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Polysomnographic sleep recording with simultaneously acquired 12 lead ECGs: a study for detection and validation of apnea related ECG changes 同时获得12导联心电图的多导睡眠图睡眠记录:一项检测和验证呼吸暂停相关心电图变化的研究
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166837
C. Zywietz, B. Widiger, T. Penzel
The aim of our study was to investigate whether morphological ECG parameters are changed during sleep disorders, in particular during apnea. We have set up jointly with the sleep laboratory of Marburg University a new database with polysomnographic and simultaneously recorded 12 lead ECG data. Analyses results on single cases and on a data set of 9 patients are presented. They confirm our hypothesis that morphologic ECG parameters vary systematically with apnea phases. While mean values differences seem to be small between regular and apnea respiration, standard deviations of these parameters are marked. From a separate analysis of data for each type of apnea and a joint processing of heart rate variability we expect additional insight into the reasons for the morphologic ECG changes.
我们研究的目的是探讨在睡眠障碍期间,特别是在呼吸暂停期间,形态学心电图参数是否发生改变。我们与马尔堡大学睡眠实验室联合建立了一个新的多导睡眠图数据库,同时记录了12个导联心电图数据。本文介绍了单个病例和9例患者数据集的分析结果。他们证实了我们的假设,即形态心电图参数随呼吸暂停期系统性地变化。虽然正常呼吸和呼吸暂停之间的平均值差异似乎很小,但这些参数的标准差是明显的。通过对每种呼吸暂停类型的单独数据分析和心率变异性的联合处理,我们期望进一步了解心电图形态学变化的原因。
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引用次数: 4
Comparison of segmentation methods for analysis of endocardial wall motion with real-time three-dimensional ultrasound 实时三维超声心内膜壁运动分析分割方法的比较
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166846
E. Angelini, D. Hamming, S. Homma, J. Holmes, A. Laine
This paper presents a new methodology for validation of endocardial surface segmentation with real-time three-dimensional (RT3D) ultrasound via analysis of ventricular anatomical shape and deformations. When comparing manual tracing and deformable model segmentation methods, we observe high correlation for volume quantification while 3D shapes show significant differences when directly compared by point matching. In the absence of real three-dimensional ground truth for screening of ventricular anatomy, this study aims to define new tests to compare segmented shapes and analyze their accuracy in the context of wall motion analysis. Endocardial surfaces are fitted with finite element modeling in spheroidal prolate coordinates and analysis is performed via construction of node parameter maps in time. Comparison of parameter maps for healthy volunteers and patients with abnormal wall motion are reported.
本文提出了一种通过分析心室解剖形状和变形来验证实时三维超声心内膜表面分割的新方法。在对比手工跟踪和变形模型分割方法时,我们观察到体积量化具有较高的相关性,而3D形状在直接进行点匹配时则存在显著差异。在没有真正的三维基础真理来筛选心室解剖的情况下,本研究旨在定义新的测试来比较分割形状并分析其在壁运动分析背景下的准确性。心内膜表面在球面长坐标下进行有限元拟合,并通过构造节点参数图及时进行分析。本文报道了健康志愿者与壁运动异常患者参数图的比较。
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引用次数: 9
Automatic classification and differentiation of atherosclerotic lesions in swine using IVUS and texture features 利用IVUS和纹理特征对猪动脉粥样硬化病变进行自动分类和鉴别
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166719
P. Brathwaite, A. Nagaraj, B. Kane, D. McPherson, E. Dove
Our goal was to develop an automatic classification algorithm to differentiate between four common lesion types in atherosclerotic (AS) arteries: calcific (CAL), fibro-calcific (FBC), fibrous (FBR), and fibro-fatty (FBF). AS was induced in eight Yucatan miniswine. 22 femoral or carotid arteries were imaged with intravascular ultrasound using a pull-back procedure. Both 2D and 3D texture measures were used, followed by a principal components analysis to reduce dimension. The classifiers were applied to the test dataset, and the results were compared with two independent experts. There was no difference between the 2D and 3D classification of the CA and E1, and of the CA and E2 (ANOVA, F = 2.00). The difference between CA and E1 (or E2) was not larger than the difference between E1 and E2 for any lesion type (ANOVA, F = 0.76). We conclude that using 3D information in the classification scheme improved the algorithm's ability to correctly classify lesion type.
