Pub Date : 2025-04-01DOI: 10.1146/annurev-food-111523-122039
Lu Zhang, Remko M Boom, Yizhou Ma
Industrial food processing is rapidly transforming into automation and digitalization. Automated food processing systems adapt to variations in raw materials and product quality requirements. Implementing automated processing systems can potentially improve the sustainability of our food systems by improving productivity while reducing environmental impacts. Nevertheless, the adoption of automated food processing systems is still relatively low. In this review, we discuss the concept of automated food processing and summarize the recent advances in applications of machine learning technologies to enable automated food processing. Machine learning can find its applications in formulation development, process control, and product quality assessment. We share our vision on the potential of automated food processing systems to adapt to complex raw materials, mass customization, personalized nutrition, and human-machine interaction. Finally, we pinpoint relevant research questions and stress that future research on automated food processing requires multidisciplinary approaches.
{"title":"Machine Learning in Automated Food Processing: A Mini Review.","authors":"Lu Zhang, Remko M Boom, Yizhou Ma","doi":"10.1146/annurev-food-111523-122039","DOIUrl":"10.1146/annurev-food-111523-122039","url":null,"abstract":"<p><p>Industrial food processing is rapidly transforming into automation and digitalization. Automated food processing systems adapt to variations in raw materials and product quality requirements. Implementing automated processing systems can potentially improve the sustainability of our food systems by improving productivity while reducing environmental impacts. Nevertheless, the adoption of automated food processing systems is still relatively low. In this review, we discuss the concept of automated food processing and summarize the recent advances in applications of machine learning technologies to enable automated food processing. Machine learning can find its applications in formulation development, process control, and product quality assessment. We share our vision on the potential of automated food processing systems to adapt to complex raw materials, mass customization, personalized nutrition, and human-machine interaction. Finally, we pinpoint relevant research questions and stress that future research on automated food processing requires multidisciplinary approaches.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":"16 1","pages":"25-37"},"PeriodicalIF":12.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2024-12-20DOI: 10.1146/annurev-food-111523-121744
M C Onwezen, G Nassar, J A Bouma
Consumer resistance significantly impedes the transition from animal-derived proteins to alternative protein sources through a dual mechanism: consumer reluctance to change entrenched meat-eating habits and hesitation among policymakers, marketers, and practitioners due to anticipated resistance. The concept of resistance is intricate and viewed diversely across research disciplines. We conducted an extensive systematic literature review supplemented by an artificial intelligence-based approach. We evaluated 3,387 studies to identify 51 key papers. The results reveal that resistance is under-researched. Resistance to plant-based diets is associated with practical barriers, whereas resistance to reducing meat consumption is tied more to moral and social aspects. Resistance predominantly manifests among unmotivated meat lovers with strong meat-eating habits. On a positive note, resistance reflects consumer concerns, tends to diminish over time, is overrated, and is specifically linked to specific consumer groups. Thus, addressing resistance is vital, as it facilitates the transition to a more sustainable and healthy food supply that relies less on animal proteins.
{"title":"Change Meat Resistance: Systematic Literature Review on Consumer Resistance to the Alternative Protein Transition.","authors":"M C Onwezen, G Nassar, J A Bouma","doi":"10.1146/annurev-food-111523-121744","DOIUrl":"10.1146/annurev-food-111523-121744","url":null,"abstract":"<p><p>Consumer resistance significantly impedes the transition from animal-derived proteins to alternative protein sources through a dual mechanism: consumer reluctance to change entrenched meat-eating habits and hesitation among policymakers, marketers, and practitioners due to anticipated resistance. The concept of resistance is intricate and viewed diversely across research disciplines. We conducted an extensive systematic literature review supplemented by an artificial intelligence-based approach. We evaluated 3,387 studies to identify 51 key papers. The results reveal that resistance is under-researched. Resistance to plant-based diets is associated with practical barriers, whereas resistance to reducing meat consumption is tied more to moral and social aspects. Resistance predominantly manifests among unmotivated meat lovers with strong meat-eating habits. On a positive note, resistance reflects consumer concerns, tends to diminish over time, is overrated, and is specifically linked to specific consumer groups. Thus, addressing resistance is vital, as it facilitates the transition to a more sustainable and healthy food supply that relies less on animal proteins.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"127-146"},"PeriodicalIF":12.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2024-11-13DOI: 10.1146/annurev-food-111523-122028
Job Ubbink, Allen S Levine
The impact of food technology and product development on the nutritional quality of foods is discussed in the context of food classification schemes, clinical research, and sociocultural studies. Food processing operations are analyzed in terms of their beneficial and detrimental consequences for the nutritional value of foods and ingredients. Several classification schemes are discussed, including dietary guidelines, nutrition information panels, and nutritional scores. The health impact of processed and ultraprocessed foods is discussed in connection with the processing-formulation scheme previously developed by the authors. The importance of product development as a driver for the food industry is highlighted, and formulation-based approaches to improve the healthfulness of industrially produced foods are discussed. Finally, the public perception of processed foods and its impact on the industry are discussed, and the need for a broad engagement among stakeholders to ensure the sustainability of our food system and healthy diets for individuals is emphasized.
