Pub Date : 2000-08-01DOI: 10.1016/S0169-4758(00)01730-0
W.A Petri Jr. , R Haque , D Lyerly , R.R Vines
{"title":"Estimating the Impact of Amebiasis on Health","authors":"W.A Petri Jr. , R Haque , D Lyerly , R.R Vines","doi":"10.1016/S0169-4758(00)01730-0","DOIUrl":"10.1016/S0169-4758(00)01730-0","url":null,"abstract":"","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01730-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21742110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-08-01DOI: 10.1016/S0169-4758(00)01712-9
Jozef Vercruysse
{"title":"Nematode Parasites of Vertebrates: Their Development and Transmission (2nd edn), R.C. Anderson","authors":"Jozef Vercruysse","doi":"10.1016/S0169-4758(00)01712-9","DOIUrl":"10.1016/S0169-4758(00)01712-9","url":null,"abstract":"","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01712-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55960268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-07-01DOI: 10.1016/S0169-4758(00)01691-4
A.P. Plaisier, W.A. Stolk, G.J. van Oortmarssen, J.D.F. Habbema
Using estimates for the anthelmintic efficacy of a single dose of ivermectin in the treatment of lymphatic filariasis patients, Anton Plaisier, Wilma Stolk, Gerrit van Oortmarssen and Dik Habbema here present and discuss model predictions of the impact of a five-year programme of annual community treatment on the intensity of infection. They show that the effectiveness of such programmes in terms of reductions in the microfilarial density depends critically on the treatment coverage and the pattern of attendance at repeated mass administrations. Improving these factors will possibly be more important than improving the efficacy of ivermectin by increasing its dosage or by adding other drugs.
Anton Plaisier、Wilma Stolk、Gerrit van Oortmarssen和Dik Habbema利用对单剂量伊维菌素治疗淋巴丝虫病患者的驱虫效果的估计，在这里介绍并讨论了五年年度社区治疗规划对感染强度影响的模型预测。它们表明，这些方案在减少微丝虫密度方面的有效性主要取决于治疗的覆盖范围和反复进行大规模治疗的模式。改善这些因素可能比通过增加伊维菌素的剂量或添加其他药物来提高其疗效更重要。
{"title":"Effectiveness of Annual Ivermectin Treatment for Wuchereria bancrofti infection","authors":"A.P. Plaisier, W.A. Stolk, G.J. van Oortmarssen, J.D.F. Habbema","doi":"10.1016/S0169-4758(00)01691-4","DOIUrl":"10.1016/S0169-4758(00)01691-4","url":null,"abstract":"<div><p>Using estimates for the anthelmintic efficacy of a single dose of ivermectin in the treatment of lymphatic filariasis patients, Anton Plaisier, Wilma Stolk, Gerrit van Oortmarssen and Dik Habbema here present and discuss model predictions of the impact of a five-year programme of annual community treatment on the intensity of infection. They show that the effectiveness of such programmes in terms of reductions in the microfilarial density depends critically on the treatment coverage and the pattern of attendance at repeated mass administrations. Improving these factors will possibly be more important than improving the efficacy of ivermectin by increasing its dosage or by adding other drugs.</p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01691-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21701563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-07-01DOI: 10.1016/S0169-4758(00)01676-8
M.T Ferdig, X-z Su
Whole-genome methods are changing the scope of biological questions that can be addressed in malaria research. In the rich context provided by Plasmodium falciparum genome sequencing, genetic mapping is a powerful tool for identifying genes involved in parasite development, invasion, transmission and drug resistance. The recent development of a high-resolution P. falciparum linkage map consisting of hundreds of microsatellite markers will facilitate an integrated genomic approach to understanding the relationship between genetic variations and biological phenotypes. Here, Michael Ferdig and Xin-zhuan Su provide an overview for applying microsatellite markers and genetic maps to gene mapping, parasite typing and studies of parasite population changes.
{"title":"Microsatellite Markers and Genetic Mapping in Plasmodium falciparum","authors":"M.T Ferdig, X-z Su","doi":"10.1016/S0169-4758(00)01676-8","DOIUrl":"10.1016/S0169-4758(00)01676-8","url":null,"abstract":"<div><p>Whole-genome methods are changing the scope of biological questions that can be addressed in malaria research. In the rich context provided by <em>Plasmodium falciparum</em> genome sequencing, genetic mapping is a powerful tool for identifying genes involved in parasite development, invasion, transmission and drug resistance. The recent development of a high-resolution <em>P. falciparum</em> linkage map consisting of hundreds of microsatellite markers will facilitate an integrated genomic approach to understanding the relationship between genetic variations and biological phenotypes. Here, Michael Ferdig and Xin-zhuan Su provide an overview for applying microsatellite markers and genetic maps to gene mapping, parasite typing and studies of parasite population changes.</p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01676-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21701565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-07-01DOI: 10.1016/S0169-4758(00)01668-9
C.J Shiff
{"title":"Can Roll Back Malaria Achieve its Goal?","authors":"C.J Shiff","doi":"10.1016/S0169-4758(00)01668-9","DOIUrl":"10.1016/S0169-4758(00)01668-9","url":null,"abstract":"","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01668-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21701671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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