Pub Date : 2022-03-11DOI: 10.21608/anj.2022.121976.1046
Alaa-eldin Hassan, M. Ezzat, Walid Elmorsy
{"title":"Evaluation of the Role of Ambroxol in Treatment of Respiratory Distress Syndrome","authors":"Alaa-eldin Hassan, M. Ezzat, Walid Elmorsy","doi":"10.21608/anj.2022.121976.1046","DOIUrl":"https://doi.org/10.21608/anj.2022.121976.1046","url":null,"abstract":"","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81508355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.21608/anj.2022.125131.1051
A. Hamed, Ismael El-Lebedy, Kariman Hamza
{"title":"The Rule of Inhaled Salbutamol on the Outcome of Transient Tachypnea of Newborn","authors":"A. Hamed, Ismael El-Lebedy, Kariman Hamza","doi":"10.21608/anj.2022.125131.1051","DOIUrl":"https://doi.org/10.21608/anj.2022.125131.1051","url":null,"abstract":"","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88222039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-06DOI: 10.21608/anj.2022.122114.1047
Mostafa Ali, A. Bayoumi, M. Younis, K. Awad
{"title":"Analytical Study of Different Modes of Continuous Positive Airway Pressure (CPAP) in Management of Respiratory Distress Syndrome (RDS) Preterm Neonates","authors":"Mostafa Ali, A. Bayoumi, M. Younis, K. Awad","doi":"10.21608/anj.2022.122114.1047","DOIUrl":"https://doi.org/10.21608/anj.2022.122114.1047","url":null,"abstract":"","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88929167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-06DOI: 10.21608/anj.2022.121894.1045
Mahmoud Shames El-dine, Abdel-Azeem M. El-Mazary, Moustafa Abo-Elela, Ashraf Abdel-Fadil
{"title":"Tandom Mass Spectrometry in Neonates Suspected to have Inborn Errors of Metabolism","authors":"Mahmoud Shames El-dine, Abdel-Azeem M. El-Mazary, Moustafa Abo-Elela, Ashraf Abdel-Fadil","doi":"10.21608/anj.2022.121894.1045","DOIUrl":"https://doi.org/10.21608/anj.2022.121894.1045","url":null,"abstract":"","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80256173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.21608/anj.2022.216437
D. Ahmed, S. Hasan
{"title":"The Relationship between Isolated Oligohydramnios at Term and Labor Mode. A Prospective-Observational Study","authors":"D. Ahmed, S. Hasan","doi":"10.21608/anj.2022.216437","DOIUrl":"https://doi.org/10.21608/anj.2022.216437","url":null,"abstract":"","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76002377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.21608/anj.2022.114062.1044
Abdel-Azeem M. El-Mazary
There is no doubt that the existence of guidelines is an important and great work in any of medical branches especially in the field of pediatrics and neonatology. Especially for novice junior doctors who are looking for the best sources guiding them how to deal with different clinical scenarios especially those whose treatment plans may differ from one country to another in the light of the possible aetiology and outcome. The idea for the Egyptian pediatric clinical practice guidelines (EPG) project aspired to set standardized safe practice that is pertinent to our community needs. The mission of the Egyptian pediatric clinical practice guidelines (EPG) committee was to oversee the adaptation of guidelines that will improve the practice of pediatricians and neonatologists all over Egypt. Many guidelines in pediatric pulmonology, infections, neurology, neonatology and gastroenterology are available now on the website. In the field of neonatology; there are 3 guidelines had already finished and published in its final format; guidelines for management of neonatal jaundice, neonatal sepsis and feeding of low birth weight infants. Many challenges are facing this work which needs more and more effort and decisions to overcome. Achievement of many of other pediatric guidelines, orientation of junior physicians and the clinical application in different hospitals may be the most apparent. In conclusion: Existence of the Egyptian pediatric guidelines is a great scientific work started four years ago and still updating by group of eminent professors from different Egyptian universities who shared as volunteers in this work. Many challenges are facing this work which needs more and more effort and decisions to overcome.