{"title":"From Processed Foods to Ultraprocessed Foods: Evolution of an Industry Model and Impact on Dietary Quality, Health, and Society.","authors":"Job Ubbink, Allen S Levine","doi":"10.1146/annurev-food-111523-122028","DOIUrl":"10.1146/annurev-food-111523-122028","url":null,"abstract":"<p><p>The impact of food technology and product development on the nutritional quality of foods is discussed in the context of food classification schemes, clinical research, and sociocultural studies. Food processing operations are analyzed in terms of their beneficial and detrimental consequences for the nutritional value of foods and ingredients. Several classification schemes are discussed, including dietary guidelines, nutrition information panels, and nutritional scores. The health impact of processed and ultraprocessed foods is discussed in connection with the processing-formulation scheme previously developed by the authors. The importance of product development as a driver for the food industry is highlighted, and formulation-based approaches to improve the healthfulness of industrially produced foods are discussed. Finally, the public perception of processed foods and its impact on the industry are discussed, and the need for a broad engagement among stakeholders to ensure the sustainability of our food system and healthy diets for individuals is emphasized.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"1-24"},"PeriodicalIF":12.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2025-01-13DOI: 10.1146/annurev-food-072023-034549
Arnav Sharma, Sherry Bansal, Matthew D Moore, Yaguang Luo, Keith R Schneider, Boce Zhang
Foodborne illnesses are a significant global public health challenge, with an estimated 600 million cases annually. Conventional food microbiology methods tend to be laborious and time consuming, pose difficulties in real-time utilization, and can display subpar accuracy or typing capabilities. With the recent advancements in third-generation sequencing and microbial omics, nanopore sequencing technology and its long-read sequencing capabilities have emerged as a promising platform. In recent years, nanopore sequencing technology has been benchmarked for its amplicon sequencing, whole-genome and transcriptome analysis, meta-analysis, and other advanced omics approaches. This review comprehensively covers nanopore sequencing technology's current advances in food safety applications, including outbreak investigation, pathogen surveillance, and antimicrobial resistance profiling. Despite significant progress, ongoing research and development are crucial to overcoming challenges in sequencing chemistry, accuracy, bioinformatics, and real-time adaptive sampling to fully realize nanopore sequencing technology's potential in food safety and food microbiology.
{"title":"Exploring the Frontiers of Nanopore Sequencing in Food Safety and Food Microbiology.","authors":"Arnav Sharma, Sherry Bansal, Matthew D Moore, Yaguang Luo, Keith R Schneider, Boce Zhang","doi":"10.1146/annurev-food-072023-034549","DOIUrl":"10.1146/annurev-food-072023-034549","url":null,"abstract":"<p><p>Foodborne illnesses are a significant global public health challenge, with an estimated 600 million cases annually. Conventional food microbiology methods tend to be laborious and time consuming, pose difficulties in real-time utilization, and can display subpar accuracy or typing capabilities. With the recent advancements in third-generation sequencing and microbial omics, nanopore sequencing technology and its long-read sequencing capabilities have emerged as a promising platform. In recent years, nanopore sequencing technology has been benchmarked for its amplicon sequencing, whole-genome and transcriptome analysis, meta-analysis, and other advanced omics approaches. This review comprehensively covers nanopore sequencing technology's current advances in food safety applications, including outbreak investigation, pathogen surveillance, and antimicrobial resistance profiling. Despite significant progress, ongoing research and development are crucial to overcoming challenges in sequencing chemistry, accuracy, bioinformatics, and real-time adaptive sampling to fully realize nanopore sequencing technology's potential in food safety and food microbiology.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"219-244"},"PeriodicalIF":12.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2024-12-02DOI: 10.1146/annurev-food-111523-121811
Yue Liu, Xuchuan Ma, Monica Cazzaniga, Cormac G M Gahan, Heidy M W den Besten, Tjakko Abee
In this article, we highlight novel components of foodborne pathogens that influence their response, physiology, adaptation, and survival in the face of diverse stresses, and consequently have implications for their transmission in the food chain and their pathogenesis. Recent insights into the role of bacteriophages/prophages, bacterial extracellular vesicles, and bacterial microcompartments, which make up the emerging field we coined as "nano in micro," are presented, together with the role of understudied food-relevant substrates in pathogen fitness and virulence. These new insights also lead to reflections on generally adopted laboratory conditions in the long-standing research field of adaptive stress response in foodborne pathogens. In addition, selected examples of the impact of diet and microbiota on intestinal colonization and host invasion are discussed. A final section on risk assessment presents an overview of tools for (kinetic) data modeling and perspectives for the implementation of information derived from whole-genome sequencing, combined with advancements in dose-response models and exposure assessments.
