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Common congenital cardiac disease with uncommon postoperative complication 常见先天性心脏病,术后并发症少见
Pub Date : 2017-02-13 DOI: 10.1136/archdischild-2016-311497
C. Oakley, Sarita Makam, Y. Aung, S. Shebani
A boy was born at term, in good condition, with an antenatal cardiac diagnosis. The diagnosis was confirmed on echocardiography. Initial genetic bloods were taken including karyotype and fluorescence in situ hybridisation and he was discharged with outpatient follow-up.He was reviewed in clinic at 5 months of age. On examination, his saturations were 85% with a normal first heart sound, soft second heart sound and a loud ejection systolic murmur. The bloods showed a normal karyotype and 22q11 status.Following a local joint cardiac meeting he was accepted for surgical repair. Figures 1 and 2 are his preoperative and postoperative chest radiographs (CXRs).Figure 1 Preoperative chest radiograph.Figure 2 Chest radiograph taken first day postoperatively.1. What is the most likely underlying cardiac diagnosis?2. What potentially life-threatening presentation of this condition needs to be monitored for before surgical correction?3. What is the most prominent complication that is seen on the postoperative CXR?4. What are the management options for this?Answers to the questions are on page …
一名男婴足月出生,情况良好,产前心脏诊断。超声心动图证实了诊断。取初始遗传血,包括核型和荧光原位杂交,出院,门诊随访。他在5个月大的时候接受了门诊检查。经检查,他的饱和度为85%,第一心音正常,第二心音柔和,收缩期射血杂音大。血液显示正常核型和22q11状态。在当地联合心脏会议之后,他接受了手术修复。图1和2是他术前和术后的胸片(cxr)。图1术前胸片。图2术后第一天胸片。最可能的潜在心脏诊断是什么?手术矫正前需要监测哪些可能危及生命的症状?术后x光检查中最突出的并发症是什么?对此有什么管理选择?问题的答案在…
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引用次数: 0
Fifteen minute consultation: A structured approach to the management of children and adolescents with medically unstable anorexia nervosa 15分钟咨询:治疗医学上不稳定神经性厌食症的儿童和青少年的结构化方法
Pub Date : 2017-02-13 DOI: 10.1136/archdischild-2016-311394
E. Allison, N. Dawson, J. Phillips, C. Lynch, Jacinta Coleman
Assessing and managing children who are underweight is an integral part of paediatric practice. Young people with anorexia nervosa (AN) are mainly cared for in the community by specialist eating disorder services. However, increasing numbers require admission to paediatric wards with medical instability due to the complications of starvation. Despite recommendations published in the junior MARSIPAN report in 2012, many paediatricians still feel poorly equipped to care for these high-risk patients. This article aims to provide a safe and structured approach to the assessment and management of children and adolescents with medically unstable AN.
