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Short-Term Monitoring of Graft Regeneration in Partial Liver Transplantation Recipients 部分肝移植受者移植物再生的短期监测
4区 医学 Q2 Medicine Pub Date : 2023-11-06 DOI: 10.12659/aot.941444
Yuying Shan, Xi Yu, Yuhao Du, Jiongze Fang, Jing Huang, Jiangnan Sun, Yong Yang, Shuqi Mao, Shengdong Wu, Caide Lu
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引用次数: 0
Three-Dimensional Printing of Polycaprolactone/Nano-Hydroxyapatite Composite Scaffolds with a Pore Size of 300/500 µm is Histocompatible and Promotes Osteogenesis Using Rabbit Cortical Bone Marrow Stem Cells. 孔径为300/500µm的聚己内酯/纳米羟基磷灰石复合支架的三维打印具有组织相容性,并使用兔皮质骨髓干细胞促进成骨。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2023-10-31 DOI: 10.12659/AOT.940365
Yang Yang, Bing Qiu, Zhuxing Zhou, Chaoran Hu, Jia Li, Cheng Zhou

BACKGROUND Many patients have bone defects that exceed the healing size. This study aimed to construct polycaprolactone/nano-hydroxyapatite (PCL/nHA) composite scaffolds with different pore sizes and investigate the osteogenesis and histocompatibility of cortical bone mesenchymal stem cells (BMSCs-C) seeded on it after inoculation. MATERIAL AND METHODS After mixing PCL and nHA proportionally, three-dimensional (3D) printing was used to print scaffolds. Porosity, compressive strength, and elastic modulus of PCL/nHA scaffolds were tested. The proliferation of BMSCs-C cells was examined and osteogenesis, chondrogenesis, and adipogenesis were evaluated. BMSCs-C cells were inoculated into 3D printing scaffolds, and histocompatibility between BMSCs-C cells and scaffolds was observed by the cell count kit (CCK-8) assay and LIVE/DEAD staining. After inoculating BMSCs-C cells into scaffolds, alkaline phosphatase (ALP) activity and calcium content were measured. RESULTS There was no obvious difference in characteristics between the 3 PCL/nHA composite scaffolds. The porosity, compressive strength, and elastic modulus of the 300/500-μm scaffold were between those of the 300-μm and 500-μm scaffolds. With increasing pore size, the mechanical properties of the scaffold decrease. BMSCs-C cells demonstrated faster growth and better osteogenic, adipogenic, and chondrogenic differentiation; therefore, BMSCs-C cells were selected as seed cells. PCL/nHA composite scaffolds with different pore sizes had no obvious toxicity and demonstrated good biocompatibility. All scaffolds showed higher ALP activity and calcium content. CONCLUSIONS The 300/500 μm mixed pore size scaffold took into account the mechanical properties of the 300 μm scaffold and the cell culture area of the 500 μm scaffold, therefore, 300/500 μm scaffold is a better model for the construction of tissue engineering scaffolds.

背景许多患者的骨缺损超过了愈合范围。本研究旨在构建不同孔径的聚己内酯/纳米羟基磷灰石(PCL/nHA)复合支架,并研究其上接种的皮质骨间充质干细胞(BMSCs-C)的成骨和组织相容性。材料和方法将PCL和nHA按比例混合后,使用三维(3D)打印来打印支架。测试了PCL/nHA支架的孔隙率、抗压强度和弹性模量。检测BMSCs-C细胞的增殖,并评估成骨、软骨生成和脂肪生成。将BMSCs-C细胞接种到3D打印支架中,并通过细胞计数试剂盒(CCK-8)测定和LIVE/DEAD染色观察BMSCs-C细胞与支架之间的组织相容性。将BMSCs-C细胞接种到支架中后,测量碱性磷酸酶(ALP)活性和钙含量。结果3种PCL/nHA复合支架在性能上无明显差异。300/500μm支架的孔隙率、抗压强度和弹性模量介于300μm和500μm支架之间。随着孔径的增大,支架的力学性能下降。BMSCs-C细胞表现出更快的生长和更好的成骨、成脂和软骨分化;因此选择BMSCs-C细胞作为种子细胞。不同孔径的PCL/nHA复合支架无明显毒性,具有良好的生物相容性。所有支架均显示出较高的ALP活性和钙含量。结论300/500μm混合孔径支架考虑了300μm支架的力学性能和500μm支架细胞培养面积,因此300/500微米支架是构建组织工程支架的较好模型。
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引用次数: 0
Survival Outcomes After Double-Lung Transplantation for Refractory Lung-Limited Cancers and Incidence of Post-Transplant Lung Cancer 难治性肺局限性肿瘤双肺移植后的生存结局和移植后肺癌的发病率
4区 医学 Q2 Medicine Pub Date : 2023-10-30 DOI: 10.12659/aot.941301
Jeeyeon Lee, Maria Jose Aguilera Chuchuca, Jisang Yu, Liam Il-Young Chung, Ankit Bharat, Young Kwang Chae