{"title":"Nano in Micro: Novel Concepts in Foodborne Pathogen Transmission and Pathogenesis.","authors":"Yue Liu, Xuchuan Ma, Monica Cazzaniga, Cormac G M Gahan, Heidy M W den Besten, Tjakko Abee","doi":"10.1146/annurev-food-111523-121811","DOIUrl":"10.1146/annurev-food-111523-121811","url":null,"abstract":"<p><p>In this article, we highlight novel components of foodborne pathogens that influence their response, physiology, adaptation, and survival in the face of diverse stresses, and consequently have implications for their transmission in the food chain and their pathogenesis. Recent insights into the role of bacteriophages/prophages, bacterial extracellular vesicles, and bacterial microcompartments, which make up the emerging field we coined as \"nano in micro,\" are presented, together with the role of understudied food-relevant substrates in pathogen fitness and virulence. These new insights also lead to reflections on generally adopted laboratory conditions in the long-standing research field of adaptive stress response in foodborne pathogens. In addition, selected examples of the impact of diet and microbiota on intestinal colonization and host invasion are discussed. A final section on risk assessment presents an overview of tools for (kinetic) data modeling and perspectives for the implementation of information derived from whole-genome sequencing, combined with advancements in dose-response models and exposure assessments.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"245-268"},"PeriodicalIF":12.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2025-01-23DOI: 10.1146/annurev-food-111523-121916
Yaqiong Zhang, Yinghua Luo, Boyan Gao, Liangli Yu
Psyllium is an excellent natural source of soluble and insoluble dietary fiber. It has been used as a nutraceutical and functional ingredient in foods. Many efforts have been made to understand and improve its physicochemical, biological, and functional properties to promote its food applications. This manuscript reviews and discusses the current knowledge of psyllium, focusing on its health benefits, utilizations as a functional additive in foods and hydrogel delivery carrier, approaches to modify its molecular and chemical structures, nonfood utilizations, and potential side effects and toxicity. Perspectives on future research and development of psyllium are also provided. This review may serve as a scientific foundation for improved food application of psyllium to enhance human health and food quality.
{"title":"Psyllium: A Nutraceutical and Functional Ingredient in Foods.","authors":"Yaqiong Zhang, Yinghua Luo, Boyan Gao, Liangli Yu","doi":"10.1146/annurev-food-111523-121916","DOIUrl":"10.1146/annurev-food-111523-121916","url":null,"abstract":"<p><p>Psyllium is an excellent natural source of soluble and insoluble dietary fiber. It has been used as a nutraceutical and functional ingredient in foods. Many efforts have been made to understand and improve its physicochemical, biological, and functional properties to promote its food applications. This manuscript reviews and discusses the current knowledge of psyllium, focusing on its health benefits, utilizations as a functional additive in foods and hydrogel delivery carrier, approaches to modify its molecular and chemical structures, nonfood utilizations, and potential side effects and toxicity. Perspectives on future research and development of psyllium are also provided. This review may serve as a scientific foundation for improved food application of psyllium to enhance human health and food quality.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"355-377"},"PeriodicalIF":12.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01Epub Date: 2024-06-20DOI: 10.1146/annurev-food-072023-034423
Katherine Uhl, Alyson E Mitchell
Elderberry, the fruit of Sambucus nigra, has become a popular inclusion in foods, beverages, supplements, and more in recent years. Although the European subspecies, S. nigra ssp. nigra, has been widely studied for its composition, particularly for phenolic and volatile profiles, other subspecies, such as the American elderberry S. nigra ssp. canadensis and the blue elderberry S. nigra ssp. cerulea, have also become contenders in the elderberry supply chain. For the first time, the composition (including micronutrients, macronutrients, organic acids, titratable acid, soluble solids, phenolic compounds, and cyanogenic glycosides) of these three subspecies of elderberry is compared, highlighting the unique qualities of each subspecies and identifying gaps in the available data on the three subspecies.
