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Pan-Driver-Negatives versus Epidermal Growth Factor Receptor Mutants for C-Stage IA Lung Adenocarcinoma with Ground-Glass Opacity 泛驱动阴性与表皮生长因子受体突变对c期IA型肺腺癌磨玻璃样混浊的影响
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-05-28 DOI: 10.5761/atcs.oa.22-00058
Ming Li, Junjie Xi, Huan Zhang, Xing Jin, Jianrong Zhang, M. Feng, C. Zhan, Qun Wang
Purpose: We aimed to verify the prognosis of epidermal growth factor receptor (EGFR) mutation of clinical (c)-stage IA lung adenocarcinoma with the ground-glass opacity (GGO) component. Methods: We evaluated 226 cases of surgically resected c-stage IA lung adenocarcinoma with GGO component. Endpoints were overall survival (OS) and recurrence-free survival (RFS). Kaplan–Meier analysis and the log-rank test were used to estimate the survival differences. Prognostic factors were assessed using the univariable and multivariable Cox proportional hazards model. Results: Among the 226 cases, 177 cases harbored the EGFR-mutant adenocarcinoma with the GGO component. The mean duration of follow-up time was 54.4 ± 1.2 months. The 5-year OS and RFS did not differ significantly between the EGFR-mutant and wild-type groups (5-year OS 100% vs. 94.3%, hazard ratio [HR] 0.276, P = 0.168; 5-year RFS 94.7% vs. 95.7%, HR 0.873, P = 0.864). Multivariable Cox hazard model revealed that radiologically solid component size (P = 0.010) and pathological node-positive (P = 0.036) were significant predictors of an inferior RFS. Conclusion: EGFR-mutant was not a prognostic factor of OS and RFS for c-stage IA lung adenocarcinoma with the GGO component. Radiologically solid component size and pathological lymph node status were independent prognostic factors of worse RFS.
目的:我们旨在验证具有磨玻璃样混浊(GGO)成分的临床(c)期IA肺腺癌的表皮生长因子受体(EGFR)突变的预后。方法:我们对226例经手术切除的带有GGO成分的c期IA肺腺癌进行了评估。终点为总生存期(OS)和无复发生存期(RFS)。Kaplan–Meier分析和对数秩检验用于估计生存差异。使用单变量和多变量Cox比例风险模型评估预后因素。结果:226例中,177例携带EGFR突变型腺癌,其中GGO组分。平均随访时间为54.4±1.2个月。EGFR突变组和野生型组之间的5年OS和RFS没有显著差异(5年OS 100%对94.3%,风险比[HR]0.276,P=0.168;5年RFS 94.7%对95.7%,HR0.873,P=0.864)。多变量Cox风险模型显示,放射学固体成分大小(P=0.010)和病理结阳性(P=0.036)是较差RFS的重要预测因素。结论:EGFR突变不是具有GGO成分的c期IA肺腺癌OS和RFS的预后因素。放射学实体成分大小和病理性淋巴结状况是RFS恶化的独立预后因素。
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引用次数: 2
Durability of Bioprosthetic Valves in Patients on Dialysis 透析患者生物假体瓣膜的耐久性
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-05-10 DOI: 10.5761/atcs.oa.21-00093
T. Uzuka, Masanori Nakamura, Hirotaro Sugiyama, Mayo Kondo, J. Sakata
Purpose: This study focused on clarifying the durability of bioprosthetic valves in current practice. Methods: A total of 238 consecutive patients who underwent aortic valve replacement at a single institution from 2011 to 2020 were reviewed. We evaluated valve-related outcomes such as structural valve deterioration (SVD), especially in dialysis patients who received bioprosthetic valve. Results: Among the tissue valves implanted in 212 patients, 5 SVDs were recorded and 3 valves were replaced. All early valve failures occurred in relatively young dialysis patients and were recorded 3 to 5 years after the initial operation. Freedom from SVD at 6 years was 49.9% in patients on dialysis, compared with 100% in non-dialysis patients. Predictors of better survival in dialysis patients were better preoperative functional class and larger prosthetic valve size. Conclusions: The durability of bioprosthetic valves in the aortic position was suboptimal in dialysis patients. Mechanical valves can be an option for young, healthy dialysis patients with a large aortic valve annulus.
