Pub Date : 2000-11-01DOI: 10.1016/S0169-4758(00)01808-1
Barry C Elford
{"title":"Patch Clamping the Malaria-infected Red Blood Cell","authors":"Barry C Elford","doi":"10.1016/S0169-4758(00)01808-1","DOIUrl":"10.1016/S0169-4758(00)01808-1","url":null,"abstract":"","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 11","pages":"Page 462"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01808-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21890563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S0169-4758(00)01788-9
T.A Wynn , K.F Hoffmann
Successful vaccine development for schistosomiasis has been hindered by a lack of consensus on the type of immune response that would provide maximum levels of protective immunity and incomplete knowledge of the key antiparasite effector mechanisms. Many vaccine studies conducted in mice support type-1-cytokine-mediated effector mechanisms, while acquired resistance in humans correlates with type-2-cytokine-mediated responses. However, recent data from cytokine-knockout mice suggest that choosing between these opposing pathways may be less important than previously hypothesized, as discussed here by Thomas Wynn and Karl Hoffmann.
{"title":"Defining a Schistosomiasis Vaccination Strategy – Is it really Th1 versus Th2?","authors":"T.A Wynn , K.F Hoffmann","doi":"10.1016/S0169-4758(00)01788-9","DOIUrl":"10.1016/S0169-4758(00)01788-9","url":null,"abstract":"<div><p>Successful vaccine development for schistosomiasis has been hindered by a lack of consensus on the type of immune response that would provide maximum levels of protective immunity and incomplete knowledge of the key antiparasite effector mechanisms. Many vaccine studies conducted in mice support type-1-cytokine-mediated effector mechanisms, while acquired resistance in humans correlates with type-2-cytokine-mediated responses. However, recent data from cytokine-knockout mice suggest that choosing between these opposing pathways may be less important than previously hypothesized, as discussed here by Thomas Wynn and Karl Hoffmann.</p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 11","pages":"Pages 497-501"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01788-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21891811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S0169-4758(00)01759-2
Aaron G Maule
{"title":"Trematode Infections and Diseases of Man and Animals","authors":"Aaron G Maule","doi":"10.1016/S0169-4758(00)01759-2","DOIUrl":"10.1016/S0169-4758(00)01759-2","url":null,"abstract":"","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 11","pages":"Page 502"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01759-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55960380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parasite-derived mucin-like molecules might be involved in parasite attachment to and invasion of host cells. In addition, parasites might secrete mucin-degrading enzymes, enabling the penetration of protective mucus gels that overlie the mucosal surfaces of their potential hosts. Furthermore, they might generate binding ligands on the membrane-bound mucins of host cells by using specific glycosidases. It is possible that host mucins and mucin-like molecules prevent the establishment of parasites or facilitate parasite expulsion. They might also serve as a source of metabolic energy and adhesion ligands for those parasites adapted to exploit them. Sally Hicks and colleagues here review the biochemical properties of mucins and mucin-like molecules in relation to interactions (established and putative) between protozoan parasites and their hosts.
{"title":"The Role of Mucins in Host–Parasite Interactions. Part I – Protozoan Parasites","authors":"S.J. Hicks , G. Theodoropoulos , S.D. Carrington , A.P. Corfield","doi":"10.1016/S0169-4758(00)01773-7","DOIUrl":"10.1016/S0169-4758(00)01773-7","url":null,"abstract":"<div><p>Parasite-derived mucin-like molecules might be involved in parasite attachment to and invasion of host cells. In addition, parasites might secrete mucin-degrading enzymes, enabling the penetration of protective mucus gels that overlie the mucosal surfaces of their potential hosts. Furthermore, they might generate binding ligands on the membrane-bound mucins of host cells by using specific glycosidases. It is possible that host mucins and mucin-like molecules prevent the establishment of parasites or facilitate parasite expulsion. They might also serve as a source of metabolic energy and adhesion ligands for those parasites adapted to exploit them. Sally Hicks and colleagues here review the biochemical properties of mucins and mucin-like molecules in relation to interactions (established and putative) between protozoan parasites and their hosts.</p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 11","pages":"Pages 476-481"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01773-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21891808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S0169-4758(00)01791-9
T. Ilg
Proteophosphoglycans are an expanding family of highly glycosylated Leishmania proteins with many unusual and some unique structural features. The novel protein–glycan linkage in proteophosphoglycans – phosphoglycosylation of Ser by lipophosphoglycan-like structures – emerges as a major form of protein glycosylation in Leishmania. Here, Thomas Ilg reviews the chemical structure, the ultrastructure, the genes and the potential functions of different members of this novel family of parasite glycoproteins.
{"title":"Proteophosphoglycans of Leishmania","authors":"T. Ilg","doi":"10.1016/S0169-4758(00)01791-9","DOIUrl":"10.1016/S0169-4758(00)01791-9","url":null,"abstract":"<div><p>Proteophosphoglycans are an expanding family of highly glycosylated Leishmania proteins with many unusual and some unique structural features. The novel protein–glycan linkage in proteophosphoglycans – phosphoglycosylation of Ser by lipophosphoglycan-like structures – emerges as a major form of protein glycosylation in Leishmania. Here, Thomas Ilg reviews the chemical structure, the ultrastructure, the genes and the potential functions of different members of this novel family of parasite glycoproteins.</p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 11","pages":"Pages 489-497"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01791-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21891810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S0169-4758(00)01786-5
M. Kavaliers , D.D. Colwell , E. Choleris
Ethopharmacology combines an ethological approach to the understanding of the causes and functions of behaviour with pharmacological analysis of the underlying neuromodulatory mechanisms. Recently, this approach has been applied to the analysis of the responses of animals to parasitized individuals and to the effects of parasites on various host behaviours (eg. host defences, mate responses) and their neurobiological correlates. Martin Kavaliers, Douglas Colwell and Elena Choleris explain here how ethopharmacology can be used to address the mechanisms that underlie the often subtle effects of parasites on host behaviour.
{"title":"Parasites and Behaviour:","authors":"M. Kavaliers , D.D. Colwell , E. Choleris","doi":"10.1016/S0169-4758(00)01786-5","DOIUrl":"https://doi.org/10.1016/S0169-4758(00)01786-5","url":null,"abstract":"<div><p>Ethopharmacology combines an ethological approach to the understanding of the causes and functions of behaviour with pharmacological analysis of the underlying neuromodulatory mechanisms. Recently, this approach has been applied to the analysis of the responses of animals to parasitized individuals and to the effects of parasites on various host behaviours (eg. host defences, mate responses) and their neurobiological correlates. Martin Kavaliers, Douglas Colwell and Elena Choleris explain here how ethopharmacology can be used to address the mechanisms that underlie the often subtle effects of parasites on host behaviour.</p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 11","pages":"Pages 464-468"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01786-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92065682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S0169-4758(00)01765-8
Elvis N Shu
{"title":"Reply to Grant from Shu","authors":"Elvis N Shu","doi":"10.1016/S0169-4758(00)01765-8","DOIUrl":"10.1016/S0169-4758(00)01765-8","url":null,"abstract":"","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 11","pages":"Page 501"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01765-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55960392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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