评估和管理体重不足的儿童是儿科实践的一个组成部分。患有神经性厌食症的年轻人主要在社区由专门的饮食失调服务机构照顾。然而,由于饥饿并发症导致医疗不稳定,需要住进儿科病房的人数越来越多。尽管2012年MARSIPAN初级报告中发表了建议,但许多儿科医生仍然觉得自己没有能力照顾这些高风险患者。本文旨在提供一种安全、结构化的方法来评估和管理医学上不稳定的AN的儿童和青少年。
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引用次数: 3
Something for the weak-end? Electromyography appearances of myasthenia gravis 为弱者准备的东西?重症肌无力的肌电图表现
Pub Date : 2017-02-08 DOI: 10.1136/archdischild-2017-312641
F. Britton, A. Osei-Lah, M. Tighe
A 13-year-old girl, with a background of stage 4 thoracic neuroblastoma (diagnosed 2003) and residual spastic paraplegia with neuropathic bladder and irregular bowel habit, presented with increasing muscle fatigue and decreased exercise ability over the past 6 months. She reported symptoms including periodic slurring of speech, difficulty swallowing and the inability to smile or blink. These episodes were reported to last between 10 and 90 min. She also presented with ongoing nausea and a reduced appetite.On inspection, she had an indistinct smile and loss of the left nasolabial fold. Examination of the cranial nerves elucidated a bilateral facial weakness, decrease palate movement and bilateral reduced corneal reflexes. She had normal eye movements, no ptosis and her pupils were equal and reactive to light. Neurological examination of the upper limbs demonstrated weakness in C4–5 but otherwise she had normal power in her arms and hands. Tone, reflexes, coordination and sensation were normal.In light of her …
一名13岁女孩,患有4期胸椎神经母细胞瘤(2003年诊断),伴有神经性膀胱和排便习惯不规则的残余痉挛性截瘫,在过去6个月里表现为肌肉疲劳增加和运动能力下降。她报告的症状包括周期性的口齿不清、吞咽困难、无法微笑或眨眼。据报道,这些发作持续10到90分钟。她还表现出持续的恶心和食欲减退。经检查,她有一个模糊的微笑,并失去了左鼻唇沟。颅神经检查显示双侧面部无力,上颚运动减少,双侧角膜反射减少。患者眼球运动正常,无上睑下垂,瞳孔大小相等,对光有反应。上肢神经学检查显示C4-5无力,但除此之外,她的手臂和双手力量正常。张力、反射、协调和感觉均正常。鉴于她……
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引用次数: 0
Jaundice in newborn babies under 28 days: NICE guideline 2016 (CG98) 28天以下新生儿黄疸:NICE指南2016 (CG98)
Pub Date : 2017-02-08 DOI: 10.1136/archdischild-2016-311556
Rachel C Amos, H. Jacob, W. Leith
In May 2016, the National Institute for Health and Care Excellence (NICE) published updated guidelines entitled ‘Jaundice in newborn babies under 28 days’ (box 1).1 The guideline covers diagnosis and treatment of neonates with jaundice, aiming ‘to help detect and prevent very high levels of bilirubin’. New recommendations focus on measuring and monitoring bilirubin levels and the type of phototherapy. Here, we summarise the guideline, highlighting updates and relevance to clinical practice. Box 1 ### Resourceswww.nice.org.uk/guidance/CG98 Link to NICE guideline and threshold tablewww.nice.org.uk/guidance/cg98/resources Link to treatment threshold graphswww.nice.org.uk/Guidance/cg98/evidence Link to guideline committee's discussion and evidence reviewsThe original NICE guideline CG98, published in May 2010, was jointly developed with the National Collaborating Centre for Women and Children's Health (now part of the National Guideline Alliance) to encourage more uniform, evidence-based practice.
2016年5月,国家健康和护理卓越研究所(NICE)发布了题为“28天以下新生儿黄疸”的最新指南(方框1)该指南涵盖了新生儿黄疸的诊断和治疗,旨在“帮助发现和预防胆红素水平过高”。新的建议侧重于测量和监测胆红素水平和光疗的类型。在这里,我们总结了指南,强调了更新和与临床实践的相关性。框1 ###资源www.nice.org.uk/guidance/CG98链接到NICE指南和阈值表www.nice.org.uk/guidance/cg98/resources链接到治疗阈值图表www.nice.org.uk/Guidance/cg98/evidence链接到指南委员会的讨论和证据审查2010年5月出版的最初的NICE指南CG98,是与国家妇女和儿童健康合作中心(现在是国家指南联盟的一部分)共同制定的,以鼓励更统一的,以证据为基础的做法。