目的:本研究旨在阐明生物瓣膜在当前实践中的耐用性。方法:对2011年至2020年在单一机构接受主动脉瓣置换术的238名连续患者进行回顾性分析。我们评估了瓣膜相关的结果,如结构瓣膜恶化(SVD),尤其是接受生物瓣膜的透析患者。结果:在212例植入的组织瓣膜中,记录了5例SVD,并更换了3例瓣膜。所有早期瓣膜失效均发生在相对年轻的透析患者中,并在初次手术后3至5年记录在案。接受透析的患者在6年时免于SVD的发生率为49.9%,而非透析患者为100%。透析患者生存率较高的预测因素是术前功能级别较好和人工瓣膜尺寸较大。结论:生物瓣膜在主动脉位置的耐久性在透析患者中是次优的。对于患有大主动脉瓣环的年轻健康透析患者,机械瓣膜是一种选择。
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引用次数: 1
The Association of Vacuum-Assisted Closure Therapy with Dynamic Volume Change of a Muscle Flap Transposed in an Empyema Cavity for Chronic Empyema: A Case Report. 真空辅助关闭治疗与慢性脓胸腔内转位肌瓣动态体积变化的关系:1例报告。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-20 DOI: 10.5761/atcs.cr.19-00235
Kensuke Kojima, Tetsuki Sakamoto, Teiko Sakurai, Yuriko Yagi, Tomoki Utsumi, Hyungeun Yoon

A 62-year-old woman with a history of lung resection for lung cancer was admitted to our hospital due to cough, which became progressively more severe. She was diagnosed with chronic empyema with bronchopleural fistula (BPF) of the right upper bronchial stump. Although a pedicled muscle flap was transposed to the empyema cavity, the fistula remained. We used a vacuum-assisted closure system after open-window thoracotomy and observed the cavity reduction with expansion of the transposed muscle flap. We quantitatively evaluated the dynamics of the cavity change using a three-dimensional image analysis system. A reduction of the volume of the muscle flap by prolonged empyema and expansion of the muscle flap was observed immediately after vacuum-assisted management. However, expansion of the right residual lung was not recognized. Pedicled muscle flap transposition followed by vacuum-assisted management after open-window thoracotomy may be effective for treating chronic empyema caused by BPF.

一名62岁女性因肺癌行肺切除术,因咳嗽进行性加重而入院。她被诊断为慢性脓胸伴支气管胸膜瘘(BPF)右上支气管残端。虽然带蒂肌瓣转置到脓胸腔,瘘管仍然存在。我们在开窗开胸后采用真空辅助封闭系统,观察转置肌瓣扩张后的腔缩小情况。我们使用三维图像分析系统定量评估了腔体变化的动力学。在真空辅助治疗后立即观察到肌瓣的体积因延长脓胸和扩张而减少。但未发现右残肺扩张。开窗开胸后带蒂肌瓣转位加真空辅助处理可有效治疗BPF引起的慢性脓胸。
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引用次数: 0
Video-Assisted Thoracoscopic Surgery Management of Subacute Retained Blood Syndrome after Cardiac Surgery. 心脏手术后亚急性血潴留综合征的电视胸腔镜手术治疗。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-20 DOI: 10.5761/atcs.oa.21-00102
Vasileios Drosos, Koray Durak, Rüdiger Autschbach, Jan Spillner, Katharina Nubbemeyer, Rashad Zayat, Sebastian Kalverkamp

Purpose: Blood loss along with inadequate evacuation after cardiac surgery leads to retained blood syndrome (RBS) in the pleural and/or pericardial cavity. Re-sternotomy is often needed for clot evacuation. Video-assisted thoracoscopic surgery (VATS) evacuation is a less-invasive procedure. However, sufficient evidence on safety and outcomes is lacking.

Methods: Thirty patients who developed hemothorax and/or hemopericardium after cardiac surgery and underwent VATS evacuation between April 2015 and September 2020 were included in this retrospective single-center analysis.

