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Predictors of Adults’ Mental Health During Initial Stage of Covid-19 Pandemic in Croatia 克罗地亚Covid-19大流行初期成人心理健康的预测因素
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2022.59.02.03
V. Boričević Maršanić, Krešimir Prijatelj, Ana Raguž, N. Kavaric, Gordana Buljan Flander
Besides causing serious threats to people’s physical health and lives, pandemics can lead to psychological distress. This study aimed to investigate the relationship between the COVID-19 pandemic and mental health among adults in Croatia and its association with sociodemographic factors, perceptions of pandemic, locus of control, coping with stress and perceived social support. A cross-sectional, observational study was conducted using a snowball sampling technique. The online survey collected information on sociodemographics, chronic health conditions, self-isolation measure, perception of COVID-19, mental health status, locus of control, coping with stress and perception of social support. Mental health status was assessed by the Depression, Anxiety and Stress Scale (DASS-21). A total of 1482 participants (252 males and 1230 females) completed the study. The mean age of the participants was 33.3 ± 12.2 years, 43 % of the participants had elevated levels of anxiety and 18 % suffered from severe and extremely severe anxiety, 33 % had elevated levels of depression and 12 % suffered from severe and extremely severe depression, and 55 % had elevated levels of stress with 13 % suffering from severe and extremely severe stress. The strongest predictors of mental health symptoms were coping with stress, locus of control, and perceived social support. These results highlight the necessity of implementing psychological interventions during the pandemic to improve the mental health of the adults and vulnerable groups in particular that should include identified factors associated with better mental health status such as coping with stress focused on problem, social diversion and social support.
流行病不仅会对人们的身体健康和生命造成严重威胁,还会导致心理困扰。本研究旨在调查新冠肺炎大流行与克罗地亚成年人心理健康之间的关系及其与社会人口统计学因素、对大流行的认知、控制点、应对压力和感知的社会支持的关系。采用滚雪球抽样技术进行了一项横断面观察性研究。这项在线调查收集了有关社会人口统计、慢性健康状况、自我安慰测量、对新冠肺炎的认知、心理健康状况、控制点、应对压力和对社会支持的认知的信息。心理健康状况采用抑郁、焦虑和压力量表(DAS-21)进行评估。共有1482名参与者(252名男性和1230名女性)完成了这项研究。参与者的平均年龄为33.3±12.2岁,43%的参与者焦虑程度升高,18%的参与者患有严重和极重度焦虑,33%的参与者抑郁程度升高,12%的参与者患有重度和极重度抑郁,55%的参与者压力程度升高,13%的参与者患有重重和极重度压力。心理健康症状的最强预测因素是应对压力、控制源和感知的社会支持。这些结果强调了在疫情期间实施心理干预的必要性,以改善成年人和弱势群体的心理健康,特别是应包括与更好的心理健康状况相关的已确定因素,如应对专注于问题的压力、社会转移和社会支持。
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引用次数: 0
Severe Isolated Cognitive Relapse in Multiple Sclerosis - Indication for High Efficacy Therapy? 多发性硬化症的严重孤立性认知复发-高效治疗的指征?
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2023.59.02.17
M. Mioč, B. Barun, M. Boban, D. Ozretić, M. Habek
Isolated cognitive relapses (ICRs) are transient deficits in cognitive performance that are not accompanied with other symptoms typical for multiple sclerosis (MS). They are often missed and can lead to long-term cognitive decline. Considering possible devastating consequences of cognitive impairment, especially in working adults, and high economic burden of MS, it is of great importance to establish whether ICRs are sufficient to start with high efficacy therapy. 42-year- old women with a recent diagnosis of relapsing-remitting multiple sclerosis developed significant impairment in almost all cognitive domains, with dominant difficulties in naming and low performance in phonemic fluency tasks, consistent with ICR. Her brain MRI showed new lesions affecting the anterior part of the thalamus and her condition partially improved on intravenous corticosteroid therapy. While waiting the disease-modifying therapy to begin, for what was now highly active MS, she developed subarachnoid haemorrhage which further narrowed the treatment options. This case illustrates the complexity of managing patients with MS and ICRs in at least three aspects. Firstly, the lack of uniform definition resulting in diagnostic delay of highly active MS and ICRs. Secondly, optimal treatment choices are often limited due to safety issues and reimbursement reasons. And thirdly, there is still an open question about the right treatment option for ICRs, so more research is needed.
