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Automatic border detection through a cardiac cycle to analyze left ventricular function 自动边界检测通过心脏周期分析左心室功能
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166737
P. Negrini, P. Tomassini, G. Cella, M. Magrini, M. Ercolani, A. Mazzarisi, V. Gemignani, A. Ciampa, P. Marcheschi, P. Marraccini
The evaluation of the ventricular function has a key role in determining therapy and prognosis in patients with heart disease. The standard analysis is limited to quantification of tele-diastolic and tele-systolic frames. An analysis of wall kinetic in each frame of cardiac cycle might allow further information about contractility and diastolic function. The developed algorithms are aimed to achieve an automatic detection of left ventricular wall kinetic during a cardiac cycle in routine clinical activity.
心室功能的评估在确定心脏病患者的治疗和预后方面具有关键作用。标准分析仅限于远舒张和远收缩框架的量化。分析心脏周期每一帧的壁动力学可以进一步了解收缩力和舒张功能。所开发的算法旨在实现在常规临床活动中心脏周期中左心室壁动力学的自动检测。
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引用次数: 4
Knowledge-guided automatic segmentation of the left ventricle from MR 知识引导下的左心室MR自动分割
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166740
A. Pednekar, I. A. Kadadiaris, R. Muthupillai, S. Flamm
The routinely used clinical practice of manual tracing of the blood pool from short axis cine MR images to compute ejection fraction (EF) is cumbersome, time consuming, and operator dependent. In this paper we present an algorithm that automatically segments the left ventricle (LV) using the a priori knowledge of the intensity responses of the tissue in different MR modalities, along with the LV morphology. Our method for the automatic computation of the EF is based on segmenting the left ventricle by combining the fuzzy connectedness and the physics-based deformable model frameworks. We have validated our method against manual delineation performed by experienced radiologists on the data from nine asymptomatic volunteers with very encouraging results.
常规使用的临床实践是从短轴电影MR图像中手动追踪血池以计算射血分数(EF)是繁琐,耗时且依赖于操作员的。在本文中,我们提出了一种算法,该算法使用不同MR模式下组织强度响应的先验知识自动分割左心室(LV),以及LV形态。我们将模糊连通性和基于物理的可变形模型框架相结合,在分割左心室的基础上实现了EF的自动计算。我们在9名无症状志愿者的数据上验证了我们的方法,与经验丰富的放射科医生进行的手动划定进行了对比,结果非常令人鼓舞。
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引用次数: 2
Optimal myocardial boundary estimation for MR cardio perfusion measurements using sensitivity analysis 最佳心肌边界估计磁共振心脏灌注测量使用敏感性分析
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166741
L. Spreeuwers, F. Wierda, M. Breeuwer
Recent advances in Magnetic Resonance Imaging allow fast recording of contrast enhanced myocardial perfusion scans. MR perfusion scans are made by recording, during a period of 20-40 seconds a number of short-axis slices through the myocardium. For perfusion analysis, the myocardial boundaries must be traced, dividing the heart into the left and right ventricle blood volumes and the myocardium of the left ventricle. Extreme care must be taken not to include any part of the left or right ventricle blood volumes in the myocardium segment, because this has a significant effect on the perfusion analysis. On the other hand, for accurate estimation of the perfusion parameters, all available myocardium area in the image is required. In this paper a method is proposed to correct for any inclusion of left and right ventricle and optimally place the myocardial contours.