Background To evaluate the role of double-lung transplantation (DLT) for lung cancer, the survival outcomes of patients who underwent DLT for lung cancer and the incidence of de novo lung cancer after DLT were assessed. Material/Methods Data from all cases reported in the literature were pooled for analysis and additional data were collected from the Organ Procurement Transplantation Network (OPTN) registry. Recurrence-free survival (RFS), overall survival (OS), and cancer-specific survival (CSS) of patients who underwent DLT for lung cancer were determined. Moreover, the incidence of de novo lung cancer and associated OS in lung transplant recipients were examined. Results Of the 20 cases series and 15 cases from the OPTN registry, the 5-year RFS was 55.0% and 66.7% and the 5-year OS was 55.0% and 26.7%, respectively, and the median CSS was 48.0 (range, 2.0–144.0) and 27.7 (range, 0.2–66.6) months, respectively. In the OPTN data, the incidence of post-transplant lung cancer in patients who underwent DLT for the non-cancerous disease was 0.8% and the 5-year OS was 47.3%. Conclusions In conclusion, our integrated analysis of the case series and the OPTN registry demonstrated promising survival outcomes for patients with refractory bilateral lung cancer who underwent DLT. Although there are limitations to consider, the results of this study underscore the potential benefits of DLT in managing refractory lung-limited lung cancer.
{"title":"Survival Outcomes After Double-Lung Transplantation for Refractory Lung-Limited Cancers and Incidence of Post-Transplant Lung Cancer","authors":"Jeeyeon Lee, Maria Jose Aguilera Chuchuca, Jisang Yu, Liam Il-Young Chung, Ankit Bharat, Young Kwang Chae","doi":"10.12659/aot.941301","DOIUrl":"https://doi.org/10.12659/aot.941301","url":null,"abstract":"Background To evaluate the role of double-lung transplantation (DLT) for lung cancer, the survival outcomes of patients who underwent DLT for lung cancer and the incidence of de novo lung cancer after DLT were assessed. Material/Methods Data from all cases reported in the literature were pooled for analysis and additional data were collected from the Organ Procurement Transplantation Network (OPTN) registry. Recurrence-free survival (RFS), overall survival (OS), and cancer-specific survival (CSS) of patients who underwent DLT for lung cancer were determined. Moreover, the incidence of de novo lung cancer and associated OS in lung transplant recipients were examined. Results Of the 20 cases series and 15 cases from the OPTN registry, the 5-year RFS was 55.0% and 66.7% and the 5-year OS was 55.0% and 26.7%, respectively, and the median CSS was 48.0 (range, 2.0–144.0) and 27.7 (range, 0.2–66.6) months, respectively. In the OPTN data, the incidence of post-transplant lung cancer in patients who underwent DLT for the non-cancerous disease was 0.8% and the 5-year OS was 47.3%. Conclusions In conclusion, our integrated analysis of the case series and the OPTN registry demonstrated promising survival outcomes for patients with refractory bilateral lung cancer who underwent DLT. Although there are limitations to consider, the results of this study underscore the potential benefits of DLT in managing refractory lung-limited lung cancer.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136132748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Outcomes of Administration of Rituximab for Desensitization in Liver Transplant Patients with Preformed Donor-Specific Antibodies: A Single-Center Experience 利妥昔单抗治疗预形成供体特异性抗体的肝移植患者脱敏的临床结果:单中心经验
4区 医学 Q2 Medicine Pub Date : 2023-10-27 DOI: 10.12659/aot.941456
Masato Shizuku, Nobuhiko Kurata, Kanta Jobara, Yasuhiro Fujimoto, Yasuhiro Ogura
Background
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引用次数: 0
Naples Prognostic Score for Graft Functions After Renal Transplantation: A Retrospective Analysis. Naples肾移植术后移植物功能预后评分:回顾性分析。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2023-10-24 DOI: 10.12659/AOT.942007
İsmail Aytaç, Betül Güven Aytaç, Oya Kilci, Erkan Ölçücüoğlu