孤立性认知复发(ICRs)是一种短暂的认知功能缺陷,不伴有多发性硬化症(MS)的其他典型症状。它们经常被忽略,并可能导致长期的认知能力下降。考虑到认知功能障碍可能带来的毁灭性后果,尤其是在工作的成年人中,以及MS的高经济负担,确定ICRs是否足以开始高效治疗是非常重要的。最近诊断为复发缓解型多发性硬化症的42岁女性在几乎所有认知领域都出现了明显的损害,主要是命名困难和语音流畅性任务的低表现,与ICR一致。她的脑部核磁共振显示丘脑前部有新的病变,静脉注射皮质类固醇治疗后病情部分好转。在等待疾病改善治疗开始的过程中,她出现了蛛网膜下腔出血,这进一步缩小了治疗选择。本病例至少从三个方面说明了管理MS和ICRs患者的复杂性。首先,缺乏统一的定义导致高活性MS和ICRs的诊断延迟。其次,由于安全问题和报销原因,最佳治疗选择往往受到限制。第三,对于ICRs的正确治疗选择仍然存在一个悬而未决的问题,因此需要进行更多的研究。
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引用次数: 0
Translation and Validation of the Yale Physical Activity Survey (YPAS) Questionnaire for the Elderly in Croatia 耶鲁大学克罗地亚老年人体育活动调查问卷的翻译与验证
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/may.2023.59.02.09
Vesna Mijoč
This research aimed to validate the Yale Physical Activity Survey (YPAS) questionnaire in the context of population of the Republic of Croatia. The research was conducted on 135 participants who are users of four homes for the elderly and infirm in the City of Zagreb. The participants are people over 65 years old, they are Croatian speakers, and they do not have any neurological diagnosis (dementia, Parkinson’s disease and they did not survive a cerebrovascular insult). People who are recovering from a cold or flu or who are unable to move independently are not included in the research. The research used the original YPAS questionnaire, i.e., a list of activities in one part and categories of activities in the other. Physical activity is shown in the average hours reported per week. Calories are calculated for each activity separately, depending on how many kcal/min each activity brings. In this research, the original YPAS questionnaire was used, to examine the levels of physical activity, and the calories for each activity were calculated using a formula. Through the research, the YPAS questionnaire was validated for the Croatian context, and the results showed that participants spend most of their time shopping, washing dishes, and walking. A certain percentage of participants do not engage in any physical activity, which confirmed the theoretical assumptions about the sedentary behaviour of elderly people.
本研究旨在验证耶鲁大学体育活动调查(YPAS)问卷在克罗地亚共和国人口背景下的有效性。这项研究是对135名参与者进行的,他们是萨格勒布市四所养老院的使用者。参与者是65岁以上的人,他们说克罗地亚语,没有任何神经系统诊断(痴呆症、帕金森氏症,他们没有从脑血管损伤中幸存下来)。正在从感冒或流感中康复或无法独立行动的人不包括在研究中。该研究使用了原始的YPAS问卷,即一部分中的活动列表和另一部分中活动类别。体力活动以每周报告的平均小时数表示。根据每项活动带来的kcal/min热量,分别计算每项活动的热量。在这项研究中,使用原始的YPAS问卷来检查身体活动水平,并使用公式计算每次活动的卡路里。通过研究,YPAS问卷在克罗地亚背景下得到了验证,结果显示,参与者大部分时间都在购物、洗碗和散步。一定比例的参与者不参加任何体育活动,这证实了关于老年人久坐行为的理论假设。
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引用次数: 0
Prevalence and Correlates of Extrapyramidal Side Effects Among Patients with Schizophrenia Spectrum Disorders on Typical and Atypical Antipsychotics 精神分裂症谱系障碍患者使用典型和非典型抗精神病药物时锥体外系副作用的患病率及相关因素
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2023.59.02.06
Falmata Baba Shettima, Taiwo Lateef Sheikh, Musa Abba Wakil, M. Abdulaziz, Isa Bukar Rabebbe, J. Abdulmalik
Background: Antipsychotic medication for the treatment of schizophrenia spectrum disorders are associated with adverse effects with extrapyramidal side effects constituting one of the most notable effects associated with poor medication adherence and poor quality of life. Aims: The study aims to compare the prevalence of extrapyramidal side effects (EPSE), among patients with schizophrenia spectrum disorders on typical and atypical antipsychotic medications. The secondary aim is to determine the association of extra-pyramidal side effects with socio-clinical variables. Methodology: A cross-sectional hospital-based study with systematic random sampling recruitment of 340 participants and 303 completed the study. Variables with significant association on chi square analysis were subjected to logistic regression analysis. Results: The overall prevalence of extrapyramidal side effects among patients with schizophrenia spectrum disorder on antipsychotic medication was 42.6 %. The prevalence of tardive dyskinesia, parkinsonism and akathisia were 7.9 %, 38.6 and 3.6 %, respectively. The prevalence of extra-pyramidal side effects due to use of typical, atypical and combination drug was 44.4 %, 51.2 % and 34.5 %, respectively with haloperidol (59.4 %) and risperidone (71.4 %) having the greatest effect. Being elderly was associated with tardive dyskinesia, duration of treatment, severity of illness and type of illness with parkinsonism and severity of illness with akathisia. Conclusion: The findings of this study support the high prevalence of extrapyramidal side effects from either using typical and atypical antipsychotic medications. Therefore, Clinicians should discuss on these side effects and proffer possible solutions with their patients prior to commencement of antipsychotic medications in order to promote medication adherence.
