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Up-to-Date, Skeletonized or Pedicle Bilateral Internal Mammary Artery; Does It Matter? 双侧乳腺内动脉,骨化或带蒂;这有关系吗?
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-04-20 DOI: 10.5761/atcs.ra.22-00094
Haralabos Parissis, Mondrian Parissis

Purpose: In this article, we reported on the up-to-date literature regarding skeletonized bilateral internal mammary artery (BIMA) flow and the effect on sternal perfusion. We also reviewed the pros and cons of the skeletonization technique versus the conventional pedicle technique for harvesting the BIMA.

Methods: We performed an up-to-date review using the PubMed database, with a specific focus on the contemporary published literature.

Results: BIMA skeletonization can preserve the sternal microcirculation, minimize tissue damage, and maintain blood supply to the chest wall at the tissue level. This effect is also apparent in diabetics. Deep sternal wound infection (DSWI) rates are significantly less with skeletonization versus the conventional pedicle technique and are comparable to single internal mammary artery harvesting.

Conclusions: Contemporary large-scale studies demonstrate that skeletonization of the BIMA increases conduit length, provides superior flow, reduces the incidence of DSWIs, and improves late survival. Hopefully, this review will increase awareness of the compelling evidence in favor of using skeletonized internal mammary arteries and stimulate increased uptake of BIMA revascularization surgery.

目的:在这篇文章中,我们报道了最新的关于双侧乳腺内动脉(BIMA)骨化血流及其对胸骨灌注的影响的文献。我们还回顾了骨骼化技术与传统椎弓根技术的优缺点。方法:我们使用PubMed数据库进行了最新的综述,特别关注当代发表的文献。结果:BIMA骨化能保持胸骨微循环,减少组织损伤,在组织水平上维持胸壁血供。这种效果在糖尿病患者中也很明显。与传统的椎弓根技术相比,骨化术的胸骨深部伤口感染(DSWI)率显著降低,与单次乳腺内动脉切除相当。结论:当代大规模研究表明,BIMA骨化增加了导管长度,提供了更好的血流,减少了DSWIs的发生率,并提高了晚期生存率。有希望的是,这篇综述将提高人们对使用骨化乳腺内动脉的有力证据的认识,并刺激BIMA血运重建术的增加。
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引用次数: 0
Safety of Left Subclavian Artery Selective Coverage without Revascularization in Thoracic Endovascular Aortic Repair for Type B Aortic Dissections. B型主动脉夹层胸腔内主动脉修复术中左锁骨下动脉选择性覆盖无血运重建的安全性。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-04-20 DOI: 10.5761/atcs.oa.22-00146
Mingyu Sun, Yasong Wang, Tienan Zhou, Xuanze Liu, Quanmin Jing, Haiwei Liu, Xiaozeng Wang

Purpose: Whether to proceed left subclavian artery (LSA) revascularization in patients with LSA coverage due to insufficient proximal landing zone (PLZ) during thoracic endovascular aortic repair (TEVAR) remains controversial.

Methods: A total of 903 patients who received TEVAR were retrospectively analyzed. LSA could be covered if the PLZ was less than 15 mm accompanied with 1) a dominant or balanced right vertebral artery, 2) a complete circle of Willis, and 3) a left vertebral artery with a diameter ≥3 mm and without severe stenosis.

Results: LSA selective coverage was necessary for 35.0% (316/903) of the patients to extend the PLZ. Patients presented with weakness, pain, cooling and discoloration of the left upper extremity (LUE), and pulselessness of the left brachial artery were more in the LSA-covered group. The ischemia of LUE occurred more often in patients with LSA covered completely than in those with LSA covered partially. Functional arm status showed no significant difference in the arm, shoulder, and hand questionnaire scores at 12 months postoperative between the LSA-covered group and LSA-uncovered group, or between the LSA-covered completely group and LSA-covered partially group.

Conclusion: It was safe to cover the LSA origin without revascularization if the PLZ was less than 15 mm accompanied with careful evaluation (description in method).