Results: The median patient age was 70 (interquartile range: IQR 62-75) years, body mass index (BMI) was 24.7 (IQR 22.8-29) kg/m2, time between initial cardiac surgery and VATS was 17 (IQR 11-21) days, 30% of the patients were female, 60% resided in the ICU, and 17% were nicotine users. Coronary artery bypass graft was the most frequent initial cardiac procedure. Median operation time was 120 (IQR 90-143) min, 23% of the patients needed an additional VATS, and the median length of hospital stay after VATS was 8 (IQR 5-14) days. All patients survived VATS, and we experienced no mortality related to the VATS procedure.

Conclusion: In our study, VATS for evacuation of RBS after cardiac surgery was a feasible, safe, and efficient alternative approach to re-sternotomy in selected patients.

目的:心脏手术后失血和引流不当导致胸膜和/或心包腔积血综合征(RBS)。为了清除血块,通常需要重新切开胸骨。视频胸腔镜手术(VATS)是一种微创手术。然而,缺乏足够的安全性和结果证据。方法:2015年4月至2020年9月期间,30例心脏手术后出现胸血和/或心包积血并接受VATS引流的患者纳入本回顾性单中心分析。结果:患者年龄中位数为70岁(四分位数间距:IQR 62-75),体重指数(BMI)为24.7 (IQR 22.8-29) kg/m2,首次心脏手术至VATS间隔时间为17 (IQR 11-21)天,30%的患者为女性,60%住在ICU, 17%为尼古丁使用者。冠状动脉旁路移植术是最常见的初始心脏手术。中位手术时间为120 (IQR 90-143) min, 23%的患者需要额外的VATS, VATS后的中位住院时间为8 (IQR 5-14)天。所有患者均在VATS手术中存活,我们没有经历与VATS手术相关的死亡。结论:在我们的研究中,在选定的患者中,VATS用于心脏手术后RBS的清除是一种可行、安全、有效的替代方法。
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引用次数: 2
Effects of Suprarenal Aortic Cross-Clamping and Adjunctive Renal Reconstruction on Outcomes of Open Abdominal Aortic Aneurysm Repair 肾上主动脉交叉夹持和辅助肾重建对腹主动脉瘤开放性修复效果的影响
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-07 DOI: 10.5761/atcs.oa.21-00258
Y. Yamamoto, Hidetoshi Uchiyama, M. Oonuki
Purpose: To analyze our contemporary experience in open abdominal aortic aneurysm (AAA) repair. We focused on the effects of suprarenal (SR) aortic cross-clamping and adjunctive renal reconstruction (RR) on postoperative outcomes. Methods: We retrospectively reviewed our institutional data of 141 consecutive patients who received elective open AAA repair between January 2014 and December 2020. Results: Seventy-five procedures were performed with SR aortic cross-clamping, 20 of which required an adjunctive RR. Patients in the SR group had a higher incidence of postoperative acute kidney injury (AKI) (18.7% vs. 7.6%, P = 0.045). There were no significant between-group differences in other major complications. The 30-day mortality rate in the infrarenal (IR) and SR groups was 0% and 1.3%, respectively. After a median follow-up of 33 months, the rates of chronic renal decline in the IR (18.2%) and SR (21.3%) groups were similar. All reconstructed renal arteries were patent without reintervention. The 5-year overall survival rate in the IR and SR groups was 88.8% and 83.2%, respectively. Conclusions: SR aortic cross-clamping was associated with postoperative AKI but neither SR aortic cross-clamping nor RR affected the long-term renal function or mortality. Open repair remains an essential option for patients with AAA, especially those with complex anatomy.
