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E-Bayesian Estimation Using Spacing Function for Inverse Lindley Adaptive Type-I Progressively Censored Samples: Comparative Study with Applications. 使用间距函数对反林德雷自适应 I 型渐进删失样本进行 E-Bayesian 估计:比较研究与应用》。
IF 1.8 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5567457
Mazen Nassar, Refah Alotaibi, Ahmed Elshahhat

For the first time, this paper offers the Bayesian and E-Bayesian estimation methods using the spacing function (SF) instead of the classical likelihood function. The inverse Lindley distribution, including its parameter and reliability measures, is discussed in this study through the mentioned methods, along with some other classical approaches. Six-point and six-interval estimations based on an adaptive Type-I progressively censored sample are considered. The likelihood and product of spacing methods are used in classical inferential setups. The approximate confidence intervals are discussed using both classical approaches. For various parameters, the Bayesian methodology is studied by taking both likelihood and SFs as observed data sources to derive the posterior distributions. Moreover, the E-Bayesian estimation method is considered by using the same data sources in the usual Bayesian approach. The Bayes and E-Bayes credible intervals using both likelihood and SFs are also taken into consideration. Several Monte Carlo experiments are carried out to assess the performance of the acquired estimators, depending on different accuracy criteria and experimental scenarios. Finally, two data sets from the engineering and physics sectors are analyzed to demonstrate the superiority and practicality of the suggested approaches.

本文首次提出了使用间距函数(SF)代替经典似然函数的贝叶斯和电子贝叶斯估计方法。本研究通过上述方法讨论了逆 Lindley 分布,包括其参数和可靠性度量,以及其他一些经典方法。研究还考虑了基于自适应 I 型逐步删减样本的六点和六区间估计。在经典推论设置中使用了似然法和间隔乘积法。使用这两种经典方法讨论了近似置信区间。对于各种参数,研究了贝叶斯方法,将似然法和 SFs 作为观测数据源,得出后验分布。此外,还考虑了 E-Bayesian 估计方法,即在通常的贝叶斯方法中使用相同的数据源。还考虑了使用似然和 SF 的贝叶斯和 E-Bayes 可信区间。根据不同的精度标准和实验情况,进行了若干蒙特卡罗实验,以评估所获得的估计器的性能。最后,对工程和物理领域的两个数据集进行了分析,以证明所建议方法的优越性和实用性。
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引用次数: 0
Research on Modeling and Motion Optimization for an Underactuated Bionic Scorpion Robot Arm 欠驱动仿生蝎子机械臂的建模和运动优化研究
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-05-31 DOI: 10.1155/2024/9439878
Ning Cao, Jinsheng Liu, Feiling Shen, Xuming Pei, Yupu Liu, Hengyu Li
Flexible screen possessing a high-contrast ratio to accomplish high-definition display can be attributed to the accuracy of polarizer assembly. Different from the existing polarizer attached onto a flexible screen, resulting in low-accuracy and nonalignment attaching behaviors, a unique approach of underactuated bionic scorpion robot arms can be developed to explore the stable capture and accurate alignment motion operations. Overall structure design and D–H kinematic simulation of bionic scorpion robot arm can be conducted to analyze virtual three-key typical motions. Motion optimization of structural parameters and corresponding motion workspaces verification can be adopted to evaluate motion range and ability. Experiments can be utilized to verify the rationality of theoretical modeling and optimization simulation of bionic scorpion robot arm. Experimental results illustrate that it is evident to demonstrate that the motion behaviors of bionic scorpion robot arm can be verified to be consistent with three key states of virtual theoretical motions. The key joints possessing minor errors may also be utilized to illustrate the relatively excellent dynamic motions existing in bionic scorpion robot arm. Further, advancing the stable motion behaviors of bionic scorpion robot arm may solve the problems of low-accuracy and misalignment polarizer attachments.
