Pub Date : 2024-03-01Epub Date: 2024-02-28DOI: 10.4103/aian.aian_828_23
R Kartheka, Rajeswari Aghoram, A Joel Faith, Vaibhav Wadwekar
Objective: Diabetic peripheral neuropathy (DPN), a complication of diabetes, is detected only in later stages. Medial plantar nerve (MPL) can identify earlier stages of neuropathy. We evaluated the correlation of MPL sensory nerve action potentials (SNAPs) and severity of DPN measured using the Toronto Clinical Neuropathy Score (TCNS).
Methods: In this hospital-based, cross-sectional study, we recruited diabetic subjects referred for suspected DPN. Neuropathy was graded with TCNS. Sural nerve conduction studies were performed using standard techniques. MPL studies were conducted using the modified Ponsford technique. All evaluations were performed on Nihon Kohden (model MEB 9200K). Averaged MPL SNAP was correlated with TCNS using Pearson's correlation coefficient. To estimate a correlation of 0.4 with 80% power (P = 0.05), we needed 46 subjects. Linear regression was conducted to adjust for age, duration, and diabetic control. Receiver operating characteristic (ROC) curve analysis was performed to obtain the cutoff for MPL SNAP values using the Youden index.
Results: Fifty-one subjects with a mean age of 53.5 years (8.7) and mean duration of diabetes of 10.2 years (7.2) were included. MPL SNAPs were recordable in 12 patients, and the mean amplitude was 5.15 (2.9) µV. There was correlation between MPL SNAP and TCNS (r = -0.43, P = 0.02). No confounding was seen. Use of MPL SNAP resulted in diagnosis of DPN in an additional six (11.8%) patients. The ROC curve suggested that MPL SNAP cutoff of 1.05 µV had an accuracy of 67% in identifying neuropathy as defined by TCNS.
Conclusions: MPL SNAP has a moderate correlation with clinical score and identifies more diabetic neuropathy than sural nerve.
{"title":"Cross-Sectional Study of the Relationship Between Medial Plantar Nerve Conduction Studies and Severity of Diabetic Neuropathy.","authors":"R Kartheka, Rajeswari Aghoram, A Joel Faith, Vaibhav Wadwekar","doi":"10.4103/aian.aian_828_23","DOIUrl":"10.4103/aian.aian_828_23","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic peripheral neuropathy (DPN), a complication of diabetes, is detected only in later stages. Medial plantar nerve (MPL) can identify earlier stages of neuropathy. We evaluated the correlation of MPL sensory nerve action potentials (SNAPs) and severity of DPN measured using the Toronto Clinical Neuropathy Score (TCNS).</p><p><strong>Methods: </strong>In this hospital-based, cross-sectional study, we recruited diabetic subjects referred for suspected DPN. Neuropathy was graded with TCNS. Sural nerve conduction studies were performed using standard techniques. MPL studies were conducted using the modified Ponsford technique. All evaluations were performed on Nihon Kohden (model MEB 9200K). Averaged MPL SNAP was correlated with TCNS using Pearson's correlation coefficient. To estimate a correlation of 0.4 with 80% power (<i>P</i> = 0.05), we needed 46 subjects. Linear regression was conducted to adjust for age, duration, and diabetic control. Receiver operating characteristic (ROC) curve analysis was performed to obtain the cutoff for MPL SNAP values using the Youden index.</p><p><strong>Results: </strong>Fifty-one subjects with a mean age of 53.5 years (8.7) and mean duration of diabetes of 10.2 years (7.2) were included. MPL SNAPs were recordable in 12 patients, and the mean amplitude was 5.15 (2.9) µV. There was correlation between MPL SNAP and TCNS (<i>r</i> = -0.43, <i>P</i> = 0.02). No confounding was seen. Use of MPL SNAP resulted in diagnosis of DPN in an additional six (11.8%) patients. The ROC curve suggested that MPL SNAP cutoff of 1.05 µV had an accuracy of 67% in identifying neuropathy as defined by TCNS.</p><p><strong>Conclusions: </strong>MPL SNAP has a moderate correlation with clinical score and identifies more diabetic neuropathy than sural nerve.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-04-26DOI: 10.4103/aian.aian_31_24
Rajat Manchanda, Ramanuj Samanta, Manishi L Narayan, Mritunjai Kumar, Ashutosh Tiwari, Ajai Agarwal, Yogesh Bahurupi, Sweety Kumari, Niraj Kumar
Background and objective: While optical coherence tomography (OCT) is explored as a potential biomarker in Parkinson's disease (PD), technetium-99m-labeled tropane derivative (99mTc-TRODAT-1) single-photon emission computed tomography (SPECT) imaging has a proven role in diagnosing PD. Our objective was to compare the OCT parameters in PD patients and healthy controls (HCs) and correlate them with 99mTc-TRODAT-1 parameters in PD patients.