目的:分析我院腹主动脉瘤开腹修补术的临床经验。我们关注的是肾上动脉(SR)主动脉交叉夹持和辅助肾重建(RR)对术后预后的影响。方法:我们回顾性回顾了2014年1月至2020年12月期间141例连续接受选择性开放式AAA修复的患者的机构数据。结果:75例进行了SR主动脉交叉夹紧手术,其中20例需要辅助RR。SR组患者术后急性肾损伤(AKI)发生率较高(18.7% vs. 7.6%, P = 0.045)。其他主要并发症组间差异无统计学意义。IR组和SR组30天死亡率分别为0%和1.3%。中位随访33个月后,IR组(18.2%)和SR组(21.3%)的慢性肾功能下降率相似。所有重建的肾动脉均通畅,无再介入。IR组和SR组5年总生存率分别为88.8%和83.2%。结论:SR主动脉交叉夹紧与术后AKI相关,但SR主动脉交叉夹紧和RR均不影响长期肾功能或死亡率。对于AAA患者,特别是那些解剖结构复杂的患者,开放式修复仍然是必不可少的选择。
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引用次数: 0
Transit-Time Flow Measurement of Saphenous Vein Graft Used for Surgery of Acute Type A Aortic Dissection with Coronary Malperfusion 急性A型主动脉夹层合并冠状动脉灌注不良手术中隐静脉移植物的瞬时血流测量
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-05 DOI: 10.5761/atcs.oa.21-00255
Naoshi Minamidate, Noriyuki Takashima, Takeshi Kinoshita, Tomoaki Suzuki
Purpose: Transit-time flow measurement (TTFM), consisting of pulsatility index (PI), mean graft flow, and diastolic filling, is mainly used as a bypass assessment for coronary artery disease (CAD). However, little was known about TTFM in the case of coronary malperfusion (CMP). This study aimed to clarify the difference in the results of TTFM between two different diseases. Methods: Between 2010 and 2020, 138 patients underwent aortic surgery and coronary artery bypass grafting (CABG) with vein grafts. Patients were divided into two groups: CMP (n = 26) and CAD (n = 27). Their results were compared. The primary endpoints were the results of TTFM. Secondary endpoints were the relation between TTFM and mortality, morbidity, and short-term patency in each group. Results: The PI in the CMP group was significantly higher than the other group (4.7 ± 2.9 vs. 3.4 ± 1.9, p = 0.04). There was no statistical significance in the other two elements. In both groups, the short-term graft patency, mortality, and morbidity but for cardiac tamponade did not significantly change depending on the TTFM results. Conclusions: Patients with CMP tended to have a higher PI than those with CAD. With additional CABG for aortic dissection, insufficient TTFM results did not necessarily mean poor short-term graft patency, complications, or case mortality.
目的:瞬时血流测量(TTFM)由脉搏指数(PI)、平均移植物流量和舒张充血组成,主要用于冠状动脉疾病(CAD)的旁路评估。然而,对冠状动脉灌注不良(CMP)的TTFM知之甚少。本研究旨在阐明两种不同疾病之间TTFM结果的差异。方法:2010年至2020年,138例患者接受了主动脉手术和冠状动脉旁路移植术(CABG)。患者分为两组:CMP (n = 26)和CAD (n = 27)。比较了他们的结果。主要终点是TTFM的结果。次要终点是各组TTFM与死亡率、发病率和短期通畅的关系。结果:CMP组PI明显高于对照组(4.7±2.9比3.4±1.9,p = 0.04)。其他两项差异无统计学意义。在两组中,除了心脏填塞外,短期移植物通畅、死亡率和发病率均未因TTFM结果而发生显著变化。结论:CMP患者PI高于CAD患者。对于主动脉夹层的额外冠脉搭桥,不充分的TTFM结果并不一定意味着短期移植物通畅不良、并发症或病例死亡率。
{"title":"Transit-Time Flow Measurement of Saphenous Vein Graft Used for Surgery of Acute Type A Aortic Dissection with Coronary Malperfusion","authors":"Naoshi Minamidate, Noriyuki Takashima, Takeshi Kinoshita, Tomoaki Suzuki","doi":"10.5761/atcs.oa.21-00255","DOIUrl":"https://doi.org/10.5761/atcs.oa.21-00255","url":null,"abstract":"Purpose: Transit-time flow measurement (TTFM), consisting of pulsatility index (PI), mean graft flow, and diastolic filling, is mainly used as a bypass assessment for coronary artery disease (CAD). However, little was known about TTFM in the case of coronary malperfusion (CMP). This study aimed to clarify the difference in the results of TTFM between two different diseases. Methods: Between 2010 and 2020, 138 patients underwent aortic surgery and coronary artery bypass grafting (CABG) with vein grafts. Patients were divided into two groups: CMP (n = 26) and CAD (n = 27). Their results were compared. The primary endpoints were the results of TTFM. Secondary endpoints were the relation between TTFM and mortality, morbidity, and short-term patency in each group. Results: The PI in the CMP group was significantly higher than the other group (4.7 ± 2.9 vs. 3.4 ± 1.9, p = 0.04). There was no statistical significance in the other two elements. In both groups, the short-term graft patency, mortality, and morbidity but for cardiac tamponade did not significantly change depending on the TTFM results. Conclusions: Patients with CMP tended to have a higher PI than those with CAD. With additional CABG for aortic dissection, insufficient TTFM results did not necessarily mean poor short-term graft patency, complications, or case mortality.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"28 1","pages":"271 - 277"},"PeriodicalIF":1.3,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42798092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer 肌肉质量预测早期非小细胞肺癌手术后预后
