Introduction The concept of “intestinal drinking” in this study refers to the continued absorption of alcohol in the gastrointestinal tract until adequate defecation occurs. Material and methods A longitudinal observation of hangover symptoms and alcohol metabolites in healthy humans following binge drinking was conducted. Results The hangover symptoms resulting from binge alcohol consumption were relieved by defecation. Following the defecation process, not only the blood ethanol levels, but also the concentrations of blood acetaldehyde, methanol, and iso-propanol, exhibited significant reductions. Conclusions This pilot study provides a different perspective for addressing hangovers and potentially mitigating the risks of alcoholic liver diseases.
{"title":"Defecation alleviates hangover by terminating intestinal drinking","authors":"Tom Ryu, Keungmo Yang, Beom Sun Chung","doi":"10.5114/aoms/174445","DOIUrl":"https://doi.org/10.5114/aoms/174445","url":null,"abstract":"Introduction The concept of “intestinal drinking” in this study refers to the continued absorption of alcohol in the gastrointestinal tract until adequate defecation occurs. Material and methods A longitudinal observation of hangover symptoms and alcohol metabolites in healthy humans following binge drinking was conducted. Results The hangover symptoms resulting from binge alcohol consumption were relieved by defecation. Following the defecation process, not only the blood ethanol levels, but also the concentrations of blood acetaldehyde, methanol, and iso-propanol, exhibited significant reductions. Conclusions This pilot study provides a different perspective for addressing hangovers and potentially mitigating the risks of alcoholic liver diseases.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135979584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction To investigate shared gene signatures between COVID-19 and ischemic stroke. Material and methods Combining the existing bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) data for COVID-19 to obtain a more comprehensive understanding of the role of dysregulated metabolism. Results A total of 19 up-regulated differentially expressed genes (DEGs) and 24 down-regulated genes were selected for subsequent analyses. Nine genes were finally identified with the machine learning method as a potential diagnostic model in both ischemic stroke and COVID-19. In addition, the hub genes were related to both immune infiltration and metabolic pathways. Conclusions Our study revealed the common molecular profile of COVID-19 and ischemic stroke.
{"title":"Shared immune metabolic reprogramming between COVID-19 patients in the intensive care unit and ischemic stroke: a pilot study","authors":"Jie Li, Fushen Li, Bin He, Cong Yu, Ping Zheng","doi":"10.5114/aoms/172161","DOIUrl":"https://doi.org/10.5114/aoms/172161","url":null,"abstract":"Introduction To investigate shared gene signatures between COVID-19 and ischemic stroke. Material and methods Combining the existing bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) data for COVID-19 to obtain a more comprehensive understanding of the role of dysregulated metabolism. Results A total of 19 up-regulated differentially expressed genes (DEGs) and 24 down-regulated genes were selected for subsequent analyses. Nine genes were finally identified with the machine learning method as a potential diagnostic model in both ischemic stroke and COVID-19. In addition, the hub genes were related to both immune infiltration and metabolic pathways. Conclusions Our study revealed the common molecular profile of COVID-19 and ischemic stroke.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"29 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction The aim of the study was to examine the burden of uterine fibroids at global, regional and national levels in terms of age and the Socio-demographic Index (SDI). Material and methods Data were extracted from the GBD 2019 dataset. Estimated annual percentage changes (EAPCs) were calculated to assess the incidence of uterine fibroids, and trends in disability-adjusted life years (DALYs) were examined. All measures examined were stratified by region, country, age and SDI to assess the effects of these variables on the incidence of uterine fibroids. Results The global age-standardized incidence rate of uterine fibroids increased from 1990 to 2019, with an EAPC of 0.25 (95% confidence interval (CI): 0.24 to 0.27). In contrast, the global age-standardized DALY rate decreased from 1990 to 2019, with an EAPC of –0.27 (95% CI: –0.31 to –0.23). High and low-middle SDI regions experienced significantly higher age-standardized incidence rates. Moreover, in 2019, low and low-middle SDI regions had significantly higher age-standardized DALY rates due to uterine fibroids than other SDI regions. Regionally, Eastern Europe had the highest age-standardized incidence rate of uterine fibroids in 2019, and Tropical Latin America experienced the greatest increase in age-standardized incidence rates from 1990 to 2019. Nationally, Brazil (EAPC = 1.46; 95% CI: 1.35–1.57) and India (EAPC = 1.09; 95% CI: 0.94–1.25) experienced the most significant increases in age-standardized uterine fibroid incidence. Age-standardized DALY rates increased the most in Tropical Latin America, high-income North America and Oceania. Conclusions Globally, the age-standardized incidence of uterine fibroids has been increasing in recent years. In contrast, age-standardized DALY rates have exhibited a decreasing trend. Eastern Europe, Tropical Latin America, Brazil and India experience the greatest uterine fibroid burden. Globally, women aged 35–39 years and older have an increased risk of uterine fibroids, as reflected in the higher incidence rates among these age groups.