Materials and methods: This cross-sectional study included 30 PD patients and 30 age- and gender-matched HCs. Demographic data, PD details including Movement Disorders Society Unified Parkinson's Disease Rating Scale-III (MDS-UPDRS-III) and Hoehn-Yahr (HY) staging, and OCT parameters including macular and peripapillary retinal nerve fiber layer (RNFL) thickness in bilateral eyes were recorded. PD patients underwent 99mTc-TRODAT-1 SPECT imaging. The terms "ipsilateral" and "contralateral" were used with reference to more severely affected body side in PD patients and compared with corresponding sides in HCs.
Results: PD patients showed significant ipsilateral superior parafoveal quadrant (mean ± standard deviation [SD] = 311.10 ± 15.90 vs. 297.57 ± 26.55, P = 0.02) and contralateral average perifoveal (mean ± SD = 278.75 ± 18.97 vs. 269.08 ± 16.91, P = 0.04) thinning compared to HCs. Peripapillary RNFL parameters were comparable between PD patients and HCs. MDS-UPDRS-III score and HY stage were inversely correlated to both ipsilateral (Spearman rho = -0.52, P = 0.003; Spearman rho = -0.47, P = 0.008) and contralateral (Spearman rho = -0.53, P = 0.002; Spearman rho = -0.58, P < 0.001) macular volumes, respectively. PD duration was inversely correlated with ipsilateral temporal parafoveal thickness (ρ = -0.41, P = 0.02). No correlation was observed between OCT and 99mTc-TRODAT-1 SPECT parameters in PD patients.
Conclusion: Compared to HCs, a significant thinning was observed in the ipsilateral superior parafoveal quadrant and the contralateral average perifoveal region in PD patients. Macular volume and ipsilateral temporal parafoveal thickness were inversely correlated with disease severity and duration, respectively. OCT and 99mTc-TRODAT-1 SPECT parameters failed to correlate in PD patients.
{"title":"Connecting the Dots: Exploring the Relationship between Optical Coherence Tomography and <sup>99m</sup>Tc-TRODAT-1 SPECT Parameters in Parkinson's Disease.","authors":"Rajat Manchanda, Ramanuj Samanta, Manishi L Narayan, Mritunjai Kumar, Ashutosh Tiwari, Ajai Agarwal, Yogesh Bahurupi, Sweety Kumari, Niraj Kumar","doi":"10.4103/aian.aian_31_24","DOIUrl":"10.4103/aian.aian_31_24","url":null,"abstract":"<p><strong>Background and objective: </strong>While optical coherence tomography (OCT) is explored as a potential biomarker in Parkinson's disease (PD), technetium-99m-labeled tropane derivative (<sup>99m</sup>Tc-TRODAT-1) single-photon emission computed tomography (SPECT) imaging has a proven role in diagnosing PD. Our objective was to compare the OCT parameters in PD patients and healthy controls (HCs) and correlate them with <sup>99m</sup>Tc-TRODAT-1 parameters in PD patients.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 30 PD patients and 30 age- and gender-matched HCs. Demographic data, PD details including Movement Disorders Society Unified Parkinson's Disease Rating Scale-III (MDS-UPDRS-III) and Hoehn-Yahr (HY) staging, and OCT parameters including macular and peripapillary retinal nerve fiber layer (RNFL) thickness in bilateral eyes were recorded. PD patients underwent <sup>99m</sup>Tc-TRODAT-1 SPECT imaging. The terms \"ipsilateral\" and \"contralateral\" were used with reference to more severely affected body side in PD patients and compared with corresponding sides in HCs.</p><p><strong>Results: </strong>PD patients showed significant ipsilateral superior parafoveal quadrant (mean ± standard deviation [SD] = 311.10 ± 15.90 vs. 297.57 ± 26.55, <i>P</i> = 0.02) and contralateral average perifoveal (mean ± SD = 278.75 ± 18.97 vs. 269.08 ± 16.91, <i>P</i> = 0.04) thinning compared to HCs. Peripapillary RNFL parameters were comparable between PD patients and HCs. MDS-UPDRS-III score and HY stage were inversely correlated to both ipsilateral (Spearman rho = -0.52, <i>P</i> = 0.003; Spearman rho = -0.47, <i>P</i> = 0.008) and contralateral (Spearman rho = -0.53, <i>P</i> = 0.002; Spearman rho = -0.58, <i>P</i> < 0.001) macular volumes, respectively. PD duration was inversely correlated with ipsilateral temporal parafoveal thickness (ρ = -0.41, <i>P</i> = 0.02). No correlation was observed between OCT and <sup>99m</sup>Tc-TRODAT-1 SPECT parameters in PD patients.