F. Ghiasi, M. Hadian, H. Bagheri, M. Yekaninejad, H. Saberi, A. Noroozi
{"title":"Change of Spasticity Following Robotic-Assisted Gait Training in Patients with Chronic Incomplete Spinal Cord Injury: Preliminary Results","authors":"F. Ghiasi, M. Hadian, H. Bagheri, M. Yekaninejad, H. Saberi, A. Noroozi","doi":"10.1166/AJNN.2012.1041","DOIUrl":"https://doi.org/10.1166/AJNN.2012.1041","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81014830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Figueiredo, V. Aroniadou-Anderjaska, Felicia M. Qashu, J. P. Apland, A. P. Souza, M. Braga
{"title":"Efficacy of Topiramate Against Soman Intoxication: Attenuation of Seizures Without Neuroprotection","authors":"T. Figueiredo, V. Aroniadou-Anderjaska, Felicia M. Qashu, J. P. Apland, A. P. Souza, M. Braga","doi":"10.1166/AJNN.2011.1026","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1026","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77151488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Tosi, R. Fano, L. Badiali, L. Bondioli, B. Ruozi, A. Vergoni, F. Rivasi, R. Benassi, M. Vandelli, F. Forni
{"title":"Nanoparticles for Brain Delivery of Drugs: In Vivo Experiments and Mechanism of Blood-Brain Barrier Crossing","authors":"G. Tosi, R. Fano, L. Badiali, L. Bondioli, B. Ruozi, A. Vergoni, F. Rivasi, R. Benassi, M. Vandelli, F. Forni","doi":"10.1166/AJNN.2011.1032","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1032","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91483596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Lazarovici, H. Arien-Zakay, S. Lecht, H. Galski, E. Shohami, A. Nagler, C. Marcinkiewicz, P. Lelkes
Human umbilical cord blood (HUCB), a valuable source for cell therapy of hematologic diseases, was recently found to confer neuroprotection in animal models of brain injury. To explore the neuroprotective properties of HUCB in an ischemic environment, we studied a unique sub-population of collagen-adherent cells. In the presence of nerve growth factor (NGF) and interferon-gamma, these cells differentiate in vitro into a neuronal phenotype (termed HUCBNPs). Using a closed-head injury brain trauma model, we recently demonstrated neuroprotective effects of HUCB upon their local injection into the brain. Our in-vitro studies indicated that upon co-culture with ischemia exposed PC12 cells, HUCBNP conferred about 30% neuroprotection, as assessed by decreased lactate dehydrogenase (LDH) release and inhibition of caspase-3 activity. HUCBNP decreased by 95% the level of free radicals in the insulted-PC12 cells, which was in correlation with the appearance of antioxidants and NGF in the medium. HUCBNP-induced neuroprotection also correlated with changes in NGF mRNA expression levels, a process which was blocked by K252a, an antagonist of the NGF-neurotrophin receptor TrkA. To further extend the possible contribution of NGF-mediated protective role, we investigated its neuroprotective mechanisms using PC12 cells and brain capillary endothelial cells exposed to ischemic insult. Pretreatment of the cultures with NGF conferred neuroprotection in a dose- and time-dependent fashion. Time course experiments indicated marked activation of mitogen activated protein kinasas (MAPKs) during the ischemic insult, while treatment of the cultures with NGF inhibited them to different degrees. It appears that both neuronal and endothelial compartments may be protected by NGF under ischemic conditions. Therefore, in future neuroprotection studies, we propose to address additional components of the neurovascular unit such as astrocytes and pericytes in mono-, co- and multi-culture setups. In conclusion, our findings indicate that HUCBNP-induced neuroprotection involves antioxidant(s) and NGF, which by paracrine and/or autocrine route, affects all components of the neurovascular unit.
