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Innervated Local Flap Reconstruction for Digital Soft Tissue Defects: A Systematic Review. 带神经的局部皮瓣重建修复手指软组织缺损的系统综述。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-19 DOI: 10.1111/ans.70622
Ines Prasidha, Joshua Xu, Owen Ou Yang, Brahman Shankar Sivakumar

Restoration of tactile sensation in fingertip reconstruction is essential for hand function. This systematic review aimed to evaluate differences in the outcomes of innervated (IF) and noninnervated local flap (NIF) reconstruction for digital soft tissue defects. PubMed, MEDLINE, Cochrane, and EMBASE databases were systematically searched. English-language articles reporting sensibility outcomes were included. Eleven studies, published between 1983 and 2023, with a total of 591 flaps were included in the analysis. The sensibility outcome of the reconstructed fingers in IF is significantly better than that of NIF. Neurorrhaphy should be performed in local flap fingertip reconstruction to improve the sensory outcome.

指尖重建中触觉的恢复对手部功能的恢复至关重要。本系统综述旨在评价神经支配局部皮瓣(IF)和非神经支配局部皮瓣(NIF)重建手指软组织缺损的结果差异。系统检索PubMed、MEDLINE、Cochrane和EMBASE数据库。纳入了报道敏感性结果的英文文章。在1983年至2023年间发表的11项研究中,共有591个皮瓣被纳入分析。移植后重建手指的敏感性明显优于非移植。局部皮瓣指尖重建应行神经吻合,以改善感觉效果。
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引用次数: 0
Sleepless Surgeons: Insights From a Study on Consultant On-Call Interruptions. 失眠的外科医生:来自咨询师随叫随到的干扰研究的见解。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-19 DOI: 10.1111/ans.70630
Colin Chong, Elly Henner-Cwirn, Kavesha Sarangadasa, Mersidon Fernandez, Nick Bui, Jonathan Gani, Christine J O'Neill
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引用次数: 0
Re: Pelvic Ring Fixation Metalware Retention and Birth Modality in Women of Childbearing Age: A Systematic Review and Meta-Analysis. 育龄妇女盆腔环固定金属器皿保留与分娩方式:系统回顾和荟萃分析。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-18 DOI: 10.1111/ans.70532
Jing Wang, Huansheng Zhou
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引用次数: 0
Machine Learning for Predicting Colorectal Cancer-Specific Mortality: The Role of Socioeconomic Inequalities in Public Policy. 预测结直肠癌特异性死亡率的机器学习:社会经济不平等在公共政策中的作用。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-18 DOI: 10.1111/ans.70572
Felipe Mendes Delpino, Rocco Friebel, Francisco Tustumi, Marina Martins Siqueira, Gabriely Rangel Pereira, Marcelo Passos Teivelis, Lucas Hernandes Correa, Nelson Wolosker

Background: Colorectal cancer remains a leading cause of mortality worldwide. We investigated whether adding socioeconomic information to machine learning models can improve the prediction of colorectal cancer-specific mortality.

Methods: Using data from the Fundação Oncocentro de São Paulo (FOSP), we analyzed individuals diagnosed with colorectal cancer between 2000 and 2023; however, predictive models were developed using patients diagnosed from 2000 to 2021, ensuring a minimum follow-up of 24 months for the 2-year mortality outcome. Thirty predictor variables were included, including clinical factors associated with the disease and socioeconomic factors such as income, educational attainment, HDI components, as well as distance and travel time to healthcare facilities. We tested seven machine learning algorithms using a 70/30 training/testing split. Discrimination was measured by the area under the receiver operating characteristic curve (AUC-ROC), comparing versions with and without socioeconomic factors.

Results: The Random Forest algorithm provided the best discrimination for predicting the risk of death due to colorectal cancer within 2 years after diagnosis (AUC-ROC = 0.92). The addition of socioeconomic and access-related predictors (Human Development Index [HDI] components, education, distance/travel time to healthcare facilities, and type of coverage) improved the AUROC by 0.13 (0.79-0.92) compared with the clinical-only model.

Conclusion: The inclusion of socioeconomic variables in conjunction with clinical data in machine learning models has the potential to enhance the ability to predict colorectal cancer-specific mortality in patients with colorectal cancer.