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-16 DOI: 10.5761/atcs.oa.21-00274
A. Kamigaichi, H. Harada, S. Shibata
Purpose: This study investigated the impact of skeletal muscle quality on the outcomes of patients undergoing surgery for early-stage non–small-cell lung cancer (NSCLC). Methods: A total of 98 patients with pathological stage I–II NSCLC who underwent lobectomy or segmentectomy were retrospectively analyzed. Along with skeletal muscle quantity, muscle quality was evaluated by intramuscular adipose tissue content (IMAC) at the first lumbar vertebral level; a higher IMAC indicates lower skeletal muscle quality. Patients were divided into two groups according to the gender-specific quartiles of IMAC, and the prognostic impact of IMAC was investigated. Results: No significant differences in the body and skeletal mass indices, which indicate skeletal muscle quantity, were observed between patients with high and those with normal IMAC. Patients with high IMAC (n = 23) showed a significantly poorer prognosis in overall and disease-specific survivals than those with normal IMAC (n = 75; P <0.001 and P = 0.048, respectively). In a bivariate analysis that included other clinicopathological factors, a high IMAC was independently associated with worse overall survival. Conclusion: The skeletal muscle quality evaluated by IMAC could be used to predict survival risk after surgery for early-stage NSCLC.
目的:本研究旨在探讨骨骼肌质量对早期非小细胞肺癌癌症(NSCLC)手术患者预后的影响。方法:回顾性分析98例病理I~II期NSCLC患者行肺叶切除术或节段切除术的临床资料。与骨骼肌数量一起,通过第一腰椎水平的肌内脂肪组织含量(IMAC)来评估肌肉质量;IMAC越高表示骨骼肌质量越低。根据IMAC的性别特异性四分位数,将患者分为两组,并研究IMAC对预后的影响。结果:高IMAC患者和正常IMAC患者的身体和骨骼质量指数(表示骨骼肌数量)没有显著差异。IMAC高的患者(n=23)的总体生存率和疾病特异性生存率明显低于IMAC正常的患者(n=75;分别为P<0.001和P=0.048)。在包括其他临床病理因素的双变量分析中,高IMAC与较差的总生存率独立相关。结论:IMAC评估的骨骼肌质量可用于预测早期NSCLC手术后的生存风险。
{"title":"Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer","authors":"A. Kamigaichi, H. Harada, S. Shibata","doi":"10.5761/atcs.oa.21-00274","DOIUrl":"https://doi.org/10.5761/atcs.oa.21-00274","url":null,"abstract":"Purpose: This study investigated the impact of skeletal muscle quality on the outcomes of patients undergoing surgery for early-stage non–small-cell lung cancer (NSCLC). Methods: A total of 98 patients with pathological stage I–II NSCLC who underwent lobectomy or segmentectomy were retrospectively analyzed. Along with skeletal muscle quantity, muscle quality was evaluated by intramuscular adipose tissue content (IMAC) at the first lumbar vertebral level; a higher IMAC indicates lower skeletal muscle quality. Patients were divided into two groups according to the gender-specific quartiles of IMAC, and the prognostic impact of IMAC was investigated. Results: No significant differences in the body and skeletal mass indices, which indicate skeletal muscle quantity, were observed between patients with high and those with normal IMAC. Patients with high IMAC (n = 23) showed a significantly poorer prognosis in overall and disease-specific survivals than those with normal IMAC (n = 75; P <0.001 and P = 0.048, respectively). In a bivariate analysis that included other clinicopathological factors, a high IMAC was independently associated with worse overall survival. Conclusion: The skeletal muscle quality evaluated by IMAC could be used to predict survival risk after surgery for early-stage NSCLC.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"28 1","pages":"262 - 270"},"PeriodicalIF":1.3,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46549569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Acute Mediastinitis – Outcomes and Prognostic Factors of Surgical Therapy (A Single-Center Experience) 急性纵隔炎——外科治疗的结果和预后因素(单中心经验)