柔性屏幕具有高对比度,可实现高清显示,这与偏振片装配的精确性密不可分。有别于现有将偏振片固定在柔性屏幕上导致的低精度和不对准的固定行为,可以开发一种独特的欠驱动仿生蝎子机械臂方法,探索稳定捕捉和精确对准的运动操作。可对仿生蝎子机械臂进行整体结构设计和 D-H 运动学仿真,分析虚拟三键典型运动。可通过结构参数的运动优化和相应的运动工作空间验证来评估运动范围和能力。利用实验验证仿生蝎子机械臂理论建模和优化仿真的合理性。实验结果表明,仿生蝎子机械臂的运动行为可以验证与虚拟理论运动的三个关键状态一致。误差较小的关键关节也可用于说明仿生蝎子机械臂存在相对出色的动态运动。此外,推进仿生蝎子机械臂的稳定运动行为可解决偏振器附件精度低和不对中的问题。
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引用次数: 0
Motion Accuracy of Pneumatic Stepper Motor-Driven Robotic System Developed for MRI-Guided High-Intensity Focused Ultrasound Treatment of Prostate Disease 为核磁共振成像引导的高强度聚焦超声治疗前列腺疾病而开发的气动步进电机驱动机器人系统的运动精度
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-05-10 DOI: 10.1155/2024/5556537
Hyunkwan Seo, Sung Kwan Hwang, Hee-Won Kim, Kyu Chan Lee
The latest advancement in high-intensity focused ultrasound (HIFU) treatment technology integrates magnetic resonance imaging (MRI) guidance for precise treatment of prostate disease. As conventional electromagnetic motors are not applicable for utilization within MRI scanners, we have developed a prototype robotic system driven by pneumatic stepper motors to control the movement of the HIFU transducer within an intrarectal probe during MRI-guided HIFU treatment procedures. These pneumatic stepper motors were constructed entirely from MRI-compatible plastic materials. Assessment of the robotic system’s MRI compatibility was conducted utilizing a 3.0T MRI scanner, revealing no discernible MRI image distortion with a minor decrease in the signal-to-noise ratio (2.8%) during the motor operation. The robotic system enabled the transducer to move inside the probe with two degrees of freedom, allowing both linear and rotational motion. The positional accuracy of the transducer movement was assessed, yielding ±0.20 and ±0.22 mm accuracies in the forward and backward linear movements, respectively, and ±0.79° and ±0.74° accuracies in the clockwise and counterclockwise rotational motions, respectively. Emulation of authentic HIFU procedures involved creating a two-dimensional array of thermal lesions in a tissue-mimicking phantom, achieving positional accuracy within ±1 mm for the generated HIFU focal spots. The prototype robotic system incorporating pneumatic stepper motors fabricated entirely from MRI-compatible plastic materials has demonstrated the requisite positional accuracy necessary for effective HIFU treatment of prostate disease, indicating substantial promise for future clinical application.
高强度聚焦超声(HIFU)治疗技术的最新进展是整合了磁共振成像(MRI)引导,以精确治疗前列腺疾病。由于传统的电磁电机不适用于核磁共振扫描仪,我们开发了一种由气动步进电机驱动的机器人系统原型,用于在核磁共振引导的 HIFU 治疗过程中控制直肠内探头中 HIFU 传感器的移动。这些气动步进电机完全由磁共振成像兼容的塑料材料制成。利用 3.0T 核磁共振成像扫描仪对机器人系统的核磁共振成像兼容性进行了评估,结果显示,在电机运行期间,核磁共振成像图像没有明显失真,信噪比略有下降(2.8%)。机器人系统使传感器能在探头内以两个自由度移动,允许线性和旋转运动。对换能器运动的位置精度进行了评估,结果显示,向前和向后直线运动的精度分别为±0.20毫米和±0.22毫米,顺时针和逆时针旋转运动的精度分别为±0.79°和±0.74°。真实 HIFU 程序的模拟包括在组织模拟模型中创建二维热病灶阵列,生成的 HIFU 病灶位置精度在 ±1 毫米以内。机器人系统原型采用气动步进电机,完全由核磁共振成像兼容的塑料材料制造而成,已显示出有效治疗前列腺疾病所需的定位精度,为未来的临床应用带来了巨大希望。
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引用次数: 0
Artificial Intelligence in Cardiology and Atherosclerosis in the Context of Precision Medicine: A Scoping Review 精准医疗背景下心脏病学和动脉粥样硬化中的人工智能:范围综述
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-04-30 DOI: 10.1155/2024/2991243
Oliwia Kolaszyńska, Jacek Lorkowski
Cardiovascular diseases remain the main cause of death worldwide which makes it essential to better understand, diagnose, and treat atherosclerosis. Artificial intelligence (AI) and novel technological solutions offer us new possibilities and enable the practice of individually tailored medicine. The study was performed using the PRISMA protocol. As of January 10, 2023, the analysis has been based on a review of 457 identified articles in PubMed and MEDLINE databases. The search covered reviews, original articles, meta-analyses, comments, and editorials published in the years 2009–2023. In total, 123 articles met inclusion criteria. The results were divided into the subsections presented in the review (genome-wide association studies, radiomics, and other studies). This paper presents actual knowledge concerning atherosclerosis, in silico, and big data analyses in cardiology that affect the way medicine is practiced in order to create an individual approach and adjust the therapy of atherosclerosis.
