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Polysomnographic sleep recording with simultaneously acquired 12 lead ECGs: a study for detection and validation of apnea related ECG changes 同时获得12导联心电图的多导睡眠图睡眠记录:一项检测和验证呼吸暂停相关心电图变化的研究
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166837
C. Zywietz, B. Widiger, T. Penzel
The aim of our study was to investigate whether morphological ECG parameters are changed during sleep disorders, in particular during apnea. We have set up jointly with the sleep laboratory of Marburg University a new database with polysomnographic and simultaneously recorded 12 lead ECG data. Analyses results on single cases and on a data set of 9 patients are presented. They confirm our hypothesis that morphologic ECG parameters vary systematically with apnea phases. While mean values differences seem to be small between regular and apnea respiration, standard deviations of these parameters are marked. From a separate analysis of data for each type of apnea and a joint processing of heart rate variability we expect additional insight into the reasons for the morphologic ECG changes.
我们研究的目的是探讨在睡眠障碍期间,特别是在呼吸暂停期间,形态学心电图参数是否发生改变。我们与马尔堡大学睡眠实验室联合建立了一个新的多导睡眠图数据库,同时记录了12个导联心电图数据。本文介绍了单个病例和9例患者数据集的分析结果。他们证实了我们的假设,即形态心电图参数随呼吸暂停期系统性地变化。虽然正常呼吸和呼吸暂停之间的平均值差异似乎很小,但这些参数的标准差是明显的。通过对每种呼吸暂停类型的单独数据分析和心率变异性的联合处理,我们期望进一步了解心电图形态学变化的原因。
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引用次数: 4
Comparison of segmentation methods for analysis of endocardial wall motion with real-time three-dimensional ultrasound 实时三维超声心内膜壁运动分析分割方法的比较
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166846
E. Angelini, D. Hamming, S. Homma, J. Holmes, A. Laine
This paper presents a new methodology for validation of endocardial surface segmentation with real-time three-dimensional (RT3D) ultrasound via analysis of ventricular anatomical shape and deformations. When comparing manual tracing and deformable model segmentation methods, we observe high correlation for volume quantification while 3D shapes show significant differences when directly compared by point matching. In the absence of real three-dimensional ground truth for screening of ventricular anatomy, this study aims to define new tests to compare segmented shapes and analyze their accuracy in the context of wall motion analysis. Endocardial surfaces are fitted with finite element modeling in spheroidal prolate coordinates and analysis is performed via construction of node parameter maps in time. Comparison of parameter maps for healthy volunteers and patients with abnormal wall motion are reported.
本文提出了一种通过分析心室解剖形状和变形来验证实时三维超声心内膜表面分割的新方法。在对比手工跟踪和变形模型分割方法时,我们观察到体积量化具有较高的相关性,而3D形状在直接进行点匹配时则存在显著差异。在没有真正的三维基础真理来筛选心室解剖的情况下,本研究旨在定义新的测试来比较分割形状并分析其在壁运动分析背景下的准确性。心内膜表面在球面长坐标下进行有限元拟合,并通过构造节点参数图及时进行分析。本文报道了健康志愿者与壁运动异常患者参数图的比较。
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引用次数: 9
Comparison of atrial rhythm extraction techniques for the estimation of the main atrial frequency from the 12-lead electrocardiogram in atrial fibrillation 从12导联心电图估计心房颤动主频率的心房节律提取技术的比较
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166699
P. Langley, M. Stridh, J. J. Rieta, L. Sornmo, J. Millet-Roig, A. Murray
One of the greatest challenges in analysis of the atrial rhythm from the ECG is to distinguish the atrial component from the large ventricular components. Our aim was to compare three techniques of atrial rhythm extraction from three groups working on this problem. 12-lead ECG data from 7 patients in atrial fibrillation were analysed. For extraction of the atrial rhythm, spatiotemporal QRST cancellation was performed by the Lund group, blind source separation by the Valencia group, and principal component analysis by the Newcastle group. Peak atrial frequency was determined by Fourier transform of the signal with the largest atrial activity. All algorithms were successful in distinguishing the atrial rhythm from the low frequency ventricular rhythm. The mean (range) atrial frequency was 6.5 (5.9 7.6) Hz (Lund), 6.7 (5.7 - 7.9) Hz (Valencia) and 6.5 (5.9 - 8.2) Hz (Newcastle). There were no significant differences between the atrial frequencies estimated by each of the techniques.