磁共振成像的最新进展允许快速记录造影剂增强心肌灌注扫描。MR灌注扫描是在20-40秒的时间内通过心肌记录一些短轴切片。在进行灌注分析时,必须描出心肌边界,将心脏分为左、右心室血容量和左心室心肌。必须特别注意不要将左、右心室血容量的任何部分包括在心肌段,因为这对灌注分析有重大影响。另一方面,为了准确估计灌注参数,需要图像中所有可用的心肌面积。本文提出了一种校正左、右心室的方法,并对心肌轮廓进行了优化定位。
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引用次数: 6
Automatic measurement of carotid diameter and wall thickness in ultrasound images 自动测量颈动脉直径和壁厚超声图像
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166783
M. A. Gutierrez, P. E. Pilon, S. Lage, L. Kopel, R. T. Carvalho, Sergio Shiguemi Furuie
Carotid vessel ultrasound imaging is a reliable noninvasive technique to measure the arterial morphology. Lumen Diameter (LD), intima-media thickness (IMT) of the far wall, and plaque presence can be reliably determined using B-mode ultrasound. In order to measure the carotid IMT as well as any other more complex quantitative indices of vessel morphology, it is necessary to identify lumen-intima and media-adventitia borders in the ultrasound images. In this paper we describe an automatic approach to measure LD and IMT based on an active contour technique improved by a multiresolution analysis. The measurements of LD and IMT were compared to manual tracing of the vessels border in terms of coefficients of variability (CV) and correlation (R). The results have shown that the method is a reliable and reproducible way of assessing the LD and far wall IMT in the carotid artery.
颈动脉血管超声成像是一种可靠的无创技术来测量动脉形态。b超可以可靠地确定远壁管腔直径(LD)、内膜-中膜厚度(IMT)和斑块的存在。为了测量颈动脉IMT以及任何其他更复杂的血管形态学定量指标,有必要在超声图像中识别管腔内膜和中膜外膜边界。本文描述了一种基于多分辨率分析改进的主动轮廓技术的LD和IMT自动测量方法。在变异系数(CV)和相关系数(R)方面,将LD和IMT的测量与手工追踪血管边界进行比较。结果表明,该方法是评估颈动脉LD和远壁IMT的可靠且可重复的方法。
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引用次数: 92
Modelling blood flow in coronary arteries with junctions 冠状动脉连接血流模型
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166784
S. Corney, P. Johnston, D. Kilpatrick
Numerical modelling of the coronary tree is well established. Solutions of the Navier-Stokes equations can produce wall shear stress distributions which can be used to correlate the position of shear stress distribution with coronary artery disease. We have previously demonstrated a technique for reconstructing a single branch of the coronary tree. The introduction of junctions into the model allows for accurate reconstruction of potentially the entire arterial tree. However the introduction of a realistic junction has proven to be difficult. A four section method for branching has been adopted, utilising three tubular segments and a small junction section as the join. This allows for automatic generation of the majority of the artery (the tubes), and a semi-automated procedure concentrating specifically on the junction. A structured mesh is used for the tubes, allowing for easy generation and improved computation time, whilst an unstructured mesh is used to accurately model the irregular shape of the junction. The four section method allows for easy insertion of more branches, depending on the level of detail required. Another advantage is that as time evolves, inducing conformational changes throughout the cardiac cycle, the tubes can be regenerated, whilst the junction needs only slight modification. Marked changes are induced in wall shear stress by either adding extra junctions to an arterial tree, or altering the shape of major branches.
冠状树的数值模拟已经建立。Navier-Stokes方程的解可以得到壁面剪应力分布,可以用来将剪应力分布的位置与冠状动脉疾病联系起来。我们之前已经展示了一种重建冠状动脉树单个分支的技术。在模型中引入连接可以精确地重建整个动脉树。然而,事实证明,引入一个现实的连接点是困难的。分支采用了四段方法,利用三个管状段和一个小连接段作为连接。这允许自动生成大多数动脉(管),以及专门集中在连接处的半自动程序。结构网格用于管,允许易于生成和改进计算时间,而非结构网格用于准确地模拟结的不规则形状。根据所需的详细程度,四段方法允许轻松插入更多分支。另一个优点是,随着时间的推移,诱导整个心脏周期的构象变化,导管可以再生,而连接只需要轻微的修改。通过在动脉树上增加额外的连接点或改变主要分支的形状,可以引起壁面剪切应力的显著变化。
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引用次数: 2
New data acquisition using variable graphic display of the coronary vessel anatomy for rapid and easy creation of angiography reports 新的数据采集使用可变图形显示冠状血管解剖快速和容易创建血管造影报告
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166785
J. Petersen, M. Petersen, A. Lauk, V. Brand, F. Neumann
In this newly developed software, the anatomical variation of the three-dimensional coronary vessel system can be recreated. A few mouse clicks are sufficient to reproduce an anatomically correct model of the patients own coronary artery system with respect to vessel size and number. The localization, the severity and type of stenosis can be entered, as well as grafts and stents. Through the use of anatomically accurate visual representations of coronary anatomy, the transfer of complex coronary angiography information between operators, cardiologists, and surgeons is enhanced and expedited.
