Applied Neuropsychology: Child最新文献

Pediatric cancer treatments may contribute to slower processing, while cultural considerations (e.g., SES) can influence outcomes and tend to be disproportionately lower in racial/ethnic minorities. Given increased risk for certain cancers in Hispanic/Latine children and rising Spanish exposure in the United States, the purpose of this study was to examine differences in processing speed between cancer survivors based on household language exposure: English vs. mixed language (ML; i.e. monolingual Spanish-speaking or bilingual Spanish/English-speaking). 128 patients ages 8-21 with leukemia/lymphoma completed screening. As expected, SES was lower in patients from ML households based on parental education (U = 355.00, p<.001) and estimated household income (U = 1031.500, p<.001). Despite this, processing speed (assessed using the written and oral trials of the Symbol Digit Modalities Test; SDMT) was average (SDMT-W x̅=-.13, SDMT-O x̅=.32), with no significant differences between language groups (F(2,120)=0.966, p=.384). Post-hoc analyses revealed time since diagnosis did not predict performance on oral trial for either group or the whole sample, while poorer performance on written trial was noted among the English-only group when further from diagnosis (SDMT-W F(1,57)=7.829, p=.007). Stable ML group trajectory regardless of time since diagnosis may reflect resiliency among children with Spanish exposure.

Objectives: Mental chronometry is the scientific study of cognitive processing speed measured by reaction time (RT), which is the elapsed time between the onset of a stimulus and an individual's response. This study aims at measuring the RT among young children with autism spectrum disorders (ASD) and comparing it with normal (typically developing) children.

Methods: 60 ASD children were selected from different ASD centers, and 60 normal children were selected from different kindergartens for participation in this study. Participants were aged 3-6 years old. The RT was measured using the Fitlight trainer device. The findings were statistically evaluated using independent t-tests and ANOVA tests.

Result: Significant differences (p < 0.0001) were found between both groups in all tasks, and ASD children demonstrated slower RT compared to the normal group. The RT measured through three senses (visual, auditory, and touch) for ASD and normal were 3.64 ± 2.16, 13.19 ± 2.41(trial), 1835.23 ± 757.95, 697.12 ± 87.83 (second), and 1550.89 ± 499.76, 752.67 ± 124.02 (second) respectively.

Conclusion: The evaluated RT showed significant impairment in RT among ASD in comparison to normal children and this was true for the three senses. The Fitlight trainer could be used to assess RT and stimulus-response among ASD children in various cognitive tasks. Similar studies, involving larger samples from different areas and involving other sense organs, are indicated to confirm the results.

Objective: The present study was designed to assess the neuropsychological test performances of non-concussed female and male high school athletes of different ages in high and low contact sports.

Method: Large samples of 2,510 high school athletes in High Contact sports (e.g., football) and 1,437 in Low Contact sports (e.g., basketball) were examined. The participants were administered a baseline Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) prior to their respective seasons.

Results: Multivariate linear regression showed that the High Contact athletes had significantly poorer results than the Low Contact athletes in all four ImPACT Composite scores and the Total Symptom scores. No age differences were found, but in all three age groups, the High Contact athletes had lower Visual Motor Speed scores than the Low Contact athletes. No test score differences were noted between the females in the High and Low Contact groups, but the High Contact males had poorer Visual Motor Speed and Reaction Time than the Low Contact males.

Conclusions: The present results were consistent with prior studies of subconcussive head trauma, with High Contact athletes obtaining overall poorer neuropsychological test results than Low Contact athletes. More investigations in this age group seems is warranted.

The Children's Color Trail Test (CCTT) is considered a culture fair equivalent of the Trail Making Test for the assessment of cognitive flexibility in pediatric populations, while others emphasize its additional validity as a measure of attention, perceptual tracking, processing speed, susceptibility to interference and inhibition. The need for standardized neuropsychological tests in Greece, especially for the pediatric population is significant. In the present study, considering the relatively good psychometric properties of the CCTT and its wide cross-cultural application, we decided that such a tool would be useful to Greek clinicians and researchers, and therefore developed norms for the Greek child and adolescent population. Additionally, we examined the clinical validity of the test, administering it to two groups of patients (children with Traumatic Brain Injury and Attention Deficit - Hyperactivity Disorder). We administered the test to 417 native healthy Greek children 6-15 years, recruited primarily from Southwestern Greece from several public schools. Linear regression analysis revealed a significant influence of age on completion time in both parts of the CCTT, whereas sex did not influence time to completion. Older children consistently completed the test faster than younger children, whereas girls and boys performed similarly on both conditions. In addition, CCTT differentiated the performance of children who have had a TBI and those diagnosed with ADHD from the performances of their typically developing peers. This study provides much needed performance and clinical utility data for the pediatric population in Greece on a promising neuropsychological tool for use in clinical and research settings.

Graphophonological-semantic flexibility is the cognitive flexibility in reading that enables individuals to manage multiple phonological and semantic aspects of text simultaneously. This study investigated graphophonological-semantic flexibility and its contribution to reading comprehension in children with dyslexia, comparing them to age-matched, typically developing peers. Thirty children aged 8-11 were assessed using a reading-specific sorting task, where they categorized word cards by initial phoneme and meaning within a 2x2 matrix. After sorting, participants explained their arrangements, and their sorting speed, accuracy, and composite scores were evaluated. Additionally, reading comprehension was assessed through passages followed by questions. Results revealed significant differences between children with dyslexia and their peers in sorting accuracy and composite scores. Children with dyslexia exhibited poorer accuracy and longer sorting times, leading to lower composite scores indicative of reduced graphophonological-semantic flexibility. Age showed a positive correlation with sorting accuracy and composite scores. Moreover, sorting accuracy and composite scores were strong predictors of reading comprehension. These findings suggest that children with dyslexia face challenges in managing both phonological and semantic aspects of text concurrently, highlighting the importance of graphophonological-semantic flexibility in reading development.

