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Integrated access to function test results from within a cardiology information system 集成访问功能测试结果从一个心脏病学信息系统
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166796
E. T. van der Velde, W.H.G.J. Hoekstra, T. Witteman, C. Brobbel, D. Atsma, M. Baljon
A dedicated cardiology information system (CARIS) has been developed in our department to record all information pertaining to studies performed in the cathlab and pacemaker lab. However, information stored in other systems in the cardiac function lab was not available in CARIS. This includes ECGs (rest ECGs, stress ECGs and Holter ECGs), and reports from echo studies and stress ECG studies. Data obtained from these functional studies are stored in various database systems. For each of these systems a different, dedicated interface was developed to allow the cardiologist to obtain access to the data from within CARIS. These results show that integration of all information available in the cardiology department is feasible. Presently, we are developing a completely new version of CARIS that will allow optimal integration of cardiology based information (as well as in the CARIS database, as in separate systems) with data in the hospital information system.
专门的心脏科信息系统(CARIS)已在我们的部门开发,以记录所有有关的研究在心脏导管实验室和起搏器实验室进行的信息。然而,存储在心功能实验室其他系统中的信息在CARIS中是不可用的。这包括心电图(静息心电图、应激心电图和动态心电图),以及回声研究和应激心电图研究的报告。从这些功能研究中获得的数据存储在不同的数据库系统中。对于这些系统中的每一个,都开发了一个不同的专用接口,以允许心脏病专家从CARIS中获取数据。这些结果表明,整合所有可用的信息在心内科是可行的。目前,我们正在开发一个全新版本的CARIS,它将允许基于心脏病学的信息(以及CARIS数据库中的数据,就像在单独的系统中一样)与医院信息系统中的数据进行最佳整合。
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引用次数: 1
Spectral analysis of multiunit action potential trains of muscle sympathetic nerve activity in humans 人体肌肉交感神经活动多单元动作电位序列的频谱分析
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166808
R. Brychtal, W. Charoensuk, L. Bernardi, R. Furlan, R. Shiavi, A. Diedrich
The application of conventional signal processing methods used to obtain an integrated signal from muscle sympathetic nerve activity (MSNA) reduces the amount of information and may confound the spectral characteristics. We present a novel alternative method of processing the raw MSNA signal using a wavelet transform denoising technique that enables detection of individual action potentials and facilitates spectral analysis. A spike density function (SDF) is generated from the denoised signal by replacing the detected action potentials with delta functions and convolving with a 3 Hz Gaussian filter. This method was validated using data from a sinusoidal neck suction (NS) experiment in humans. The results of the analysis indicate that the oscillations of sympathetic nerve firings closely followed the NS frequency. In conclusion, the SDF representation allows for a novel and insightful analysis of spectral components of action potential trains in raw MSNA.
传统的信号处理方法用于从肌肉交感神经活动(MSNA)中获得综合信号,减少了信息量,并可能混淆频谱特征。我们提出了一种新的替代方法来处理原始MSNA信号,使用小波变换去噪技术,可以检测单个动作电位并促进频谱分析。用delta函数代替检测到的动作电位,用3hz高斯滤波器卷积,得到去噪信号的峰值密度函数(SDF)。该方法通过人体正弦颈部吸痰(NS)实验数据得到验证。分析结果表明,交感神经放电振荡与NS频率密切相关。总之,SDF表示允许对原始MSNA中动作电位序列的频谱成分进行新颖而深刻的分析。
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引用次数: 4
3D navigator for localization of peripheral coronary segments by magnetic resonance imaging angiography 三维导航定位冠状动脉周围段的磁共振成像血管造影
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166851
P. Marcheschi, M. Lombardi, A. Mazzarisi, R. Testa, A. Pingitore, A. Benassi, P. Marraccini
Aim of the study was to assess a new method to followup patients with angiographically documented coronary artery disease (CAD), by noninvasive MRI angiography. The method is based on 3D reconstruction of planar cineangiographic images. It is addressed to expand informative content and to extract data from conventional 2D-images, aiming to guide and optimize the use of magnetic resonance for coronary artery visualization. The preliminary tests have shown that it is possible to obtain a fast MRI localization of peripheral coronary segments due to a more precise target volume of scan. This could overcome some limits of MRI examination of coronary tree and expands the use of noninvasive MRI technique in CAD follow-up.