目的:胸椎血管内主动脉修复术(TEVAR)中,由于近端着陆区(PLZ)不足,导致左锁骨下动脉(LSA)覆盖的患者是否进行左锁骨下动脉(LSA)血运重建术仍存在争议。方法:对903例接受TEVAR治疗的患者进行回顾性分析。如果PLZ小于15mm,伴有1)右侧椎动脉占优势或平衡,2)完整的Willis圈,3)左侧椎动脉直径≥3mm且无严重狭窄,则可以覆盖LSA。结果:35.0%(316/903)的患者需要LSA选择性覆盖才能延长PLZ。lsa覆盖组患者表现为左上肢(LUE)无力、疼痛、冷却和变色,左肱动脉无脉。完全覆盖LSA的患者比部分覆盖LSA的患者更容易发生LUE缺血。术后12个月,手臂功能状态在手臂、肩部和手部问卷得分上,在覆盖lsa组和未覆盖lsa组之间,或者在完全覆盖lsa组和部分覆盖lsa组之间没有显著差异。结论:如果PLZ小于15mm,并经过仔细的评估(方法中有描述),可以安全地覆盖LSA起源而不需要血运重建。
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引用次数: 1
Mechanical Tricuspid Valves Have Higher Rate of Reintervention: A Single Center Experience. 机械三尖瓣有更高的再介入率:单中心经验。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-04-20 DOI: 10.5761/atcs.oa.22-00086
Turki B Albacker, Amr A Arafat, Abdulaziz M Alotaibi, Haneen Alghosoon, Khalid D Algarni

Purpose: We compared the composite outcome of tricuspid valve (TV) reintervention or heart failure (HF) admission in patients who underwent tricuspid valve replacement (TVR) with tissue vs. mechanical valves.

Patients and methods: The study included 159 patients who underwent TVR from 2009 to 2019. We grouped the patients according to the valve's type into tissue valve group (n = 139) and mechanical valve group (n = 20).

Results: The mean age of patients was 52.4 ± 12.8 years, and 117 patients were females (73.6%). Hospital mortality occurred in 20 patients (12.6%); all of them were in the tissue valve group. The composite outcome of reintervention and HF readmission occurred in 8 patients with mechanical valves (40%) vs. 24 patients with tissue valves (17.3%), (P = 0.018). Predictors of reintervention and HF admission were female (subdistributional hazard ratio [SHR]: 1.38-34.3, P = 0.019), stroke (SHR: 1.25-8.76, P = 0.016), hypertension (SHR: 1.13-5.36, P = 0.024), and mechanical valves (SHR: 1.6-10.7, P = 0.003). In post hoc analysis, the difference in the composite outcome was derived from the difference in the reintervention rate that was higher in mechanical valves. Survival did not differ significantly between groups (P = 0.12).

Conclusion: Mechanical TVs have a higher rate of composite outcome of reintervention or HF readmission than tissue TVs that are related mainly to higher rate of reintervention.

目的:我们比较三尖瓣置换术(TVR)与机械瓣膜置换术(TVR)患者三尖瓣(TV)再干预或心力衰竭(HF)入院的综合结果。患者和方法:该研究包括2009年至2019年接受TVR的159例患者。根据瓣膜类型将患者分为组织瓣膜组(n = 139)和机械瓣膜组(n = 20)。结果:患者平均年龄52.4±12.8岁,女性117例(73.6%)。住院死亡20例(12.6%);所有患者均为组织瓣膜组。机械瓣膜8例(40%)与组织瓣膜24例(17.3%)出现再干预和HF再入院的复合结局(P = 0.018)。再干预和HF入院的预测因子为女性(亚分布风险比[SHR]: 1.38 ~ 34.3, P = 0.019)、卒中(SHR: 1.25 ~ 8.76, P = 0.016)、高血压(SHR: 1.13 ~ 5.36, P = 0.024)和机械瓣膜(SHR: 1.6 ~ 10.7, P = 0.003)。在事后分析中,复合结果的差异源于机械瓣膜再干预率较高的差异。两组间生存率无显著差异(P = 0.12)。结论:机械电视的再干预率和HF再入院率均高于组织电视,而组织电视的再干预率主要与机械电视的再干预率有关。
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引用次数: 2
Multifocal Cholesterol Granulomas of the Thymus: A Case Report of Positron Emission Tomography- Positive Benign Tumor of the Anterior Mediastinum. 胸腺多灶性胆固醇肉芽肿:前纵隔正电子发射断层扫描阳性良性肿瘤1例。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-04-20 DOI: 10.5761/atcs.cr.21-00198
Mikito Suzuki, Hirotoshi Horio, Azusa Yamada, Reiko Shimizu, Toshiyuki Shima, Masahiko Harada, Tsunekazu Hishima