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-08 DOI: 10.5761/atcs.oa.21-00147
Josef Vodicˇka, J. Geiger, A. Židková, P. Andrle, H. Mírka, Martin Svatonˇ, Tomáš Kostlivý
Purpose: The aims of this work were the retrospective analysis of a cohort of patients with acute mediastinitis treated at the authors’ worksite over a 15-year period and the identification of factors that significantly affect the outcomes of the therapy. Methods: During the period 2006–2020, 80 patients with acute mediastinitis were treated. Within the cohort, the following were observed: the causes and the type of acute mediastinitis, length of anamnesis, comorbidities, diagnostic methods, time from the diagnosis to surgery, types and number of surgical procedures, results of microbiological tests, complications, and outcomes of the treatment. Results: The most common type of acute mediastinitis was descending mediastinitis (48.75%). A total of 116 surgical procedures were performed. Ten patients in the cohort died (12.5%). Patients older than 60 years were at a 6.8 times higher risk of death. Patients with more than two comorbidities were at a 14.3 times higher risk of death. The presence of yeasts in the culture material increased the risk of death by 4.4 times. Conclusion: Early diagnosis, removal of the cause of mediastinitis, sufficient mediastinal debridement, and multiple drainage thereof with the possibility of continual postoperative lavage are essential for the successful treatment of acute mediastinitis.
目的:这项工作的目的是对一组在作者工作场所接受治疗的急性纵隔炎患者进行为期15年的回顾性分析,并确定显著影响治疗结果的因素。方法:在2006年至2020年期间,对80例急性纵隔炎患者进行了治疗。在队列中,观察到以下内容:急性纵隔炎的病因和类型、记忆时间、合并症、诊断方法、从诊断到手术的时间、手术程序的类型和次数、微生物检测结果、并发症和治疗结果。结果:急性纵隔炎最常见的类型是降纵隔炎(48.75%),共进行了116次手术。队列中有10名患者死亡(12.5%)。60岁以上的患者死亡风险高出6.8倍。患有两种以上合并症的患者的死亡风险高出14.3倍。培养材料中酵母的存在使死亡风险增加了4.4倍。结论:早期诊断、排除纵隔炎的病因、充分的纵隔清创术、多次引流及术后持续灌洗是成功治疗急性纵隔炎的关键。
{"title":"Acute Mediastinitis – Outcomes and Prognostic Factors of Surgical Therapy (A Single-Center Experience)","authors":"Josef Vodicˇka, J. Geiger, A. Židková, P. Andrle, H. Mírka, Martin Svatonˇ, Tomáš Kostlivý","doi":"10.5761/atcs.oa.21-00147","DOIUrl":"https://doi.org/10.5761/atcs.oa.21-00147","url":null,"abstract":"Purpose: The aims of this work were the retrospective analysis of a cohort of patients with acute mediastinitis treated at the authors’ worksite over a 15-year period and the identification of factors that significantly affect the outcomes of the therapy. Methods: During the period 2006–2020, 80 patients with acute mediastinitis were treated. Within the cohort, the following were observed: the causes and the type of acute mediastinitis, length of anamnesis, comorbidities, diagnostic methods, time from the diagnosis to surgery, types and number of surgical procedures, results of microbiological tests, complications, and outcomes of the treatment. Results: The most common type of acute mediastinitis was descending mediastinitis (48.75%). A total of 116 surgical procedures were performed. Ten patients in the cohort died (12.5%). Patients older than 60 years were at a 6.8 times higher risk of death. Patients with more than two comorbidities were at a 14.3 times higher risk of death. The presence of yeasts in the culture material increased the risk of death by 4.4 times. Conclusion: Early diagnosis, removal of the cause of mediastinitis, sufficient mediastinal debridement, and multiple drainage thereof with the possibility of continual postoperative lavage are essential for the successful treatment of acute mediastinitis.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"28 1","pages":"171 - 179"},"PeriodicalIF":1.3,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42837135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Extensive Arch Repair with a Novel Two-Branched Stent Graft in Acute Type A Aortic Dissection 新型双支支架移植广泛修复急性a型主动脉夹层足弓
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-02-26 DOI: 10.5761/atcs.oa.21-00261