心血管疾病仍然是全球死亡的主要原因,因此必须更好地了解、诊断和治疗动脉粥样硬化。人工智能(AI)和新颖的技术解决方案为我们提供了新的可能性,使我们能够实践量身定制的医疗。本研究采用 PRISMA 协议进行。截至 2023 年 1 月 10 日,分析基于对 PubMed 和 MEDLINE 数据库中 457 篇已识别文章的审查。搜索范围包括 2009-2023 年间发表的综述、原创文章、荟萃分析、评论和社论。共有 123 篇文章符合纳入标准。研究结果分为综述中的几个子部分(全基因组关联研究、放射组学和其他研究)。本文介绍了心脏病学中有关动脉粥样硬化、硅学和大数据分析的实际知识,这些知识影响着医学实践的方式,以便创建个性化方法并调整动脉粥样硬化的治疗。
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引用次数: 0
Design and Performance Analysis of a Mecanum-Built Perturbation-Based Balance Training Device 基于惯性的平衡训练装置的设计和性能分析
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-03-29 DOI: 10.1155/2024/3622556
Jaison Jacob Mathunny, Hari Krishnan S, Ashokkumar Devaraj, Varshini Karthik
This study proposes a mecanum-built perturbation-based balance training device aimed at improving motor adaptive skills for fall prevention in individuals with neurological disorders or the elderly. Incorporating multidirectional fall simulations in line with modified constraint-induced movement therapy, the device’s efficacy was evaluated by measuring the distance traveled and peak acceleration under different static loads (20, 30, and 40 kg) and input accelerations (1, 2, and 3 m/s2). A pilot study with 10 subjects was conducted to assess device performance, utilizing repeated measures analysis of variance and Bonferroni’s post hoc analysis. Results indicated a load-dependent reduction in distance traveled, with an average mean difference of 0.74–1.23 cm between the 20 and 40 kg loads for trials of 9 and 18 cm, respectively. Despite varying loads, the device consistently achieved near-anticipated peak accelerations, suggesting its capability to induce effective perturbations. The study also observed a significant lateral movement preference, suggesting adjustments to pulse width modulation and time period may optimize lateral movement performance.
本研究提出了一种基于扰动的机械平衡训练装置,旨在提高神经系统疾病患者或老年人的运动适应能力,预防跌倒。该装置结合了与改良约束诱导运动疗法一致的多向跌倒模拟,通过测量不同静态负载(20、30 和 40 千克)和输入加速度(1、2 和 3 m/s2)下的行走距离和峰值加速度来评估其功效。利用重复测量方差分析和 Bonferroni 的事后分析,对 10 名受试者进行了试点研究,以评估设备性能。结果表明,行走距离的减少与负载有关,在 9 厘米和 18 厘米的试验中,20 千克和 40 千克负载之间的平均差异分别为 0.74-1.23 厘米。尽管载荷不同,该装置始终能达到接近预期的峰值加速度,这表明它有能力诱发有效的扰动。研究还观察到了明显的横向运动偏好,表明调整脉冲宽度调制和时间周期可优化横向运动性能。
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引用次数: 0
Different Dual-Task Paradigm Reduce Postural Control Ability and Dynamic Stability of Healthy Young Adults during Stair Descent 不同的双重任务范式降低了健康年轻人下楼梯时的姿势控制能力和动态稳定性
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-03-11 DOI: 10.1155/2024/9942042
Jiankang Yang, Shifang Yan, Chuanbao Cao
Objective. This study aimed to compare the impacts of different dual-task paradigms on the postural control ability and dynamic stability of the youth during stair descent. Method. Twenty young adults without regular exercise habits were randomly recruited to perform stair descent tasks with three different paradigms: single-task, cognitive dual-task, and manual dual-task. Kinematic and dynamic data were collected using an 8 Vicon motion analysis system and a Kistler force plate to evaluate postural control ability and dynamic stability during stair descent. Results. The variation trends of lower limb joint moment were similar under the three task models. Compared with a single-task, both dual-task paradigms significantly reduced the mechanical parameters and dynamic stability during stair descent. Conclusion. The dual-task paradigm increases the risk of stair-related falls. Both cognitive and manual tasks have similar impacts on postural control ability and dynamic stability during stair walking. It is recommended that people avoid performing dual tasks during stair descent.