Cholesterol granulomas of the thymus are extremely rare benign entities. Herein, we describe a case of cholesterol granuloma in a 45-year-old man who presented with multifocal anterior mediastinal lesions on computed tomography (CT). Positron emission tomography (PET)-CT revealed increased fluorodeoxyglucose uptake, with a maximum standardized uptake value of 8.3. Diffusion-weighted magnetic resonance imaging (MRI) revealed extreme hypointensity. He underwent total thymectomy by median sternotomy for presumed multiple thymoma. On histopathological analysis, cholesterol granuloma of the thymus was confirmed, and the patient had an uneventful postoperative course without recurrence for 28 months. Cholesterol granuloma of the thymus is a PET-CT-positive benign tumor with unique histological findings. The MRI findings were indicative of hypocellularity associated with a benign entity, whereas the PET-CT findings corresponded to granulomatous inflammation. Therefore, concurrent use of PET-CT and MRI can be helpful in distinguishing between benign cholesterol granulomas and malignant anterior mediastinal tumors.

胸腺胆固醇肉芽肿是极为罕见的良性肿瘤。在此,我们描述一个45岁男性胆固醇肉芽肿的病例,他在计算机断层扫描(CT)上表现为多灶前纵隔病变。正电子发射断层扫描(PET)-CT显示氟脱氧葡萄糖摄取增加,最大标准化摄取值为8.3。弥散加权磁共振成像(MRI)显示极低。他接受了全胸腺切除术,胸骨正中切开术推定多发胸腺瘤。经组织病理学分析,证实胸腺胆固醇肉芽肿,患者术后28个月无复发。胸腺胆固醇肉芽肿是一种pet - ct阳性的良性肿瘤,具有独特的组织学表现。MRI表现为良性细胞增多,而PET-CT表现为肉芽肿性炎症。因此,同时使用PET-CT和MRI可以帮助区分良性胆固醇肉芽肿和恶性前纵隔肿瘤。
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引用次数: 1
I-Composite Graft with Right Internal Thoracic Artery and Right Gastroepiploic Artery in Coronary Artery Bypass Grafting. 右胸内动脉与右胃网膜动脉复合移植在冠状动脉搭桥术中的应用。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-04-20 DOI: 10.5761/atcs.oa.22-00171
Makoto Shirakawa, Masami Ochi, Yosuke Ishii

Purpose: When added to the internal thoracic artery (ITA), the right gastroepiploic artery (GEA) has been used as an in-situ graft or an I-composite right ITA-right GEA graft in coronary artery bypass grafting (CABG). We aimed to verify its potential.

Methods: We evaluated 104 patients who underwent first isolated CABG with this I-composite graft. The number of distal anastomoses, graft flow (GF) and pulsatility index (PI) during surgery, and graft patency in the early term regarding this I-composite graft were evaluated.

Results: The number of total distal anastomoses and distal anastomoses with arterial grafts were 4.17 ± 0.81 and 3.63 ± 0.81, respectively. This I-composite graft achieved 2.38 ± 0.69 distal anastomoses. GF tended to increase according to the increased number of distal anastomoses (p = 0.241), and the PI maintained a low score regardless of the number of distal anastomoses (p = 0.834). Graft patency was 95.5%; moreover, the number of distal anastomoses with this I-composite graft did not affect early-term graft patency.

Conclusion: Right GEA utility was expanded as this I-composite graft in addition to in-situ graft. This I-composite graft has an adequate flow capacity for revascularization in non-left anterior descending coronary artery lesions.