Zhao An, Yangyong Sun, R. Fan, Shi-qiang Yu, Junming Zhu, Qing-qi Han, Lin Han
Purpose: In this study, we compared the early results between the extensive arch repair with a novel two-branched stent graft (TSG) and the traditional technique. Methods: Between 2013 July and 2015 March, 63 acute type A aortic dissection (ATAAD) patients from four cardiac centers with indications for extensive arch repair were included in this study. Finally, 28 patients were involved in the traditional procedure (TP) group (23 males with the age of 49.75 ± 9.26 years) and 35 patients were involved in the TSG group (29 males with the age of 53.82 ± 8.17 years). Results: The operation was successful in all patients. The selective cerebral perfusion time, total operation time, and chest drainage within 24 hours after the operation in the TSG group were significantly less than those in the TP group (P ≤0.05). The mean follow-up time was 11.17 ± 1.74 months in the TP group and 11.94 ± 4.29 months in the TSG group. No statistical differences were found in aortic diameter, false lumen diameter, and true lumen diameter at the diaphragmatic level during the follow-up. Conclusion: Our technique with a novel TSG simplified the extensive arch repair procedure and was an effective way for the treatment of ATAAD.
目的:在本研究中,我们比较了新型双分支支架移植物(TSG)广泛修复足弓与传统技术的早期结果。方法:在2013年7月至2015年3月期间,本研究纳入了来自四个心脏中心的63名具有广泛足弓修复适应症的急性A型主动脉夹层(ATAAD)患者。最后,28名患者参与传统手术(TP)组(23名男性,年龄49.75±9.26岁),35名患者参与TSG组(29名男性,性别53.82±8.17岁)。结果:所有患者的手术均获得成功。TSG组术后24小时内选择性脑灌注时间、总手术时间和胸腔引流时间均显著少于TP组(P≤0.05),平均随访时间TP组为11.17±1.74个月,TSG组为11.94±4.29个月。随访期间,膈水平的主动脉直径、假管腔直径和真管腔直径没有发现统计学差异。结论:我们的新TSG技术简化了广泛的足弓修复程序,是治疗ATAAD的有效方法。
{"title":"Extensive Arch Repair with a Novel Two-Branched Stent Graft in Acute Type A Aortic Dissection","authors":"Zhao An, Yangyong Sun, R. Fan, Shi-qiang Yu, Junming Zhu, Qing-qi Han, Lin Han","doi":"10.5761/atcs.oa.21-00261","DOIUrl":"https://doi.org/10.5761/atcs.oa.21-00261","url":null,"abstract":"Purpose: In this study, we compared the early results between the extensive arch repair with a novel two-branched stent graft (TSG) and the traditional technique. Methods: Between 2013 July and 2015 March, 63 acute type A aortic dissection (ATAAD) patients from four cardiac centers with indications for extensive arch repair were included in this study. Finally, 28 patients were involved in the traditional procedure (TP) group (23 males with the age of 49.75 ± 9.26 years) and 35 patients were involved in the TSG group (29 males with the age of 53.82 ± 8.17 years). Results: The operation was successful in all patients. The selective cerebral perfusion time, total operation time, and chest drainage within 24 hours after the operation in the TSG group were significantly less than those in the TP group (P ≤0.05). The mean follow-up time was 11.17 ± 1.74 months in the TP group and 11.94 ± 4.29 months in the TSG group. No statistical differences were found in aortic diameter, false lumen diameter, and true lumen diameter at the diaphragmatic level during the follow-up. Conclusion: Our technique with a novel TSG simplified the extensive arch repair procedure and was an effective way for the treatment of ATAAD.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"28 1","pages":"255 - 261"},"PeriodicalIF":1.3,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45941529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Applicability of Continuous Retrograde Cardioplegia in Minimally Invasive Aortic Valve Replacement: New Approaches. 持续逆行心脏停搏术在微创主动脉瓣置换术中的安全性和适用性:新方法。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-02-20 Epub Date: 2021-08-04 DOI: 10.5761/atcs.nm.20-00293
Shunsuke Sato, Takashi Azami, Tatsuya Kawamoto, Kyozo Inoue, Kenji Okada

Purpose: To discuss minimally invasive cardiac surgery aortic valve replacement (MICS-AVR) approach via anterior thoracotomy using continuous retrograde cardioplegia. Continuous retrograde cardioplegia facilitates excellent continuous homogeneous cooling of the heart during cardiac arrest.

