Pub Date : 2024-09-30DOI: 10.4103/aian.aian_430_24
Thomas Mathew, Amitoj S Chadha, Sita Jayalakshmi, Surabhi Garg, Aditya H Ravindranath, Uday Murgod, Shagun Bhardwaj, Pranjali Ektare, Saji K John, Raghunandan Nadig, Gosala R K Sarma
{"title":"Levetiracetam-Induced Parkinsonism: A Short Case Series.","authors":"Thomas Mathew, Amitoj S Chadha, Sita Jayalakshmi, Surabhi Garg, Aditya H Ravindranath, Uday Murgod, Shagun Bhardwaj, Pranjali Ektare, Saji K John, Raghunandan Nadig, Gosala R K Sarma","doi":"10.4103/aian.aian_430_24","DOIUrl":"https://doi.org/10.4103/aian.aian_430_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reversible Peripheral Vestibular Deficit due to Migraine.","authors":"Sandeep Kumar, Vijay Ghughe, Nishi Gupta, Srinivas Dorasala","doi":"10.4103/aian.aian_373_24","DOIUrl":"https://doi.org/10.4103/aian.aian_373_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-09DOI: 10.4103/aian.aian_401_24
Thomas Mathew, Akshata Huddar, Shagun Bhardwaj, Sharath Kumar Goddu Govindappa
{"title":"Piriformis Syndrome as a Cause of Non-discogenic Sciatic Pain in a Young Bharatanatyam Dancer.","authors":"Thomas Mathew, Akshata Huddar, Shagun Bhardwaj, Sharath Kumar Goddu Govindappa","doi":"10.4103/aian.aian_401_24","DOIUrl":"https://doi.org/10.4103/aian.aian_401_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-09DOI: 10.4103/aian.aian_419_24
Abhishek Vaingankar, Divyani Garg, Ayush Agarwal, Divya M Radhakrishnan, Awadh Kishor Pandit, Madhavi Tripathi, Achal K Srivastava
Abstract: We report two cases of established Wilson's disease (WD) presenting with calcific myonecrosis of the pelvic girdle in association with pelvic fractures. Despite initial improvement with chelation, subacute worsening of ambulation in both led to a consideration of neurologic deterioration on chelation therapy. However, evaluation revealed calcific myonecrosis of the hip joint and adjacent muscles as the cause. Both patients improved with intensive rehabilitation. A review of literature indicates that although osseomuscular complications are reported in WD, calcific myonecrosis is a hitherto unknown entity which, if recognized early, may be reversed, preventing disability and unnecessary change in chelation regimens.
{"title":"Loss of Ambulation Due to Calcific Myonecrosis: A Rare but Reversible Complication of Wilson's Disease.","authors":"Abhishek Vaingankar, Divyani Garg, Ayush Agarwal, Divya M Radhakrishnan, Awadh Kishor Pandit, Madhavi Tripathi, Achal K Srivastava","doi":"10.4103/aian.aian_419_24","DOIUrl":"https://doi.org/10.4103/aian.aian_419_24","url":null,"abstract":"<p><strong>Abstract: </strong>We report two cases of established Wilson's disease (WD) presenting with calcific myonecrosis of the pelvic girdle in association with pelvic fractures. Despite initial improvement with chelation, subacute worsening of ambulation in both led to a consideration of neurologic deterioration on chelation therapy. However, evaluation revealed calcific myonecrosis of the hip joint and adjacent muscles as the cause. Both patients improved with intensive rehabilitation. A review of literature indicates that although osseomuscular complications are reported in WD, calcific myonecrosis is a hitherto unknown entity which, if recognized early, may be reversed, preventing disability and unnecessary change in chelation regimens.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-06DOI: 10.4103/aian.aian_280_24
S Pramod Kumar, S Haritha, P R Sowmini, S Lakshmanan, S Sakthi Velayutham, K Malcolm Jeyaraj, V Kannan, R Viveka Saravanan, K Mugundhan
{"title":"A Case of Facial-Onset Sensory Motor Neuronopathy - A Rare Variant of Motor Neuron Disease.","authors":"S Pramod Kumar, S Haritha, P R Sowmini, S Lakshmanan, S Sakthi Velayutham, K Malcolm Jeyaraj, V Kannan, R Viveka Saravanan, K Mugundhan","doi":"10.4103/aian.aian_280_24","DOIUrl":"https://doi.org/10.4103/aian.aian_280_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Familial Creutzfeldt-Jakob Disease (CJD) Kindred - An Unusual Case Report from India.","authors":"Bhawna Sharma, Deepali Chiddarwar, Pankaj Kumar Sharma, Ashish Gupta, Pranjal Sharma","doi":"10.4103/aian.aian_870_23","DOIUrl":"10.4103/aian.aian_870_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An 8.5-year-old boy presented with a history of progressive unilateral foot drop. A contrast magnetic resonance imaging of the pelvic girdle and the lumbosacral plexus revealed a diffuse fusiform thickening of the right lumbosacral trunk and the sciatic nerve in the intrapelvic and gluteal regions, with findings characteristic of a choristoma. Clinical and radiologic features as well as complications of this unusual entity are described.
