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ABBIOS (ABbott BIOsignal System): a workbench system software for data mining in biosignals, with applications in drug research and development ABBIOS (ABbott BIOsignal System):用于生物信号数据挖掘的工作台系统软件,应用于药物研究和开发
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166856
A. Safer, W. Bystricky, M. Schweizer
ABBIOS software is designed to facilitate extraction of biosignal features for an industrial environment in drug research and development. It is dedicated to handling large amounts of data with a high level of user control. Its purpose is to enable high quality data elaboration for the improvement of drug safety and efficacy, and to ensure improved economic efficacy.
ABBIOS软件旨在促进提取生物信号特征,用于药物研究和开发的工业环境。它专门用于处理具有高水平用户控制的大量数据。其目的是为提高药物安全性和有效性提供高质量的数据阐述,并确保提高经济效益。
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引用次数: 3
Effect of 2,3 Butanedione Monoxime (BDM) on ventricular fibrillation 2,3丁二酮单肟(BDM)对心室颤动的影响
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166877
M. Malik, M. Gopalakrishnan, R. Malkin
Optical mapping is commonly used to study ventricular fibrillation (VF). Electro-contractile uncouplers like 2,3 Butanedione Monaxime (BDM) are used in these studies to stop the mechanical activity wider the assumption that they do not have an effect on the electrical activity. Our objective is to test this assumption. Male guinea pigs were used in this study. The Animals were anaesthetized and median sternotomy and pericardiectomy were performed to expose the heart An Intracardiac injection of BDM was administered and VF was induced Epicardial unipolar recordings were made for 4s using an electrode array along with a video recording of the heart The procedure was repeated for saline and control. Quantitative analysis of the data was performed using autocorrelation analysis. BDM significantly decreases the mechanical activity of the heart and increased the level of temporal organization during VF.
光学成像是研究心室颤动(VF)的常用方法。像2,3丁二酮单胺(BDM)这样的电收缩解耦剂在这些研究中被用来阻止机械活动,更广泛地假设它们对电活动没有影响。我们的目标是验证这个假设。本研究使用雄性豚鼠。麻醉动物,切开胸骨正中切口和心包切开术暴露心脏,在心内注射BDM并诱导VF,使用电极阵列记录心外膜单极记录45秒,并记录心脏的视频,盐水和对照组重复该过程。采用自相关分析对数据进行定量分析。BDM显著降低心脏的机械活动,增加VF期间的颞叶组织水平。
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引用次数: 1
Presence of T wave alternans in the statistical context - a new approach to low amplitude alternans measurement 统计背景下T波交替的存在——一种测量低振幅交替的新方法
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166864
T. Srikanth, D. Lin, N. Kanaan, H. Gu
Detection of T wave alternans is constructed as a statistical problem in the present work. The objective was to evaluate the performance of a group of statistical tests in detecting a set of artificially generated alternans episodes and in the European ST (EST) database. Three statistical tests, standard t-test, matched pair t-test, and Rayleigh test, were performed on numerically generated sequences and also on simulated alternans episodes in a rolling sequence of 32 beats. Application of statistical tests to the numerical simulations and beat simulations resulted in 100% detection accuracy. Statistical tests also detected multiple episodes of both visible and invisible alternans in the EST database. Statistical tests seem to provide a complementary and a computationally efficient solution to alternans detection problem in surface ECG.