Methods: We performed AVR using the proposed method in nine patients between June 2018 and September 2019. The median age of the patients was 73 (range: 43-84) years. The pleural space was entered via anterior thoracotomy. After opening of the right atrium, a retrograde cardioplegic cannula was inserted into the coronary sinus with a purse-string suture. Continuous cold blood retrograde cardioplegia was initiated at 700 mL/h.

Results: Extubation in the operating room was performed in five (56%) patients. No new decreased function of the left and right ventricles was observed in intraoperative transesophageal echography or transthoracic echocardiogram.

Conclusion: MICA-AVR through continuous retrograde cardioplegia is a safe technique.

目的:探讨连续逆行心脏截瘫经前开胸的微创心脏手术主动脉瓣置换术(MICS-AVR)。在心脏骤停期间,持续逆行心脏骤停有利于心脏的持续均匀冷却。方法:我们于2018年6月至2019年9月对9例患者进行了AVR。患者的中位年龄为73岁(43-84岁)。胸膜间隙通过前开胸进入。打开右心房后,用荷包缝合将逆行心脏截瘫插管插入冠状窦。700 mL/h开始持续低温逆行心脏骤停。结果:5例(56%)患者在手术室拔管。术中经食管超声和经胸超声心动图未见新的左、右心室功能下降。结论:MICA-AVR经持续逆行心脏骤停是一种安全的技术。
{"title":"Safety and Applicability of Continuous Retrograde Cardioplegia in Minimally Invasive Aortic Valve Replacement: New Approaches.","authors":"Shunsuke Sato,&nbsp;Takashi Azami,&nbsp;Tatsuya Kawamoto,&nbsp;Kyozo Inoue,&nbsp;Kenji Okada","doi":"10.5761/atcs.nm.20-00293","DOIUrl":"https://doi.org/10.5761/atcs.nm.20-00293","url":null,"abstract":"<p><strong>Purpose: </strong>To discuss minimally invasive cardiac surgery aortic valve replacement (MICS-AVR) approach via anterior thoracotomy using continuous retrograde cardioplegia. Continuous retrograde cardioplegia facilitates excellent continuous homogeneous cooling of the heart during cardiac arrest.</p><p><strong>Methods: </strong>We performed AVR using the proposed method in nine patients between June 2018 and September 2019. The median age of the patients was 73 (range: 43-84) years. The pleural space was entered via anterior thoracotomy. After opening of the right atrium, a retrograde cardioplegic cannula was inserted into the coronary sinus with a purse-string suture. Continuous cold blood retrograde cardioplegia was initiated at 700 mL/h.</p><p><strong>Results: </strong>Extubation in the operating room was performed in five (56%) patients. No new decreased function of the left and right ventricles was observed in intraoperative transesophageal echography or transthoracic echocardiogram.</p><p><strong>Conclusion: </strong>MICA-AVR through continuous retrograde cardioplegia is a safe technique.</p>","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"28 1","pages":"36-40"},"PeriodicalIF":1.3,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/0f/atcs-28-036.PMC8915936.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39277597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Annals of Thoracic and Cardiovascular Surgery
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