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引用次数: 65
Consumption of artificial sweeteners in pregnancy increased overweight risk in infants 怀孕期间食用人造甜味剂会增加婴儿超重的风险
Pub Date : 2017-02-08 DOI: 10.1136/archdischild-2017-312618
Fahimeda Ali
Cohort study of mother–infant dyads.Setting: Canadian Healthy Infant Longitudinal Development Study. A population-based study with four contributing sites.Patients: Mothers of singleton pregnancies and their 1-year-old infants.Exposure: Maternal artificial and sugar-sweetened beverage intake from questionnaire, classified according to the number of servings per day/week/month.Outcomes: Primary outcome was infant body mass index (BMI) z-score at 1 year of age. Secondary outcome was the risk of being overweight (BMI z-score >97th centile) at 1 year of age.Follow-up period : Women recruited over 5 years (2009–2013). Infant BMI was calculated at 1 year of age.Patient follow-up : 3033 mother–infant dyads were recruited. 2682 completed follow-up of BMI and 2413 …
母子二代的队列研究。背景:加拿大健康婴儿纵向发展研究。一项有四个贡献地点的基于人群的研究。患者:单胎孕妇及其1岁婴儿。暴露情况:根据每天/每周/每月的食用次数,调查问卷中母亲人工饮料和含糖饮料的摄入量。结果:主要结果为1岁时婴儿体重指数(BMI) z-score。次要终点是1岁时超重的风险(BMI z-score >97百分位)。随访期:女性招募时间超过5年(2009-2013)。婴儿BMI在1岁时计算。患者随访:招募了3033对母婴。2682例BMI随访完成,2413例BMI随访完成。
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引用次数: 7
Handy paediatric dermatology 方便的儿科皮肤科
Pub Date : 2017-02-01 DOI: 10.1136/archdischild-2016-312358
E. Valerio, Francesca Parata, M. Cutrone
Dermatological hand signs are common and can be benign (with or without treatment implications), linked to a change in patient's behaviour or herald more severe systemic conditions (dermatomyositis). Despite the peculiarity of underlying diseases, their visual appearances may overlap and sometimes be deceptive. It is therefore important for clinicians to be aware of the possible similarities in such diverse conditions, in order to make a correct diagnosis and target treatment.### Which would be the most likely diagnosis for each image based on the cases below:1. Gottron's papules2. Psoriasis3. Cutaneous T-cell lymphoma4. Chewing pads5. Knuckle calluses6. Herpetic lesions7. Idiopathic/familial knuckle pads8. Cold burns (frost bites)9. Common warts10. Occupational lesionsWe evaluated a 17-year-old girl with dark phototype with an upper respiratory tract infection. Physical examination incidentally revealed plaque lesions located only at the extensor surface of her right hand, at the proximal interphalangeal joints (IJ) (figure 1A). Left hand was unharmed. The rest of the examination, apart from the concomitant respiratory infection, was negative. The girl also reported a recent school change as a current stressor.Figure 1 (A) Self-induced ‘chewing pads’, (B) Gottron’s papules, …
皮肤病手征很常见,可能是良性的(有或没有治疗意义),与患者行为的改变有关,或预示着更严重的全身疾病(皮肌炎)。尽管潜在疾病具有特殊性,但它们的视觉外观可能重叠,有时具有欺骗性。因此,对于临床医生来说,重要的是要意识到在这些不同的条件下可能存在的相似性,以便做出正确的诊断和有针对性的治疗。根据下面的案例,哪一种诊断是最可能的?Gottron papules2。Psoriasis3。皮肤t细胞淋巴瘤。咀嚼pads5。关节calluses6。疱疹的lesions7。特发性/家族性指关节垫。冷烧伤(冻伤)常见的warts10。职业性病变我们评估了一个17岁的女孩暗照相术与上呼吸道感染。体检偶然发现斑块病变仅位于其右手伸肌面,近端指间关节(IJ)(图1A)。左手没有受伤。除合并呼吸道感染外,其余检查均为阴性。这名女孩还报告说,最近学校的变化是她当前的压力源。图1 (A)自我诱导的“咀嚼垫”,(B) Gottron丘疹,…
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引用次数: 1
Subcutaneous calcifications and hypothyroidism: Is there a missing link? 皮下钙化和甲状腺功能减退:是否有缺失的环节?