背景:用于治疗精神分裂症谱系障碍的抗精神病药物与不良反应相关,锥体外系副作用是与药物依从性差和生活质量差相关的最显著的副作用之一。目的:本研究旨在比较典型和非典型抗精神病药物在精神分裂症谱系障碍患者中锥体外系副作用(EPSE)的发生率。第二个目的是确定锥体外副作用与社会临床变量的关系。方法:以医院为基础的横断面研究,系统随机抽样招募340名参与者,完成研究的303人。对卡方分析中有显著相关性的变量进行逻辑回归分析。结果:精神分裂症谱系障碍患者在抗精神病药物治疗中锥体外系副反应的总体发生率为42.6%。迟发性运动障碍、帕金森病和静坐症的患病率分别为7.9%、38.6%和3.6%。典型用药、非典型用药和联合用药引起的锥体外副作用发生率分别为44.4%、51.2%和34.5%,其中氟哌啶醇(59.4%)和利培酮(71.4%)的影响最大。老年与迟发性运动障碍、治疗持续时间、疾病的严重程度和帕金森病的疾病类型以及静坐症的严重程度有关。结论:本研究结果支持使用典型和非典型抗精神病药物的高患病率锥体外系副作用。因此,临床医生应该在开始服用抗精神病药物之前与患者讨论这些副作用,并提供可能的解决方案,以促进药物依从性。
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引用次数: 0
“Maniac” and “Crazy Ex-Girlfriend”: A Novel Adaptation of Two TV Series for Classroom Undergraduate Psychiatry Education in an Age of COVID-19 Social Distancing “疯子”和“疯狂的前女友”:新冠肺炎社交距离时代两部本科精神病学课堂教育电视剧的小说改编
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2023.59.02.18
Nicholas Tze Ping Pang, Eugene Boon Yau Koh
Aim: Psychiatry has traditionally been taught bedside. Multiple ethical and logistics issues preclude use of certain patient groups, and in the current COVID-19 pandemic, there is the additional obstacle of not being able to access bedside patients. There is utility in using new media, e.g., television and movies, in psychiatry education. Methods: “Maniac” and “Crazy Ex-Girlfriend”, both available on Netflix, were used in an undergraduate psychiatry module to illustrate clinical lessons regarding schizophrenia and borderline personality disorder respectively. Results: “Maniac” was helpful in illustrating subtle changes in affect, occupational and social dysfunction, and showcasing disrupted family dynamics and distress from experiencing hallucinations and delusions. “Crazy Ex-Girlfriend” was instructional in crystallising psychopathology of borderline personality disorder and providing more nuanced, less cross-sectional views of psychiatric illness. Conclusions: Even though television and movies will and should not replace face-to-face bedside teaching as a primary mode of education, they are an adjunct to stimulate discussion and observe psychopathologies that are ethically difficult to capture. Both of them can be used judiciously in the current COVID-19 pandemic as bedside teaching substitutes.
目的:精神病学传统上是在病床边教授的。多重伦理和后勤问题阻碍了某些患者群体的使用,而且在当前的COVID-19大流行中,还存在无法接触床边患者的额外障碍。在精神病学教育中使用新媒体,例如电视和电影是有用的。方法:利用Netflix上的《疯子》和《疯狂的前女友》作为本科精神病学模块,分别说明精神分裂症和边缘型人格障碍的临床经验教训。结果:“狂躁”有助于说明情感、职业和社会功能障碍的微妙变化,并展示了因经历幻觉和妄想而中断的家庭动态和痛苦。《疯狂的前女友》在明确边缘型人格障碍的精神病理学方面具有指导意义,并提供了更细致、更少横断面的精神疾病观点。结论:尽管电视和电影将也不应该取代面对面的床边教学作为主要的教育模式,但它们是激发讨论和观察道德上难以捕捉的精神病理的辅助手段。在当前的COVID-19大流行中,这两种方法都可以作为床边教学的替代品。
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引用次数: 0
Challenges of the Social Workers in the Field of Discharge Planning and Promotion of Patients’ Right to Self-Determination - a Case Report 社会工作者在出院计划和促进患者自决权领域面临的挑战——一个案例报告
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2023.59.02.15
Andreja Balaž Gilja
The aim of this paper was to show the challenges of the social worker in the Clinical Hospital Centre Rijeka in the process of planned discharge and at the same time promoting the right to self-determination of an elderly patient with impaired functioning who has no close family members. The paper presents the tasks of a social worker in the pro- cess of planned discharge, which range from targeted and short analyzes of specific needs, to comprehensive psychosocial assessments and risk assessments of a whole range of social and psychological needs, strengths and stressors. The challenges that were imposed and ultimately overcome were the patient’s lack of social support, different perceptions of the problem and insufficiently transparent communication between stakeholders, the patient’s weakened social capital and physical disability. Therefore, the presentation of the case shows the importance of direct mutual communication of all the mentioned stakeholders, timely exchange and transparency of information. Although, the primary and most important thing is to respect the voice of the patient and enable him to shape the vision of his future life, in accordance with the resources available to him.