在这个新开发的软件中,三维冠状动脉系统的解剖变化可以被重建。点击几下鼠标就足以复制出患者自身冠状动脉系统的血管大小和数量的解剖学正确模型。可以输入狭窄的位置、严重程度和类型,以及移植物和支架。通过使用解剖学上精确的冠状动脉解剖学视觉表征,可以增强和加快操作者、心脏病专家和外科医生之间复杂的冠状动脉造影信息的传递。
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引用次数: 0
A computer modeling study of the localization of cardiac optical mapping at discrete depths below the tissue surface 组织表面以下离散深度心脏光学成像定位的计算机建模研究
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166772
V. Ramshesh, J.H. Dumas, S. Knisley
Depth and radius of the region interrogated by cardiac optical mapping with a laser beam depend on photon travel inside the heart. It would be useful to limit range of depth and radius interrogated. Here the effects of a condensing lens to concentrate laser light at a target depth in the heart was modeled Monte Carlo computer simulations that incorporated a 0.55 NA lens in air and absorption and scattering of 488 nm laser light in 3-d cardiac tissue indicated the distribution of excitation light fluence. A subsequent computer simulation incorporating absorption and scattering of transmembrane voltage-sensitive fluorescence (669 nm) indicated locations in tissue from which fluorescence photons exiting the tissue surface originated The results indicate the heart can be interrogated at a discrete depth below the surface of myocardium with a condensing lens, although resolution is limited This may be applicable to laser scanner systems used for cardiac optical mapping.
用激光束进行心脏光学成像所询问的区域的深度和半径取决于光子在心脏内的传播。限制审问的深度和半径范围是有用的。本文模拟了聚光透镜将激光聚焦到心脏目标深度的效果,Monte Carlo计算机模拟了空气中0.55 NA透镜和三维心脏组织中488nm激光的吸收和散射,表明了激发光的分布。随后的计算机模拟结合了跨膜电压敏感荧光(669 nm)的吸收和散射,指出了组织中荧光光子从组织表面发出的位置。结果表明,尽管分辨率有限,但可以用聚光透镜在心肌表面以下的离散深度上查询心脏。这可能适用于用于心脏光学成像的激光扫描系统。
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引用次数: 0
Advanced detection of ST segment episodes in 24-hour ambulatory ECG data by automated tracking of transient ST segment reference level 通过自动跟踪暂态ST段参考水平,提前检测24小时动态心电数据中的ST段发作
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166774
A. Smrdel, F. Jager
Using the Long-Term ST Database, we developed and evaluated an advanced algorithm for automated detection of transient ST segment episodes in "real-world" 24-hour ambulatory data. To successfully detect transient ST change episodes, the algorithm automatically tracks the time-varying ST segment reference level due to clinically not important non-ischemic causes and subtracts it from the ST segment level. Evaluating of the algorithm using reference annotations of the protocol B of the database yielded gross ST episode detection sensitivity and positive predictivity of approximately 75%.