目的:在冠状动脉旁路移植术(CABG)中,将右胃网膜动脉(GEA)加入胸腔内动脉(ITA)作为原位移植物或i -复合右ITA-右GEA移植物。我们的目的是验证它的潜力。方法:我们评估了104例首次行分离性冠状动脉搭桥术的患者。评估远端吻合口数量、术中移植物流量(GF)和脉搏指数(PI),以及早期i -复合移植物的通畅性。结果:总远端吻合次数为4.17±0.81次,动脉移植远端吻合次数为3.63±0.81次。该i型复合移植物远端吻合率为2.38±0.69。GF有随远端吻合器个数增加而增加的趋势(p = 0.241), PI与远端吻合器个数无关(p = 0.834)。移植通畅率为95.5%;此外,远端吻合口的数量与这种i -复合移植物不影响早期移植物通畅。结论:除了原位移植物外,该i -复合移植物扩大了右GEA效用。这种i型复合移植物具有足够的血流能力,可用于非左前降支病变的冠状动脉血运重建。
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引用次数: 1
Operative Timing and Feasibility of Mitral Valve Repair in Active Infective Endocarditis. 活动性感染性心内膜炎二尖瓣修复术的手术时机和可行性。
IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-02-20 Epub Date: 2022-11-03 DOI: 10.5761/atcs.oa.22-00135
Tadashi Omoto, Atsushi Aoki, Kazuto Maruta, Tomoaki Masuda

Purpose: We studied the association between operative timing and the feasibility of mitral valve (MV) repair in active infective endocarditis (IE).

Methods: Forty-nine active IE patients who underwent MV operation were classified according to operative timing: within 48 hours (Term I: n = 7), between 3 and 14 days (Term II: n = 22), and ≥15 days (Term III: n = 20). Patient profiles, operative outcomes, and feasibility of MV repair were evaluated. Complexity score and severity score were used to define the feasibility of MV repair depending on the extent of infected lesion and technical difficulties.

Results: There were no differences in basic profile in the three groups. Rate of major complications was higher in Term I (86%) than II (41%, p = 0.031) and III (25%, p = 0.005). In-hospital mortality was also higher in Term I (43%) than II (9%, p = 0.039) and III (5%, p = 0.015). The three groups did not differ by feasibility of MV repair calculated by the two-score system or by frequency of MV repair (I: 57%, II: 59%, and III: 55%).

Conclusions: Morbidity and mortality were high in urgent cases. Feasibility of MV repair is associated with the extent of infected lesion and technical difficulties, and not with operative timing.

目的:我们研究了手术时机与活动性感染性心内膜炎(IE)二尖瓣(MV)修复可行性之间的关系:根据手术时间将接受二尖瓣手术的 49 例活动性 IE 患者分类:48 小时内(I 期:n = 7)、3 至 14 天(II 期:n = 22)和≥15 天(III 期:n = 20)。对患者情况、手术效果和中压修复的可行性进行了评估。根据感染病灶的范围和技术难度,用复杂性评分和严重性评分来定义中风修补术的可行性:结果:三组患者的基本情况无差异。I期(86%)的主要并发症发生率高于II期(41%,P = 0.031)和III期(25%,P = 0.005)。一期(43%)的院内死亡率也高于二期(9%,P = 0.039)和三期(5%,P = 0.015)。根据两评分系统计算的中压修复可行性或中压修复频率,三组没有差异(Ⅰ期:57%;Ⅱ期:59%;Ⅲ期:55%):结论:急诊病例的发病率和死亡率较高。中压修复的可行性与感染病灶的范围和技术难度有关,与手术时机无关。
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引用次数: 0
Solitary Cardiac Metastasis from Esophageal Cancer. 食道癌的孤立性心脏转移灶
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-02-20 Epub Date: 2021-09-07 DOI: 10.5761/atcs.cr.21-00149
Miho Akabane, Masayuki Urabe, Yu Ohkura, Shusuke Haruta, Masaki Ueno, Harushi Udagawa

A 72-year-old woman with past medical history of rectal cancer resection (adenocarcinoma, pT3N1aM0) presented with a 2-month history of dysphagia. Imaging studies found a thoracic esophageal cancer, for which subtotal esophagectomy with gastric conduit reconstruction via retrosternal route followed by chemoradiotherapy were performed (squamous cell carcinoma, pT4N1M0, RM1). Seven months after the esophagectomy, a contrast-enhanced computed tomography (CT) demonstrated a new asymptomatic mass inside the right atrium. A thrombus or a tumorous lesion was suspected. Positron emission tomography (PET)/CT showed abnormal uptake in the mass. After a thorough discussion by a multidisciplinary oncology group, we performed 1-week anticoagulant therapy first, resulting in mass enlargement. Then tumorectomy was carried out. The final pathological findings revealed that the mass was squamous cell carcinoma, yielding the diagnosis of cardiac metastasis from esophageal cancer. The patient's postoperative course was unremarkable. PET/CT may help to estimate malignancy and to omit invasive heart surgery.