研究目的本研究旨在比较不同的双重任务范式对青少年下楼梯时姿势控制能力和动态稳定性的影响。方法。随机招募 20 名无运动习惯的青少年,让他们以三种不同的范式完成下楼梯任务:单一任务、认知双任务和手动双任务。使用 8 Vicon 运动分析系统和 Kistler 力板收集运动学和动态数据,以评估下楼梯时的姿势控制能力和动态稳定性。结果显示在三种任务模式下,下肢关节力矩的变化趋势相似。与单一任务相比,两种双任务模式都显著降低了下楼梯时的机械参数和动态稳定性。结论双重任务范式会增加在楼梯上跌倒的风险。认知任务和手动任务对楼梯行走时的姿势控制能力和动态稳定性有相似的影响。建议人们在下楼梯时避免执行双重任务。
{"title":"Different Dual-Task Paradigm Reduce Postural Control Ability and Dynamic Stability of Healthy Young Adults during Stair Descent","authors":"Jiankang Yang, Shifang Yan, Chuanbao Cao","doi":"10.1155/2024/9942042","DOIUrl":"https://doi.org/10.1155/2024/9942042","url":null,"abstract":"<i>Objective</i>. This study aimed to compare the impacts of different dual-task paradigms on the postural control ability and dynamic stability of the youth during stair descent. <i>Method</i>. Twenty young adults without regular exercise habits were randomly recruited to perform stair descent tasks with three different paradigms: single-task, cognitive dual-task, and manual dual-task. Kinematic and dynamic data were collected using an 8 Vicon motion analysis system and a Kistler force plate to evaluate postural control ability and dynamic stability during stair descent. <i>Results</i>. The variation trends of lower limb joint moment were similar under the three task models. Compared with a single-task, both dual-task paradigms significantly reduced the mechanical parameters and dynamic stability during stair descent. <i>Conclusion</i>. The dual-task paradigm increases the risk of stair-related falls. Both cognitive and manual tasks have similar impacts on postural control ability and dynamic stability during stair walking. It is recommended that people avoid performing dual tasks during stair descent.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"286 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140108156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptive Approximation Sliding-Mode Control of an Uncertain Continuum Robot with Input Nonlinearities and Disturbances 具有输入非线性和干扰的不确定连续机器人的自适应逼近滑模控制
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-03-06 DOI: 10.1155/2024/8533606
Shoulin Xu
This paper develops an adaptive nonsingular fast terminal sliding-mode control (ANFTSMC) scheme for the continuum robot subjected to uncertain dynamics, external disturbances, and input nonlinearities (e.g., actuator deadzones/faults). Concretely, a function approximation technique (FAT) is utilized to estimate unknown robot dynamics and actuator deadzones/faults online. Furthermore, a disturbance observer (DO) is devised to make up for unknown external disturbances. Then, an ANFTSMC scheme combined with FAT and DO is developed, to expedite the restoration of the stability for the continuum robot. The proposed ANFTSMC not only can retain the benefits of traditional terminal sliding-mode control (TSMC), containing easy enforcement, quick response, and robustness to uncertainties but also dispose of the latent singularity for traditional faster TSMC designs. Afterward, the simulation results show that the proposed controller can effectively improve the trajectory tracking accuracy of the continuum robot, and the tracking root-mean-square errors are 0.0115 and 0.0128 rad. Finally, the effectiveness of ANFTSMC scheme is validated by experiments.