{"title":"Global epidemiological characteristics of uterine fibroids","authors":"Bo Li, Fangfang Wang, Lingying Chen, Haofei Tong","doi":"10.5114/aoms/171786","DOIUrl":"https://doi.org/10.5114/aoms/171786","url":null,"abstract":"Introduction The aim of the study was to examine the burden of uterine fibroids at global, regional and national levels in terms of age and the Socio-demographic Index (SDI). Material and methods Data were extracted from the GBD 2019 dataset. Estimated annual percentage changes (EAPCs) were calculated to assess the incidence of uterine fibroids, and trends in disability-adjusted life years (DALYs) were examined. All measures examined were stratified by region, country, age and SDI to assess the effects of these variables on the incidence of uterine fibroids. Results The global age-standardized incidence rate of uterine fibroids increased from 1990 to 2019, with an EAPC of 0.25 (95% confidence interval (CI): 0.24 to 0.27). In contrast, the global age-standardized DALY rate decreased from 1990 to 2019, with an EAPC of –0.27 (95% CI: –0.31 to –0.23). High and low-middle SDI regions experienced significantly higher age-standardized incidence rates. Moreover, in 2019, low and low-middle SDI regions had significantly higher age-standardized DALY rates due to uterine fibroids than other SDI regions. Regionally, Eastern Europe had the highest age-standardized incidence rate of uterine fibroids in 2019, and Tropical Latin America experienced the greatest increase in age-standardized incidence rates from 1990 to 2019. Nationally, Brazil (EAPC = 1.46; 95% CI: 1.35–1.57) and India (EAPC = 1.09; 95% CI: 0.94–1.25) experienced the most significant increases in age-standardized uterine fibroid incidence. Age-standardized DALY rates increased the most in Tropical Latin America, high-income North America and Oceania. Conclusions Globally, the age-standardized incidence of uterine fibroids has been increasing in recent years. In contrast, age-standardized DALY rates have exhibited a decreasing trend. Eastern Europe, Tropical Latin America, Brazil and India experience the greatest uterine fibroid burden. Globally, women aged 35–39 years and older have an increased risk of uterine fibroids, as reflected in the higher incidence rates among these age groups.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"29 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 69-year-old female patient was hospitalised for irregular vaginal bleeding for over 2 months and painful urination for over 1 month. An ultrasound examination in September 2019 revealed a vaginal mass. The vaginal wall biopsy pathology report dated 16 September 2019 (pathology No.: K1910569) showed malignant melanoma (MM). Immuno-histochemistry results were as follows: S-100 (+), HMB45 (+), MelanA (+), CK (−), Ki-67 (20–30%, +), SMA (−), CD4 (−), CD8 (−), CD68 (+) and PD-1 (−) (Figure
{"title":"A case of vaginal melanoma with multi-line immunotherapy and reflections","authors":"Xia Deng","doi":"10.5114/aoms/173154","DOIUrl":"https://doi.org/10.5114/aoms/173154","url":null,"abstract":"A 69-year-old female patient was hospitalised for irregular vaginal bleeding for over 2 months and painful urination for over 1 month. An ultrasound examination in September 2019 revealed a vaginal mass. The vaginal wall biopsy pathology report dated 16 September 2019 (pathology No.: K1910569) showed malignant melanoma (MM). Immuno-histochemistry results were as follows: S-100 (+), HMB45 (+), MelanA (+), CK (−), Ki-67 (20–30%, +), SMA (−), CD4 (−), CD8 (−), CD68 (+) and PD-1 (−) (Figure","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"375 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zixian Deng, Qiyun Liu, Huadong Liu, Jie Yuan, Jianghua Li