从心电图分析心房节律的最大挑战之一是区分心房成分和大心室成分。我们的目的是比较三组在这个问题上工作的心房节律提取的三种技术。对7例房颤患者的12导联心电图资料进行分析。对于心房节律的提取,Lund组进行时空QRST对消,Valencia组进行盲源分离,Newcastle组进行主成分分析。通过心房活动最大的信号的傅里叶变换确定心房频率峰值。所有算法都能成功地区分心房节律和低频心室节律。平均(范围)心房频率为6.5 (5.9 - 7.6)Hz(隆德),6.7 (5.7 - 7.9)Hz(瓦伦西亚)和6.5 (5.9 - 8.2)Hz(纽卡斯尔)。每一种技术估计的心房频率之间没有显著差异。
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引用次数: 27
Cardiovascular response to sinusoidal neck suction in healthy volunteers and orthostatic intolerance patients 健康志愿者和直立性不耐受患者对颈部正弦吸痰的心血管反应
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166702
L. Widesott, L. Bernardi, R. Furlan, L. Diedrich, R. Antolini, G. Nollo, A. Diedrich
The dynamic response to sinusoidal neck suction, of the RR interval, systolic arterial blood pressure and muscle sympathetic nerve activity series, was studied in 10 controls and 5 patients with orthostatic intolerance. By using different spectral techniques (autoregressive, short time Fourier transformation), the cardiovascular and MSNA variability were analyzed during 0.1 Hz and 0.2 Hz frequency of neck suction. Moreover, by using the autoregressive model, a quantitative analysis of particular power spectral frequency bands was done. Finally, a chirp neck suction input signal was applied to qualitatively compare the frequency response. The patients with orthostatic intolerance showed a partial blood pressure response to NS, particularly over 0.1 Hz compared to controls.
本文研究了10例对照和5例直立性不耐受患者对正弦颈吸的动态反应,包括RR间期、收缩压和肌肉交感神经活动系列。采用不同的频谱技术(自回归、短时傅立叶变换),分析0.1 Hz和0.2 Hz吸颈频率下心血管和MSNA的变异性。此外,利用自回归模型对特定功率谱频段进行了定量分析。最后,采用啁啾颈吸输入信号对频率响应进行定性比较。与对照组相比,直立不耐受患者对NS有部分血压反应,特别是在0.1 Hz以上。
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引用次数: 0
Automatic classification and differentiation of atherosclerotic lesions in swine using IVUS and texture features 利用IVUS和纹理特征对猪动脉粥样硬化病变进行自动分类和鉴别
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166719
P. Brathwaite, A. Nagaraj, B. Kane, D. McPherson, E. Dove
Our goal was to develop an automatic classification algorithm to differentiate between four common lesion types in atherosclerotic (AS) arteries: calcific (CAL), fibro-calcific (FBC), fibrous (FBR), and fibro-fatty (FBF). AS was induced in eight Yucatan miniswine. 22 femoral or carotid arteries were imaged with intravascular ultrasound using a pull-back procedure. Both 2D and 3D texture measures were used, followed by a principal components analysis to reduce dimension. The classifiers were applied to the test dataset, and the results were compared with two independent experts. There was no difference between the 2D and 3D classification of the CA and E1, and of the CA and E2 (ANOVA, F = 2.00). The difference between CA and E1 (or E2) was not larger than the difference between E1 and E2 for any lesion type (ANOVA, F = 0.76). We conclude that using 3D information in the classification scheme improved the algorithm's ability to correctly classify lesion type.
我们的目标是开发一种自动分类算法来区分动脉粥样硬化(AS)动脉中四种常见病变类型:钙化(CAL)、纤维钙化(FBC)、纤维性(FBR)和纤维脂肪性(FBF)。对8株尤卡坦迷你葡萄进行了AS诱导。22股动脉或颈动脉的血管内超声成像使用拉回程序。使用二维和三维纹理测量,然后进行主成分分析以降维。将分类器应用于测试数据集,并将结果与两位独立专家进行比较。CA和E1、CA和E2的2D和3D分类无差异(方差分析,F = 2.00)。在任何病变类型中,CA与E1(或E2)的差异均不大于E1与E2的差异(方差分析,F = 0.76)。我们得出结论,在分类方案中使用三维信息提高了算法正确分类病变类型的能力。
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引用次数: 3
Volumetric coronary plaque composition using intravascular ultrasound: three-dimensional segmentation and spectral analysis 血管内超声测量冠状动脉斑块组成:三维分割和光谱分析
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166720
J. Klingensmith, A. Nair, B. Kuban, D. Vince
Intravascular ultrasound provides precise tomographic assessment of coronary artery disease, allowing unique potential for analysis of both plaque geometry and composition, two critical factors related to the likelihood of plaque rupture. A novel three-dimensional segmentation technique and spectral analysis are used to create a unique tool for volumetric assessment of plaque composition. The semi-automated 3D segmentation technique was used to identify luminal and medial-adventitial borders in ECG-gated images created from radiofrequency (RF) IVUS data acquired during automated pullbacks in patients. Spectral analysis was applied to the RF data within the segmented plaque. Color-coded pseudo-histology images were created from these plaque component predictions using statistical classification trees. Quantitative analysis and visualization techniques were used to assess volumetric plaque composition and provide a unique tool for evaluation of plaque vulnerability.