Pub Date : 2017-01-30 DOI: 10.1136/archdischild-2016-311834
D. Giri, Ravi Jayaram, S. Senniappan
A 5-year-old boy was referred with a history of multiple subcutaneous nodules since infancy. He was born at 42 weeks gestation with a birth weight of 3.2 kg. At 8 months of age, he was noted to have an excessive weight gain by the health visitor and was subsequently diagnosed with primary hypothyroidism and commenced on levothyroxine 50 μg once daily. He had a normal newborn congenital hypothyroidism screen. The thyroid autoimmune antibodies were normal.By the age of 5 years, he had delayed walking, speech and learning difficulties. Mother gave a history of surgically removed calcified lesions on her back. His weight and height at presentation were 35.5 kg (+3.8 SDS) and 121.4 cm (1.6 SDS), respectively. On examination, he had multiple subcutaneous nodules over and behind the left knee, left forearm, right ankle, chest and abdomen (figures 1 and 2). Investigations revealed a …
一名5岁男童自婴儿期起就有多个皮下结节病史。他在怀孕42周时出生,出生体重为3.2公斤。8个月大时,卫生访视员注意到他体重过度增加,随后诊断为原发性甲状腺功能减退,并开始服用左旋甲状腺素50 μg,每日一次。他有一个正常的新生儿先天性甲状腺功能减退症筛查。甲状腺自身免疫抗体正常。5岁时,他出现了走路迟缓、语言和学习困难。母亲讲述了她背部手术切除钙化病灶的病史。发病时体重35.5 kg (+3.8 SDS),身高121.4 cm (1.6 SDS)。检查发现,患者左膝、左前臂、右脚踝、胸部和腹部有多发皮下结节(图1和2)。
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引用次数: 0
How to use … the Monospot and other heterophile antibody tests 如何使用单点抗体和其他异性恋抗体测试
Pub Date : 2017-01-27 DOI: 10.1136/archdischild-2016-311526
Tess Marshall-Andon, P. Heinz
Epstein-Barr virus (EBV) is a highly prevalent virus, transmitted via saliva, which often causes asymptomatic infection in children but frequently results in infectious mononucleosis in adolescents. Heterophile antibody tests, including the Monospot test, are red cell or latex agglutination assays, which detect antired cell antibodies produced as part of a polyclonal antibody response occurring during EBV infection. Heterophile antibody tests are rapid, cheap and specific tests that can be performed from the onset of symptoms of infectious mononucleosis. In adolescents, heterophile antibody tests have high specificity and sensitivity in the diagnosis of primary acute EBV infection. However, the tests have low sensitivity and low negative predictive value in young children and are not useful under the age of 4. Heterophile tests may be positive in other viral infections, autoimmune disease and haematological malignancies, but do not appear to be positive in primary bacterial infection. Virus-specific serology is required in children under the age of 4 or if an older child is heterophile negative. Virus-specific serology allows diagnosis and the pattern of positivity and negativity enables the clinician to stage the EBV infection. Virus-specific serology appears to have better sensitivity in young children, but there is cross-reaction with other herpesvirus infections, a longer turnaround time and it is more expensive to perform. Further research is needed to establish which children benefit from and hence require testing for heterophile antibodies, the cost-effectiveness of EBV investigations and whether heterophile titres have predictive value for the severity of infection and the likelihood of complications.