我们的目标是开发一种自动分类算法来区分动脉粥样硬化(AS)动脉中四种常见病变类型:钙化(CAL)、纤维钙化(FBC)、纤维性(FBR)和纤维脂肪性(FBF)。对8株尤卡坦迷你葡萄进行了AS诱导。22股动脉或颈动脉的血管内超声成像使用拉回程序。使用二维和三维纹理测量,然后进行主成分分析以降维。将分类器应用于测试数据集,并将结果与两位独立专家进行比较。CA和E1、CA和E2的2D和3D分类无差异(方差分析,F = 2.00)。在任何病变类型中,CA与E1(或E2)的差异均不大于E1与E2的差异(方差分析,F = 0.76)。我们得出结论,在分类方案中使用三维信息提高了算法正确分类病变类型的能力。
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引用次数: 3
Automatic measurement of carotid diameter and wall thickness in ultrasound images 自动测量颈动脉直径和壁厚超声图像
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166783
M. A. Gutierrez, P. E. Pilon, S. Lage, L. Kopel, R. T. Carvalho, Sergio Shiguemi Furuie
Carotid vessel ultrasound imaging is a reliable noninvasive technique to measure the arterial morphology. Lumen Diameter (LD), intima-media thickness (IMT) of the far wall, and plaque presence can be reliably determined using B-mode ultrasound. In order to measure the carotid IMT as well as any other more complex quantitative indices of vessel morphology, it is necessary to identify lumen-intima and media-adventitia borders in the ultrasound images. In this paper we describe an automatic approach to measure LD and IMT based on an active contour technique improved by a multiresolution analysis. The measurements of LD and IMT were compared to manual tracing of the vessels border in terms of coefficients of variability (CV) and correlation (R). The results have shown that the method is a reliable and reproducible way of assessing the LD and far wall IMT in the carotid artery.
颈动脉血管超声成像是一种可靠的无创技术来测量动脉形态。b超可以可靠地确定远壁管腔直径(LD)、内膜-中膜厚度(IMT)和斑块的存在。为了测量颈动脉IMT以及任何其他更复杂的血管形态学定量指标,有必要在超声图像中识别管腔内膜和中膜外膜边界。本文描述了一种基于多分辨率分析改进的主动轮廓技术的LD和IMT自动测量方法。在变异系数(CV)和相关系数(R)方面,将LD和IMT的测量与手工追踪血管边界进行比较。结果表明,该方法是评估颈动脉LD和远壁IMT的可靠且可重复的方法。
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引用次数: 92
A computer modeling study of the localization of cardiac optical mapping at discrete depths below the tissue surface 组织表面以下离散深度心脏光学成像定位的计算机建模研究
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166772
V. Ramshesh, J.H. Dumas, S. Knisley
Depth and radius of the region interrogated by cardiac optical mapping with a laser beam depend on photon travel inside the heart. It would be useful to limit range of depth and radius interrogated. Here the effects of a condensing lens to concentrate laser light at a target depth in the heart was modeled Monte Carlo computer simulations that incorporated a 0.55 NA lens in air and absorption and scattering of 488 nm laser light in 3-d cardiac tissue indicated the distribution of excitation light fluence. A subsequent computer simulation incorporating absorption and scattering of transmembrane voltage-sensitive fluorescence (669 nm) indicated locations in tissue from which fluorescence photons exiting the tissue surface originated The results indicate the heart can be interrogated at a discrete depth below the surface of myocardium with a condensing lens, although resolution is limited This may be applicable to laser scanner systems used for cardiac optical mapping.