本文针对不确定动态、外部干扰和输入非线性(如致动器死区/故障)的连续体机器人,开发了一种自适应非奇异快速终端滑模控制(ANFTSMC)方案。具体来说,利用函数逼近技术(FAT)来在线估计未知的机器人动力学和致动器死区/故障。此外,还设计了一个干扰观测器(DO)来弥补未知的外部干扰。然后,开发出一种与 FAT 和 DO 相结合的 ANFTSMC 方案,以加快连续机器人稳定性的恢复。所提出的 ANFTSMC 不仅保留了传统末端滑模控制(TSMC)的优点,包括易于执行、快速响应和对不确定性的鲁棒性,还消除了传统快速 TSMC 设计的潜在奇异性。随后,仿真结果表明,所提出的控制器能有效提高连续体机器人的轨迹跟踪精度,跟踪均方根误差分别为 0.0115 和 0.0128 rad。最后,实验验证了 ANFTSMC 方案的有效性。
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引用次数: 0
Electromechanical Coupling Model for Ionic Liquid Gel Soft Actuators 离子液体凝胶软致动器的机电耦合模型
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-02-13 DOI: 10.1155/2024/8369544
Chenghong Zhang, Chengguang Zhang, Guangping Tian, Xun Gu
A soft robot is composed of soft materials, which exhibit continuous deformation and driving structure integration and can arbitrarily change shapes and sizes over wide ranges. It shows strong adaptability to unstructured environments and has broad application prospects in military reconnaissance, medical rescues, agricultural production, etc. Soft robots based on ionic electroactive polymers (EAPs) have low-driving voltages, large-actuation displacements, fast responses, light weights, and low powers and have become a hot research field of bionic robots. Ionic liquid gels (ILGs) are new ionic EAPs. In this study, a new soft actuator was designed based on an ILG, and the electromechanical coupling model of an ILG soft actuator was studied in detail. Based on the system transfer function method, a mechatronic coupling model for the soft actuator was developed. According to the material characteristics and current response law of the ILG-containing EAP, an equivalent circuit model was used to describe transfer of the output current and input voltage. Based on the equivalent transformer model for ionic polymer–metal composite (IPMC) actuators proposed by Claudia Bonomo, the electromechanical coupling equation and a driving equation of the ILG soft actuator were established. The least-squares method was used with the coupling model of an ILG soft actuator to identify the system parameters for the model, and the effects of the structural parameters on the end displacement and driving force of the soft actuator were analyzed.
软体机器人由软性材料组成,具有连续变形和驱动结构一体化的特点,可在较大范围内任意改变形状和大小。它对非结构化环境具有很强的适应性,在军事侦察、医疗救援、农业生产等领域具有广阔的应用前景。基于离子电活性聚合物(EAPs)的软机器人具有驱动电压低、作用位移大、响应速度快、重量轻、功率低等特点,已成为仿生机器人的热门研究领域。离子液体凝胶(ILGs)是一种新型离子 EAPs。本研究基于离子液体凝胶设计了一种新型软致动器,并详细研究了离子液体凝胶软致动器的机电耦合模型。基于系统传递函数方法,建立了软致动器的机电耦合模型。根据含 ILG 的 EAP 的材料特性和电流响应规律,使用等效电路模型来描述输出电流和输入电压的传递。根据 Claudia Bonomo 提出的离子聚合物-金属复合材料 (IPMC) 致动器等效变压器模型,建立了 ILG 软致动器的机电耦合方程和驱动方程。利用最小二乘法和 ILG 软致动器耦合模型确定了模型的系统参数,并分析了结构参数对软致动器末端位移和驱动力的影响。
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引用次数: 0
SHAKF-PU: Sage-Husa Adaptive Kalman Filtering-Based Pedestrian Characteristic Parameter Update Mechanism for Enhancing Step Length Estimation in Pedestrian Dead Reckoning. SHAKF-PU:基于 Sage-Husa 自适应卡尔曼滤波的行人特征参数更新机制,用于增强行人惯性推算中的步长估计。
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-02-08 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1150076
Chinyang Henry Tseng, Jiunn-Yih Wu

Step length estimation (SLE) is the core process for pedestrian dead reckoning (PDR) for indoor positioning. Original SLE requires accurate estimations of pedestrian characteristic parameter (PCP) by the linear update, which may cause large distance errors. To enhance SLE, this paper proposes the Sage-Husa adaptive Kalman filtering-based PCP update (SHAKF-PU) mechanism for enhancing SLE in PDR. SHAKF has the characteristic of predicting the trend of historical data; the estimated PCP is closer to the true value than the linear update. Since different kinds of pedestrians can influence the PCP estimation, adaptive PCP estimation is required. Compared with the classical Kalman filter, SHAKF updates its Q and R parameters in each update period so the estimated PCP can be more accurate than other existing methods. The experimental results show that SHAKF-PU reduces the error by 24.86% compared to the linear update, and thus, the SHAKF-PU enhances the indoor positioning accuracy for PDR.