利用长期ST数据库,我们开发并评估了一种先进的算法,用于自动检测“现实世界”24小时动态数据中的瞬态ST段事件。为了成功检测瞬时ST段变化事件,该算法自动跟踪临床不重要的非缺血性原因引起的时变ST段参考水平,并从ST段水平中减去。使用数据库协议B的参考注释对算法进行评估,产生了大约75%的总ST集检测灵敏度和阳性预测。
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引用次数: 6
Robust measure of ST/HR hysteresis in stress test ECG recordings 应力测试心电图记录中ST/HR迟滞的鲁棒测量
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166775
R. Bailón, S. Olmos, P. Serrano, J. García, P. Laguna
In stress test ECG analysis, the so-called ST/HR hysteresis has recently been suggested to improve coronary artery disease (CAD) diagnosis. This parameter is estimated from the ST versus HR diagram including exercise and recovery phases. Unluckily, ST measurements are adversely affected by noise during the test. In this study we propose a method to automatically estimate the ST/HR hysteresis, incorporating multiple stage noise attenuation. The method is based on averaging and rejection of noisy beats. Evaluation is done on simulated exercise test recordings, constructed from real ECG averaged beats adding actual noise from stress test records. Results on a total of 216 different records, with RMS noise levels ranging from 114 to 979 /spl mu/V, give a reduction in estimation error in the ST/HR diagram of 77.98% (from 168 to 37 /spl mu/V) in mean and of 76.38% (from 271 to 63 /spl mu/V) in standard deviation. This method may be considered as a suitable and robust tool for reliable ST/HR hysteresis estimation.
在压力测试心电图分析中,所谓的ST/HR迟滞最近被建议用于改善冠状动脉疾病(CAD)的诊断。这个参数是从包括运动和恢复阶段的ST与HR图中估计出来的。不幸的是,测试期间的ST测量受到噪声的不利影响。在这项研究中,我们提出了一种自动估计ST/HR滞后的方法,并结合了多级噪声衰减。该方法基于噪声节拍的平均和抑制。对模拟运动测试记录进行评估,该记录由真实的心电平均心跳和压力测试记录的实际噪声组成。结果表明,在RMS噪声水平范围为114 - 979 /spl mu/V的216条不同记录上,ST/HR图的估计误差平均降低77.98%(从168 - 37 /spl mu/V),标准差降低76.38%(从271 - 63 /spl mu/V)。该方法可被认为是一种可靠的ST/HR滞后估计的合适且稳健的工具。
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引用次数: 13
Integrated access to function test results from within a cardiology information system 集成访问功能测试结果从一个心脏病学信息系统
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166796
E. T. van der Velde, W.H.G.J. Hoekstra, T. Witteman, C. Brobbel, D. Atsma, M. Baljon
A dedicated cardiology information system (CARIS) has been developed in our department to record all information pertaining to studies performed in the cathlab and pacemaker lab. However, information stored in other systems in the cardiac function lab was not available in CARIS. This includes ECGs (rest ECGs, stress ECGs and Holter ECGs), and reports from echo studies and stress ECG studies. Data obtained from these functional studies are stored in various database systems. For each of these systems a different, dedicated interface was developed to allow the cardiologist to obtain access to the data from within CARIS. These results show that integration of all information available in the cardiology department is feasible. Presently, we are developing a completely new version of CARIS that will allow optimal integration of cardiology based information (as well as in the CARIS database, as in separate systems) with data in the hospital information system.
专门的心脏科信息系统(CARIS)已在我们的部门开发,以记录所有有关的研究在心脏导管实验室和起搏器实验室进行的信息。然而,存储在心功能实验室其他系统中的信息在CARIS中是不可用的。这包括心电图(静息心电图、应激心电图和动态心电图),以及回声研究和应激心电图研究的报告。从这些功能研究中获得的数据存储在不同的数据库系统中。对于这些系统中的每一个,都开发了一个不同的专用接口,以允许心脏病专家从CARIS中获取数据。这些结果表明,整合所有可用的信息在心内科是可行的。目前,我们正在开发一个全新版本的CARIS,它将允许基于心脏病学的信息(以及CARIS数据库中的数据,就像在单独的系统中一样)与医院信息系统中的数据进行最佳整合。
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引用次数: 1
期刊
Computers in cardiology
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