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Potential of Milk-Derived Extracellular Vesicles as Carriers for Oral Delivery of Active Phytoconstituents. 牛奶衍生细胞外囊泡作为口服活性植物成分载体的潜力
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-072023-034354
Qiao Jiang, Yubo Liu, Xu Si, Li Wang, Hailong Gui, Jinlong Tian, Huijun Cui, Hongzhou Jiang, Wenjiang Dong, Bin Li

Extracellular vesicles (EVs) play a crucial role in intercellular communication and have the potential to serve as in vivo carriers for delivering active molecules. The biocompatibility advantages of EVs over artificial nanocarriers create new frontiers for delivering modern active molecules. Milk is a favorable source of EVs because of its high bioavailability, low immunogenicity, and commercial producibility. In this review, we analyzed the advantages of milk-derived EVs in the oral delivery of active molecules, discussed their research progress in delivering active phytoconstituents, and summarized the necessary technologies and critical unit operations required for the development of an oral delivery system based on EVs. The review aims to provide innovative ideas and fundamental quality control guidelines for developing the next-generation oral drug delivery system based on milk-derived EVs.

细胞外囊泡(EVs)在细胞间通信中发挥着至关重要的作用,并有可能成为体内输送活性分子的载体。与人工纳米载体相比,EVs 的生物相容性优势为现代活性分子的递送开辟了新的领域。牛奶因其生物利用度高、免疫原性低和可商业化生产而成为 EVs 的有利来源。在本研究中,我们分析了乳源 EVs 在口服递送活性分子方面的优势,讨论了其在递送活性植物成分方面的研究进展,并总结了开发基于 EVs 的口服递送系统所需的必要技术和关键单元操作。本综述旨在为开发基于乳源性 EVs 的下一代口服给药系统提供创新思路和基本质量控制指南。食品科学与技术年度综述》第15卷的最终在线出版日期预计为2024年4月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging. 饮食和生活方式如何微调肠道微生物组,促进健康老龄化。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 DOI: 10.1146/annurev-food-072023-034458
M Tamayo, M Olivares, P Ruas-Madiedo, A Margolles, J C Espín, I Medina, M V Moreno-Arribas, S Canals, C R Mirasso, S Ortín, H Beltrán-Sanchez, A Palloni, F A Tomás-Barberán, Y Sanz

Many physical, social, and psychological changes occur during aging that raise the risk of developing chronic diseases, frailty, and dependency. These changes adversely affect the gut microbiota, a phenomenon known as microbe-aging. Those microbiota alterations are, in turn, associated with the development of age-related diseases. The gut microbiota is highly responsive to lifestyle and dietary changes, displaying a flexibility that also provides anactionable tool by which healthy aging can be promoted. This review covers, firstly, the main lifestyle and socioeconomic factors that modify the gut microbiota composition and function during healthy or unhealthy aging and, secondly, the advances being made in defining and promoting healthy aging, including microbiome-informed artificial intelligence tools, personalized dietary patterns, and food probiotic systems.

衰老过程中会发生许多生理、社会和心理变化,从而增加罹患慢性疾病、虚弱和依赖性的风险。这些变化会对肠道微生物群产生不利影响,这种现象被称为微生物老化。这些微生物群的变化反过来又与老年相关疾病的发生有关。肠道微生物群对生活方式和饮食习惯的改变反应灵敏,显示出灵活性,这也为促进健康老龄化提供了可操作的工具。本综述首先介绍了在健康或不健康老龄化过程中改变肠道微生物群组成和功能的主要生活方式和社会经济因素,其次介绍了在定义和促进健康老龄化方面取得的进展,包括微生物信息人工智能工具、个性化饮食模式和食品益生菌系统。
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引用次数: 0
Sample Processing and Concentration Methods for Viruses from Foods and the Environment Prior to Detection. 食品和环境中病毒检测前的样品处理和浓缩方法。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-072023-034431
Sloane Stoufer, Anand R Soorneedi, Minji Kim, Matthew D Moore

Viruses are the leading cause of foodborne illness globally. Concentration of viruses from samples is important for detection because viral contamination of foods often occurs at low levels. In general, virus concentration methods can be classified as either nonspecific, exploiting the relatively homogeneous physicochemical properties of the virus to separate/concentrate it from the sample matrix, or specific, relying on recognition elements such as antibodies to specifically capture and separate viruses from foods. Numerous nonspecific and specific techniques for virus concentration have been reported, each with its own advantages and limitations. Factors to consider can include reagent and equipment costs, time-to-result, ease of use, and potential to eliminate matrix-associated inhibitors. The purpose of this review is to survey the different foodborne virus concentration techniques and their efficacy in various food and environmental matrices as well as discuss some emerging techniques for purification and concentration of viral pathogens from food samples.