</p><p><strong>Conclusion: </strong>Compared to HCs, a significant thinning was observed in the ipsilateral superior parafoveal quadrant and the contralateral average perifoveal region in PD patients. Macular volume and ipsilateral temporal parafoveal thickness were inversely correlated with disease severity and duration, respectively. OCT and <sup>99m</sup>Tc-TRODAT-1 SPECT parameters failed to correlate in PD patients.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.4103/aian.aian_135_24
P. Sylaja
{"title":"Obituary - Professor Sanjeev V Thomas","authors":"P. Sylaja","doi":"10.4103/aian.aian_135_24","DOIUrl":"https://doi.org/10.4103/aian.aian_135_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.4103/aian.aian_781_23
A. Nagaraj, Guduru Shravanthi, Tumulu Seetam Kumar, Raghavendra Kenchiah, RohanR Mahale, M. Sandhya, G. Udupi, P. Mailankody, P. Mathuranath, H. Padmanabha
{"title":"Pontine Tegmental Cap Dysplasia: A Rare Brainstem Malformation Mimicking Hereditary Sensory Autonomic Neuropathy","authors":"A. Nagaraj, Guduru Shravanthi, Tumulu Seetam Kumar, Raghavendra Kenchiah, RohanR Mahale, M. Sandhya, G. Udupi, P. Mailankody, P. Mathuranath, H. Padmanabha","doi":"10.4103/aian.aian_781_23","DOIUrl":"https://doi.org/10.4103/aian.aian_781_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.4103/aian.aian_1058_23
B. Maramattom
{"title":"Dermatomal Dissociated Facial Sensory Loss due to a Partial Trigeminal Pontine Principal Sensory Nucleus Lesion","authors":"B. Maramattom","doi":"10.4103/aian.aian_1058_23","DOIUrl":"https://doi.org/10.4103/aian.aian_1058_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.4103/aian.aian_1004_23
Baikuntha Panigrahi, Ayush Agarwal, Divyani Garg, V. Vishnu, M. Faruq, A. Srivastava
{"title":"Dominant Mutation in ITPR3 Gene Causing Charcot–Marie–Tooth Disease 1J in a Family from India","authors":"Baikuntha Panigrahi, Ayush Agarwal, Divyani Garg, V. Vishnu, M. Faruq, A. Srivastava","doi":"10.4103/aian.aian_1004_23","DOIUrl":"https://doi.org/10.4103/aian.aian_1004_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140451802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-27DOI: 10.4103/aian.aian_651_23
Poornima Nair, Thomas Iype, P. Panicker
{"title":"Painful Itch in a Fidgety Girl","authors":"Poornima Nair, Thomas Iype, P. Panicker","doi":"10.4103/aian.aian_651_23","DOIUrl":"https://doi.org/10.4103/aian.aian_651_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140492332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2023-12-08DOI: 10.4103/aian.aian_713_23
Ajay K Vats, Shreya Vats, Sudhir Kothari, Renu Khamesra
{"title":"Concurrent Right Horizontal Semicircular Canalolithiasis and Right Posterior Cupulolithiasis <i>Verses</i> Canal Switch: A Diagnostic Otoneurologic Conundrum.","authors":"Ajay K Vats, Shreya Vats, Sudhir Kothari, Renu Khamesra","doi":"10.4103/aian.aian_713_23","DOIUrl":"10.4103/aian.aian_713_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2023-06-08DOI: 10.4103/aian.aian_290_23
Ravi Yadav
{"title":"Restless Legs Syndrome and Impulse Control Disorders in Patients with Parkinson's Disease: An Intricate Association.","authors":"Ravi Yadav","doi":"10.4103/aian.aian_290_23","DOIUrl":"10.4103/aian.aian_290_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48855437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-02-16DOI: 10.4103/aian.aian_983_23
Lakshminarayanapuram Gopal Viswanathan, Madhu Nagappa, Doniparthi V Seshagiri, Rose Dawn Bharath, Sanjib Sinha
{"title":"Adrenoleukodystrophy-Like Presentation of MOG-Antibody-Associated Demyelination.","authors":"Lakshminarayanapuram Gopal Viswanathan, Madhu Nagappa, Doniparthi V Seshagiri, Rose Dawn Bharath, Sanjib Sinha","doi":"10.4103/aian.aian_983_23","DOIUrl":"10.4103/aian.aian_983_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}