Annals of Indian Academy of Neurology最新文献

Background and objectives: The number of people with dementia and the burden on families to care for them are increasing. As a result, families are affected in their use of time to carry out daily activities. This study compared family caregivers of dementia patients (dementia family) and non-family caregivers of dementia patients (non-dementia family), reflecting their characteristics on weekdays and weekends.

Methods: There were 92 participants each in the groups dementia family and non-dementia family. Each group was divided into 121 people on weekdays and 71 people on weekends. Time usage was measured by occupational area. The variables assessed were "lack of time," "tiredness," "life satisfaction," and "leisure satisfaction." Variables including "house chores sharing" and "role division" were also assessed. The time usage of the Korea National Statistical Office's 2019 "time use survey" was reclassified based on the occupational areas of the Occupational Therapy Practice Framework-Fourth Edition, and time usage and satisfaction were analyzed. Frequency analysis and independent t -test were used for statistical processing.

Results: On weekdays, the dementia family showed less time usage in the "leisure" area for men and "social participation" area for women than the non-dementia family. On weekends, dementia family showed less time usage in the "activities of daily living" (ADLs) area than the non-dementia family and women in dementia family showed less time usage in "ADLs" area compared to women in the non-dementia family. Satisfaction was found to be higher in terms of "lack of time" and "tiredness" on weekdays and "tiredness" on weekends in dementia family than in the non-dementia family.

Conclusions: Time usage and satisfaction of dementia family and non-dementia family showed differences during weekdays and weekends. These results suggest that for family caregivers of dementia patients, it is necessary to improve the efficient use of time and satisfaction during weekdays and holidays.

Background and objectives: Parkinson's disease (PD) is a neurodegenerative disorder involving depletion of dopaminergic neurons. Pathogenetic mechanisms leading to striatonigral degeneration are debatable. Chronic inflammation is proposed as one of the mechanisms. In any disease with underlying inflammation, immune system mediators called cytokines are released, leading to a procoagulant state. Our aim was to study the coagulation parameters in patients with PD and find their correlation with disease duration and antiparkinsonian drugs.

Methods: This cross-sectional study was conducted between January 2021 and December 2021 in a tertiary care center. Sixty-eight patients with PD were subcategorized based on disease duration (<5 and ≥5 years), number of antiparkinsonian drugs (one drug and ≥2 drugs), and levodopa equivalent daily dose (LEDD; <350 and ≥350 mg). Hemoglobin (Hb), prothrombin time (PT), fibrinogen, bleeding time, and platelet aggregation study with adenosine diphosphate and collagen were assessed.

Results: In our cohort of 68 patients, 53 were men and 15 were women. Mean disease duration was 5.97 ± 4.37 years. Hb was negatively associated with LEDD ( P = 0.012) and duration of the disease ( P = 0.02). Similarly, PT was negatively associated with disease duration ( P = 0.041) and number of antiparkinsonian drugs ( P = 0.03). LEDD showed a positive association with collagen-induced platelet aggregation ( P = 0.03).

Conclusions: In our study, patients using multiple antiparkinsonian drugs and higher LEDD were observed to have a prothrombotic state. Further studies are needed to confirm these findings.