血管内超声提供了冠状动脉疾病的精确断层扫描评估,允许分析斑块几何形状和组成的独特潜力,这两个关键因素与斑块破裂的可能性有关。一种新的三维分割技术和光谱分析被用来创建一个独特的工具,用于斑块组成的体积评估。半自动3D分割技术用于识别患者自动回拉过程中射频(RF) IVUS数据生成的ecg门控图像中的腔内和中外边界。频谱分析应用于分割斑块内的射频数据。使用统计分类树从这些斑块成分预测中创建颜色编码的伪组织学图像。定量分析和可视化技术用于评估斑块的体积组成,并为评估斑块易损性提供了独特的工具。
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引用次数: 2
A signals and systems and object oriented programming approach to development of ECG analysis software 采用信号与系统和面向对象编程的方法开发心电分析软件
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166730
S. Mohammad, A. Sureka, D.R. Ely, J. Jenkins
A Visual Software Development Framework (VSDF) has been created to facilitate the software coding process of biological signal analysis. A special purpose graphical user interface (GUI) was developed using VSDF for automating the analysis and classification of waveforms in electrocardiographic (ECG) data. Graphing capabilities were included in the program to allow the user to plot the signal as well as trigger location. Object Oriented Programming (OOP) techniques were used in the Java programming language to calculate correlation coefficients between a template QRS complex and detected QRS complexes throughout an ECG recording. The OOP techniques employed in the development of the software package allow visualization of the entire analysis process. The ECG signal, read from a file, is stored into a simple array data structure and is passed to each of the modules. The signals and systems approach allows incorporation of trigger modules, data conversion modules, and numerical analysis modules directly into the software package, providing ease of software design.
一个可视化软件开发框架(VSDF)已被创建,以方便生物信号分析的软件编码过程。利用VSDF开发了一种特殊用途的图形用户界面(GUI),用于自动分析和分类心电图(ECG)数据中的波形。绘图功能包括在程序中,允许用户绘制信号以及触发位置。在Java编程语言中使用面向对象编程(OOP)技术计算整个心电记录过程中模板QRS复合物与检测QRS复合物之间的相关系数。在软件包开发中使用的面向对象技术允许整个分析过程的可视化。从文件中读取的心电信号被存储到一个简单的数组数据结构中,并传递给每个模块。信号和系统方法允许将触发模块,数据转换模块和数值分析模块直接合并到软件包中,从而简化了软件设计。
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引用次数: 0
Are nonlinear ventricular arrhythmia characteristics lost, as signal duration decreases? 随着信号持续时间的减少,非线性室性心律失常特征是否消失?
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166747
R. Povinelli, F. M. Roberts, Michael T. Johnson, K. Ropella
A novel, nonlinear, phase space based method to quickly and accurately identify life-threatening arrhythmias is proposed. The accuracy of the proposed method in identifying sinus rhythm (SR), monomorphic ventricular tachycardia (MVT), polymorphic VT (PVT), and ventricular fibrillation (VF) for signals of at least 0.5 s duration was determined for six different ECG signal lengths. The ECG recordings were transformed into a phase space, and statistical features of the resulting attractors were learned using artificial neural networks. Classification accuracies for SR, MVT, PVT and VF were 93-96, 95-100, 79-91, and 81-88%, respectively. As expected, classification accuracy for the proposed method was essentially equivalent for ECG signals longer than 1 s. Surprisingly, classification accuracy for this new method did not degrade for 0.5 s ECG signals, indicating that even such short duration signals contain structures predictive of rhythm type. The phase space method's classification accuracy was higher for all segment durations compared to two other methods.