一名 72 岁的妇女曾接受过直肠癌切除术(腺癌,pT3N1aM0),两个月前出现吞咽困难。影像学检查发现她患有胸腔食管癌,于是对她进行了食管次全切除术,并通过胸骨后途径进行了胃导管重建,随后进行了放化疗(鳞状细胞癌,pT4N1M0,RM1)。食管切除术 7 个月后,对比增强计算机断层扫描(CT)显示右心房内出现新的无症状肿块。怀疑是血栓或肿瘤病变。正电子发射断层扫描(PET)/CT 显示肿块摄取异常。经过多学科肿瘤小组的充分讨论,我们首先进行了为期一周的抗凝治疗,结果肿块增大。然后进行了肿瘤切除术。最终病理结果显示,肿块为鳞癌,诊断为食管癌心脏转移。患者术后恢复良好。PET/CT 可以帮助估计恶性程度,避免进行侵入性心脏手术。
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引用次数: 0
Inadvertently Swallowed Needle Pierced the Pulmonary Artery in an Adult. 误吞针头刺穿成人肺动脉。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-02-20 DOI: 10.5761/atcs.cr.21-00161
Xiaoyi Dai, Shengjun Wu

Background: Esophageal foreign body (FB) is usually seen in children, prisoners, or patients with psychiatric disorders, most of which can be removed with endoscope.

Case presentation: We herein report a mentally normal adult inadvertently swallowing a needle, which pierced through the esophagus into the adventitia of pulmonary artery. Computed tomography angiography confirmed its specific location, and urgently, surgical removal was performed after the endoscopic attempt. The patient recovered well and was discharged without any complication of the esophageal perforation.

Conclusion: Surgical treatment should be carried out aggressively if the esophageal FB is out of reach for endoscopic removal or if complications cannot be resolved endoscopically.

背景:食管异物(FB)常见于儿童、囚犯或精神障碍患者,多数可通过内窥镜清除。病例介绍:我们在此报告一位精神正常的成年人无意中吞下了一根穿过食道进入肺动脉外膜的针。计算机断层血管造影证实了其具体位置,并在内镜尝试后紧急进行手术切除。患者恢复良好,出院时无任何食管穿孔并发症。结论:食管FB在内镜下无法切除或并发症无法解决时,应积极进行手术治疗。
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引用次数: 0
Development of Paraneoplastic Neuromyelitis Optica after Lung Resection in a Patient with Squamous Cell Carcinoma. 鳞状细胞癌患者肺切除术后视神经脊髓炎的发展。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-02-20 DOI: 10.5761/atcs.cr.21-00144
Shunsuke Eba, Shuhei Nishiyama, Hirotsugu Notsuda, Hisashi Oishi, Masafumi Noda, Masashi Aoki, Yoshinori Okada

Neurological paraneoplastic syndrome is a relatively rare condition in patients with malignant tumors. Recently, it has been reported that anti-Aquaporin 4 (AQP4) antibody is highly specific for neuromyelitis optica. The patient was a 76-year-old man. He underwent right upper lobectomy for squamous cell carcinoma of the lung. Although the immediate postoperative course was uneventful, neurological symptoms became apparent from postoperative day (POD) 4. Magnetic resonance imaging showed longitudinally extended edematous lesions in the spinal cord, and a cerebrospinal fluid examination was positive for anti-AQP4 antibody, leading to the diagnosis of paraneoplastic neuromyelitis optica. Despite multiple rounds of steroid pulse therapy and plasma exchange, the neurological symptoms worsened and the patient died on POD 46. The development of neuromyelitis optica in the early postoperative period could be related to the influence of surgical stress or epidural anesthesia.

