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Enhancing paracellular permeability by modulating epithelial tight junctions 通过调节上皮紧密连接增强细胞旁通透性
Pharmaceutical science & technology today
Pub Date : 2000-10-01 DOI: 10.1016/S1461-5347(00)00302-3
Peter D Ward , Tim K Tippin , Dhiren R Thakker

The intestinal epithelium is a major barrier to the absorption of hydrophilic drugs. The presence of intercellular junctional complexes, particularly the tight junctions (zona occludens), renders the epithelium impervious to hydrophilic drugs, which cannot diffuse across the cells through the lipid bilayer of the cell membranes. There have been significant advances in understanding the structure and cellular regulation of tight junctions over the past decade. This article reviews current knowledge regarding the physiological regulation of tight junctions and paracellular permeability, and recent progress towards the rational design of agents that can effectively and safely increase paracellular permeability via modulation of tight junctions.

肠上皮是亲水性药物吸收的主要屏障。细胞间连接复合物的存在，特别是紧密连接(闭塞带)，使上皮不受亲水性药物的影响，亲水性药物不能通过细胞膜的脂质双分子层在细胞内扩散。在过去的十年里，在理解紧密连接的结构和细胞调节方面取得了重大进展。本文综述了目前关于紧密连接和细胞旁通透性的生理调节的知识，以及通过调节紧密连接有效、安全地增加细胞旁通透性的药物的合理设计的最新进展。
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引用次数: 217
Monitor: PROFILE 监视器:概要
Pharmaceutical science & technology today
Pub Date : 2000-10-01 DOI: 10.1016/S1461-5347(00)00304-7
Yan Zhang, Donald W Miller

P-glycoprotein and multidrug resistance-associated protein transporters in the blood–brain barrier: another important brick in the wall

血脑屏障中的p -糖蛋白和多药耐药相关蛋白转运体:血脑屏障中的另一个重要屏障
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引用次数: 0
Making vaccinations easier to swallow 使疫苗更容易吞咽
Pharmaceutical science & technology today
Pub Date : 2000-10-01 DOI: 10.1016/S1461-5347(00)00297-2
David Bradley
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引用次数: 0
The scope and potential of vaginal drug delivery 阴道给药的范围和潜力
Pharmaceutical science & technology today
Pub Date : 2000-10-01 DOI: 10.1016/S1461-5347(00)00296-0
Kavita Vermani, Sanjay Garg

The vagina, in addition to being a genital organ with functions related to conception, serves as a potential route for drug administration. Mainly used for local action in the cervico-vaginal region, it has the potential of delivering drugs for systemic effects and uterine targeting. Currently available vaginal dosage forms have several limitations, necessitating the need to develop novel drug delivery systems. In addition, consideration of the regulatory aspects and consumer preferences for vaginal formulations is also required in the early stages of development.

阴道，除了是一个与受孕有关的生殖器官外，也是一个潜在的给药途径。它主要用于宫颈阴道区域的局部作用，具有全身作用和子宫靶向给药的潜力。目前可用的阴道剂型有几个限制，需要开发新的药物输送系统。此外，还需要在开发的早期阶段考虑管理方面和消费者对阴道配方的偏好。
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引用次数: 211
Crohn’s disease treatable in youngsters 克罗恩病在青少年中可以治愈
Pharmaceutical science & technology today
Pub Date : 2000-10-01 DOI: 10.1016/S1461-5347(00)00300-X
David Bradley
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引用次数: 0
Drug–excipient interactions and their affect on absorption 药物-赋形剂相互作用及其对吸收的影响
Pharmaceutical science & technology today
Pub Date : 2000-10-01 DOI: 10.1016/S1461-5347(00)00301-1
Kimberley Jackson, David Young, Sonia Pant

Excipient(s) are traditionally thought of as inert but they can have a tremendous impact on the ultimate pharmacological availability of a drug substance when added to a formulation. The magnitude of this effect will depend on the characteristics of the drug and on the quantity and properties of the excipients. The aim of this article is to identify the various physicochemical and physiological processes that can be altered by drug–excipient interactions and to explore mechanisms by which they might occur. The regulatory implications of drug–excipient interactions will also be discussed.

赋形剂传统上被认为是惰性的，但当它们添加到制剂中时，它们会对药物的最终药理可用性产生巨大的影响。这种作用的大小取决于药物的特性以及辅料的数量和性质。本文的目的是确定各种物理化学和生理过程，这些过程可以被药物-赋形剂相互作用所改变，并探索它们可能发生的机制。还将讨论药物赋形剂相互作用的监管意义。
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引用次数: 107
Monitor: PROGRESS 监视器:进步
Pharmaceutical science & technology today
Pub Date : 2000-10-01 DOI: 10.1016/S1461-5347(00)00303-5
Andrew W. Lloyd, A. Christy

Monitor provides an insight into the latest developments in pharmaceutical science and technology through brief synopses of recent presentations, publications and patents, and expert commentaries on the latest technologies. There are two sections: Progress summarizes the latest developments in pharmaceutical process technology, formulation, analytical technology, sterilization, controlled drug delivery systems and regulatory issues; Profiles offers expert commentary on emerging technologies, novel processes and strategic, organizational and logistic issues underlying pharmaceutical R&D.

Monitor提供了对制药科学和技术的最新发展的见解，通过最近的演讲，出版物和专利的简要介绍，以及对最新技术的专家评论。有两个部分:进展概述了制药工艺技术、配方、分析技术、灭菌、受控给药系统和监管问题的最新发展;Profiles提供对新兴技术、新工艺、战略、组织和物流问题的专家评论。
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引用次数: 0
Monitor: progress and profiles 监控:进度和概要文件
Pharmaceutical science & technology today
Pub Date : 2000-09-01 DOI: 10.1016/S1461-5347(00)00293-5
Andrew W Lloyd, A.Christy Hunter

Monitor provides an insight into the latest developments in pharmaceutical science and technology through brief synopses of recent presentations, publications and patents, and expert commentaries on the latest technologies. There are two sections: Progress summarizes the latest developments in pharmaceutical process technology, formulation, analytical technology, sterilization, controlled drug delivery systems and regulatory issues; Profiles offers expert commentary on emerging technologies, novel processes and strategic, organizational and logistic issues underlying pharmaceutical R&D.

Monitor提供了对制药科学和技术的最新发展的见解，通过最近的演讲，出版物和专利的简要介绍，以及对最新技术的专家评论。有两个部分:进展概述了制药工艺技术、配方、分析技术、灭菌、受控给药系统和监管问题的最新发展;Profiles提供对新兴技术、新工艺、战略、组织和物流问题的专家评论。
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引用次数: 0
DeForMing the AToM 取消AToM
Pharmaceutical science & technology today
Pub Date : 2000-09-01 DOI: 10.1016/S1461-5347(00)00291-1
Raymond C Rowe (Research Associate)
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引用次数: 0
EU approval for pegylated hepatitis C drug 欧盟批准聚乙二醇丙型肝炎药物
Pharmaceutical science & technology today
Pub Date : 2000-09-01 DOI: 10.1016/S1461-5347(00)00290-X
David Bradley
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引用次数: 0
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