在本工作中,T波交替的检测被构造为一个统计问题。目的是评估一组统计测试在检测一组人为产生的交替事件和欧洲ST (EST)数据库中的表现。三种统计检验,标准t检验,配对配对t检验和瑞利检验,对数字生成的序列和模拟交替发作的32拍滚动序列进行了检验。将统计测试应用于数值模拟和温度模拟,检测精度达到100%。统计测试还在EST数据库中发现了可见和不可见交替的多个片段。统计检验似乎为体表心电图的交替检测问题提供了一种补充和计算效率高的解决方案。
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引用次数: 14
Longitudinal modifications of T-loop morphology t形环形态的纵向修饰
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166865
G. Bortolan, M. Bressan, I. Christov
Serial analysis is performed to evaluate longitudinal modifications of electrocardiographic parameters concerning morphology variations of repolarization phase, using the vectorcardiogram (VCG). The orthogonal Frank leads were synthesized from the standard 12 lead ECG. For this purpose, five parameters were obtained from the VCG with two different methods of considering the zero point. The population based ECG-ILSA database (Italian Longitudinal Study on Aging) was used. All the patients present both in t/sub 1/ and t2=t1+5 years were considered, and those classified as healthy (147), with cardiac diseases (77), with hypertension (219), with angina pectoris (44) and with MI (51) were included in this study. The observed results show a stability T-loop morphology measurements in a temporal interval of 5 years. In addition, the Angina Pectoris group, characterized by a high "clinical instability" showed the most significant longitudinal modifications.
使用矢量心电图(VCG)进行了一系列分析,以评估与复极相形态变化有关的心电图参数的纵向修改。正交法兰克导联是由标准12导联心电图合成的。为此,采用两种不同的零点考虑方法,从VCG中得到5个参数。使用基于人群的ECG-ILSA数据库(意大利老龄化纵向研究)。所有在t/sub 1/和t2=t1+5年存在的患者均被纳入本研究,包括健康(147)、心脏病(77)、高血压(219)、心绞痛(44)和心肌梗死(51)。观察结果表明,在5年的时间间隔内,t型环形态测量稳定。此外,以高“临床不稳定性”为特征的心绞痛组表现出最显著的纵向改变。
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引用次数: 9
Tracking of the left ventricle in contrast enhanced echocardiography by anisotropic filtering and active contours algorithm 利用各向异性滤波和主动轮廓算法对超声造影左心室进行跟踪
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166708
M. Morales, V. Positano, O. Rodriguez, M. Passera, M. Lombardi, D. Rovai
Contrast agents together with second harmonic imaging improve endocardial border detection in echo images. Aim of the study was to assess whether non linear anisotropic filtering after segmentation of gradient vector flow (GVF) based active contour algorithm can be applied on contrast echo images for automatic detection of left ventricular (LV) contours. LV volumes were measured in 20 subjects by cine Magnetic Resonance (MR) and transthoracic second harmonic echo after intravenous administration of the contrast agent Levovist. Contrast echo images were analyzed both manually and automatically; MR images were automatically analyzed. LV volumes were calculated according to Simpson's rule. A good correlation with MR volumes was found for manual LV volumes (r.93 and .92 for end diastolic and end systolic volumes, respectively, p <.05). A still good correlation was found for the automatically assessed volumes in both phases (r=.90 and .91, p<05). Thus automatic endocardial border delineation by anisotropic filtering and GVF based active contour algorithm is feasible on contrast echo images. This method may represent an approach for automatic endocardial border analysis in ultrasonic imaging.
对比剂联合二次谐波成像改善了超声图像中的心内膜边界检测。本研究的目的是评估基于梯度矢量流(GVF)主动轮廓算法分割后的非线性各向异性滤波能否应用于对比回波图像的左室(LV)轮廓自动检测。20例患者在静脉注射造影剂Levovist后,通过电影磁共振(MR)和经胸二次谐波回波测量左室体积。对对比回波图像进行人工和自动分析;自动分析MR图像。根据辛普森法则计算左室体积。手动左室容积与MR容积有良好的相关性(舒张末期和收缩期末期容积分别为0.93和0.92,p < 0.05)。两个阶段的自动评估体积仍然有很好的相关性(r=。90和.91,p< 0.05)。因此,利用各向异性滤波和基于梯度矢量流场的主动轮廓算法在对比回波图像上自动划分心内膜边界是可行的。该方法可能是超声成像中心内膜边界自动分析的一种方法。
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引用次数: 3
A generic secure Internet-based facility to support multiple registries using modern encryption technology and client certificates 一个通用的安全的基于internet的设施,使用现代加密技术和客户端证书支持多个注册中心
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166761
W. Dassen, E. Gommer, C.C.W. Bonnemayer, H. Spruijt, W. Dijk, M. Baljon
For the management of their disease chronic patients are alternately dependent on the care of the general practitioner, (specialized) nurses or the specialist. For optimally coordinated communication there is a strong need for one single patient record containing all necessary medical information in order to get a complete overview of the condition of the patient for all healthcare providers. In this feasibility study we demonstrated that using current methods for data security and encryption over the Internet an electronic patient record could be employed to be used by only those care providers that have legitimate access to the data. The data security and encryption technology can also be used to employ various other registries not necessary requiring the same level of security.
