Reyno","doi":"10.32388/ogsz91","DOIUrl":"https://doi.org/10.32388/ogsz91","url":null,"abstract":"A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factorbeta (T GF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. T his agent also inhibits vascular endothelial growth factor (VEGF)and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04) Qeios · Definition, February 7, 2020","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"3 3 1","pages":"187-9"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41748703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-09DOI: 10.1046/j.1523-5394.2001.95104.x
{"title":"Integrating Theory and Practice: Conceptual Frameworks of the CEFP","authors":"","doi":"10.1046/j.1523-5394.2001.95104.x","DOIUrl":"10.1046/j.1523-5394.2001.95104.x","url":null,"abstract":"","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"9 s1","pages":"S17-S22"},"PeriodicalIF":0.0,"publicationDate":"2008-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1523-5394.2001.95104.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57667408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-09DOI: 10.1046/j.1523-5394.2001.95107.x
{"title":"Doing Our Part So Kids Don't Start: An Evaluation of a Statewide Public Awareness Campaign","authors":"","doi":"10.1046/j.1523-5394.2001.95107.x","DOIUrl":"10.1046/j.1523-5394.2001.95107.x","url":null,"abstract":"","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"9 s1","pages":"S37-S42"},"PeriodicalIF":0.0,"publicationDate":"2008-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1523-5394.2001.95107.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57667462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-09DOI: 10.1046/j.1523-5394.2001.951pre.x
{"title":"A Note from the Editors","authors":"","doi":"10.1046/j.1523-5394.2001.951pre.x","DOIUrl":"https://doi.org/10.1046/j.1523-5394.2001.951pre.x","url":null,"abstract":"","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"9 s1","pages":"S2"},"PeriodicalIF":0.0,"publicationDate":"2008-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1523-5394.2001.951pre.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71921006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-09DOI: 10.1046/j.1523-5394.2001.95106.x
{"title":"An Evaluation of I Can Cope: Insights into Program Design and Implementation","authors":"","doi":"10.1046/j.1523-5394.2001.95106.x","DOIUrl":"10.1046/j.1523-5394.2001.95106.x","url":null,"abstract":"","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"9 s1","pages":"S31-S36"},"PeriodicalIF":0.0,"publicationDate":"2008-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1523-5394.2001.95106.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57667452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-09DOI: 10.1046/j.1523-5394.2001.95109.x
{"title":"Investigation of Healthcare Providers' Patterns of Referring Breast Cancer Patients to Reach to Recovery","authors":"","doi":"10.1046/j.1523-5394.2001.95109.x","DOIUrl":"10.1046/j.1523-5394.2001.95109.x","url":null,"abstract":"","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"9 s1","pages":"S49-S55"},"PeriodicalIF":0.0,"publicationDate":"2008-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1523-5394.2001.95109.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57667515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-09DOI: 10.1046/j.1523-5394.2001.95101.x
{"title":"Evaluation within the American Cancer Society: Accountability, Credibility, and Responsiveness","authors":"","doi":"10.1046/j.1523-5394.2001.95101.x","DOIUrl":"https://doi.org/10.1046/j.1523-5394.2001.95101.x","url":null,"abstract":"","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"9 s1","pages":"S3"},"PeriodicalIF":0.0,"publicationDate":"2008-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1523-5394.2001.95101.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71949424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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