Objective: Attention deficit hyperactivity disorder (ADHD), is a general neurodevelopmental syndrome. This affects both adults and children, causing issues like hyperactivity, inattention, and impulsivity. Diagnosis, typically reliant on patient narratives and questionnaires, can sometimes be inaccurate, leading to distress. We propose utilizing empirical mode decomposition (EMD) for feature extraction and a machine learning (ML) algorithm to categorize ADHD and control.

Method: Publicly available Kaggle dataset is used for research. The EMD technique decomposes an electroencephalogram (EEG) waveform to 12 intrinsic mode functions (IMFs). Thirty-one statistical parameters are generated over the first 6 IMFs to create an input feature vector for the deep belief network (DBN) classifier. Principal component analysis (PCA) is utilized to reduce dimension.

Findings: Experimental results are compared on prefrontal cortex channels Fp1 and Fp2. After an in-depth evaluation of all metrics, it is observed that, in patients with ADHD, the prefrontal cortex regulates attention, behavior, and emotion. Our findings align with established neuroscience. The critical functions of the brain, such as organization, planning, attention, and decision making, are performed by the frontal lobe.

Novelty: Our work provides a novel approach to understanding the disorder's underlying neurobiological mechanisms. It has the potential to deepen our understanding of the condition, improve diagnostic accuracy, personalize treatment methods, and, ultimately, improve outcomes for those affected.

Background: Computerized neurocognitive testing is one component of a multidomain assessment of concussion. However, the use of computerized neurocognitive testing has been limited to patients aged 11 years and up, leaving clinicians with few options to evaluate younger children.

Purpose: To examine the change in Immediate Post-concussion Assessment and Cognitive Testing Pediatric (ImPACT Pediatric) (ImPACT Applications, 2021) scores and factors associated with performance in children aged 5-9 years following a concussion.

Methods: Participants included 63 children (42% [n = 27] female) aged 5-9 (M = 7.5 ± 1.0) years within 30 (M = 8.5 ± 5.9) days of a concussion. All participants completed the ImPACT Pediatric at their initial visit and at medical clearance for their return to activity (RTA) visit. The ImPACT Pediatric test is a computerized neurocognitive battery that includes 5 tests that assess memory and visual processing speed. Multivariate and univariate analyses of variance and paired t-tests were used to compare ImPACT Pediatric scores from the initial visit to medical clearance. Multivariate and univariate analyses of covariance and multiple linear regression examined factors associated with ImPACT Pediatric performance.

Results: Participants demonstrated improved overall performance from the initial visit to the medical clearance visit (F(4, 59)=3.08, p = 0.02, Wilks' Λ = 0.83, η_p²=0.17), with significant improvement in Rapid Processing Speed (F(1, 62)=7.48, p < 0.01, η_p²=0.11). When controlling for age, sex, history of ADHD, and days to clinic, the improvement in overall performance remained significant (F(4, 51)=2.99, p = 0.03, Wilks' Λ = 0.81, η_p²=0.19). Older age was significantly associated with the Rapid Processing composite score at the initial visit (F(4, 59)=5.9, p < 0.001, Adj. R²=0.25) and medical clearance visit (F(4, 59)=3.8, p = 0.008, Adj. R²=0.16), with older children associated with better performance at both time points (Initial visit: B = 8.17, p < 0.001; Medical Clearance: B = 3.62, p = 0.03).

Conclusion: Our main findings suggest that children aged 5-9 years improved significantly in Rapid Processing on the ImPACT Pediatric from the initial visit to medical clearance. However, no differences were found for the memory components of the ImPACT Pediatric. Older children also performed better on processing speed than younger children. The findings suggest that the processing speed components of ImPACT Pediatric are useful for monitoring improvements in neurocognitive functioning following concussion in children aged 5-9 years, but that age differences need to be considered when interpreting performance.

Executive functions (EFs) are a set of cognitive processes that enable individuals to manage and coordinate their thoughts and actions toward achieving specific goals. EFs include planning, organizing, initiating, and monitoring actions, and have been found to improve with age due to the maturation of the brain, especially during childhood. Therefore, our correlational study sought to determine the relationship between the performance in executive functions and age in 79 children (36 girls, 45.6%) throughout development, between the ages of 6 and 12 (mean = 9.25; SD = 2.05), using a battery designed in Chile: BEFE (Batería de Evaluación de las Funciones Ejecutivas: Executive Function Assessment Battery) based on traditional neuropsychological tests to evaluate Working Memory, Inhibitory Control, Cognitive Flexibility, and Planning skills. Our results showed various correlations between the variables age and performance in various behavioral parameters, demonstrating an increase in the number of correct responses (positive correlation) and/or a decrease in errors (negative correlation) with age (6-12) in the subtests that correspond to dimensions of Cognitive Flexibility (Semantic and Phonological Fluency, Card Sorting Game, and Tracing Tasks), Inhibitory Control (ENA-F and Sentence Completion), Working Memory (Audio-verbal WM Forward and Ordering, and Visuospatial WM Forward and Backward), and Planning (La Portada de Antofagasta and FISA Maps). These results are consistent with previous empirical evidence and support the notion of a developmental relationship between EF performance and age. Additionally, this study contributes to understanding EF development in culturally specific contexts, highlighting the importance of contextually relevant assessment tools in evaluating cognitive development.