接骨木果是黑接骨木的果实,近年来已成为食品、饮料、保健品等中的热门成分。虽然欧洲接骨木亚种 S. nigra ssp. nigra 的成分,尤其是酚类和挥发性成分已被广泛研究,但其他亚种,如美洲接骨木 S. nigra ssp. canadensis 和蓝接骨木 S. nigra ssp. cerulea 也已成为接骨木供应链中的竞争者。本研究首次对这三个接骨木亚种的成分(包括微量营养素、宏量营养素、有机酸、可滴定酸、可溶性固形物、酚类化合物和氰苷)进行了比较,突出了每个亚种的独特品质,并找出了这三个亚种现有数据的不足之处。预计《食品科学与技术年度评论》第15卷的最终在线出版日期为2024年4月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
{"title":"Elderberry, an Ancient Remedy: A Comprehensive Study of the Bioactive Compounds in Three <i>Sambucus nigra</i> L. Subspecies.","authors":"Katherine Uhl, Alyson E Mitchell","doi":"10.1146/annurev-food-072023-034423","DOIUrl":"10.1146/annurev-food-072023-034423","url":null,"abstract":"<p><p>Elderberry, the fruit of <i>Sambucus nigra</i>, has become a popular inclusion in foods, beverages, supplements, and more in recent years. Although the European subspecies, <i>S</i>. <i>nigra</i> ssp. <i>nigra</i>, has been widely studied for its composition, particularly for phenolic and volatile profiles, other subspecies, such as the American elderberry <i>S</i>. <i>nigra</i> ssp. <i>canadensis</i> and the blue elderberry <i>S</i>. <i>nigra</i> ssp. <i>cerulea</i>, have also become contenders in the elderberry supply chain. For the first time, the composition (including micronutrients, macronutrients, organic acids, titratable acid, soluble solids, phenolic compounds, and cyanogenic glycosides) of these three subspecies of elderberry is compared, highlighting the unique qualities of each subspecies and identifying gaps in the available data on the three subspecies.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"27-51"},"PeriodicalIF":12.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01Epub Date: 2024-06-20DOI: 10.1146/annurev-food-072023-034451
N Stephanie Kawecki, Kathleen K Chen, Corinne S Smith, Qingwen Xie, Julian M Cohen, Amy C Rowat
There is increasing consumer demand for alternative animal protein products that are delicious and sustainably produced to address concerns about the impacts of mass-produced meat on human and planetary health. Cultured meat has the potential to provide a source of nutritious dietary protein that both is palatable and has reduced environmental impact. However, strategies to support the production of cultured meats at the scale required for food consumption will be critical. In this review, we discuss the current challenges and opportunities of using edible scaffolds for scaling up the production of cultured meat. We provide an overview of different types of edible scaffolds, scaffold fabrication techniques, and common scaffold materials. Finally, we highlight potential advantages of using edible scaffolds to advance cultured meat production by accelerating cell growth and differentiation, providing structure to build complex 3D tissues, and enhancing the nutritional and sensory properties of cultured meat.
{"title":"Scalable Processes for Culturing Meat Using Edible Scaffolds.","authors":"N Stephanie Kawecki, Kathleen K Chen, Corinne S Smith, Qingwen Xie, Julian M Cohen, Amy C Rowat","doi":"10.1146/annurev-food-072023-034451","DOIUrl":"10.1146/annurev-food-072023-034451","url":null,"abstract":"<p><p>There is increasing consumer demand for alternative animal protein products that are delicious and sustainably produced to address concerns about the impacts of mass-produced meat on human and planetary health. Cultured meat has the potential to provide a source of nutritious dietary protein that both is palatable and has reduced environmental impact. However, strategies to support the production of cultured meats at the scale required for food consumption will be critical. In this review, we discuss the current challenges and opportunities of using edible scaffolds for scaling up the production of cultured meat. We provide an overview of different types of edible scaffolds, scaffold fabrication techniques, and common scaffold materials. Finally, we highlight potential advantages of using edible scaffolds to advance cultured meat production by accelerating cell growth and differentiation, providing structure to build complex 3D tissues, and enhancing the nutritional and sensory properties of cultured meat.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"241-264"},"PeriodicalIF":12.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01Epub Date: 2024-06-20DOI: 10.1146/annurev-food-072023-034354
Qiao Jiang, Yubo Liu, Xu Si, Li Wang, Hailong Gui, Jinlong Tian, Huijun Cui, Hongzhou Jiang, Wenjiang Dong, Bin Li
Extracellular vesicles (EVs) play a crucial role in intercellular communication and have the potential to serve as in vivo carriers for delivering active molecules. The biocompatibility advantages of EVs over artificial nanocarriers create new frontiers for delivering modern active molecules. Milk is a favorable source of EVs because of its high bioavailability, low immunogenicity, and commercial producibility. In this review, we analyzed the advantages of milk-derived EVs in the oral delivery of active molecules, discussed their research progress in delivering active phytoconstituents, and summarized the necessary technologies and critical unit operations required for the development of an oral delivery system based on EVs. The review aims to provide innovative ideas and fundamental quality control guidelines for developing the next-generation oral drug delivery system based on milk-derived EVs.