{"title":"Egyptian Pediatric Guidelines are Available Now Online.","authors":"Abdel-Azeem M. El-Mazary","doi":"10.21608/anj.2022.114062.1044","DOIUrl":"https://doi.org/10.21608/anj.2022.114062.1044","url":null,"abstract":"There is no doubt that the existence of guidelines is an important and great work in any of medical branches especially in the field of pediatrics and neonatology. Especially for novice junior doctors who are looking for the best sources guiding them how to deal with different clinical scenarios especially those whose treatment plans may differ from one country to another in the light of the possible aetiology and outcome. The idea for the Egyptian pediatric clinical practice guidelines (EPG) project aspired to set standardized safe practice that is pertinent to our community needs. The mission of the Egyptian pediatric clinical practice guidelines (EPG) committee was to oversee the adaptation of guidelines that will improve the practice of pediatricians and neonatologists all over Egypt. Many guidelines in pediatric pulmonology, infections, neurology, neonatology and gastroenterology are available now on the website. In the field of neonatology; there are 3 guidelines had already finished and published in its final format; guidelines for management of neonatal jaundice, neonatal sepsis and feeding of low birth weight infants. Many challenges are facing this work which needs more and more effort and decisions to overcome. Achievement of many of other pediatric guidelines, orientation of junior physicians and the clinical application in different hospitals may be the most apparent. In conclusion: Existence of the Egyptian pediatric guidelines is a great scientific work started four years ago and still updating by group of eminent professors from different Egyptian universities who shared as volunteers in this work. Many challenges are facing this work which needs more and more effort and decisions to overcome.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80488823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.21608/anj.2021.111306.1042
Madiha Abdallah, A. Hasan
Background: Surfactant therapy represents the cornerstone in treating respiratory distress syndrome (RDS). Different methods have been implicated for surfactant administration in the last few years. Objective: This study aimed to compare the use of surfactant therapy in the intubate, surfactant, extubate (INSURE) technique with surfactantconventional mechanical ventilation (CMV) modality. Patients and methods: A retrospective comparative study conducted between January 2015 and January 2021 at Minia university hospital for obstetrics and children included 68 preterm infants with respiratory distress syndrome treated with surfactants. They are categorized into two groups: group I included 34 preterm neonates treated by INSURE technique then continuous positive airway pressure (CPAP) and group II: included 34 preterm neonates treated by (surfactantCMV) using mechanical ventilation. Preterm infants’ demographic data, arterial blood gases, oxygen indices, response to treatment, duration of ventilation, hospital stay, and the number of surfactant doses were analyzed and compared. Results: Treatment was successful in 85.29% of INSURE-.CPAP compared to 79.42% in the surfactant-puor g VMC. Respiratory indices such as arterial/alveolar oxygen ratio(a/APO2) were significantly low and alveolar /arterial gradient (AaDo2) was significantly high in surfactantCMV group, Down’s score, the number of surfactant doses, duration of ventilation, and hospital stay all were significantly reduced in INSURE-CPAP group. Conclusions: INSURECPAP technique is a reliable and effective method for the treatment of RDS, especially in cases with high arterial alveolar ratio (a/APO2) and low arterial oxygen gradient (AaDO2).