BACKGROUND The Naples prognostic score is a comprehensive measure of patients' inflammation and nutritional status, consisting of serum albumin, total cholesterol, neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR). We compared the Naples prognostic scores of kidney transplant patients with a creatinine reduction ratio of less than 30% vs those with greater than 30%. MATERIAL AND METHODS We conducted a retrospective study on 93 patients who received kidney transplants at our hospital from January 2020 to January 2023. Naples prognostic scores were used to calculate the preoperative condition of transplant recipients. The patients were divided into 2 groups based on their creatinine reduction ratio on the second day after surgery. Group A consisted of patients with a ratio above 30%, while group B consisted of those with a ratio below 30%. RESULTS Our analysis revealed that the total cholesterol and albumin values of groups A and B showed no substantial difference. Group B had clearly more patients with Naples prognostic score 3-4 compared to the other group (P=0.032). Multivariate analysis determined that patients with Naples prognostic score 3-4 had a 3.151-fold higher likelihood of experiencing creatinine reduction below 30% (95% CI 1.209-8.215, P value 0.019). CONCLUSIONS The preoperative inflammatory and nutritional status of patients may have an impact on the functioning of grafts during the postoperative period. A high Naples prognostic score may be linked with a decrease in creatinine reduction ratio in post-transplant kidneys, which could lead to graft dysfunction.

背景Naples预后评分是衡量患者炎症和营养状况的综合指标,包括血清白蛋白、总胆固醇、中性粒细胞/淋巴细胞比率(NLR)和淋巴细胞/单核细胞比率(LMR)。我们比较了肌酸酐减少率小于30%和大于30%的肾移植患者的那不勒斯预后评分。材料和方法我们对2020年1月至2023年1月在我院接受肾移植的93名患者进行了回顾性研究。Naples预后评分用于计算移植受者的术前状况。根据术后第二天的肌酸酐减少率,将患者分为2组。A组由比率高于30%的患者组成,而B组由比率低于30%的患者构成。结果我们的分析显示,A组和B组的总胆固醇和白蛋白值没有显著差异。与另一组相比,B组Naples预后评分为3-4的患者明显更多(P=0.032)。多因素分析确定,Naples评分为3-4患者出现肌酸酐减少低于30%的可能性高3.151倍(95%CI 1.209-8.215,P值0.019)术后对移植物功能的影响。Naples预后评分高可能与移植后肾脏肌酐减少率降低有关,这可能导致移植物功能障碍。
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引用次数: 0
Analysis of Anxiety and Influencing Factors in Kidney Transplant Recipients and General Public During the COVID-19 Pandemic. 新冠肺炎大流行期间肾移植受者和公众焦虑及其影响因素分析。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2023-10-17 DOI: 10.12659/AOT.941489
Chunkai Du, Yichen Zhu

BACKGROUND The COVID-19 pandemic has had a profound impact on mental health worldwide. Kidney transplant recipients represent a vulnerable population that may experience increased anxiety due to their health concerns and the risk of infection. This study aims to delve into the psychological anxiety levels and influential factors of kidney transplant patients during the Omicron variant of COVID-19 pandemic in China. MATERIAL AND METHODS A retrospective analysis was conducted using an online survey questionnaire to investigate the anxiety levels of 203 kidney transplant recipients and 53 individuals from the general population. The Self-Rating Anxiety Scale (SAS) was employed to evaluate anxiety levels, and the influencing factors affecting anxiety levels were analyzed for both cohorts. RESULTS Among the cohort of the 203 kidney transplant recipients, 28 individuals (13.8%) had symptoms indicative of anxiety, with an average SAS score of 40.5±9.0. Out of the 53 individuals from the general population, 9 (17.0%) had symptoms of anxiety, with an average SAS score of 39.6±10.7. Notably, females and those with chronic respiratory diseases within the general population showed higher anxiety levels, and having a chronic respiratory condition was found to be an independent risk factor for anxiety levels in the general population. CONCLUSIONS This investigation demonstrates that anxiety levels in kidney transplant recipients and the general population were comparable during the Omicron variant of COVID-19 pandemic. However, kidney transplant patients showed more stable anxiety levels.