用激光束进行心脏光学成像所询问的区域的深度和半径取决于光子在心脏内的传播。限制审问的深度和半径范围是有用的。本文模拟了聚光透镜将激光聚焦到心脏目标深度的效果,Monte Carlo计算机模拟了空气中0.55 NA透镜和三维心脏组织中488nm激光的吸收和散射,表明了激发光的分布。随后的计算机模拟结合了跨膜电压敏感荧光(669 nm)的吸收和散射,指出了组织中荧光光子从组织表面发出的位置。结果表明,尽管分辨率有限,但可以用聚光透镜在心肌表面以下的离散深度上查询心脏。这可能适用于用于心脏光学成像的激光扫描系统。
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引用次数: 0
Detection of central and obstructive sleep apnea in children using pulse transit time 应用脉搏传递时间检测儿童中枢性和阻塞性睡眠呼吸暂停
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166826
J. Pagani, M. Villa, G. Calcagnini, E. Lombardozzi, F. Censi, S. Poli, P. Bartolini, V. Barbaro, R. Ronchetti
The aim of this study was to validate the use of pulse transit time (PTT) as a method to monitor sleep apnea in children. PTT was estimated as the interval between the ECGR-wave and the point at which the pulse wave at the finger reached 50% amplitude. First, we assessed changes in the PTT during breathing against known resistances in 15 awake children; resistance was applied with a modified nose and mouth two-way nonrebreathing face mask, having the inhalation valve port fitted with drilled plastic cylinders of various diameters. Second, we analyzed 20 events of obstructive apnea and 90 events of central apnea during sleep in 10 children. Our data showed good correlation between the inspiratory effort and PTT oscillation amplitude. In addition, PTT oscillation amplitude tuned out to successfully discriminate central from obstructive apnea.
本研究的目的是验证脉冲传递时间(PTT)作为监测儿童睡眠呼吸暂停的一种方法。PTT估计为ecgr波与手指处脉冲波达到50%振幅点之间的间隔。首先,我们评估了15名清醒儿童在已知阻力下呼吸时PTT的变化;使用改良的口鼻双向非再呼吸面罩施加阻力,吸入阀端口装有不同直径的钻孔塑料圆柱体。其次,我们分析了10名儿童睡眠期间20例阻塞性呼吸暂停事件和90例中枢性呼吸暂停事件。我们的数据显示吸气力与PTT振荡幅度有很好的相关性。此外,PTT振荡振幅调谐成功区分中枢和阻塞性呼吸暂停。
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引用次数: 7
Ubiquitous mobile access to real-time patient monitoring data 无处不在的移动访问实时患者监测数据
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166833
S. Nelwan, T. B. V. Dam, P. Klootwijk, Simon H. Meij
An application "Pocket WinView" was developed for a Pocket PC personal digital assistant device, which allows remote access to near real-time physiological information from a patient monitor on a commercial handheld device (iPAQ, Pocket PC). The application provides continuous display of up to six monitored physiological waveforms and parameter values. Wireless communication can be established using Wireless LAN and general packet radio service (GPRS). Data is protected with hybrid public key encryption. User authentication is required every time the application is started. Patient data can also be stored on Compact Flash memory cards for data collection purposes. Additional integration with Web-based applications on the hospital intranet make it possible to combine the near realtime signals with previously recorded 12-lead ECGs, laboratory test results, and charting information.
为Pocket PC个人数字助理设备开发了一款名为“Pocket WinView”的应用程序,该应用程序允许远程访问来自商用手持设备(iPAQ, Pocket PC)上的患者监护仪的近实时生理信息。该应用程序提供多达六个监测生理波形和参数值的连续显示。无线通信可以通过无线局域网和通用分组无线业务(GPRS)来实现。数据采用混合公钥加密保护。每次启动应用程序时都需要进行用户身份验证。病人资料亦可储存于紧凑型快闪记忆卡,以作资料收集之用。与医院内部网上基于web的应用程序的额外集成使得将近实时信号与先前记录的12导联心电图、实验室测试结果和图表信息结合起来成为可能。
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引用次数: 60
Beat-to-beat heart rate and QT interval variability in patients undergoing coronary artery bypass graft surgery 冠状动脉搭桥手术患者的单次心率和QT间期变异性
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166859
S. Frljak, V. Avbelj, R. Trobec, B. Geršak
Non-uniform recovery of myocardial excitability may be essential in triggering malignant ventricular tachycardia in patients after cardiac surgery. Beat-to-beat heart rate and QT interval variability was investigated in 27 patients scheduled for elective coronary artery bypass graft surgery (CABG) and 20 control subjects. 35 channel ECG was recorded for 6 minutes, followed by off line computer analysis. Heart rate interval duration, RR SD, QT SD and power spectra of RR variability were computed from 256-second stable heart rate and QT interval series using MECG software. Study showed that CABG caused increased QT interval variability in face of nearly constant or slowly changing heart rate, suggesting a loss of autonomic coupling between heart rate and ventricular repolarization for sympathovagal modulation.