本研究的目的是评估一种新的方法来跟踪血管造影记录的冠状动脉疾病(CAD)患者,无创MRI血管造影。该方法基于平面电影血管成像图像的三维重建。它旨在扩展信息内容并从传统的2d图像中提取数据,旨在指导和优化磁共振在冠状动脉可视化中的应用。初步试验表明,由于扫描的目标体积更精确,因此可以获得冠状动脉周围段的快速MRI定位。这可以克服MRI冠状树检查的一些局限性,扩大无创MRI技术在CAD随访中的应用。
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引用次数: 0
On-line integration of cardiological data to support medical decision making in patients with ischemic heart disease 在线整合心脏病学数据以支持缺血性心脏病患者的医疗决策
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166853
G. A. L'Abbate, C. Carpeggiani, C. Marchesi, A. L'Abbate
We have developed a system that integrates, through a virtual 3D-dynamic heart model, all the pertinent clinical and instrumental information obtained for patients hospitalized for suspected or documented ischemic heart disease (IHD). In the present study we retrospectively compared the diagnosis formulated by the cardiologist in the discharge record with that automatically provided by the system. Divergences were found in 27% of the 110 patients studied and classified into four types: I) inability of the system to provide the correct diagnosis because of the lack of pertinent diagnostic parameters in the model (3%), a cardiologist's diagnosis which was either II) not supported by objective data (3%), III) in conflict with the available information (10%), or IV) incomplete (11%). An experimental trial has been started in which the cardiologist in charge of the patient uses the automatic system during the diagnostic process and compilation of the discharge report.
我们已经开发了一个系统,通过一个虚拟的3d动态心脏模型,整合了所有相关的临床和仪器信息,这些信息是为怀疑或记录为缺血性心脏病(IHD)住院的患者获得的。在本研究中,我们回顾性地比较了出院记录中由心脏病专家制定的诊断与系统自动提供的诊断。在研究的110例患者中,有27%的患者发现了差异,并将其分为四种类型:1)由于模型中缺乏相关的诊断参数而系统无法提供正确的诊断(3%),心脏病专家的诊断II)没有客观数据支持(3%),III)与可用信息冲突(10%)或IV)不完整(11%)。一项实验性试验已经开始,负责患者的心脏病专家在诊断过程和出院报告的编写过程中使用自动系统。
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引用次数: 2
Pattern complexity and nonlinear dynamics in RR-sequences rr序列的模式复杂度和非线性动力学
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166734
A. Ripoli, M. Emdin, C. Passino, L. Zyw
The analysis of time series measured from nonlinear signals, may be performed either in the phase space or in the tie-domain. The Largest Lyapunov Exponent (LLE) characterises exponential divergence of trajectories in the phase space; fractal analysis is able to describe the complex pattern of a given time series. To evaluate the relation between the dynamic behavior and pattern complexity of the inherent biological system, RR-interval sequences were derived from 24-hour Holter recordings performed in 55 healthy subjects (37/spl plusmn/4 years, 34 males). Pattern fractal analysis (PFD) was computed on the basis of the measured length and diameter of the signal pattern. and LLE was evaluated by the Wolf algorithm. For each subject, the linear regression between computed PFD and LLE measures over the 24-hour period has been computed, extracting the correlation coefficient and the slope of the PFD vs. LLE relation. The strongest linear correlation between LLE and PFD indicates a light link between the system dynamics and the pattern of the extracted signals. This link suggests the possibility of a direct evaluation of nonlinear dynamics, even over short time intervals, exploiting the computationally less expensive PFD.