背景新冠肺炎疫情对全球心理健康产生了深远影响。肾移植受者是一个脆弱的群体,由于他们的健康问题和感染风险,他们可能会经历更多的焦虑。本研究旨在探讨新冠肺炎奥密克戎变异株在中国流行期间肾移植患者的心理焦虑水平及其影响因素。材料和方法采用在线调查问卷对203名肾移植受者和53名普通人群的焦虑水平进行回顾性分析。采用焦虑自评量表(SAS)对两组患者的焦虑水平进行评估,并分析影响焦虑水平的因素。结果在203名肾移植受者中,有28人(13.8%)出现焦虑症状,平均SAS评分为40.5±9.0。在53名普通人群中,9人(17.0%)有焦虑症状,SAS平均得分为39.6±10.7。值得注意的是,在普通人群中,女性和患有慢性呼吸道疾病的人表现出更高的焦虑水平,患有慢性呼吸系统疾病被发现是普通人群焦虑水平的独立风险因素。结论这项调查表明,在新冠肺炎大流行的奥密克戎变异株期间,肾移植受者和普通人群的焦虑水平具有可比性。然而,肾移植患者表现出更稳定的焦虑水平。
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引用次数: 0
Toll-Like Receptor 3 mRNA Expression of Peripheral Blood Mononuclear Cells Identifies Kidney Recipients with Potential for Improved Graft Performance 外周血单个核细胞toll样受体3 mRNA的表达鉴定肾脏受体具有改善移植物性能的潜力
4区 医学 Q2 Medicine Pub Date : 2023-10-13 DOI: 10.12659/aot.941266
Sławomir C. Zmonarski, Mirosław Banasik, Marcelina Żabińska, Tomasz Gołębiowski, Joanna M. Zmonarska, Magdalena Krajewska
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引用次数: 0
Prolonged Tracheal Intubation in the ICU as a Possible Risk Factor for Arytenoid Dislocation After Liver Transplant Surgery: A Retrospective Case-Control Study. ICU长期气管插管可能是肝移植术后Arynoid脱位的危险因素:一项回顾性病例对照研究。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2023-10-10 DOI: 10.12659/AOT.940727
Wenqing Yan, Weihua Dong, Zhi Chen

BACKGROUND Arytenoid dislocation (AD) is a rare complication of general anesthesia with tracheal intubation, with a published incidence of 0.009-0.097%. This retrospective case-control study aimed to identify risk factors associated with AD in patients who underwent liver transplantation. MATERIAL AND METHODS This study included 476 patients who underwent liver transplantation between January 2013 and December 2022. Patients with AD who underwent surgery were included in the AD group. For each case of AD, 4 patients matched by anesthesia type and anesthetist were randomly selected as the non-AD group. Data on patient characteristics, anesthetic factors, and surgical factors were collected and compared between patients with and without AD. Logistic regression analysis was performed to determine the risk factors for AD after liver transplantation. RESULTS Of the 476 patients who underwent liver transplantation, 17 (3.57%) had AD. AD occurred on the left side in 13 patients and on the right side in 4 patients. The 17 patients who experienced AD and 68 matched non-AD patients were enrolled. Patients in the AD group had a greater intubation depth (24 [23-24] vs 24 [24-24], P=0.043), a higher level of hemoglobin (134.5 [118-147.5] vs 112 [96.25-125], P=0.014), and prolonged tracheal intubation in the ICU (19.75 [15.87-31.87] vs 13 [10.62-15], P<0.001) compared to those in the non-dislocation group. Multivariate logistic regression analysis showed that prolonged tracheal intubation in the ICU was independently associated with the occurrence of AD in patients who underwent liver transplantation (P=0.013). CONCLUSIONS This study showed that the incidence of AD was 3.57% in patients undergoing liver transplant surgery and that prolonged tracheal intubation in the ICU was a possible risk factor for AD.