提出了一种新的、非线性的、基于相空间的快速准确识别危及生命的心律失常的方法。在6种不同的心电信号长度下,对持续时间至少为0.5 s的信号,确定该方法识别窦性心律(SR)、单形态室性心动过速(MVT)、多形态室性心动过速(PVT)和心室颤动(VF)的准确性。将心电记录转换成相空间,利用人工神经网络学习吸引子的统计特征。SR、MVT、PVT和VF的分类准确率分别为93 ~ 96、95 ~ 100、79 ~ 91和81 ~ 88%。正如预期的那样,对于超过1秒的心电信号,该方法的分类精度基本相同。令人惊讶的是,这种新方法的分类精度在0.5 s的ECG信号中没有下降,这表明即使是如此短的持续时间信号也包含预测节律类型的结构。相空间法在所有分段持续时间内的分类精度均高于其他两种方法。
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引用次数: 20
Pattern complexity and nonlinear dynamics in RR-sequences rr序列的模式复杂度和非线性动力学
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166734
A. Ripoli, M. Emdin, C. Passino, L. Zyw
The analysis of time series measured from nonlinear signals, may be performed either in the phase space or in the tie-domain. The Largest Lyapunov Exponent (LLE) characterises exponential divergence of trajectories in the phase space; fractal analysis is able to describe the complex pattern of a given time series. To evaluate the relation between the dynamic behavior and pattern complexity of the inherent biological system, RR-interval sequences were derived from 24-hour Holter recordings performed in 55 healthy subjects (37/spl plusmn/4 years, 34 males). Pattern fractal analysis (PFD) was computed on the basis of the measured length and diameter of the signal pattern. and LLE was evaluated by the Wolf algorithm. For each subject, the linear regression between computed PFD and LLE measures over the 24-hour period has been computed, extracting the correlation coefficient and the slope of the PFD vs. LLE relation. The strongest linear correlation between LLE and PFD indicates a light link between the system dynamics and the pattern of the extracted signals. This link suggests the possibility of a direct evaluation of nonlinear dynamics, even over short time intervals, exploiting the computationally less expensive PFD.
从非线性信号测量的时间序列的分析,可以在相空间或领带域进行。最大李雅普诺夫指数(LLE)表征了相空间中轨迹的指数发散;分形分析能够描述给定时间序列的复杂模式。为了评估动态行为与固有生物系统模式复杂性之间的关系,我们从55名健康受试者(37/spl + 4岁,34名男性)的24小时动态心电图记录中获得了rr间隔序列。在测量信号图案长度和直径的基础上计算图案分形分析(PFD)。采用Wolf算法对LLE进行评估。对于每个受试者,计算了24小时内PFD与LLE测量值之间的线性回归,提取了PFD与LLE关系的相关系数和斜率。LLE和PFD之间最强的线性相关性表明系统动力学与提取信号的模式之间存在轻微的联系。这种联系表明,即使在短时间间隔内,也可以利用计算成本较低的PFD直接评估非线性动力学。
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引用次数: 0
A computerized fuzzy logic system for evaluation of the cardiovascular autonomic function based on multiple functional tests 基于多项功能测试的心血管自主功能评价计算机模糊逻辑系统
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166735
H. Carvalho, L. F. Junqueira, J. Souza-Neto
The interest in the study of the Autonomic Nervous System has grown in the last years, mainly because of its important participation in the cardiovascular regulation and in many pathophysiological processes like heart failure, arrhythmias and sudden death. A great variety of tests have been employed for the functional evaluation of the Cardiovascular Autonomic Nervous System. However, the existence of variables with non-linear characteristics has made difficult the analysis of the responses. Based on this fact and considering that the Fuzzy Logic has been actually used with success in the development of classifier and analysis of control systems, its use in the investigation of the Cardiovascular Autonomic Function seems to be justified and a promise. The present paper describes the development of a system based on fuzzy logic to evaluate simultaneous cardiovascular autonomic tests results.
近年来,人们对自主神经系统的研究越来越感兴趣,主要是因为它在心血管调节和许多病理生理过程中起着重要的作用,如心力衰竭、心律失常和猝死。各种各样的测试已被用于心血管自主神经系统的功能评估。然而,非线性变量的存在给响应分析带来了困难。基于这一事实,并考虑到模糊逻辑在分类器开发和控制系统分析中的实际应用取得了成功,它在心血管自主功能研究中的应用似乎是合理的和有希望的。本文描述了一个基于模糊逻辑的系统的开发,以评估同时心血管自主测试的结果。
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引用次数: 2
期刊
Computers in cardiology
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