对于他们的疾病管理,慢性病患者交替依赖于全科医生、(专科)护士或专科医生的护理。为了实现最佳协调通信,非常需要一个包含所有必要医疗信息的单一患者记录,以便为所有医疗保健提供者获得患者状况的完整概述。在这项可行性研究中,我们证明了使用当前的互联网数据安全和加密方法,电子病历只能由那些对数据有合法访问权限的护理提供者使用。数据安全和加密技术还可用于使用不需要相同安全级别的各种其他注册中心。
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引用次数: 2
Ambient intelligence and pervasive systems for the monitoring of citizens at cardiac risk: New solutions from the EPI-MEDICS project 环境智能和普适系统用于监测心脏风险的公民:EPI-MEDICS项目的新解决方案
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166765
F. Gouaux, L. Simon-Chautemps, J. Fayn, S. Adami, M. Arzi, D. Assanelli, M. Forlini, C. Malossi, A. Martínez, J. Placide, G.L. Ziliani, P. Rubel
In western countries, heart disease is the main cause of premature death. Most of cardiac deaths occur out of hospital. Symptoms are often interpreted incorrectly. Victims do not survive long enough to benefit from in-hospital treatments. To reduce the time before treatment, the only useful diagnostic tool to assess the presence of a cardiac event is the electrocardiogram (ECG). Event and transtelephonic ECG recorders are used to improve decision-making but require setting up new infrastructures. The Pervasive solution proposed by the European EPI-MEDICS project is an intelligent Personal ECG Monitor for the early detection of cardiac events. It includes decision-making techniques, generates different alarm levels and forwards alarm messages to the relevant care providers by means of new generation wireless communication. It is cost saving, involving care provider only if necessary without specific infrastructure. Healthcare becomes personalized, wearable, ubiquitous.
在西方国家,心脏病是导致过早死亡的主要原因。大多数心脏死亡都发生在医院外。症状常常被错误地解释。受害者存活的时间不够长,无法从住院治疗中受益。为了减少治疗前的时间,评估心脏事件存在的唯一有用的诊断工具是心电图(ECG)。事件和跨电话心电记录仪用于改善决策,但需要建立新的基础设施。欧洲EPI-MEDICS项目提出的普适解决方案是一种用于早期发现心脏事件的智能个人心电监护仪。它包括决策技术,产生不同的警报级别,并通过新一代无线通信将警报信息转发给相关的护理提供者。它节省了成本,只有在必要时才涉及护理提供者,而没有特定的基础设施。医疗保健变得个性化、可穿戴、无处不在。
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引用次数: 51
Magnetic resonance image segmentation and heart motion tracking with an active mesh based system 基于有源网格的核磁共振图像分割与心脏运动跟踪
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166736
L. Legrand, C. Bordier, A. Lalande, P. Walker, F. Brunotte, C. Quantin
The work presented here relates to a method for motion tracking in sequences of medical images. The purpose is to quantify the general motions and the local deformations of a beating heart during a cardiac cycle. In order to achieve this goal, we first tessellate the first image of the sequence into triangular patches. A Delaunay triangulation is applied to find the optimal set of triangles describing this image, giving a mesh covering the organs. One imposes the contours of the organs to correspond to edges of triangles so that each part of the heart (left ventricle, right ventricle, myocardium) can he described as a different set of triangles, each set indicated by a different color. We then track the nodes of the mesh on the image sequence while imposing them to remain on the edges of the different parts of the heart.