病毒是全球食源性疾病的主要病因。从样本中浓缩病毒对于检测来说非常重要,因为食品中的病毒污染水平通常很低。一般来说,病毒浓缩方法可分为非特异性和特异性两种,前者是利用病毒相对均匀的物理化学特性将其从样品基质中分离/浓缩出来,后者则是依靠抗体等识别元素从食品中特异性地捕获和分离病毒。据报道,用于浓缩病毒的非特异性和特异性技术不胜枚举,每种技术都有自己的优势和局限性。需要考虑的因素包括试剂和设备成本、产生结果的时间、易用性以及消除基质相关抑制剂的潜力。本综述旨在调查不同的食源性病毒浓缩技术及其在各种食品和环境基质中的功效,并讨论一些从食品样本中纯化和浓缩病毒病原体的新兴技术。预计《食品科学与技术年度综述》第 15 卷的最终在线出版日期为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
Status and Perspective on Green Pesticide Utilizations and Food Security. 绿色农药利用和粮食安全的现状与前景。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-072023-034519
Runjiang Song, Yuping Zhang, Ping Lu, Jian Wu, Qing X Li, Baoan Song

Pesticides protect crops against pests, and green pesticides are referred to as effective, safe, and eco-friendly pesticides that are sustainably synthesized and manufactured (i.e., green chemistry production). Owing to their high efficacy, safety, and ecological compatibility, green pesticides have become a main direction of global pesticide research and development (R&D). Green pesticides attract attention because of their close association with the quality and safety of agricultural produce. In this review, we briefly define green pesticides and outline their significance, current registration, commercialization, and applications in China, the European Union, and the United States. Subsequently, we engage in an in-depth analysis of the impact of newly launched green pesticides on the environment and ecosystems. Finally, we focus on the potential risks of dietary exposure to green pesticides and the possible hazards of chronic toxicity and carcinogenicity. The status of and perspective on green pesticides can hopefully inspire green pesticide R&D and applications to ensure agricultural production and safeguard human and ecological health.

农药保护农作物免受害虫侵害,而绿色农药是指可持续合成和制造(即绿色化学生产)的有效、安全和生态友好型农药。由于高效、安全和生态兼容性好,绿色农药已成为全球农药研发(R&D)的主要方向。绿色农药与农产品的质量和安全密切相关,因此备受关注。在本综述中,我们将简要定义绿色农药,并概述其在中国、欧盟和美国的意义、目前的登记、商业化和应用情况。随后,我们深入分析了新推出的绿色农药对环境和生态系统的影响。最后,我们重点探讨了从饮食中接触绿色农药的潜在风险,以及可能存在的慢性毒性和致癌性危害。绿色农药的现状和前景有望激励绿色农药的研发和应用,从而确保农业生产,保障人类和生态健康。预计《食品科学与技术年鉴》第 15 卷的最终在线出版日期为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
Unleashing the Potential of Digitalization in the Agri-Food Chain for Integrated Food Systems. 为综合食品系统释放农业食品链数字化的潜力。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-012422-024649
Christian Krupitzer, Anthony Stein

Digitalization transforms many industries, especially manufacturing, with new concepts such as Industry 4.0 and the Industrial Internet of Things. However, information technology also has the potential to integrate and connect the various steps in the supply chain. For the food industry, the situation is ambivalent: It has a high level of automatization, but the potential of digitalization is so far not used today. In this review, we discuss current trends in information technology that have the potential to transform the food industry into an integrated food system. We show how this digital transformation can integrate various activities within the agri-food chain and support the idea of integrated food systems. Based on a future-use case, we derive the potential of digitalization to tackle future challenges in the food industry and present a research agenda.

数字化以工业4.0和工业物联网等新概念改变了许多行业,尤其是制造业。然而,信息技术也有潜力整合和连接供应链中的各个步骤。对于食品行业来说,情况是矛盾的:它有很高的自动化水平,但数字化的潜力到目前为止还没有得到利用。在这篇综述中,我们讨论了信息技术的当前趋势,这些趋势有可能将食品行业转变为一个综合的食品系统。我们展示了这种数字化转型如何整合农业食品链中的各种活动,并支持整合食品系统的理念。基于未来的用例,我们得出了数字化的潜力,以应对食品行业的未来挑战,并提出了研究议程。《食品科学与技术年度评论》第15卷预计最终在线出版日期为2024年4月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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引用次数: 0
Oral Astringency in Plant Proteins: An Underestimated Issue in Formulating Next-Generation Plant-Based Foods. 植物蛋白的口腔涩味:配制新一代植物性食品时被低估的一个问题。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-072023-034510
Anwesha Sarkar