背景:结直肠癌仍然是世界范围内死亡的主要原因。我们研究了在机器学习模型中加入社会经济信息是否可以提高对结直肠癌特异性死亡率的预测。方法:利用圣保罗肿瘤中心基金会(FOSP)的数据,我们分析了2000年至2023年间诊断为结直肠癌的个体;然而,使用2000年至2021年诊断的患者开发了预测模型,确保对2年死亡率结果进行至少24个月的随访。包括30个预测变量,包括与疾病相关的临床因素和社会经济因素,如收入、受教育程度、人类发展指数成分,以及到医疗机构的距离和旅行时间。我们使用70/30的训练/测试分割测试了7种机器学习算法。通过受试者工作特征曲线下面积(AUC-ROC)来衡量歧视,比较有和没有社会经济因素的版本。结果:随机森林算法在预测诊断后2年内结直肠癌死亡风险方面具有最好的判别性(AUC-ROC = 0.92)。加入社会经济和可及性相关的预测因素(人类发展指数[HDI]组成部分、教育程度、到医疗机构的距离/旅行时间和覆盖类型)后,AUROC比仅用于临床的模型提高了0.13(0.79-0.92)。结论:将社会经济变量与临床数据结合在机器学习模型中,有可能提高预测结直肠癌患者结肠直肠癌特异性死亡率的能力。
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引用次数: 0
Role of Trans-Cystic Stenting in Management of Choledocholithiasis During Cholecystectomy. 胆囊切除术中经囊支架置入治疗胆总管结石的作用。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-17 DOI: 10.1111/ans.70586
Matthew Marshall-Webb, Gili Smart, Phillip Chao, Sayed Hassen, Adrian Fox

Introduction: Choledocholithiasis detected during laparoscopic cholecystectomy is common. There is no consensus for the best management in this context. Trans-cystic biliary stent insertion is a well described but less commonly used method for managing choledocholithiasis with the gallbladder in situ.

Methods: Retrospective study including all patients undergoing trans-cystic biliary stenting followed by ERCP at Box Hill Hospital, from 2021 to 2024. Outcomes compared to control cohort of native ERCP for choledocholithiasis at the same institution. The primary outcome was post-ERCP pancreatitis.

Results: Trans-cystic stenting was attempted in 49 patients. 45 (92%) were successful. The median age was 52 years, 73.4% were female, and 67% admitted emergently. No episodes of post-ERCP pancreatitis occurred when the trans-cystic stent was in position at ERCP, compared with 5% in the control cohort. Biliary cannulation rate was 97% if a stent was present, compared with 91% in the control cohort. 20% of stents had migrated by the time of ERCP. One patient developed pancreatitis post failed trans-cystic stent attempt. No other complications were recorded. The median length of stay (LOS) was 5.0 days. A 40% of patients were discharged prior to ERCP, resulting in a shorter median LOS: 4.0 versus 6.0 days (p = 0.014). No statistical differences were detected between variables for unsuccessful stenting, stent mis-deployment, or stent migration.

Conclusion: Trans-cystic stenting resulted in a low rate of post-ERCP pancreatitis and a high rate of biliary cannulation. It can be safely implemented by general surgeons and may result in a reduced length of stay.

在腹腔镜胆囊切除术中发现胆总管结石是很常见的。在这种情况下,对最佳管理没有共识。经胆囊胆道支架置入术是一种描述良好但不常用的治疗原位胆囊胆总管结石的方法。方法:回顾性研究包括2021年至2024年在Box Hill医院接受经胆囊胆道支架植入术后ERCP的所有患者。结果与同一机构的先天性ERCP治疗胆总管结石的对照队列进行比较。主要结局为ercp后胰腺炎。结果:49例患者行经囊性支架植入术。45例(92%)成功。中位年龄52岁,73.4%为女性,67%为急诊。经囊性支架在ERCP放置时,没有发生ERCP后胰腺炎发作,而对照组为5%。如果存在支架,胆道插管率为97%,而对照组为91%。到ERCP时,20%的支架已经迁移。一名患者在尝试经囊支架失败后发生胰腺炎。无其他并发症记录。中位住院时间(LOS)为5.0天。40%的患者在ERCP之前出院,导致中位LOS较短:4.0天对6.0天(p = 0.014)。在支架置入失败、支架错置或支架移位的变量之间没有发现统计学差异。结论:经囊性支架置入导致ercp术后胰腺炎发生率低,胆道插管率高。它可以安全地由普通外科医生实施,并可能减少住院时间。
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引用次数: 0
How to Improve Surgical View Simply Without Changing the Body Position During Robotic Right-Sided Colectomy: The Scope Port Hopping Method (SCOP Method). 在机器人右侧结肠切除术中如何在不改变体位的情况下简单地改善手术视野:视野端口跳跃法(SCOP法)。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-17 DOI: 10.1111/ans.70580
Hiroshi Takeyama, Shu Okamura, Ryuta Ueda, Koji Hayashi, Yoshiki Taniguchi, Naomi Urano, Yoshiteru Katsura, Natsumi Tanaka, Kazuhiro Nishikawa