A 55-year-old man, with prior history of syphilis, was admitted to the hospital due to chest tightness with shortness of breath. Cardiac auscultation revealed a coarse continuous murmur of grade III or higher in the aortic valve auscultation area. Laboratory tests showed elevated total antibody to syphilis, and negative serotonin for syphilis. Electrocardio-gram demonstrated complete right bundle branch conduction block and secondary ST segment alterations. Echocardiography (Figures 1 A, B) displayed four perforations of the right sinus of Valsalva (SoV) aneurysm (maximum diameter 4–5 mm) that had ruptured into the right ventricle (RV). There was a sac-like structure that had undergone calcification be-tween the right aortic sinus
{"title":"Right sinus of Valsalva aneurysm rupture into the right ventricle in a rare cardiovascular case of syphilis","authors":"Zixian Deng, Qiyun Liu, Huadong Liu, Jie Yuan, Jianghua Li","doi":"10.5114/aoms/172098","DOIUrl":"https://doi.org/10.5114/aoms/172098","url":null,"abstract":"A 55-year-old man, with prior history of syphilis, was admitted to the hospital due to chest tightness with shortness of breath. Cardiac auscultation revealed a coarse continuous murmur of grade III or higher in the aortic valve auscultation area. Laboratory tests showed elevated total antibody to syphilis, and negative serotonin for syphilis. Electrocardio-gram demonstrated complete right bundle branch conduction block and secondary ST segment alterations. Echocardiography (Figures 1 A, B) displayed four perforations of the right sinus of Valsalva (SoV) aneurysm (maximum diameter 4–5 mm) that had ruptured into the right ventricle (RV). There was a sac-like structure that had undergone calcification be-tween the right aortic sinus","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"9 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135461950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huifeng Wu, Yinjun Wang, Feidi Li, Zelong Liu, Feifei Shi
Introduction We investigated the disability-adjusted life years (DALYs) of glaucoma. Material and methods The estimated annual percentage change (EAPC) was measured to assess trends in the age-standardized DALY rate from 1990 to 2019. Results The global age-standardized DALY rate of glaucoma decreased with an EAPC of –1.00. The age-standardized DALY rate decreased least in high-SDI regions. Eastern sub-Saharan Africa had highest age-standardized DALY rate in 2019. At the national level, Mali had the highest age-standardized DALY rate in 2019. Conclusions Although the global burden of glaucoma has decreased, the burden remain high in regions with low SDI values and in sub-Saharan Africa.
{"title":"The national, regional, and global impact of glaucoma as reported in the 2019 Global Burden of Disease Study","authors":"Huifeng Wu, Yinjun Wang, Feidi Li, Zelong Liu, Feifei Shi","doi":"10.5114/aoms/172929","DOIUrl":"https://doi.org/10.5114/aoms/172929","url":null,"abstract":"Introduction We investigated the disability-adjusted life years (DALYs) of glaucoma. Material and methods The estimated annual percentage change (EAPC) was measured to assess trends in the age-standardized DALY rate from 1990 to 2019. Results The global age-standardized DALY rate of glaucoma decreased with an EAPC of –1.00. The age-standardized DALY rate decreased least in high-SDI regions. Eastern sub-Saharan Africa had highest age-standardized DALY rate in 2019. At the national level, Mali had the highest age-standardized DALY rate in 2019. Conclusions Although the global burden of glaucoma has decreased, the burden remain high in regions with low SDI values and in sub-Saharan Africa.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre François Sabouret, Jean-Claude Dib, Fiona Ecarnot, Maciej Banach, Nicolas Lellouche
Introduction We determined eligibility for icosapent ethyl (EPA) treatment in coronary artery disease (CAD). Material and methods Prospective patients with type 2 diabetes and CAD were included from 03/2019 to 12/2020. Results 574 patients were included; mean age 71 years, 81% males, with a high prevalence of other risk factors (81% hypertension). Mean LDL-cholesterol was 85 mg/dL, mean HbA1c 7.1%, mean triglycerides 148 mg/dL; 82% received statins. Based on National Lipid Association criteria, 31% would be eligible for EPA. Conclusions In this contemporary survey in consecutive, unselected CAD patients in daily practice, almost a third would be potentially eligible for EPA.