背景阿氏肌脱位(AD)是气管插管全麻的一种罕见并发症,已发表的发病率为0.009-0.97%。本回顾性病例对照研究旨在确定肝移植患者中与AD相关的危险因素。材料和方法本研究包括2013年1月至2022年12月期间接受肝移植的476名患者。接受手术的AD患者被纳入AD组。对于每例AD,随机选择4名麻醉类型和麻醉师匹配的患者作为非AD组。收集患者特征、麻醉因素和手术因素的数据,并在AD患者和非AD患者之间进行比较。进行Logistic回归分析以确定肝移植后AD的危险因素。结果476例肝移植患者中,17例(3.57%)发生AD,其中左侧13例,右侧4例。入选了17名AD患者和68名匹配的非AD患者。AD组患者插管深度更大(24[23-24]vs 24[24-24],P=0.043),血红蛋白水平更高(134.5[118-147.5]vs 112[96.25-125],P=0.014),ICU气管插管时间延长(19.75[15.87-31.87]vs 13[10.62-15],P
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引用次数: 0
Predictors of Long-Term Outcomes After Liver Transplantation for Unresectable Metastatic Neuroendocrine Tumors 不可切除的转移性神经内分泌肿瘤肝移植术后远期预后的预测因素
4区 医学 Q2 Medicine Pub Date : 2023-10-06 DOI: 10.12659/aot.941212
Mikołaj Kuncewicz, Igor Piotr Jaszczyszyn, Kacper Karaban, Paweł Rykowski, Maciej Krasnodębski, Marcin Morawski, Emilia Kruk, Łukasz Koperski, Krzysztof Zieniewicz, Marek Krawczyk, Michał Grąt
Background Malignant and benign neuroendocrine tumors (NET) share many histopathological features. Liver transplantation (LT) is one of the liver-directed therapies for neuroendocrine liver metastases (NELM). The aim of this study was to determine the outcomes of patients undergoing LT for NELM. Material/Methods This was a retrospective study that included 19 patients who underwent LT for unresectable NELM between December 1989 and December 2022 in the Department of General, Transplant, and Liver Surgery of the Medical University of Warsaw. Kaplan-Meier estimator and Cox proportional hazards regression were used for statistical analyses. Results The primary tumor was located most frequently in the pancreas. The median follow-up was 72.5 months. The overall survival (OS) was 94.7%, 88.0%, 88.0%, 70.4%, and 49.3% after 1, 3, 5, 10, and 15 years, respectively. Accordingly, the recurrence-free survival (RFS) rates were 93.8%, 72.9%, 64.8%, 27.8%, and 27.8% after 1, 3, 5, 10, and 15 years, respectively. Ki-67 index ≥5% was found as a risk factor for both worse OS (hazard ratio (HR) 7.13, 95% confidence intervals (95% CI) 1.32–38.63, P=0.023) and RFS (HR 13.68, 95% CI 1.54–121.52, P=0.019). Recipient age ≥55 years was a risk factor for worse RFS (P=0.046, HR 5.47, 95% CI 1.03–29.08). Multivariable analysis revealed Ki-67 ≥5% as the sole independent factor for worse OS (HR 13.78, 95% CI 1.48–128.56, P=0.021). Conclusions Patients with unresectable NELM achieve great OS and satisfying RFS after LT. The risk factors associated with worse outcomes are attributed to primary tumor aggressiveness.