{"title":"Potential of Milk-Derived Extracellular Vesicles as Carriers for Oral Delivery of Active Phytoconstituents.","authors":"Qiao Jiang, Yubo Liu, Xu Si, Li Wang, Hailong Gui, Jinlong Tian, Huijun Cui, Hongzhou Jiang, Wenjiang Dong, Bin Li","doi":"10.1146/annurev-food-072023-034354","DOIUrl":"10.1146/annurev-food-072023-034354","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) play a crucial role in intercellular communication and have the potential to serve as in vivo carriers for delivering active molecules. The biocompatibility advantages of EVs over artificial nanocarriers create new frontiers for delivering modern active molecules. Milk is a favorable source of EVs because of its high bioavailability, low immunogenicity, and commercial producibility. In this review, we analyzed the advantages of milk-derived EVs in the oral delivery of active molecules, discussed their research progress in delivering active phytoconstituents, and summarized the necessary technologies and critical unit operations required for the development of an oral delivery system based on EVs. The review aims to provide innovative ideas and fundamental quality control guidelines for developing the next-generation oral drug delivery system based on milk-derived EVs.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":" ","pages":"431-454"},"PeriodicalIF":12.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1146/annurev-food-072023-034458
M Tamayo, M Olivares, P Ruas-Madiedo, A Margolles, J C Espín, I Medina, M V Moreno-Arribas, S Canals, C R Mirasso, S Ortín, H Beltrán-Sanchez, A Palloni, F A Tomás-Barberán, Y Sanz
Many physical, social, and psychological changes occur during aging that raise the risk of developing chronic diseases, frailty, and dependency. These changes adversely affect the gut microbiota, a phenomenon known as microbe-aging. Those microbiota alterations are, in turn, associated with the development of age-related diseases. The gut microbiota is highly responsive to lifestyle and dietary changes, displaying a flexibility that also provides anactionable tool by which healthy aging can be promoted. This review covers, firstly, the main lifestyle and socioeconomic factors that modify the gut microbiota composition and function during healthy or unhealthy aging and, secondly, the advances being made in defining and promoting healthy aging, including microbiome-informed artificial intelligence tools, personalized dietary patterns, and food probiotic systems.
{"title":"How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging.","authors":"M Tamayo, M Olivares, P Ruas-Madiedo, A Margolles, J C Espín, I Medina, M V Moreno-Arribas, S Canals, C R Mirasso, S Ortín, H Beltrán-Sanchez, A Palloni, F A Tomás-Barberán, Y Sanz","doi":"10.1146/annurev-food-072023-034458","DOIUrl":"10.1146/annurev-food-072023-034458","url":null,"abstract":"<p><p>Many physical, social, and psychological changes occur during aging that raise the risk of developing chronic diseases, frailty, and dependency. These changes adversely affect the gut microbiota, a phenomenon known as microbe-aging. Those microbiota alterations are, in turn, associated with the development of age-related diseases. The gut microbiota is highly responsive to lifestyle and dietary changes, displaying a flexibility that also provides anactionable tool by which healthy aging can be promoted. This review covers, firstly, the main lifestyle and socioeconomic factors that modify the gut microbiota composition and function during healthy or unhealthy aging and, secondly, the advances being made in defining and promoting healthy aging, including microbiome-informed artificial intelligence tools, personalized dietary patterns, and food probiotic systems.</p>","PeriodicalId":8187,"journal":{"name":"Annual review of food science and technology","volume":"15 1","pages":"283-305"},"PeriodicalIF":12.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}