Ensuring the supply of affordable, palatable, healthy, and sustainable nutrients to feed the growing population without transgressing the planetary boundaries remains a key challenge in the food science community. A dietary transition toward low-emission, plant-based foods, with less reliance on animal agriculture, is advocated for sustainability, health, and ethical reasons. A major hurdle for mainstream adoption of plant-based foods is their poor sensorial performance, such as nonjuicy and astringent textures as well as various off-flavors. This review presents the current understanding of astringency and oral friction of plant-based foods. It focuses on plant proteins and their application in plant-based meat and dairy analogs. In addition, the latest advances in the quantitative characterization of astringency using tribology, electrochemistry, and cellular tools are covered. Finally, we examine factors influencing astringency and propose easy-to-implement colloidal strategies that may mitigate astringency issues, thereby underpinning the design of the next generation of sustainable and pleasurable plant-based foods.

确保为不断增长的人口提供可负担、可口、健康和可持续的营养物质,同时又不超越地球的极限,这仍然是食品科学界面临的一项重要挑战。出于可持续发展、健康和道德方面的考虑,人们提倡饮食向低排放、以植物为基础的食品过渡,减少对畜牧业的依赖。植物性食品被主流采用的一个主要障碍是其感官表现不佳,如口感不清爽、涩味以及各种异味。本综述介绍了目前对植物性食品的涩味和口腔摩擦力的认识。重点介绍植物蛋白及其在植物基肉类和乳制品类似物中的应用。此外,还介绍了利用摩擦学、电化学和细胞工具定量表征涩味的最新进展。最后,我们研究了影响涩味的因素,并提出了可减轻涩味问题的易于实施的胶体策略,从而为设计下一代可持续和愉悦的植物性食品奠定了基础。食品科学与技术年度评论》第 15 卷的最终在线出版日期预计为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
Recent Advances in Lipid Crystallization in the Food Industry. 食品工业中脂质结晶的最新进展。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-072023-034403
Thais Lomonaco Teodoro da Silva, Silvana Martini

This review discusses fundamental concepts of fat crystallization and how various processing conditions such as crystallization temperature, cooling rate, and shear or agitation affect this process. Traditional methods used to process fats, such as the use of scraped surface heat exchangers, fractionation, and interesterification, are described. Parameters that affect fat crystallization in these systems, such as shear, crystallization temperature, type of fat, and type of process, are discussed. In addition, the use of minor components to induce or delay fat crystallization based on their chemical composition is presented. The use of novel technologies, such as high-intensity ultrasound, oleogelation, and high-pressure crystallization is also reviewed. In these cases, acoustic and high-pressure process parameters, the various types of oleogels, and the use of oleogelators of differing chemical compositions are discussed. The combination of all these techniques and future trends is also presented.

本综述讨论了脂肪结晶的基本概念,以及结晶温度、冷却速度、剪切力或搅拌等各种加工条件如何影响这一过程。文中介绍了用于加工脂肪的传统方法,如使用刮削式表面热交换器、分馏和内酯化。讨论了在这些系统中影响脂肪结晶的参数,如剪切力、结晶温度、脂肪类型和工艺类型。此外,还介绍了根据化学成分使用次要成分诱导或延迟脂肪结晶的情况。此外,还讨论了新技术的使用,如高强度超声波、油凝胶化和高压结晶。在这些案例中,讨论了声学和高压工艺参数、各种类型的油凝胶以及不同化学成分的油凝胶剂的使用。此外,还介绍了所有这些技术的组合和未来趋势。预计《食品科学与技术年度评论》第 15 卷的最终在线出版日期为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
Wheat Sourdough Breadmaking: A Scoping Review. 小麦酸面团面包制作:范围审查。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-110923-034834
Yamina De Bondt, Celine Verdonck, Markus J Brandt, Luc De Vuyst, Michael G Gänzle, Marco Gobbetti, Emanuele Zannini, Christophe M Courtin

Using sourdough in breadmaking can enhance bread's shelf-life and flavor compared to exclusive baker's yeast use and is believed to increase its nutritional quality and healthiness. Previous research established insight into the microbial ecology of sourdough, but the link between leavening agent use, processing, and bread quality remains elusive. However, such knowledge is key for standardization, research on the health benefits, and the definition of sourdough bread. In this systematic scoping review, we analyzed 253 studies and identified large variations in the type and amount of leavening agent, fermentation conditions, and bread quality (specific loaf volume and acidification). The interrelation between these elements and their effect on the extent of fermentation is discussed, together with issues preventing proper comparison of breadmaking procedures. With this review, we want to contribute to the dialogue concerning the definition of sourdough-type bread products and the research into the health benefits attributed to them.