{"title":"Predictors of Long-Term Outcomes After Liver Transplantation for Unresectable Metastatic Neuroendocrine Tumors","authors":"Mikołaj Kuncewicz, Igor Piotr Jaszczyszyn, Kacper Karaban, Paweł Rykowski, Maciej Krasnodębski, Marcin Morawski, Emilia Kruk, Łukasz Koperski, Krzysztof Zieniewicz, Marek Krawczyk, Michał Grąt","doi":"10.12659/aot.941212","DOIUrl":"https://doi.org/10.12659/aot.941212","url":null,"abstract":"Background Malignant and benign neuroendocrine tumors (NET) share many histopathological features. Liver transplantation (LT) is one of the liver-directed therapies for neuroendocrine liver metastases (NELM). The aim of this study was to determine the outcomes of patients undergoing LT for NELM. Material/Methods This was a retrospective study that included 19 patients who underwent LT for unresectable NELM between December 1989 and December 2022 in the Department of General, Transplant, and Liver Surgery of the Medical University of Warsaw. Kaplan-Meier estimator and Cox proportional hazards regression were used for statistical analyses. Results The primary tumor was located most frequently in the pancreas. The median follow-up was 72.5 months. The overall survival (OS) was 94.7%, 88.0%, 88.0%, 70.4%, and 49.3% after 1, 3, 5, 10, and 15 years, respectively. Accordingly, the recurrence-free survival (RFS) rates were 93.8%, 72.9%, 64.8%, 27.8%, and 27.8% after 1, 3, 5, 10, and 15 years, respectively. Ki-67 index ≥5% was found as a risk factor for both worse OS (hazard ratio (HR) 7.13, 95% confidence intervals (95% CI) 1.32–38.63, P=0.023) and RFS (HR 13.68, 95% CI 1.54–121.52, P=0.019). Recipient age ≥55 years was a risk factor for worse RFS (P=0.046, HR 5.47, 95% CI 1.03–29.08). Multivariable analysis revealed Ki-67 ≥5% as the sole independent factor for worse OS (HR 13.78, 95% CI 1.48–128.56, P=0.021). Conclusions Patients with unresectable NELM achieve great OS and satisfying RFS after LT. The risk factors associated with worse outcomes are attributed to primary tumor aggressiveness.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134945386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Blood Pressure on Risk of Graft Failure or Death Among Patients After Kidney Transplantation in a 10-Year Observational Period: A Single-Center Retrospective Analysis. 10年观察期内血压对肾移植患者移植物衰竭或死亡风险的影响:一项单中心回顾性分析。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2023-10-03 DOI: 10.12659/AOT.939472
Tomasz Pilecki, Bożena Czarkowska-Pączek, Wojciech Lisik, Sławomir Nazarewski, Leszek Pączek

BACKGROUND Hypertension is a risk factor for graft failure and mortality among kidney transplant recipients (KTRs). The aim of the study was to examine blood pressure (BP) as a factor that contributes to graft failure or death during a 10-year observation period. MATERIAL AND METHODS The study group comprised 70 KTRs who were treated according to their clinical state. Data were collected at 1 month and 1 year after transplantation and included office and ambulatory BP monitoring (ABPM) BP values, eGFR, proteinuria, and BMI. During the observation period, 6 patients died, and 10 lost the graft, but not during the first year. RESULTS Office and ABPM BP values were within normal ranges and did not differ from each other. eGRF and BMI were higher at 1 year compared to 1 month after transplantation, and proteinuria decreased. Among those who died, DBP was lower compared to those of survivors with graft failure. Proteinuria and donor age were positively correlated with BP. CONCLUSIONS Monitoring of BP and adequate treatment of hypertension resulting in BP values within normal values among KTRs contribute to longer survival of the graft and recipient. Older donor age and proteinuria could predict post-transplant hypertension. Low diastolic BP of the recipient could increase the risk of death among KTRs. Despite the fact that ABPM is the blood pressure measurement method of choice, appropriate standard office measurement could also be used for BP monitoring.

背景高血压是肾移植受者移植物衰竭和死亡的危险因素。该研究的目的是在10年的观察期内,检查血压(BP)是否是导致移植物衰竭或死亡的因素。材料和方法研究组包括70名KTR,根据其临床状态进行治疗。数据收集于移植后1个月和1年,包括办公室和门诊血压监测(ABPM)血压值、eGFR、蛋白尿和BMI。在观察期间,6名患者死亡,10名患者失去移植物,但在第一年没有。结果Office和ABPM BP值在正常范围内,彼此之间没有差异。与移植后1个月相比,eGRF和BMI在移植后1年时更高,蛋白尿减少。在死亡的患者中,DBP低于移植失败的幸存者。蛋白尿和供体年龄与血压呈正相关。结论监测血压并适当治疗高血压,使KTR中的血压值在正常值范围内,有助于移植物和受体的长期生存。年龄较大的供体和蛋白尿可以预测移植后的高血压。受体舒张压低可能增加KTR的死亡风险。尽管ABPM是首选的血压测量方法,但适当的标准办公室测量也可以用于血压监测。
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引用次数: 0
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Annals of Transplantation
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