从非线性信号测量的时间序列的分析,可以在相空间或领带域进行。最大李雅普诺夫指数(LLE)表征了相空间中轨迹的指数发散;分形分析能够描述给定时间序列的复杂模式。为了评估动态行为与固有生物系统模式复杂性之间的关系,我们从55名健康受试者(37/spl + 4岁,34名男性)的24小时动态心电图记录中获得了rr间隔序列。在测量信号图案长度和直径的基础上计算图案分形分析(PFD)。采用Wolf算法对LLE进行评估。对于每个受试者,计算了24小时内PFD与LLE测量值之间的线性回归,提取了PFD与LLE关系的相关系数和斜率。LLE和PFD之间最强的线性相关性表明系统动力学与提取信号的模式之间存在轻微的联系。这种联系表明,即使在短时间间隔内,也可以利用计算成本较低的PFD直接评估非线性动力学。
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引用次数: 0
Automatic border detection through a cardiac cycle to analyze left ventricular function 自动边界检测通过心脏周期分析左心室功能
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166737
P. Negrini, P. Tomassini, G. Cella, M. Magrini, M. Ercolani, A. Mazzarisi, V. Gemignani, A. Ciampa, P. Marcheschi, P. Marraccini
The evaluation of the ventricular function has a key role in determining therapy and prognosis in patients with heart disease. The standard analysis is limited to quantification of tele-diastolic and tele-systolic frames. An analysis of wall kinetic in each frame of cardiac cycle might allow further information about contractility and diastolic function. The developed algorithms are aimed to achieve an automatic detection of left ventricular wall kinetic during a cardiac cycle in routine clinical activity.
心室功能的评估在确定心脏病患者的治疗和预后方面具有关键作用。标准分析仅限于远舒张和远收缩框架的量化。分析心脏周期每一帧的壁动力学可以进一步了解收缩力和舒张功能。所开发的算法旨在实现在常规临床活动中心脏周期中左心室壁动力学的自动检测。
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引用次数: 4
Knowledge-guided automatic segmentation of the left ventricle from MR 知识引导下的左心室MR自动分割
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166740
A. Pednekar, I. A. Kadadiaris, R. Muthupillai, S. Flamm
The routinely used clinical practice of manual tracing of the blood pool from short axis cine MR images to compute ejection fraction (EF) is cumbersome, time consuming, and operator dependent. In this paper we present an algorithm that automatically segments the left ventricle (LV) using the a priori knowledge of the intensity responses of the tissue in different MR modalities, along with the LV morphology. Our method for the automatic computation of the EF is based on segmenting the left ventricle by combining the fuzzy connectedness and the physics-based deformable model frameworks. We have validated our method against manual delineation performed by experienced radiologists on the data from nine asymptomatic volunteers with very encouraging results.
常规使用的临床实践是从短轴电影MR图像中手动追踪血池以计算射血分数(EF)是繁琐,耗时且依赖于操作员的。在本文中,我们提出了一种算法,该算法使用不同MR模式下组织强度响应的先验知识自动分割左心室(LV),以及LV形态。我们将模糊连通性和基于物理的可变形模型框架相结合,在分割左心室的基础上实现了EF的自动计算。我们在9名无症状志愿者的数据上验证了我们的方法,与经验丰富的放射科医生进行的手动划定进行了对比,结果非常令人鼓舞。
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引用次数: 2
Modelling blood flow in coronary arteries with junctions 冠状动脉连接血流模型
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166784
S. Corney, P. Johnston, D. Kilpatrick
Numerical modelling of the coronary tree is well established. Solutions of the Navier-Stokes equations can produce wall shear stress distributions which can be used to correlate the position of shear stress distribution with coronary artery disease. We have previously demonstrated a technique for reconstructing a single branch of the coronary tree. The introduction of junctions into the model allows for accurate reconstruction of potentially the entire arterial tree. However the introduction of a realistic junction has proven to be difficult. A four section method for branching has been adopted, utilising three tubular segments and a small junction section as the join. This allows for automatic generation of the majority of the artery (the tubes), and a semi-automated procedure concentrating specifically on the junction. A structured mesh is used for the tubes, allowing for easy generation and improved computation time, whilst an unstructured mesh is used to accurately model the irregular shape of the junction. The four section method allows for easy insertion of more branches, depending on the level of detail required. Another advantage is that as time evolves, inducing conformational changes throughout the cardiac cycle, the tubes can be regenerated, whilst the junction needs only slight modification. Marked changes are induced in wall shear stress by either adding extra junctions to an arterial tree, or altering the shape of major branches.