{"title":"Surfactant Therapy in Preterm Infants with Respiratory Distress Syndrome in Two Treatment Modalities. (A Single - Center Experience)","authors":"Madiha Abdallah, A. Hasan","doi":"10.21608/anj.2021.111306.1042","DOIUrl":"https://doi.org/10.21608/anj.2021.111306.1042","url":null,"abstract":"Background: Surfactant therapy represents the cornerstone in treating respiratory distress syndrome (RDS). Different methods have been implicated for surfactant administration in the last few years. Objective: This study aimed to compare the use of surfactant therapy in the intubate, surfactant, extubate (INSURE) technique with surfactantconventional mechanical ventilation (CMV) modality. Patients and methods: A retrospective comparative study conducted between January 2015 and January 2021 at Minia university hospital for obstetrics and children included 68 preterm infants with respiratory distress syndrome treated with surfactants. They are categorized into two groups: group I included 34 preterm neonates treated by INSURE technique then continuous positive airway pressure (CPAP) and group II: included 34 preterm neonates treated by (surfactantCMV) using mechanical ventilation. Preterm infants’ demographic data, arterial blood gases, oxygen indices, response to treatment, duration of ventilation, hospital stay, and the number of surfactant doses were analyzed and compared. Results: Treatment was successful in 85.29% of INSURE-.CPAP compared to 79.42% in the surfactant-puor g VMC. Respiratory indices such as arterial/alveolar oxygen ratio(a/APO2) were significantly low and alveolar /arterial gradient (AaDo2) was significantly high in surfactantCMV group, Down’s score, the number of surfactant doses, duration of ventilation, and hospital stay all were significantly reduced in INSURE-CPAP group. Conclusions: INSURECPAP technique is a reliable and effective method for the treatment of RDS, especially in cases with high arterial alveolar ratio (a/APO2) and low arterial oxygen gradient (AaDO2).","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87928360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-16DOI: 10.21608/anj.2021.105474.1041
P. Ikhurionan, K. Akhimienho, Chukwudi Ochuba, E. Eyo-Ita
Background: Birth weight is among the most common measures for assessment of intrauterine growth, particularly in developing countries. Aberrations in intrauterine growth can result in profound sequelae in the immediate neonatal period and later in life. In Nigeria, there is generally a poor national summary of abnormal birth weight pattern. Aim of work: To describe the patterns of birth weight and associated factors among term babies delivered in an urban private hospital setting. Patients and methods: This was a single-center cross-sectional study. Records of all babies delivered from January 1 st , 2020, to December 31 st , 2020, were retrospectively reviewed. Preterm deliveries were excluded from the data. Results: There were 411 term deliveries during the study period, 255 vaginal deliveries and 156 caesarean deliveries. 407 babies were from singleton pregnancies and 8 by twin pregnancies. Thirty-one (7.5%) of the term babies had macrosomia and 14 (3.4%) had low birth weights. Bivariate analysis shows statistically significant association between birth weights of term babies and type of gestation (χ 2 – 11.288, p – 0.002) and mode of delivery (χ 2 – 9.718, p 0.035). There was however no association between birth weights and mother’s age or parity and baby’s sex. Conclusions: Our findings show that newborn under-nutrition (LBW) and over-nutrition (HBW) are significant public health problems even among high income mothers in Benin City.
背景:出生体重是评估宫内生长最常用的指标之一，特别是在发展中国家。在宫内生长的畸变可导致深刻的后遗症在新生儿期和以后的生活。在尼日利亚，对异常出生体重模式的全国总结普遍较差。工作目的:描述在城市私立医院环境中分娩的足月婴儿的出生体重和相关因素的模式。患者和方法:这是一项单中心横断面研究。回顾性分析2020年1月1日至2020年12月31日出生的所有婴儿的记录。早产被排除在数据之外。结果:研究期间足月分娩411例，阴道分娩255例，剖宫产156例。407名婴儿是单胎妊娠，8名是双胎妊娠。31例(7.5%)足月儿有巨大儿，14例(3.4%)有低出生体重。双因素分析显示，足月儿出生体重与妊娠类型(χ 2 ~ 11.288, p ~ 0.002)和分娩方式(χ 2 ~ 9.718, p ~ 0.035)有统计学意义。然而，出生体重与母亲的年龄、胎次和婴儿的性别之间没有关联。结论:我们的研究结果表明，即使在贝宁市的高收入母亲中，新生儿营养不足(LBW)和营养过剩(HBW)也是一个重大的公共卫生问题。