神经副肿瘤综合征在恶性肿瘤患者中是一种相对罕见的疾病。最近有报道称,抗水通道蛋白4 (AQP4)抗体对视神经脊髓炎具有高度特异性。患者为一名76岁男性。他接受了右上肺叶切除肺鳞状细胞癌。虽然术后的直接过程是平静的,但从术后一天(POD)开始,神经系统症状变得明显。mri示脊髓纵向延伸水肿病变,脑脊液抗aqp4抗体阳性,诊断为副肿瘤性视神经脊髓炎。尽管进行了多轮类固醇脉冲治疗和血浆置换,但神经系统症状恶化,患者于POD 46死亡。术后早期视神经脊髓炎的发生可能与手术应激或硬膜外麻醉的影响有关。
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引用次数: 2
Circ_0006220 Contributes to NSCLC Progression through miR-342-3p/GOT2 Axis. Circ_0006220通过miR-342-3p/GOT2轴促进NSCLC进展。
IF 1.3 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-02-20 DOI: 10.5761/atcs.oa.22-00090
Jichun Tang, Xuan Li, Lili Zhao, Jiajun Hui, Ning Ding

Purpose: Dysregulated circular RNAs (circRNAs) have shown crucial modulatory functions in tumorigenesis, containing non-small cell lung cancer (NSCLC). The purpose of this study was to explore the biological functions and regulatory theory of circ_0006220 in NSCLC.

Methods: Reverse transcription-quantitative polymerase chain reaction and Western blot assay were conducted to measure RNA and protein expression, respectively. A total of 73 cases of NSCLC tumor samples were collected for expression analysis, and A-549 and NCI-H1299 cell lines were used for functional experiments. Cell proliferation was assessed by cell counting kit-8 assay, colony formation assay, 5-ethynyl-2'-deoxyuridine assay, and flow cytometry. Cell apoptosis, motility, and angiogenesis ability were analyzed by flow cytometry, transwell assays, and capillary-like network formation assay. Dual-luciferase reporter assay and RNA immunoprecipitation assay were conducted to verify the target relationships.

Results: Circ_0006220 was highly expressed in NSCLC tissues and cell lines. Circ_0006220 silencing inhibited the proliferation, migration, invasion, and angiogenesis but induced the apoptosis of NSCLC cells. Circ_0006220 acted as a microRNA-342-3p (miR-342-3p) sponge, and circ_0006220 knockdown-induced changes on the phenotypes of NSCLC cells were largely overturned by the knockdown of miR-342-3p. miR-342-3p interacted with the 3' untranslated region of glutamic-oxaloacetic transaminase 2 (GOT2), and GOT2 overexpression largely diminished miR-342-3p overexpression-mediated influences in NSCLC cells. Circ_0006220 could up-regulate GOT2 expression by sponging miR-342-3p.

Conclusion: Circ_0006220 promoted the malignant behaviors of NSCLC cells through mediating the miR-342-3p/GOT2 regulation cascade.

目的:失调的环状rna (circRNAs)在非小细胞肺癌(NSCLC)的肿瘤发生中显示出至关重要的调节功能。本研究旨在探讨circ_0006220在非小细胞肺癌中的生物学功能及调控理论。方法:采用逆转录-定量聚合酶链反应法和Western blot法分别检测RNA和蛋白的表达。共收集73例NSCLC肿瘤样本进行表达分析,并采用A-549和NCI-H1299细胞系进行功能实验。通过细胞计数试剂盒-8法、集落形成法、5-乙基-2′-脱氧尿苷法和流式细胞术评估细胞增殖情况。通过流式细胞术、transwell实验和毛细血管样网络形成实验分析细胞凋亡、运动和血管生成能力。采用双荧光素酶报告基因法和RNA免疫沉淀法验证靶关系。结果:Circ_0006220在NSCLC组织和细胞系中高表达。Circ_0006220沉默抑制非小细胞肺癌细胞的增殖、迁移、侵袭和血管生成,但诱导细胞凋亡。Circ_0006220作为microRNA-342-3p (miR-342-3p)海绵,Circ_0006220敲低诱导的NSCLC细胞表型变化在很大程度上被miR-342-3p敲低所推翻。miR-342-3p与谷草转氨酶2 (GOT2)的3'非翻译区相互作用,GOT2过表达在NSCLC细胞中大大降低了miR-342-3p过表达介导的影响。Circ_0006220可通过海绵转染miR-342-3p上调GOT2的表达。结论:Circ_0006220通过介导miR-342-3p/GOT2调控级联促进NSCLC细胞的恶性行为。
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引用次数: 1
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Annals of Thoracic and Cardiovascular Surgery
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