During robotic right-sided colectomy, although changing body position is required to change the surgical view, it can be a complicated and troublesome procedure in robotic surgery, especially without an integrated table motion. We describe an efficient, simple surgical method to smoothly change the surgical view during robotic right-sided colectomy without changing the body position, called the scope port hopping method (SCOP) method.

在机器人右侧结肠切除术中,虽然需要改变身体位置来改变手术视角,但在机器人手术中,这可能是一个复杂而麻烦的过程,特别是没有集成的工作台运动。我们描述了一种高效、简单的手术方法,可以在不改变身体位置的情况下平滑地改变机器人右侧结肠切除术的手术视图,称为范围端口跳跃法(SCOP)方法。
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引用次数: 0
Unaccredited Specialty Surgery "Training": The Impact of the Years Prior to SET Entry. 未经认证的专业外科“培训”:SET进入前几年的影响。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-16 DOI: 10.1111/ans.70590
Caroline R Dowling, Ben O'Gorman, Emily Schembri, Jenepher Martin, Shomik Sengupta
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引用次数: 0
Click, Watch, Consent: Assessing the Quality of YouTube Information on Ivor-Lewis Oesophagectomy. 点击,观看,同意:评估YouTube上关于Ivor-Lewis食道切除术信息的质量。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-16 DOI: 10.1111/ans.70539
Aayaz Alam, Aadil Rahim, Clare Bouffler, Michael Devadas

Background and aims: With modern healthcare now shifting towards a more patient-centred approach, informed consent and expectation management relies on both easily accessible and accurate information. YouTube is a popular source of medical information for patients, but its lack of regulation, especially on procedures like Ivor-Lewis oesophagectomies, warrants analysis of the quality of content available. This study aims to assess the quality of information on YouTube related to the Ivor-Lewis oesophagectomy for patient education.

Methods: A search of YouTube (www.youtube.com) videos was conducted in May 2025 with the term 'Ivor-Lewis oesophagectomy'. The inclusion criteria required the videos to discuss Ivor-Lewis oesophagectomies, be narrated/subtitled in English, intended for patients and educational in nature. The exclusion criteria removed videos that were non-English, technical surgical videos aimed at healthcare providers, and promotional videos. The videos were evaluated using the DISCERN tool and the Global Quality Score (GQS) and other descriptive statistics.

Results: A total of 226 videos were assessed against the inclusion and exclusion criteria. Twelve videos were deemed eligible as per the criteria and were included for analysis. The median view count was 10 961 views and the median length of the videos were 162 s. The median DISCERN score was 52.5/80 with medical institutions garnering the highest median out of all the source categories (58/80). The median GQS score was 4 points.

Conclusion: YouTube videos on Ivor-Lewis oesophagectomies were largely of poor quality, indicating greater need for regulation and standards for medical information on video-hosting platforms.