{"title":"Eligibility for Icosapent Ethyl in a French Population of Coronary Outpatients With Type 2 Diabetes","authors":"Pierre François Sabouret, Jean-Claude Dib, Fiona Ecarnot, Maciej Banach, Nicolas Lellouche","doi":"10.5114/aoms/173511","DOIUrl":"https://doi.org/10.5114/aoms/173511","url":null,"abstract":"Introduction We determined eligibility for icosapent ethyl (EPA) treatment in coronary artery disease (CAD). Material and methods Prospective patients with type 2 diabetes and CAD were included from 03/2019 to 12/2020. Results 574 patients were included; mean age 71 years, 81% males, with a high prevalence of other risk factors (81% hypertension). Mean LDL-cholesterol was 85 mg/dL, mean HbA1c 7.1%, mean triglycerides 148 mg/dL; 82% received statins. Based on National Lipid Association criteria, 31% would be eligible for EPA. Conclusions In this contemporary survey in consecutive, unselected CAD patients in daily practice, almost a third would be potentially eligible for EPA.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135197831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamil Piotr Marczewski, Magdalena Piegza, Natalia Justyna Gospodarczyk, Alicja Zofia Gospodarczyk, Mateusz Marcinek, Michał Tkocz, Krystyn Sosada
Introduction Sleep disorders can develop as a result of exposure to stressors. The out-break of the COVID-19 pandemic was an additional source of stress for paramedics, due to the fear of the unknown nature of the new pathogen. The main aim of this study was to identify factors influencing the development of sleep disorders among paramedics working during the COVID-19 pandemic. Material and methods This was a cross-sectional, anonymous, voluntary, online survey conducted on social networks among paramedics working during the COVID-19 pandemic in Poland from 10/11/2020-14/01/2021. The survey included 387 participants, the majority of whom were men (72.35%). A proprietary questionnaire and standardized scales were used to identify risk factors: Athens Insomnia Scale (AIS) and Epworth Sleepiness Scale. Results Among all participants, there were 107 women (27.65%) and 280 men (72.35%). Significantly higher scores of the analyzed scales were observed in the female gender. Based on the AIS scale, mild sleep disorders were found in 3.6% of women and 2.9% of men. Excessive sleepiness on the Epworth scale was assessed in more than 70% of women and 58.8% of men working in Emergency Medical Teams (EMTs). Conclusions The main factors influencing the development of sleep disorders were female gender, use of sleep aids and not having a life partner. In contrast, older age and longer job tenure, being married, and having good relationships with family members had a protective effect.
{"title":"Evaluation of Selected Factors Influencing Sleep Disorders in Paramedics during the COVID-19 pandemic","authors":"Kamil Piotr Marczewski, Magdalena Piegza, Natalia Justyna Gospodarczyk, Alicja Zofia Gospodarczyk, Mateusz Marcinek, Michał Tkocz, Krystyn Sosada","doi":"10.5114/aoms/169909","DOIUrl":"https://doi.org/10.5114/aoms/169909","url":null,"abstract":"Introduction Sleep disorders can develop as a result of exposure to stressors. The out-break of the COVID-19 pandemic was an additional source of stress for paramedics, due to the fear of the unknown nature of the new pathogen. The main aim of this study was to identify factors influencing the development of sleep disorders among paramedics working during the COVID-19 pandemic. Material and methods This was a cross-sectional, anonymous, voluntary, online survey conducted on social networks among paramedics working during the COVID-19 pandemic in Poland from 10/11/2020-14/01/2021. The survey included 387 participants, the majority of whom were men (72.35%). A proprietary questionnaire and standardized scales were used to identify risk factors: Athens Insomnia Scale (AIS) and Epworth Sleepiness Scale. Results Among all participants, there were 107 women (27.65%) and 280 men (72.35%). Significantly higher scores of the analyzed scales were observed in the female gender. Based on the AIS scale, mild sleep disorders were found in 3.6% of women and 2.9% of men. Excessive sleepiness on the Epworth scale was assessed in more than 70% of women and 58.8% of men working in Emergency Medical Teams (EMTs). Conclusions The main factors influencing the development of sleep disorders were female gender, use of sleep aids and not having a life partner. In contrast, older age and longer job tenure, being married, and having good relationships with family members had a protective effect.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"335 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136061201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bartłomiej Stańczykiewicz, Mateusz Łuc, Maciej Banach, Agnieszka Zabłocka
Cystatins, a family of proteins known for their inhibitory role against cysteine proteases, have garnered significant attention in the field of neurodegeneration. Numerous genetic, experimental and clinical studies concerning cystatin C suggest it plays an important role in the course of neurodegenerative diseases. Its beneficial effects are associated with cysteine protease inhibition, impact on β-amyloid aggregation as well as regulation of cell proliferation, autophagy and apoptosis. Cystatin isolated from chicken egg white, called Ovocystatin, has been widely used in medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. This article focuses on the potential use of cystatins, with special emphasis on easily-obtained Ovocystatin, in the treatment of neurodegenerative diseases, such as dementia. The current evidence on cystatin use has been portrayed shedding light on their mechanisms of action and therapeutic implications for neuroprotection and maintenance of cognitive functions.
