Romanian journal of virology最新文献

Two groups of children were set up: children infected with HIV and hepatitis viruses and children infected with HIV, but not with hepatitis viruses, too. The immunological aspects investigated referred to the Ig serum value, the absolute number of T CD4 lymphocytes and the T CD4/T CD8 ratio. The subjects of the first group (in whom hepatitis markers were present) displayed increased IgA and IgM values at a higher rate than those of the second group (54.87% against 32%, 83.3% against 53%), as well as a lowering below 300/ml of the number of T CD4 lymphocytes (50% against 29.4%). On the other hand, increased IgG levels and values below 0.8 of the T CD4/T CD8 ratio were found at similar rates in the two groups of children (77.4% against 80% and 70.5% against 70% respectively). By means of the data obtained, the authors try to point out one of the ways by which hepatitis viruses, considered as a potential cofactor in the AIDS development, contribute to the course of this disease, namely by intensifying the immunological disorders.

In white mice, the associated infections with the influenza virus type A(H3N2), the adenovirus type 3 and the long strain of the respiratory syncytial virus, detected by the appearance of homologous serum antibodies and by positive I.F. reactions in pulmonary tissue, induce histological, histochemical and histo-enzymatic lesions, the severity of which exceeds that of the lesions in animals infected with only one of the mentioned viruses. In comparison with the morphological picture in animals inoculated with a single virus, expressed by inflammatory, infiltrative, lymphohistiocytic pulmonary (infiltrative, interstitial, diffuse, sometimes "cuffing", peribronchial and perivascular broncho-pneumonias), hepatic and renal processes, in the case of associate infections pathomorphological changes appear on wider surfaces and with a high frequency, manifested also by hyalinosis of the vascular media in the lung and the spleen, vacuolization of the cytoplasm of hepatocytes, hypertrophy of the lymphoid follicles in the spleen and the lymph nodes (in associated infection due to the influenza virus+adenovirus and vice versa) or, on the contrary, hypotrophy of the lymphoid follicles in the spleen and lymph nodes (in the associated infection due to the influenza virus+respiratory syncytial virus and vice versa).

A generalized neural network was adapted for the simulation of processes strongly dependent upon the history, imposed by the inner own history of an individual neuronal activation. This involves the dependence of the neural network parameters upon the cumulated values of the corresponding neuron activations. When in the neural network weakly coupled blocks with strong inner couplings can be identified, the activation wave on the entire network (associated with the overall epidemic) can be decomposed into quasi-independent intra-block local activation waves, with characteristic delays between them (corresponding to the simultaneous and successive local epidemics). Special simulations on strongly connex neural network determine the typical local activation waves for various block parameters and the mentioned delays between two such successive activation waves in two coupled blocks. Another type of neural network is used to achieve the empirical decomposition of the overall epidemic into simultaneous (corresponding to a layer) and successive local epidemics (corresponding to the various epidemic waves, associated with different layers). A simpler approximative algorithm for the estimation of the number of the mentioned simultaneous local typical epidemics is also presented.

A complex immuno-chemical treatment (immuno-stimulation, blockage of virus replication, interferon induction) was applied to 23 patients with warts and vegetations with various localisations. Results confirmed the treatment efficiency.

A study was conducted on 61 polytransfused patients, 24 patients submitted to long lasting parenteral treatments, 116 blood donors and 132 controls. Immuno-enzymatic tests were used for detection of antibodies against hepatitis C virus (HCV). They were found in 56 (91.8%) out of the 61 polytransfused patients, in 5 (4.3%) of the donors, in 5 (20.8%) of the patients with multiple treatments and in 5 (3.7%) controls. The VHB markers were detected at variable rates in all investigated groups. The high rate of seropositivity indicates that hepatitis C is becoming an important public health problem in Romania.

The use of fluorescent probes for the appraisal of microviscosity properties of cell membranes, both inside the lipid double layer and/or near the double layer surface, are today an usual tool in cell biology. In the present paper an attempt was made to establish if there are significant changes in the mechanical properties of the host cell membranes.

The individuals are distributed in 9 risk groups (adults and children), in which an HIV transmission way is predominant. Taking into account a simplified graph of the HIV infection evolution, kinetic equations for the number of individuals from each risk group--situated in various stages of HIV infection--are written. The approximative solutions of these equations give us: the characteristic exponents of the temporal evolutions of the main and secondary local epidemics; the ratios Ci/Bi and Di/Bi of asymptomatically contaminated and dead (as consequence of AIDS)--versus symptomatically contaminated; the onset of local epidemics in various risk groups; the relative amplitude of the secondary local epidemics versus the main local ones.

AgHBs incidence in various population groups from the Iassy region was relatively high in 1991, ranging from 3.8% in blood donors to 75.0% in patients with severe acute virus hepatitis. As compared to the incidence values recorded in 1973, 18 years ago, in the population of the same territory, some mutations were observed, the most important being the more then threefold reduction of the AgHBs incidence in blood donors. In subjects with liver diseases and in risk groups, the frequency of AgHBs carriers maintains at a high level.

Viral and serological studies led to the conclusion that parainfluenza type 3 and influenza type A(H3N2) viruses were the most implicated in the etiology of acute respiratory diseases (ARD), viral pneumonia and clinical influenza in nine districts of the south-east area of Romania during the November 1992-March 1993 period. Epidemiological survey pointed on the 0-1 year group of age as the most affected by the above mentioned respiratory diseases.