背景和目的:随着现代医疗保健现在转向更加以患者为中心的方法,知情同意和期望管理依赖于易于获取和准确的信息。YouTube是一个受患者欢迎的医疗信息来源,但它缺乏监管,尤其是在Ivor-Lewis食道切除术等手术方面,因此有必要对现有内容的质量进行分析。本研究旨在评估YouTube上有关Ivor-Lewis食管切除术患者教育的信息质量。方法:于2025年5月在YouTube (www.youtube.com)上搜索“Ivor-Lewis食道切除术”视频。纳入标准要求视频讨论Ivor-Lewis食道切除术,用英语解说/字幕,旨在为患者提供教育性质的视频。排除标准删除了非英语视频、针对医疗保健提供者的技术外科视频和宣传视频。使用DISCERN工具和全球质量评分(GQS)以及其他描述性统计对视频进行评估。结果:根据纳入和排除标准对226个视频进行了评估。根据标准,有12个录像被认为是合格的,并列入分析。观看次数的中位数为10961次,视频长度的中位数为162秒。DISCERN评分中位数为52.5/80,医疗机构在所有来源类别中得分最高,为58/80。GQS得分中位数为4分。结论:YouTube上关于Ivor-Lewis食道切除术的视频质量普遍较差,表明视频托管平台上的医疗信息更需要监管和标准。
{"title":"Click, Watch, Consent: Assessing the Quality of YouTube Information on Ivor-Lewis Oesophagectomy.","authors":"Aayaz Alam, Aadil Rahim, Clare Bouffler, Michael Devadas","doi":"10.1111/ans.70539","DOIUrl":"https://doi.org/10.1111/ans.70539","url":null,"abstract":"<p><strong>Background and aims: </strong>With modern healthcare now shifting towards a more patient-centred approach, informed consent and expectation management relies on both easily accessible and accurate information. YouTube is a popular source of medical information for patients, but its lack of regulation, especially on procedures like Ivor-Lewis oesophagectomies, warrants analysis of the quality of content available. This study aims to assess the quality of information on YouTube related to the Ivor-Lewis oesophagectomy for patient education.</p><p><strong>Methods: </strong>A search of YouTube (www.youtube.com) videos was conducted in May 2025 with the term 'Ivor-Lewis oesophagectomy'. The inclusion criteria required the videos to discuss Ivor-Lewis oesophagectomies, be narrated/subtitled in English, intended for patients and educational in nature. The exclusion criteria removed videos that were non-English, technical surgical videos aimed at healthcare providers, and promotional videos. The videos were evaluated using the DISCERN tool and the Global Quality Score (GQS) and other descriptive statistics.</p><p><strong>Results: </strong>A total of 226 videos were assessed against the inclusion and exclusion criteria. Twelve videos were deemed eligible as per the criteria and were included for analysis. The median view count was 10 961 views and the median length of the videos were 162 s. The median DISCERN score was 52.5/80 with medical institutions garnering the highest median out of all the source categories (58/80). The median GQS score was 4 points.</p><p><strong>Conclusion: </strong>YouTube videos on Ivor-Lewis oesophagectomies were largely of poor quality, indicating greater need for regulation and standards for medical information on video-hosting platforms.</p>","PeriodicalId":8158,"journal":{"name":"ANZ Journal of Surgery","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women With Low Falls Are Less Likely To Be Admitted to a Specialist Trauma Unit: A Single Centre Observational Study of Older Adults. 低跌倒的女性不太可能被专科创伤科收治:一项针对老年人的单中心观察研究。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-16 DOI: 10.1111/ans.70581
Katherine Gregorevic, Kwang Lim, Rachel Aitken, Alyssa Griffiths, David Read

Background: Undertriage of women with trauma is associated with preventable deaths. This project was developed to determine whether older women with trauma were less likely to be admitted to a specialist trauma unit.

Methods: The study was undertaken at a specialist, level one trauma service and included all people aged 65 and older admitted following trauma over a twelve-month period. Patients were included if they were admitted to general medicine, trauma or orthopaedics. The primary outcome was admission to general medicine versus trauma. Baseline data included age, sex, Charlson Comorbidity Index (CCI), mechanism of injury (low fall vs. other) and baseline function. Injury Severity Score (ISS) was calculated by trained assessors.

Results: A total of 648 (50.3%) were admitted to trauma, 286 (22.2%) to orthopaedics and 352 (27.4%) to General medicine (GM). 686 (53%) of patients were women. Low fall was the most common mechanism of injury (75.6% of women, 51.3% of men). In a multivariate model to look at admission to GM versus trauma, including age, sex, language other than English, CCI and ISS, women were more likely to be admitted to GM (1.67 (1.14, 2.44)). Low fall was the biggest predictor of general medical admission versus trauma (11.4 (6.7, 18.9)) Low fall was associated with mortality (2.0 (1.11, 3.67)).

Conclusions: Accounting for age and frailty women and people with low falls were more likely to be admitted to a general medical unit than a trauma unit compared to men. This supports the need for standard admission guidelines for trauma.