{"title":"Patterns and Determinants of Birth Weight in Term Babies Delivered at an Urban Multi-Specialty Private Hospital in Southern Nigeria. A Retrospective Cross-Sectional Study","authors":"P. Ikhurionan, K. Akhimienho, Chukwudi Ochuba, E. Eyo-Ita","doi":"10.21608/anj.2021.105474.1041","DOIUrl":"https://doi.org/10.21608/anj.2021.105474.1041","url":null,"abstract":"Background: Birth weight is among the most common measures for assessment of intrauterine growth, particularly in developing countries. Aberrations in intrauterine growth can result in profound sequelae in the immediate neonatal period and later in life. In Nigeria, there is generally a poor national summary of abnormal birth weight pattern. Aim of work: To describe the patterns of birth weight and associated factors among term babies delivered in an urban private hospital setting. Patients and methods: This was a single-center cross-sectional study. Records of all babies delivered from January 1 st , 2020, to December 31 st , 2020, were retrospectively reviewed. Preterm deliveries were excluded from the data. Results: There were 411 term deliveries during the study period, 255 vaginal deliveries and 156 caesarean deliveries. 407 babies were from singleton pregnancies and 8 by twin pregnancies. Thirty-one (7.5%) of the term babies had macrosomia and 14 (3.4%) had low birth weights. Bivariate analysis shows statistically significant association between birth weights of term babies and type of gestation (χ 2 – 11.288, p – 0.002) and mode of delivery (χ 2 – 9.718, p 0.035). There was however no association between birth weights and mother’s age or parity and baby’s sex. Conclusions: Our findings show that newborn under-nutrition (LBW) and over-nutrition (HBW) are significant public health problems even among high income mothers in Benin City.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"815 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79699840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-11DOI: 10.21608/anj.2021.103934.1040
Dina Ali, Amira M. M. Hamed, M. Aladawy, A. Ismail
Background: Infants of diabetic mothers (IDMs) are more prone to develop congenital anomalies and defects than healthy non-diabetic mothers. Aim of work: To evaluate the frequency of cardiac complications in infants of diabetic mothers in our NICU unit as well as the effect of diabetes control on them. Patients and methods: This study was a cross sectional prospective study conducted at neonatal intensive care unit of pediatric department, Al-Azhar Assuit university hospital, Minia health insurance hospital and Minia university hospital between January 2021 and June 2021. The study included 60 neonates subdivided into two groups as follow: Group I (30 cases): Included infants of diabetic mother with a diagnosis of congenital heart disease. Group II (30 controls): Included normal healthy infants of diabetic mother. Results: The frequency and patterns of different cardiac malformations in neonates in group I were as follow: Patent ductus arteriosus (PDA) [46%], Patent foramen ovale (PFO) [40%], hypertrophic cardiomyopathy (HCMP) [30%], ventricular septal defect (VSD) [20%], and atrial septal defect (ASD) [20%]. There was a statistically increase in pulmonary artery systolic pressure in group I compared to the control group (p <0.001). Conclusions: The frequency of cardiovascular anomalies in infants of diabetic mothers is significantly higher than in the infants of non-diabetic mothers. Infants of poor controlled diabetic mothers have higher incidence of cardiac complications than those in the controlled diabetic mothers.
{"title":"Cardiac Complications in Infants of Diabetic Mothers in NICU, A Cross Sectional Prospective Study","authors":"Dina Ali, Amira M. M. Hamed, M. Aladawy, A. Ismail","doi":"10.21608/anj.2021.103934.1040","DOIUrl":"https://doi.org/10.21608/anj.2021.103934.1040","url":null,"abstract":"Background: Infants of diabetic mothers (IDMs) are more prone to develop congenital anomalies and defects than healthy non-diabetic mothers. Aim of work: To evaluate the frequency of cardiac complications in infants of diabetic mothers in our NICU unit as well as the effect of diabetes control on them. Patients and methods: This study was a cross sectional prospective study conducted at neonatal intensive care unit of pediatric department, Al-Azhar Assuit university hospital, Minia health insurance hospital and Minia university hospital between January 2021 and June 2021. The study included 60 neonates subdivided into two groups as follow: Group I (30 cases): Included infants of diabetic mother with a diagnosis of congenital heart disease. Group II (30 controls): Included normal healthy infants of diabetic mother. Results: The frequency and patterns of different cardiac malformations in neonates in group I were as follow: Patent ductus arteriosus (PDA) [46%], Patent foramen ovale (PFO) [40%], hypertrophic cardiomyopathy (HCMP) [30%], ventricular septal defect (VSD) [20%], and atrial septal defect (ASD) [20%]. There was a statistically increase in pulmonary artery systolic pressure in group I compared to the control group (p <0.001). Conclusions: The frequency of cardiovascular anomalies in infants of diabetic mothers is significantly higher than in the infants of non-diabetic mothers. Infants of poor controlled diabetic mothers have higher incidence of cardiac complications than those in the controlled diabetic mothers.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81369060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-19DOI: 10.21608/anj.2021.49236.1039