eb病毒(EBV)是一种高度流行的病毒,通过唾液传播,通常在儿童中引起无症状感染,但在青少年中经常导致传染性单核细胞增多症。包括单斑试验在内的嗜异性抗体试验是红细胞或乳胶凝集试验,用于检测EBV感染期间作为多克隆抗体反应的一部分产生的红细胞抗体。嗜异性抗体测试是一种快速、廉价和特异性的测试,可以从传染性单核细胞增多症的症状开始进行。在青少年中,异性恋抗体试验在诊断原发性急性EBV感染方面具有很高的特异性和敏感性。然而,该测试在幼儿中灵敏度低,阴性预测值低,并且在4岁以下儿童中不适用。在其他病毒感染、自身免疫性疾病和血液系统恶性肿瘤中,异性恋试验可能呈阳性,但在原发性细菌感染中似乎不呈阳性。4岁以下儿童或较大儿童嗜异性恋阴性时需要进行病毒特异性血清学检查。病毒特异性血清学有助于诊断,阳性和阴性的模式使临床医生能够对EBV感染进行分期。病毒特异性血清学在幼儿中似乎具有更好的敏感性,但与其他疱疹病毒感染存在交叉反应,周转时间较长,而且成本较高。需要进一步的研究来确定哪些儿童受益并因此需要检测异性恋抗体,eb病毒调查的成本效益,以及异性恋滴度是否对感染的严重程度和并发症的可能性具有预测价值。
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引用次数: 20
Distal forearm fractures can be reliably diagnosed using ultrasound 使用超声可以可靠地诊断前臂远端骨折
Pub Date : 2017-01-24 DOI: 10.1136/archdischild-2016-312428
A. Friend, D. Roland
In patients with possible distal forearm fracture, is ultrasound scanning a reliable method of diagnosis when compared with X-ray?Design : Systematic review and meta-analysis.Data source : Medline, Web of Science, the Cochrane Library.Study inclusion criteria : Comparison of ultrasound and X-ray in patients with potential distal forearm fractures; written in English, French, German or Spanish language.A total of 16 studies involving 1204 patients with 641 fractures were included. Twelve studies involving 951 patients looked specifically at children. Included studies all used X-ray as their ‘gold standard’ for diagnosing fractures and compared ultrasound to this. Most studies …
对于可能发生前臂远端骨折的患者,与x线相比,超声扫描是一种可靠的诊断方法吗?设计:系统回顾和荟萃分析。数据来源:Medline, Web of Science, Cochrane图书馆。研究纳入标准:潜在前臂远端骨折患者的超声与x线比较;用英语、法语、德语或西班牙语书写。共纳入16项研究,涉及1204例641例骨折。涉及951名患者的12项研究专门针对儿童。所有纳入的研究都使用x光作为诊断骨折的“金标准”,并将其与超声波进行比较。大多数研究……
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引用次数: 2
Highlights from this issue 本期重点报道
Pub Date : 2017-01-18 DOI: 10.1136/archdischild-2016-312564
I. Wacogne
In the odd delay built into a journal like E&P, I’m writing this in the immediate aftermath of attending the Royal College of Paediatrics and Child Health Spring Conference. It’s interesting that in this age of more real print and virtual print than we can even begin to think of completing, and more resources for learning than our predecessors could have imagined, we still make the time to travel and to sit in the same room as a speaker, to hear them talk. I wonder why we do this? I suspect there are a few reasons. One of them is to do with trusting that an eminent speaker will have prepared an interesting and stimulating talk, which introduces us to a new set of ideas. Another is to listen to how people have responded to difficulties similar to our own. But I suspect that the main reason is the buzz of meeting a bunch of people, some of whom you’ve never met before, some of whom you’ve not seen for a year or two, and, well, chatting. It would be easy to create a misunderstanding here—after all, our employing bodies are often supporting us financially to attend, and I’m pretty sure they’d be reluctant to fund us to go on a general gossip. So, to clarify, it’s more than a gossip—it’s the pollination of different ideas across multiple people, and the creation of exciting new thoughts. And