背景:创伤妇女分诊不足与可预防的死亡有关。该项目旨在确定老年创伤妇女是否更不可能被专科创伤科收治。方法:这项研究是在一个专业的一级创伤服务机构进行的,包括所有65岁及以上的人在12个月的时间里因创伤而入院。如果患者被纳入普通内科、创伤科或骨科。主要结局是普通内科住院与创伤住院。基线数据包括年龄、性别、Charlson合并症指数(CCI)、损伤机制(低跌倒vs.其他)和基线功能。损伤严重程度评分(ISS)由训练有素的评估人员计算。结果:创伤科648例(50.3%),骨科286例(22.2%),普通内科352例(27.4%)。686例(53%)患者为女性。低位跌倒是最常见的损伤机制(75.6%的女性,51.3%的男性)。在一个多变量模型中,包括年龄、性别、英语以外的语言、CCI和ISS,女性更有可能接受GM(1.67(1.14, 2.44))。低跌倒是普通住院与创伤住院的最大预测因子(11.4(6.7,18.9))。低跌倒与死亡率相关(2.0(1.11,3.67))。结论:考虑到年龄和身体虚弱,与男性相比,女性和低跌倒的人更有可能进入普通医疗部门,而不是创伤部门。这支持了制定创伤标准入院指南的必要性。
{"title":"Women With Low Falls Are Less Likely To Be Admitted to a Specialist Trauma Unit: A Single Centre Observational Study of Older Adults.","authors":"Katherine Gregorevic, Kwang Lim, Rachel Aitken, Alyssa Griffiths, David Read","doi":"10.1111/ans.70581","DOIUrl":"https://doi.org/10.1111/ans.70581","url":null,"abstract":"<p><strong>Background: </strong>Undertriage of women with trauma is associated with preventable deaths. This project was developed to determine whether older women with trauma were less likely to be admitted to a specialist trauma unit.</p><p><strong>Methods: </strong>The study was undertaken at a specialist, level one trauma service and included all people aged 65 and older admitted following trauma over a twelve-month period. Patients were included if they were admitted to general medicine, trauma or orthopaedics. The primary outcome was admission to general medicine versus trauma. Baseline data included age, sex, Charlson Comorbidity Index (CCI), mechanism of injury (low fall vs. other) and baseline function. Injury Severity Score (ISS) was calculated by trained assessors.</p><p><strong>Results: </strong>A total of 648 (50.3%) were admitted to trauma, 286 (22.2%) to orthopaedics and 352 (27.4%) to General medicine (GM). 686 (53%) of patients were women. Low fall was the most common mechanism of injury (75.6% of women, 51.3% of men). In a multivariate model to look at admission to GM versus trauma, including age, sex, language other than English, CCI and ISS, women were more likely to be admitted to GM (1.67 (1.14, 2.44)). Low fall was the biggest predictor of general medical admission versus trauma (11.4 (6.7, 18.9)) Low fall was associated with mortality (2.0 (1.11, 3.67)).</p><p><strong>Conclusions: </strong>Accounting for age and frailty women and people with low falls were more likely to be admitted to a general medical unit than a trauma unit compared to men. This supports the need for standard admission guidelines for trauma.</p>","PeriodicalId":8158,"journal":{"name":"ANZ Journal of Surgery","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Enzymes Mislead: Assessing the Value of MRCP in Suspected Choledocholithiasis. 当酶误导:评估MRCP在疑似胆总管结石中的价值。
IF 1.6 4区 医学 Q3 SURGERY Pub Date : 2026-03-15 DOI: 10.1111/ans.70584
Renato Pitesa, Wai Yan Rachel Yuen, Nadia Meyer, Garth Poole, Primal Parry Singh

Background: The diagnosis of choledocholithiasis (CDL) requires balancing timely intervention against the risks of unnecessary invasive procedures. Although liver function tests (LFTs) are widely used for risk stratification, their static values and short-term trends remain poorly defined in predicting persistent common bile duct stones. This study evaluated the association between static and dynamic LFTs and CDL and assessed the diagnostic performance of magnetic resonance cholangiopancreatography (MRCP).

Methods: A retrospective review was conducted at Middlemore Hospital involving 504 acute inpatient MRCP scans within 2022. The collected clinical variables included patient demographics, LFTs and imaging modalities. 2 × 2 tables were constructed for those who had both MRCP and ERCP to assess the diagnostic utility of MRCP. Logistic regression and linear mixed-effects models were used to analyse the association between LFTs and CDL. Receiver operating characteristic curve analysis was performed to assess the diagnostic performance of each LFT.