与只使用面包酵母相比,在面包制作过程中使用酸包粉可提高面包的保质期和风味,并被认为可提高面包的营养质量和健康水平。以往的研究深入了解了酸包粉的微生物生态学,但发酵剂的使用、加工过程和面包质量之间的联系仍然难以捉摸。然而,这些知识对于酸包粉面包的标准化、健康益处研究和定义至关重要。在这次系统性的范围综述中,我们分析了 253 项研究,发现发酵剂的类型和用量、发酵条件和面包质量(特定面包体积和酸度)之间存在很大差异。我们讨论了这些因素之间的相互关系及其对发酵程度的影响,以及妨碍对面包制作过程进行适当比较的问题。通过这篇综述,我们希望为有关酸包粉类面包产品定义的对话以及对其健康益处的研究做出贡献。食品科学与技术年度综述》第 15 卷的最终在线出版日期预计为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
Starter Culture Development and Innovation for Novel Fermented Foods. 新型发酵食品的起始培养基开发与创新。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-072023-034207
Michael G Gänzle, Ludovic Monnin, Jinshui Zheng, Lingxiao Zhang, Monika Coton, Delphine Sicard, Jens Walter

Interest in fermented foods is increasing because fermented foods are promising solutions for more secure food systems with an increased proportion of minimally processed plant foods and a smaller environmental footprint. These developments also pertain to novel fermented food for which no traditional template exists, raising the question of how to develop starter cultures for such fermentations. This review establishes a framework that integrates traditional and scientific knowledge systems for the selection of suitable cultures. Safety considerations, the use of organisms in traditional food fermentations, and the link of phylogeny to metabolic properties provide criteria for culture selection. Such approaches can also select for microbial strains that have health benefits. A science-based approach to the development of novel fermented foods can substantially advance their value through more secure food systems, food products that provide health-promoting microbes, and the provision of foods that improve human health.

人们对发酵食品的兴趣与日俱增,因为发酵食品是更安全的食品系统的有前途的解决方案,它增加了微加工植物食品的比例,并减少了对环境的影响。这些发展也涉及到没有传统模板的新型发酵食品,从而提出了如何为这类发酵培养启动培养物的问题。本综述为选择合适的培养物建立了一个整合传统和科学知识体系的框架。安全考虑因素、生物在传统食品发酵中的使用以及系统发育与代谢特性之间的联系为选择培养物提供了标准。这种方法还可以选择对健康有益的微生物菌株。以科学为基础的新型发酵食品开发方法可以通过更安全的食品系统、提供促进健康的微生物的食品以及改善人类健康的食品,大大提高其价值。食品科学与技术年鉴》第15卷的最终在线出版日期预计为2024年4月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
Medium- and Long-Chain Triacylglycerol: Preparation, Health Benefits, and Food Utilization. 中链和长链三酰甘油:制备、健康益处和食品利用。
IF 12.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-food-072023-034539
Xinyi Cheng, Chenyu Jiang, Jun Jin, Qingzhe Jin, Casimir C Akoh, Wei Wei, Xingguo Wang

Medium- and long-chain triacylglycerol (MLCT) is a structured lipid with both medium- and long-chain fatty acids in one triacylglycerol molecule. Compared with long-chain triacylglycerol (LCT), which is mainly present in common edible oils, and the physical blend of medium-chain triacylglycerol with LCT (MCT/LCT), MLCT has different physicochemical properties, metabolic characteristics, and nutritional values. In this article, the recent advances in the use of MLCT in food formulations are reviewed. The natural sources and preparation of MLCT are discussed. A comprehensive summary of MLCT digestion, absorption, transport, and oxidation is provided as well as its health benefits, including reducing the risk of overweight, hypolipidemic and hypoglycemic effects, etc. The potential MLCT uses in food formulations, such as infant formulas, healthy foods for weight loss, and sports foods, are summarized. Finally, the current safety assessment and regulatory status of MLCT in food formulations are reviewed.

中长链三酰甘油(MLCT)是一种结构脂质,在一个三酰甘油分子中同时含有中链和长链脂肪酸。与主要存在于普通食用油中的长链三酰甘油(LCT)以及中链三酰甘油与长链三酰甘油的物理混合物(MCT/LCT)相比,中长链三酰甘油具有不同的理化性质、代谢特征和营养价值。本文综述了在食品配方中使用中链三酰甘油的最新进展。文章讨论了 MLCT 的天然来源和制备方法。全面总结了 MLCT 的消化、吸收、运输和氧化过程及其对健康的益处,包括降低超重风险、降血脂和降血糖作用等。总结了 MLCT 在食品配方中的潜在用途,如婴儿配方奶粉、减肥健康食品和运动食品。最后,回顾了目前对食品配方中 MLCT 的安全性评估和监管状况。食品科学与技术年度综述》第 15 卷的最终在线出版日期预计为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
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Annual review of food science and technology
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