{"title":"Progressive Unilateral Foot Drop in a Child due to Neuromuscular Choristoma.","authors":"Gouri Rao Passi, Shailendra Maheshwari, Vrajesh Udani","doi":"10.4103/aian.aian_226_24","DOIUrl":"https://doi.org/10.4103/aian.aian_226_24","url":null,"abstract":"<p><p>An 8.5-year-old boy presented with a history of progressive unilateral foot drop. A contrast magnetic resonance imaging of the pelvic girdle and the lumbosacral plexus revealed a diffuse fusiform thickening of the right lumbosacral trunk and the sciatic nerve in the intrapelvic and gluteal regions, with findings characteristic of a choristoma. Clinical and radiologic features as well as complications of this unusual entity are described.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-06-05DOI: 10.4103/aian.aian_234_24
Sanjay Prakash, Chetsi Shah
{"title":"Idiopathic Serotonin Syndrome - Does It Exist?","authors":"Sanjay Prakash, Chetsi Shah","doi":"10.4103/aian.aian_234_24","DOIUrl":"10.4103/aian.aian_234_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-09-20DOI: 10.4103/aian.aian_391_24
Deepak Menon, Priyanka Chakkera, Shreyashi Jha, B Pradeep Kumar, Jss Anjusha, M Chandra Sena, Shilpa Rao, Faheem Arshad, Saraswati Nashi, Seena Vengalil, Suvarna Alladi, Atchayaram Nalini
{"title":"Morvan's Syndrome with Myasthenia Gravis: An Autoimmune or Paraneoplastic Association?","authors":"Deepak Menon, Priyanka Chakkera, Shreyashi Jha, B Pradeep Kumar, Jss Anjusha, M Chandra Sena, Shilpa Rao, Faheem Arshad, Saraswati Nashi, Seena Vengalil, Suvarna Alladi, Atchayaram Nalini","doi":"10.4103/aian.aian_391_24","DOIUrl":"https://doi.org/10.4103/aian.aian_391_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-10-21DOI: 10.4103/aian.aian_349_24
Varun Kodam, Sandesh Nanisetty, Sravan K Goud, Rukmini M Kandadai, Surya P Turaga, Shaik A Jabeen, Rupam Borgohain
Background and objectives: Parkinson's disease (PD) is a neurodegenerative disorder involving depletion of dopaminergic neurons. Pathogenetic mechanisms leading to striatonigral degeneration are debatable. Chronic inflammation is proposed as one of the mechanisms. In any disease with underlying inflammation, immune system mediators called cytokines are released, leading to a procoagulant state. Our aim was to study the coagulation parameters in patients with PD and find their correlation with disease duration and antiparkinsonian drugs.
Methods: This cross-sectional study was conducted between January 2021 and December 2021 in a tertiary care center. Sixty-eight patients with PD were subcategorized based on disease duration (<5 and ≥5 years), number of antiparkinsonian drugs (one drug and ≥2 drugs), and levodopa equivalent daily dose (LEDD; <350 and ≥350 mg). Hemoglobin (Hb), prothrombin time (PT), fibrinogen, bleeding time, and platelet aggregation study with adenosine diphosphate and collagen were assessed.
Results: In our cohort of 68 patients, 53 were men and 15 were women. Mean disease duration was 5.97 ± 4.37 years. Hb was negatively associated with LEDD ( P = 0.012) and duration of the disease ( P = 0.02). Similarly, PT was negatively associated with disease duration ( P = 0.041) and number of antiparkinsonian drugs ( P = 0.03). LEDD showed a positive association with collagen-induced platelet aggregation ( P = 0.03).
Conclusions: In our study, patients using multiple antiparkinsonian drugs and higher LEDD were observed to have a prothrombotic state. Further studies are needed to confirm these findings.
{"title":"Impact of Duration of Parkinsonism and Antiparkinsonian Drugs on Coagulation Parameters in Patients with Parkinson's Disease.","authors":"Varun Kodam, Sandesh Nanisetty, Sravan K Goud, Rukmini M Kandadai, Surya P Turaga, Shaik A Jabeen, Rupam Borgohain","doi":"10.4103/aian.aian_349_24","DOIUrl":"10.4103/aian.aian_349_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Parkinson's disease (PD) is a neurodegenerative disorder involving depletion of dopaminergic neurons. Pathogenetic mechanisms leading to striatonigral degeneration are debatable. Chronic inflammation is proposed as one of the mechanisms. In any disease with underlying inflammation, immune system mediators called cytokines are released, leading to a procoagulant state. Our aim was to study the coagulation parameters in patients with PD and find their correlation with disease duration and antiparkinsonian drugs.</p><p><strong>Methods: </strong>This cross-sectional study was conducted between January 2021 and December 2021 in a tertiary care center. Sixty-eight patients with PD were subcategorized based on disease duration (<5 and ≥5 years), number of antiparkinsonian drugs (one drug and ≥2 drugs), and levodopa equivalent daily dose (LEDD; <350 and ≥350 mg). Hemoglobin (Hb), prothrombin time (PT), fibrinogen, bleeding time, and platelet aggregation study with adenosine diphosphate and collagen were assessed.</p><p><strong>Results: </strong>In our cohort of 68 patients, 53 were men and 15 were women. Mean disease duration was 5.97 ± 4.37 years. Hb was negatively associated with LEDD ( P = 0.012) and duration of the disease ( P = 0.02). Similarly, PT was negatively associated with disease duration ( P = 0.041) and number of antiparkinsonian drugs ( P = 0.03). LEDD showed a positive association with collagen-induced platelet aggregation ( P = 0.03).</p><p><strong>Conclusions: </strong>In our study, patients using multiple antiparkinsonian drugs and higher LEDD were observed to have a prothrombotic state. Further studies are needed to confirm these findings.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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