这里提出的工作涉及一种方法运动跟踪序列的医学图像。目的是量化在心脏周期中跳动的心脏的一般运动和局部变形。为了实现这一目标,我们首先将序列的第一张图像镶嵌成三角形块。应用Delaunay三角剖分来找到描述该图像的最优三角形集,给出覆盖器官的网格。一种方法是将器官的轮廓与三角形的边缘相对应,这样心脏的每个部分(左心室、右心室、心肌)就可以被描述为一组不同的三角形,每一组用不同的颜色表示。然后我们在图像序列上跟踪网格的节点,同时将它们保留在心脏不同部位的边缘上。
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引用次数: 3
Using wavelets for smoothing and denoising gated blood pool images 用小波对血池图像进行平滑和去噪
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166739
O. Blagosklonov, L. Comas, R. Sabbah, J. Verdenet, M. Baud, J. Cardot
This paper presents a method of wavelet application for the denoising of gated blood pool image series. Our method is based on the transformation of image series into periodical 1D signal followed by the application of 1D wavelets. We used visual analysis of resulting images, Fourier analysis, analysis of gradient images and analysis of time-activity curves to compare the performances of the method presented and the "classical" image-by-image 2D wavelet spatial smoothing. Our results showed that the series smoothing by ID wavelets may be a good alternative to 2D wavelet smoothing and may offer more accurate image denoising. We suggest that after validation on a statistically sufficient number of patients, the method presented can be easily introduced and used in routine nuclear cardiology practice.
提出了一种将小波变换应用于门控血池图像序列去噪的方法。该方法首先将图像序列转化为周期一维信号,然后应用一维小波。通过对结果图像的视觉分析、傅里叶分析、梯度图像分析和时间-活动曲线分析,比较了该方法与“经典”逐图二维小波空间平滑的性能。结果表明,基于ID小波的序列平滑可以很好地替代二维小波平滑,并且可以提供更准确的图像去噪。我们认为,在统计上足够数量的患者验证后,所提出的方法可以很容易地引入并用于常规核心脏病学实践。
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引用次数: 3
Large-scale modeling of cardiac electrophysiology 心脏电生理的大规模建模
Pub Date : 2002-09-22 DOI: 10.1109/CIC.2002.1166757
J.B. Pormann, J.A. Board, D. Rose, C. Henriquez
Simulation of wavefront propagation in the whole heart requires significant computational resources. The growth of cluster computing has made it possible to simulate very large scale problems in a lab environment. In this work, we present computational results of simulating a reaction diffusion system of equations of various sizes on a Beowulf cluster. To facilitate comparisons at different spatial resolutions, an idealized ventricular geometry was used. The model incorporates anisotropy, fiber rotation, and realistic membrane dynamics to determine the computational constraints for the most detailed situations of interest. Three meshes with mesh spacings of 378/spl mu/m, 238/spl mu/m, and 150/spl mu/m, corresponding to roughly 1M, 4M, and 16M nodes in the computational domain, were considered. The results show that good parallel performance is possible on a cluster up to 32 processors.
波前在整个心脏中的传播模拟需要大量的计算资源。集群计算的发展使得在实验室环境中模拟非常大规模的问题成为可能。在这项工作中,我们给出了在贝奥武夫簇上模拟不同尺寸方程的反应扩散系统的计算结果。为了便于在不同空间分辨率下进行比较,使用了理想化的心室几何形状。该模型结合了各向异性、纤维旋转和真实膜动力学,以确定最详细情况的计算约束。考虑网格间距分别为378/spl mu/m、238/spl mu/m和150/spl mu/m的三个网格,分别对应计算域中大约1M、4M和16M个节点。结果表明,在多达32个处理器的集群上可以实现良好的并行性能。
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引用次数: 7
期刊
Computers in cardiology
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