B. Fahmy, Manal Abdelmgeed, R. Galal, A. Galal
Background: By the help of urinary proteins, the mechanism of kidney damage can be understood and diagnosis of renal dysfunction in sick neonates can be reached. Objective: Usage of specific urinary proteins to assess renal function in ill full term infants with different early disorders. Methods: One hundred full term infants were included in this cross sectional study. They were grouped by Neonatal Therapeutic Intervention Scoring System (NTISS) into 40 healthy infants, 30 infants manifested by clinical signs of moderate disorders of early neonatal period, 19 infants manifested by severe disorders without acute kidney injury (AKI), and 11 infants manifested by severe disorders and AKI. Renal angina index was estimated, albumin/creatinine ratio and the urinary β2-microglobulin (Uβ2-MG) were evaluated. Results: Means (± SD) of urinary β2-microglobulin (Uβ2-MG) values, albumin/creatinine ratio (ACR) and renal angina index were significantly higher in severely sick infants with AKI group IIIB (p-value <0.5 and 0.00, 0.00 respectively). ROC curves were plotted for those three parameters to determine the best cutoff for diagnosis of AKI. Uβ2-MG >8961 ug/L exhibited a sensitivity of 100%, specificity 93.88%, ACR level >144.2 mg/g displayed a sensitivity of 81.82% and specificity of 93.88% and RAI >9 demonstrated a sensitivity of 81.82% and specificity of 87.76%. Conclusions: Cut off value >9 for RAI can predict the development of AKI in full term infants that is accompanied with complex disorders affecting all structural elements of the nephron, assessed by increased concentrations of urinary protein markers of glomerular (albumin/creatinine ratio) and tubular (β2-microglobulin) malfunction.
{"title":"Urinary Protein Biomarkers and Renal Angina Index for Detection of Renal Dysfunction in Sick Full-Term Neonates","authors":"B. Fahmy, Manal Abdelmgeed, R. Galal, A. Galal","doi":"10.21608/anj.2021.49236.1039","DOIUrl":"https://doi.org/10.21608/anj.2021.49236.1039","url":null,"abstract":"Background: By the help of urinary proteins, the mechanism of kidney damage can be understood and diagnosis of renal dysfunction in sick neonates can be reached. Objective: Usage of specific urinary proteins to assess renal function in ill full term infants with different early disorders. Methods: One hundred full term infants were included in this cross sectional study. They were grouped by Neonatal Therapeutic Intervention Scoring System (NTISS) into 40 healthy infants, 30 infants manifested by clinical signs of moderate disorders of early neonatal period, 19 infants manifested by severe disorders without acute kidney injury (AKI), and 11 infants manifested by severe disorders and AKI. Renal angina index was estimated, albumin/creatinine ratio and the urinary β2-microglobulin (Uβ2-MG) were evaluated. Results: Means (± SD) of urinary β2-microglobulin (Uβ2-MG) values, albumin/creatinine ratio (ACR) and renal angina index were significantly higher in severely sick infants with AKI group IIIB (p-value <0.5 and 0.00, 0.00 respectively). ROC curves were plotted for those three parameters to determine the best cutoff for diagnosis of AKI. Uβ2-MG >8961 ug/L exhibited a sensitivity of 100%, specificity 93.88%, ACR level >144.2 mg/g displayed a sensitivity of 81.82% and specificity of 93.88% and RAI >9 demonstrated a sensitivity of 81.82% and specificity of 87.76%. Conclusions: Cut off value >9 for RAI can predict the development of AKI in full term infants that is accompanied with complex disorders affecting all structural elements of the nephron, assessed by increased concentrations of urinary protein markers of glomerular (albumin/creatinine ratio) and tubular (β2-microglobulin) malfunction.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"421 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89083920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：