冠状树的数值模拟已经建立。Navier-Stokes方程的解可以得到壁面剪应力分布,可以用来将剪应力分布的位置与冠状动脉疾病联系起来。我们之前已经展示了一种重建冠状动脉树单个分支的技术。在模型中引入连接可以精确地重建整个动脉树。然而,事实证明,引入一个现实的连接点是困难的。分支采用了四段方法,利用三个管状段和一个小连接段作为连接。这允许自动生成大多数动脉(管),以及专门集中在连接处的半自动程序。结构网格用于管,允许易于生成和改进计算时间,而非结构网格用于准确地模拟结的不规则形状。根据所需的详细程度,四段方法允许轻松插入更多分支。另一个优点是,随着时间的推移,诱导整个心脏周期的构象变化,导管可以再生,而连接只需要轻微的修改。通过在动脉树上增加额外的连接点或改变主要分支的形状,可以引起壁面剪切应力的显著变化。
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引用次数: 2
New data acquisition using variable graphic display of the coronary vessel anatomy for rapid and easy creation of angiography reports 新的数据采集使用可变图形显示冠状血管解剖快速和容易创建血管造影报告
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166785
J. Petersen, M. Petersen, A. Lauk, V. Brand, F. Neumann
In this newly developed software, the anatomical variation of the three-dimensional coronary vessel system can be recreated. A few mouse clicks are sufficient to reproduce an anatomically correct model of the patients own coronary artery system with respect to vessel size and number. The localization, the severity and type of stenosis can be entered, as well as grafts and stents. Through the use of anatomically accurate visual representations of coronary anatomy, the transfer of complex coronary angiography information between operators, cardiologists, and surgeons is enhanced and expedited.
在这个新开发的软件中,三维冠状动脉系统的解剖变化可以被重建。点击几下鼠标就足以复制出患者自身冠状动脉系统的血管大小和数量的解剖学正确模型。可以输入狭窄的位置、严重程度和类型,以及移植物和支架。通过使用解剖学上精确的冠状动脉解剖学视觉表征,可以增强和加快操作者、心脏病专家和外科医生之间复杂的冠状动脉造影信息的传递。
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引用次数: 0
Advanced detection of ST segment episodes in 24-hour ambulatory ECG data by automated tracking of transient ST segment reference level 通过自动跟踪暂态ST段参考水平,提前检测24小时动态心电数据中的ST段发作
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166774
A. Smrdel, F. Jager
Using the Long-Term ST Database, we developed and evaluated an advanced algorithm for automated detection of transient ST segment episodes in "real-world" 24-hour ambulatory data. To successfully detect transient ST change episodes, the algorithm automatically tracks the time-varying ST segment reference level due to clinically not important non-ischemic causes and subtracts it from the ST segment level. Evaluating of the algorithm using reference annotations of the protocol B of the database yielded gross ST episode detection sensitivity and positive predictivity of approximately 75%.
利用长期ST数据库,我们开发并评估了一种先进的算法,用于自动检测“现实世界”24小时动态数据中的瞬态ST段事件。为了成功检测瞬时ST段变化事件,该算法自动跟踪临床不重要的非缺血性原因引起的时变ST段参考水平,并从ST段水平中减去。使用数据库协议B的参考注释对算法进行评估,产生了大约75%的总ST集检测灵敏度和阳性预测。
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引用次数: 6
期刊
Computers in cardiology
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