what about when you’re in the same room as a bad speaker? Well, these days there is always WiFi. But, that aside, I also find value in a conference where I can unfocus a little, and let the thoughts rattle around a bit. What can a journal do to recreate the best parts of a conference? Well, obviously it can’t simulate putting people in the same room. But it can bring the thoughts of some diverse people into the room you’re in— which, by some accounts, might be the littlest room in the house. This issue we’ve got lymph nodes, croup, BCG abscess, mouth ulcers, neonatal antibiotics, haemangiomas, odd X-rays, capillary refill time, pulse oximetry, and a Picket on cooling after brain injury. I reckon that’s pretty eclectic, and should, if you unfocus a little while reading, give you a few fairly diverse thoughts. My Editor’s choice is the paper on recurrent oral ulceration in children (see page 82). Esse Menson, who wrote this paper with Kirsty Le Doare, Esther Hullah and Stephen Challacombe, has been helping curate a infectious diseases subseries within the Fifteen-Minute Consultation section, so expect a lot of these over the next few months. Oral ulceration is a clinical scenario I find tricky; the range of possibilities, from idiopathic to some very serious diagnoses, and the high incidence—from 1 to 10% of children —make it important to pick the right child to investigate robustly. The authors provide a helpful table of first line investigations with the useful caveat that the absence of systemic features, you can usually avoid testing. Awhile ago I used to take copious notes in talks, convinced that I’d pore over them later, absorbing the knowledge and becoming a
我是在参加完皇家儿科学院和儿童健康春季会议之后,才写这篇文章的。有趣的是,在这个真实印刷和虚拟印刷的时代,我们甚至无法想象完成,学习资源比我们的前辈想象的要多,我们仍然有时间去旅行,和演讲者坐在同一个房间里,听他们说话。我想知道我们为什么要这样做?我怀疑有以下几个原因。其中之一是相信一位杰出的演讲者会准备一场有趣而刺激的演讲,向我们介绍一套新的思想。另一种方法是倾听人们如何应对与我们相似的困难。但我怀疑主要原因是见到一群人的兴奋,有些人你以前从未见过,有些人你已经一两年没见了,还有,嗯,聊天。这很容易造成误解——毕竟,我们的雇主经常在经济上支持我们参加,我很确定他们不愿意资助我们去八卦。所以,澄清一下,这不仅仅是闲聊——这是不同想法在多人之间的传播,以及令人兴奋的新想法的创造。当你和一个差劲的演讲者在一个房间里的时候呢?现在到处都有WiFi。但是,除此之外,我也发现了会议的价值,在那里我可以稍微分散一下注意力,让思想在周围摇摆。期刊怎样才能重现会议的精华呢?很明显,它不能模拟把人放在同一个房间里。但它可以把一些不同的人的想法带到你所在的房间——从某些方面来说,你所在的房间可能是房子里最小的房间。这期我们有淋巴结,群,卡介苗脓肿,口腔溃疡,新生儿抗生素,血管瘤,奇怪的x光片,毛细血管重新充血时间,脉搏血氧测量,以及脑损伤后冷却的问题。我认为这是相当兼收并蓄的,如果你在阅读时稍微分散一下注意力,应该会给你一些相当不同的想法。我的编辑选择是关于儿童复发性口腔溃疡的论文(见第82页)。Esse Menson,他和Kirsty Le Doare, Esther Hullah和Stephen Challacombe一起写了这篇论文,他一直在帮助策划十五分钟咨询部分的传染病子系列,所以在接下来的几个月里,我们会看到很多这样的文章。口腔溃疡是一个我觉得棘手的临床情况;从特发性到一些非常严重的诊断的可能性范围,以及从1%到10%的高发病率,使得选择合适的孩子进行强有力的调查变得非常重要。作者提供了一个有用的第一线调查表,并给出了一个有用的警告,即如果没有系统特性,通常可以避免测试。不久前,我常常在演讲中做大量的笔记,相信我以后会仔细研究它们,吸收知识,成为一名更好的医生。当然,我再也没有拿起它们,所以多年来我调整了我的风格,并试图限制自己每次演讲只讲几件事。我不再考虑“这里有什么信息”,而是考虑“因此我将采取什么行动”。在一个会议上呆上几天仍然可以给我一个比我完成的要做的事情清单,但我发现我所采取的行动,真的让我走了很长一段路。菲利帕·普伦蒂斯以这种方式出色地编辑了指南部分——确保作者给你列出要做的事情,有时更重要的是,不要做的事情。我很想知道你在看完这个月的E&P之后会做什么,或者不再做什么。只要稍微分散一下注意力,一切就都有意义了。
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引用次数: 0
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Archives of Disease in Childhood: Education & Practice Edition
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