Results: Of 504 MRCPs, 131 (26%) were positive for stones. Bilirubin, alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were significantly higher in the CDL group on admission and repeat testing. Paradoxically, CDL was associated with a downward 24-h trend in ALP and GGT. Elevated GGT demonstrated the strongest independent association with CDL (adjusted OR: 5.27, 95% CI: 2.46-13.21; p < 0.001). Discriminatory performance of individual enzymes was modest (AUC: ALP 0.69; GGT 0.68; bilirubin 0.63). Among 157 patients undergoing both MRCP and ERCP, MRCP demonstrated high sensitivity (91.4%) but low specificity (32.7%).

Conclusion: Static and dynamic LFTs provide limited discrimination for persistent CDL and improving biochemical trends do not reliably exclude stones. This study underscores the diagnostic utility of MRCP to prevent both missed CDL and avoidable ERCP, and the need for standardised diagnostic protocols.

背景:胆总管结石(CDL)的诊断需要及时干预与不必要的侵入性手术风险之间的平衡。尽管肝功能检查(LFTs)被广泛用于风险分层,但其静态值和短期趋势在预测持久性胆总管结石方面仍然定义不清。本研究评估了静态和动态LFTs与CDL之间的关系,并评估了磁共振胰胆管造影(MRCP)的诊断性能。方法:对Middlemore医院在2022年进行的504例急性住院患者MRCP扫描进行回顾性分析。收集的临床变量包括患者人口统计学、LFTs和成像方式。对同时患有MRCP和ERCP的患者构建2 × 2表,以评估MRCP的诊断价值。采用Logistic回归和线性混合效应模型分析LFTs与CDL之间的关系。进行受试者工作特征曲线分析,评估各LFT的诊断性能。结果:504例MRCPs中,131例(26%)为结石阳性。CDL组患者入院及重复检测时胆红素、碱性磷酸酶(ALP)、γ -谷氨酰转移酶(GGT)均显著升高。矛盾的是,CDL与ALP和GGT的24小时下降趋势有关。GGT升高与CDL的独立相关性最强(调整后OR: 5.27, 95% CI: 2.46-13.21; p)结论:静态和动态LFTs对持续性CDL的区分有限,改善生化趋势并不能可靠地排除结石。本研究强调了MRCP在预防遗漏的CDL和可避免的ERCP方面的诊断效用,以及标准化诊断方案的必要性。
{"title":"When Enzymes Mislead: Assessing the Value of MRCP in Suspected Choledocholithiasis.","authors":"Renato Pitesa, Wai Yan Rachel Yuen, Nadia Meyer, Garth Poole, Primal Parry Singh","doi":"10.1111/ans.70584","DOIUrl":"https://doi.org/10.1111/ans.70584","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of choledocholithiasis (CDL) requires balancing timely intervention against the risks of unnecessary invasive procedures. Although liver function tests (LFTs) are widely used for risk stratification, their static values and short-term trends remain poorly defined in predicting persistent common bile duct stones. This study evaluated the association between static and dynamic LFTs and CDL and assessed the diagnostic performance of magnetic resonance cholangiopancreatography (MRCP).</p><p><strong>Methods: </strong>A retrospective review was conducted at Middlemore Hospital involving 504 acute inpatient MRCP scans within 2022. The collected clinical variables included patient demographics, LFTs and imaging modalities. 2 × 2 tables were constructed for those who had both MRCP and ERCP to assess the diagnostic utility of MRCP. Logistic regression and linear mixed-effects models were used to analyse the association between LFTs and CDL. Receiver operating characteristic curve analysis was performed to assess the diagnostic performance of each LFT.</p><p><strong>Results: </strong>Of 504 MRCPs, 131 (26%) were positive for stones. Bilirubin, alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were significantly higher in the CDL group on admission and repeat testing. Paradoxically, CDL was associated with a downward 24-h trend in ALP and GGT. Elevated GGT demonstrated the strongest independent association with CDL (adjusted OR: 5.27, 95% CI: 2.46-13.21; p < 0.001). Discriminatory performance of individual enzymes was modest (AUC: ALP 0.69; GGT 0.68; bilirubin 0.63). Among 157 patients undergoing both MRCP and ERCP, MRCP demonstrated high sensitivity (91.4%) but low specificity (32.7%).</p><p><strong>Conclusion: </strong>Static and dynamic LFTs provide limited discrimination for persistent CDL and improving biochemical trends do not reliably exclude stones. This study underscores the diagnostic utility of MRCP to prevent both missed CDL and avoidable ERCP, and the need for standardised diagnostic protocols.</p>","PeriodicalId":8158,"journal":{"name":"ANZ Journal of Surgery","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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ANZ Journal of Surgery
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