{"title":"Cystatins: Unraveling the Biological Implications for Neuroprotection","authors":"Bartłomiej Stańczykiewicz, Mateusz Łuc, Maciej Banach, Agnieszka Zabłocka","doi":"10.5114/aoms/171706","DOIUrl":"https://doi.org/10.5114/aoms/171706","url":null,"abstract":"Cystatins, a family of proteins known for their inhibitory role against cysteine proteases, have garnered significant attention in the field of neurodegeneration. Numerous genetic, experimental and clinical studies concerning cystatin C suggest it plays an important role in the course of neurodegenerative diseases. Its beneficial effects are associated with cysteine protease inhibition, impact on β-amyloid aggregation as well as regulation of cell proliferation, autophagy and apoptosis. Cystatin isolated from chicken egg white, called Ovocystatin, has been widely used in medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. This article focuses on the potential use of cystatins, with special emphasis on easily-obtained Ovocystatin, in the treatment of neurodegenerative diseases, such as dementia. The current evidence on cystatin use has been portrayed shedding light on their mechanisms of action and therapeutic implications for neuroprotection and maintenance of cognitive functions.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135063988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Slovakia belongs among the countries with the highest cardiovascular mortality, nevertheless extensive data on the effectiveness of dyslipidaemia management is lacking. The aim of this study was to assess the implementation of European guidelines in the very high-risk population in Slovakia.We retrospectively analysed anonymised LDL C values of patients at very high cardiovascular risk gathered between 2017 and 2019 from collaborating laboratory with nationwide reach. CV risk was based on patient’s ICD diagnoses. LDL C target values were based on the 2016ESC/EAS recommendations, as well as current recommendations from 2019. Patients diagnosed with ACS, stroke, or overall very high-risk CVD were selected.A total of 220 657 LDL-C test results from 72 039 patients were processed. Only 8 9% of patients with ACS attained target LDL-C in a follow-up test each year. 6-9% of patients had LDL-C levels ≥ 4.9 mmol/l. Only 9-10% of patients with stroke achieved target LDL-C levels, and 7-8% had levels ≥ 4.9 mmol/l. In the very high CV risk group, only 7% of patients achieved target levels, and 7-8% had extremely high LDL-C levels ≥ 4.9 mmol/l. With the ESC/EAS2019 recommendations only 2-3% of patients in each group achieved target levels each year.Based on our results, we found that over 90% of patients with very high CVD risk do not achieve target LDL-C levels. This percentage is even higher when implementing the 2019 guidelines. These patients remain at high risk of subsequent CVD events and would benefit significantly from intensified hypolipemic therapy.
{"title":"Success in achieving LDL-C target values in a high-risk population in Slovakia: SlovakLipid retrospective study","authors":"Stefan Toth, Martin Turek, D. Pella","doi":"10.5114/aoms/170961","DOIUrl":"https://doi.org/10.5114/aoms/170961","url":null,"abstract":"Slovakia belongs among the countries with the highest cardiovascular mortality, nevertheless extensive data on the effectiveness of dyslipidaemia management is lacking. The aim of this study was to assess the implementation of European guidelines in the very high-risk population in Slovakia.We retrospectively analysed anonymised LDL C values of patients at very high cardiovascular risk gathered between 2017 and 2019 from collaborating laboratory with nationwide reach. CV risk was based on patient’s ICD diagnoses. LDL C target values were based on the 2016ESC/EAS recommendations, as well as current recommendations from 2019. Patients diagnosed with ACS, stroke, or overall very high-risk CVD were selected.A total of 220 657 LDL-C test results from 72 039 patients were processed. Only 8 9% of patients with ACS attained target LDL-C in a follow-up test each year. 6-9% of patients had LDL-C levels ≥ 4.9 mmol/l. Only 9-10% of patients with stroke achieved target LDL-C levels, and 7-8% had levels ≥ 4.9 mmol/l. In the very high CV risk group, only 7% of patients achieved target levels, and 7-8% had extremely high LDL-C levels ≥ 4.9 mmol/l. With the ESC/EAS2019 recommendations only 2-3% of patients in each group achieved target levels each year.Based on our results, we found that over 90% of patients with very high CVD risk do not achieve target LDL-C levels. This percentage is even higher when implementing the 2019 guidelines. These patients remain at high risk of subsequent CVD events and would benefit significantly from intensified hypolipemic therapy.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46270425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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