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More on the Ecological Impact of Fungal Infections on Wildlife Populations 更多关于真菌感染对野生动物种群的生态影响
Parasitology today (Personal ed.)
Pub Date : 2000-09-01 DOI: 10.1016/S0169-4758(00)01714-2
Peter Daszak , Andrew A Cunningham
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引用次数: 6
A Mitochondrion in Entamoeba histolytica? 溶组织内阿米巴的线粒体?
Parasitology today (Personal ed.)
Pub Date : 2000-09-01 DOI: 10.1016/S0169-4758(00)01732-4
Miklós Müller
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引用次数: 13
US Sandflies and Leishmaniasis on the Web 网络上的美国白蛉和利什曼病
Parasitology today (Personal ed.)
Pub Date : 2000-09-01 DOI: 10.1016/S0169-4758(00)01751-8
Janice Taverne
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引用次数: 2
The Nematode Polyprotein Allergens/Antigens 线虫多蛋白过敏原/抗原
Parasitology today (Personal ed.)
Pub Date : 2000-09-01 DOI: 10.1016/S0169-4758(00)01743-9
Malcolm Kennedy

Interest in the nematode polyprotein allergens/antigens (NPAs) originally arose because they were often found to be immunodominant antigens of nematode parasites, and in some cases also potent allergens. Quite separately, they attracted attention as the ‘ladder’ proteins found close to the surface of filarial nematodes. Screening of cDNA expression libraries with antibody from infected humans or domestic animals continues to reveal more NPAs. The search for the biochemical function(s) of NPAs was originally hampered by the lack of amino acid sequence similarities between NPAs and proteins of known function, but much is now known about their biochemical activity, the highly unusual means of their biosynthesis and their gene structure. Here, Malcolm Kennedy provides an update on these intriguing proteins.

对线虫多蛋白过敏原/抗原(NPAs)的兴趣最初是由于它们经常被发现是线虫寄生虫的免疫优势抗原，在某些情况下也是强效过敏原。它们分别引起了人们的注意，因为在丝状线虫表面附近发现了“阶梯”蛋白。用受感染的人或家畜的抗体筛选cDNA表达文库，继续发现更多的NPAs。对NPAs生物化学功能的研究最初受到NPAs与已知功能蛋白质之间缺乏氨基酸序列相似性的阻碍，但现在对其生物化学活性，其生物合成的高度不寻常的方式和基因结构有了很多了解。这里，马尔科姆·肯尼迪提供了关于这些有趣蛋白质的最新信息。
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引用次数: 53
‘Transfection’ vs ‘Transformation’: Defining Terms “转染”与“转化”:定义术语
Parasitology today (Personal ed.)
Pub Date : 2000-09-01 DOI: 10.1016/S0169-4758(00)01736-1
Frank Seeber
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引用次数: 1
Blood-sucking: Old or New? Unravelling the Evolution of Trypanosoma cruzi 吸血:新还是旧?揭示克氏锥虫的进化
Parasitology today (Personal ed.)
Pub Date : 2000-08-01 DOI: 10.1016/S0169-4758(00)01727-0
Jamie Stevens

Schofield, C.J. (2000) Trypanosoma cruzi – the vector–parasite paradox. Mem. Inst. Oswaldo Cruz 95, 535–544

Gaunt, M. and Miles, M. (2000) The ecotopes and evolution of triatomine bugs (Triatominae) and their associated trypanosomes. Mem. Inst. Oswaldo Cruz 95, 557–566

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引用次数: 0
Virtual Tools Against Trypanosomatids 对付锥虫病的虚拟工具
Parasitology today (Personal ed.)
Pub Date : 2000-08-01 DOI: 10.1016/S0169-4758(00)01719-1
Alberto M.R. Dávila
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引用次数: 3
Modelling a Predictable Disaster: 模拟可预测的灾难:
Parasitology today (Personal ed.)
Pub Date : 2000-08-01 DOI: 10.1016/S0169-4758(00)01707-5
I.M. Hastings , U. D’Alessandro

The evolution of drug-resistant malaria is one of the most important factors thwarting the development of effective malaria disease control. Several mathematical models have been developed to try and understand the dynamics of this process and how it can be slowed or even avoided. Much of the mathematics describing the evolution of drug resistance in malaria focuses on the derivation and mechanics of the calculations, which can make it inaccessible to experimentalists and field workers. In this article, Ian Hastings and Umberto D’Alessandro describe general model results without recourse to mathematical details, identify the factors that should be considered in the design of drug control programmes, and discuss the crucial parameters that remain unknown and need to be measured in the field or laboratory.

耐药疟疾的演变是阻碍疟疾疾病有效控制发展的最重要因素之一。一些数学模型已经被开发出来，试图理解这一过程的动力学，以及如何减缓甚至避免这一过程。描述疟疾耐药性演变的许多数学集中在计算的推导和机制上，这可能使实验人员和现场工作人员无法获得。在这篇文章中，Ian Hastings和Umberto D 'Alessandro描述了一般的模型结果，没有诉诸数学细节，确定了在药物控制规划设计中应该考虑的因素，并讨论了仍然未知的关键参数，需要在现场或实验室进行测量。
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引用次数: 173
The Schistosoma japonicum Angle on Vaccine Research 日本血吸虫疫苗研究的角度
Parasitology today (Personal ed.)
Pub Date : 2000-08-01 DOI: 10.1016/S0169-4758(00)01720-8
Don McManus
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引用次数: 5
Hurrah for Genome Projects! 基因组计划万岁!
Parasitology today (Personal ed.)
Pub Date : 2000-08-01 DOI: 10.1016/S0169-4758(00)01713-0
A. Ivens
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引用次数: 4
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