心肌兴奋性的不均匀恢复可能是引发心脏手术后患者恶性室性心动过速的必要条件。研究了27例计划择期冠状动脉搭桥手术(CABG)患者和20例对照者的次搏动心率和QT间期变异性。记录35通道心电图6分钟,然后进行计算机离线分析。采用MECG软件计算256秒稳定心率和QT间期序列的心率间期持续时间、RR SD、QT SD和RR变异性的功率谱。研究表明,面对几乎恒定或缓慢变化的心率,冠状动脉搭桥导致QT间期变异性增加,提示心率和心室复极之间的自主耦合丧失了交感病理迷走神经调节。
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引用次数: 3
The response of intact guinea pigs to AC leakage currents 完整豚鼠对交流漏电流的反应
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166876
S. Patel, R. Malkin
There was a difference in the standard for leakage current in the US and Europe. This difference existed largely because there was very little data on AC stimulation of the heart in situ. In this study, we examine AC stimulation of the intact guinea pig. Nine male guinea pigs were anesthetized with isoflurane, intubated and monitored with the lead II ECG and optical plethysmograph. For AC stimulation, a stainless steel electrode was used The return electrode was applied to the right rear paw. Five seconds of AC stimuli at various frequencies was used The minimum VF threshold in these animals was found to be 558/spl plusmn/314 /spl mu/A at 100 Hz. Frequencies both below (20 Hz: 1584/spl plusmn/753 /spl mu/A) and above (160 Hz: 1355/spl plusmn/1007 pA) were found to be significantly different from 100 Hz (20 Hz: p=0.0017 and 100 Hz: p=0.0085). By contrast the minimum current required to have any effect on the heart only increased with frequency from 10 Hz (119/spl plusmn/53 pA), to 160 Hz (183/spl plusmn/50 pA, p<0. 0001).
美国和欧洲的漏电电流标准有所不同。这种差异的存在很大程度上是因为关于原位心脏交流电刺激的数据很少。在这项研究中,我们研究了完整豚鼠的交流刺激。9只雄性豚鼠用异氟醚麻醉,插管,用导联II心电图和光学体积描记仪监测。交流刺激采用不锈钢电极,返回电极置于右后爪。用不同频率的交流刺激5秒,发现这些动物在100 Hz时的最小VF阈值为558/spl + 314 /spl mu/A。频率低于(20 Hz: 1584/spl plusmn/753 /spl mu/A)和高于(160 Hz: 1355/spl plusmn/1007 pA)与100 Hz (20 Hz: p=0.0017和100 Hz: p=0.0085)有显著差异。相比之下,对心脏产生任何影响所需的最小电流仅随频率从10 Hz (119/spl plusmn/53 pA)增加到160 Hz (183/spl plusmn/50 pA, p<0。0001)。
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引用次数: 0
A computerized fuzzy logic system for evaluation of the cardiovascular autonomic function based on multiple functional tests 基于多项功能测试的心血管自主功能评价计算机模糊逻辑系统
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166735
H. Carvalho, L. F. Junqueira, J. Souza-Neto
The interest in the study of the Autonomic Nervous System has grown in the last years, mainly because of its important participation in the cardiovascular regulation and in many pathophysiological processes like heart failure, arrhythmias and sudden death. A great variety of tests have been employed for the functional evaluation of the Cardiovascular Autonomic Nervous System. However, the existence of variables with non-linear characteristics has made difficult the analysis of the responses. Based on this fact and considering that the Fuzzy Logic has been actually used with success in the development of classifier and analysis of control systems, its use in the investigation of the Cardiovascular Autonomic Function seems to be justified and a promise. The present paper describes the development of a system based on fuzzy logic to evaluate simultaneous cardiovascular autonomic tests results.
近年来,人们对自主神经系统的研究越来越感兴趣,主要是因为它在心血管调节和许多病理生理过程中起着重要的作用,如心力衰竭、心律失常和猝死。各种各样的测试已被用于心血管自主神经系统的功能评估。然而,非线性变量的存在给响应分析带来了困难。基于这一事实,并考虑到模糊逻辑在分类器开发和控制系统分析中的实际应用取得了成功,它在心血管自主功能研究中的应用似乎是合理的和有希望的。本文描述了一个基于模糊逻辑的系统的开发,以评估同时心血管自主测试的结果。
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引用次数: 2
期刊
Computers in cardiology
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