步长估计(SLE)是室内定位行人惯性推算(PDR)的核心过程。原始 SLE 需要通过线性更新来准确估计行人特征参数(PCP),这可能会导致较大的距离误差。为了增强 SLE,本文提出了基于 Sage-Husa 自适应卡尔曼滤波的 PCP 更新(SHAKF-PU)机制,以增强 PDR 中的 SLE。SHAKF 具有预测历史数据趋势的特点,与线性更新相比,估计的 PCP 更接近真实值。由于不同类型的行人会影响 PCP 估计,因此需要自适应 PCP 估计。与经典卡尔曼滤波器相比,SHAKF 在每个更新周期都会更新 Q 和 R 参数,因此估计的 PCP 比其他现有方法更准确。实验结果表明,与线性更新相比,SHAKF-PU 的误差减少了 24.86%,因此,SHAKF-PU 提高了 PDR 的室内定位精度。
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引用次数: 0
Nanoparticle Delivery in Microvascular after Cerebral Ischemia: A Simulation Study 脑缺血后微血管中的纳米粒子输送:模拟研究
IF 2.2 4区 计算机科学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-02-07 DOI: 10.1155/2024/6637846
Peiqian Chen, Bing Dong, Weiwu Yao
Nanodrug delivery systems have been used in the diagnosis and treatment of ischemic stroke. However, the delivery mechanisms of nanoparticles within microvascular after cerebral ischemia have not been systematically revealed. This study aims to investigate the binding of different nanoparticles to the walls of ischemic brain microvascular through numerical simulations. In this study, 3D models of cerebral microvascular based on ischemic pathological changes are constructed. After building the mesh of microvascular, computational fluid dynamics is used to simulate blood flow and nanoparticle delivery. The simulation results show that the total amount of binding nanoparticles with small size is higher than that with large size. The large-sized nanoparticles are more easily delivered to the stenosis. The density of the nanoparticles has no significant effect on delivery. Furthermore, the study finds that the presence of red blood cells can significantly enhance the delivery efficiency of nanoparticles. In addition to evaluating the forces exerted on the nanoparticles, the impact of the binding affinity of the modified ligand on nanoparticles to the target receptor on delivery is investigated. In summary, selecting suitable nanoparticles according to different targets will improve the delivery efficiency of nanodrugs. The microvascular delivery model of nanoparticles proposed in this study may be helpful in the design of nanoparticles for diagnosis and treatment of cerebral ischemia.
纳米药物输送系统已被用于缺血性中风的诊断和治疗。然而,纳米颗粒在脑缺血后微血管内的输送机制尚未被系统揭示。本研究旨在通过数值模拟研究不同纳米粒子与缺血性脑微血管壁的结合。本研究构建了基于缺血病理变化的脑微血管三维模型。建立微血管网格后,利用计算流体动力学模拟血流和纳米粒子的输送。模拟结果表明,小尺寸纳米粒子的结合总量高于大尺寸纳米粒子。大尺寸的纳米粒子更容易输送到狭窄处。纳米粒子的密度对输送没有明显影响。此外,研究还发现,红细胞的存在能显著提高纳米粒子的输送效率。除了评估纳米粒子所受的力之外,还研究了纳米粒子上的修饰配体与目标受体的结合亲和力对递送的影响。总之,根据不同的靶点选择合适的纳米颗粒将提高纳米药物的递送效率。本研究提出的纳米颗粒微血管递送模型可能有助于设计用于诊断和治疗脑缺血的纳米颗粒。
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引用次数: 0
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Applied Bionics and Biomechanics
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