Pub Date : 2000-12-01DOI: 10.1016/S1461-5347(00)00321-7
David Bradley
{"title":"Polymer gel passes safety tests, and is set to deliver drugs","authors":"David Bradley","doi":"10.1016/S1461-5347(00)00321-7","DOIUrl":"10.1016/S1461-5347(00)00321-7","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00321-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21938982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S1461-5347(00)00310-2
Malcolm J.W Povey
Ultrasound is a technique that is capable of tremendous accuracy and precision, whether in the laboratory or on-line in the factory. Data acquisition rates of the order of kHz transform process monitoring, providing unprecedented information of high statistical value. Ultrasound is complementary to other measurement modalities, probing the elastic and thermal properties of materials. In the absence of air bubbles, ultrasound travels through concentrated systems of particles, providing information about size, compressibility, structure, distribution, chemical and phase state. It is safe, can be non-invasive and can be economical. In these respects, it is unique.
{"title":"Particulate characterization by ultrasound","authors":"Malcolm J.W Povey","doi":"10.1016/S1461-5347(00)00310-2","DOIUrl":"10.1016/S1461-5347(00)00310-2","url":null,"abstract":"<div><p>Ultrasound is a technique that is capable of tremendous accuracy and precision, whether in the laboratory or on-line in the factory. Data acquisition rates of the order of kHz transform process monitoring, providing unprecedented information of high statistical value. Ultrasound is complementary to other measurement modalities, probing the elastic and thermal properties of materials. In the absence of air bubbles, ultrasound travels through concentrated systems of particles, providing information about size, compressibility, structure, distribution, chemical and phase state. It is safe, can be non-invasive and can be economical. In these respects, it is unique.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00310-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21916162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S1461-5347(00)00307-2
David Bradley
{"title":"Breast cancer drug for women who fail to respond to tamoxifen","authors":"David Bradley","doi":"10.1016/S1461-5347(00)00307-2","DOIUrl":"10.1016/S1461-5347(00)00307-2","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00307-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21916158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S1461-5347(00)00312-6
Andrew W Lloyd , A.Christy Hunter , Monitor Editors
Monitor provides an insight into the latest developments in pharmaceutical science and technology through brief synopses of recent presentations, publications and patents, and expert commentaries on the latest technologies. There are two sections: Progress summarizes the latest developments in pharmaceutical process technology, formulation, analytical technology, sterilization, controlled drug delivery systems and regulatory issues; Profiles offers expert commentary on emerging technologies, novel processes and strategic, organizational and logistic issues underlying pharmaceutical R&D.
{"title":"Monitor: progress and profiles","authors":"Andrew W Lloyd , A.Christy Hunter , Monitor Editors","doi":"10.1016/S1461-5347(00)00312-6","DOIUrl":"10.1016/S1461-5347(00)00312-6","url":null,"abstract":"<div><p>Monitor provides an insight into the latest developments in pharmaceutical science and technology through brief synopses of recent presentations, publications and patents, and expert commentaries on the latest technologies. There are two sections: Progress summarizes the latest developments in pharmaceutical process technology, formulation, analytical technology, sterilization, controlled drug delivery systems and regulatory issues; Profiles offers expert commentary on emerging technologies, novel processes and strategic, organizational and logistic issues underlying pharmaceutical R&D.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00312-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21916165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S1461-5347(00)00305-9
Sara-Kaye Madsen , David J Mooney
DNA delivery from polymers is currently being applied to the multidisciplinary science of gene therapy and tissue engineering. This is motivated by the potential of treating a wide range of diseases and the provision of alternatives to tissue and organ transplantation. The combination of these fields involves the incorporation of genes into polymeric matrices that can be injected or implanted to promote tissue regeneration. This review presents an overview of current and developing polymer systems for gene delivery and tissue engineering.
{"title":"Delivering DNA with polymer matrices: applications in tissue engineering and gene therapy","authors":"Sara-Kaye Madsen , David J Mooney","doi":"10.1016/S1461-5347(00)00305-9","DOIUrl":"10.1016/S1461-5347(00)00305-9","url":null,"abstract":"<div><p>DNA delivery from polymers is currently being applied to the multidisciplinary science of gene therapy and tissue engineering. This is motivated by the potential of treating a wide range of diseases and the provision of alternatives to tissue and organ transplantation. The combination of these fields involves the incorporation of genes into polymeric matrices that can be injected or implanted to promote tissue regeneration. This review presents an overview of current and developing polymer systems for gene delivery and tissue engineering.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00305-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21916163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-11-01DOI: 10.1016/S1461-5347(00)00311-4
Ian Wilding , Peter Hirst , Alyson Connor
Over recent years, there has been a significant growth in the number of new drugs entering development with challenging pharmaceutical (e.g. solubility) and biopharmaceutical (e.g. permeability) properties. As a consequence, there is an increasing number of pharmaceutical companies using human absorption studies to provide a ‘route map’ for development. These projects are typically undertaken early in clinical development and utilize engineering-based capsules to provide non-invasive drug delivery to the selected sites of the human gut. The Enterion capsule has recently been developed to provide for the delivery of a wide range of different drug formulations, for example, solution, powder and granulate, into any region of the gut, both easily and efficiently.
{"title":"Development of a new engineering-based capsule for human drug absorption studies","authors":"Ian Wilding , Peter Hirst , Alyson Connor","doi":"10.1016/S1461-5347(00)00311-4","DOIUrl":"10.1016/S1461-5347(00)00311-4","url":null,"abstract":"<div><p>Over recent years, there has been a significant growth in the number of new drugs entering development with challenging pharmaceutical (e.g. solubility) and biopharmaceutical (e.g. permeability) properties. As a consequence, there is an increasing number of pharmaceutical companies using human absorption studies to provide a ‘route map’ for development. These projects are typically undertaken early in clinical development and utilize engineering-based capsules to provide non-invasive drug delivery to the selected sites of the human gut. The Enterion capsule has recently been developed to provide for the delivery of a wide range of different drug formulations, for example, solution, powder and granulate, into any region of the gut, both easily and efficiently.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00311-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21916164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-10-01DOI: 10.1016/S1461-5347(00)00299-6
David Bradley
{"title":"Alternative uses found for cancer drug","authors":"David Bradley","doi":"10.1016/S1461-5347(00)00299-6","DOIUrl":"10.1016/S1461-5347(00)00299-6","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(00)00299-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21878158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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