{"title":"Nerve Growth Factor and Human Umbilical Cord Blood-Derived Cells Confer Neurovascular Protection in Ischemia","authors":"P. Lazarovici, H. Arien-Zakay, S. Lecht, H. Galski, E. Shohami, A. Nagler, C. Marcinkiewicz, P. Lelkes","doi":"10.1166/AJNN.2011.1028","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1028","url":null,"abstract":"Human umbilical cord blood (HUCB), a valuable source for cell therapy of hematologic diseases, was recently found to confer neuroprotection in animal models of brain injury. To explore the neuroprotective properties of HUCB in an ischemic environment, we studied a unique sub-population of collagen-adherent cells. In the presence of nerve growth factor (NGF) and interferon-gamma, these cells differentiate in vitro into a neuronal phenotype (termed HUCBNPs). Using a closed-head injury brain trauma model, we recently demonstrated neuroprotective effects of HUCB upon their local injection into the brain. Our in-vitro studies indicated that upon co-culture with ischemia exposed PC12 cells, HUCBNP conferred about 30% neuroprotection, as assessed by decreased lactate dehydrogenase (LDH) release and inhibition of caspase-3 activity. HUCBNP decreased by 95% the level of free radicals in the insulted-PC12 cells, which was in correlation with the appearance of antioxidants and NGF in the medium. HUCBNP-induced neuroprotection also correlated with changes in NGF mRNA expression levels, a process which was blocked by K252a, an antagonist of the NGF-neurotrophin receptor TrkA. To further extend the possible contribution of NGF-mediated protective role, we investigated its neuroprotective mechanisms using PC12 cells and brain capillary endothelial cells exposed to ischemic insult. Pretreatment of the cultures with NGF conferred neuroprotection in a dose- and time-dependent fashion. Time course experiments indicated marked activation of mitogen activated protein kinasas (MAPKs) during the ischemic insult, while treatment of the cultures with NGF inhibited them to different degrees. It appears that both neuronal and endothelial compartments may be protected by NGF under ischemic conditions. Therefore, in future neuroprotection studies, we propose to address additional components of the neurovascular unit such as astrocytes and pericytes in mono-, co- and multi-culture setups. In conclusion, our findings indicate that HUCBNP-induced neuroprotection involves antioxidant(s) and NGF, which by paracrine and/or autocrine route, affects all components of the neurovascular unit.","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72783388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Gabr, Osama Ghannam, M. Awad, K. Wild, W. A. Elkheir, Ibrahim Ewes
{"title":"Autologous Mesenchymal Stem Cell Therapy for Spinal Cord Injury: Long Term Safety and Clinical Efficacy","authors":"H. Gabr, Osama Ghannam, M. Awad, K. Wild, W. A. Elkheir, Ibrahim Ewes","doi":"10.1166/AJNN.2011.1034","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1034","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80066440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. L. Grevés, E. Enhamre, Qin Zhou, K. Fhölenhag, M. Berg, B. Meyerson, F. Nyberg
{"title":"Growth Hormone Enhances Cognitive Functions in Hypophys-Ectomized Male Rats","authors":"M. L. Grevés, E. Enhamre, Qin Zhou, K. Fhölenhag, M. Berg, B. Meyerson, F. Nyberg","doi":"10.1166/AJNN.2011.1023","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1023","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74566308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Promoting Predictive Diagnosis, Targeted Preventive Measures and Personalised Medicine in Handling of Neurodegeneration: Time for New Guidelines","authors":"O. Golubnitschaja, S. Mandel","doi":"10.1166/AJNN.2011.1031","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1031","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83562714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroprotection Against Excitotoxicity and Oxidative Stress by Hypothermia and Alkalinization","authors":"D. Kuffler, I. Berrios","doi":"10.1166/AJNN.2011.1029","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1029","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83767802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanism of Action of Lepidium meyenii (Maca): An Explanation for Its Neuroprotective Activity","authors":"A. Pino‐Figueroa, Huyen Vu, C. Kelley, T. Maher","doi":"10.1166/AJNN.2011.1035","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1035","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87126413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yonggang Wang, B. Bontempi, X. Leinekugel, Edith Lesburguères, Wei Liu, P. Weinstein, Ji-zong Zhao, G. Abrams, Jialing Liu
{"title":"Environmental Enrichment Preserves Cortical Inputs to the Parahippocampal Areas and Reduces Post Stroke Diaschisis","authors":"Yonggang Wang, B. Bontempi, X. Leinekugel, Edith Lesburguères, Wei Liu, P. Weinstein, Ji-zong Zhao, G. Abrams, Jialing Liu","doi":"10.1166/AJNN.2011.1027","DOIUrl":"https://doi.org/10.1166/AJNN.2011.1027","url":null,"abstract":"","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89313455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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