本文的目的是展示里耶卡临床医院中心的社会工作者在计划出院过程中面临的挑战,同时促进没有亲密家庭成员的功能受损老年患者的自决权。本文介绍了社会工作者在计划出院过程中的任务,包括对特定需求的有针对性的短期分析,以及对各种社会和心理需求、优势和压力源的全面心理社会评估和风险评估。强加并最终克服的挑战是患者缺乏社会支持、对问题的不同看法以及利益相关者之间的沟通不够透明、患者社会资本弱化和身体残疾。因此,本案的陈述表明了上述所有利益攸关方直接相互沟通、及时交流和信息透明的重要性。尽管如此,首要也是最重要的是尊重患者的声音,并使他能够根据可用的资源来塑造未来生活的愿景。
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引用次数: 0
GABAergic Psychoactive Substance-Induced Delirium: Narrative Literature Review GABA能精神活性物质引起的谵妄:叙述性文献综述
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2023.59.02.13
Lea Tomašić, Zrnka Kovačić Petrović
Psychoactive substance-induced delirium is delirium which occurs during or immediate after psychoactive substance intoxication, withdrawal or during the use of specific psychoactive substance. It is characterized by sudden onset of disturbed consciousness, disorientation, hallucinations, changed psychomotor activity, insomnia, acute memory impairment, violent, and bizarre behaviour. The most commonly abused psychoactive substances which may induce delirium are those acting on the major inhibitory neurotransmitter gamma aminobutyric acid (alcohol, anxiolytics, sedatives, hypnotics, and gammahydroxybutyrate- GHB. Psychoactive substance-induced delirium may have hyperactive, hypoactive or mixed clinical presentation. Treatment of delirium induced by psychoactive substances is carried out with antipsychotics, anxiolytics, and sedatives, but each of the listed abused psychoactive substances has its own treatment peculiarities. This narrative literature review describes the epidemiology, pathophysiology, clinical presentation, and treatment of delirium induced by intoxication and withdrawal from GABAergic psychoactive substances. The paper summarizes well-known knowledge with the latest research in psychoactive substances-induced delirium.
精神活性物质诱导性谵妄是指在精神活性物质中毒、戒断或使用特定精神活性物质期间或之后立即发生的谵妄。其特征是突然出现意识障碍、定向障碍、幻觉、精神运动活动改变、失眠、急性记忆障碍、暴力和怪异行为。可能诱发谵妄的最常见滥用精神活性物质是那些对主要抑制性神经递质γ-氨基丁酸起作用的物质(酒精、抗焦虑药、镇静剂、催眠药和γ-羟基丁酸-GHB。精神活性物质诱导的谵妄可能具有高活性、低活性或混合临床表现。精神活性药物诱导的谵谵妄的治疗是用抗精神病药、抗焦虑剂和镇静剂进行的,但每种被滥用的精神活性物质都有自己的治疗特点相关文献综述了中毒和GABA能精神活性物质戒断引起的谵妄的流行病学、病理生理学、临床表现和治疗。本文通过对精神活性物质所致谵妄的最新研究,总结了一些众所周知的知识。
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引用次数: 0
Impact of COVID-19 Lockdown on Mental Health, Physical Activity, and Eating Behaviours Among IT Professionals in India 新冠肺炎封锁对印度IT专业人员心理健康、体育活动和饮食行为的影响
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2023.59.02.04
Joshi Animish, Muley Arti, Medithi Srujana
Governments took preventive measures like lockdown to curb the spread of the global COVID-19 pandemic, which affected mental health of many, their eating behaviours, and physical activity. This study focused on evaluating the impact of the COVID-19 lockdown on these aspects among IT professionals considering their change in working patterns. This was a web-based cross-sectional study conducted in Pune city. A total of 103 participants participated in the study by completing an online structured questionnaire shared through various social media platforms. Information regarding their vitals, physical activity, and eating behaviour was collected. The DASS-21 scale was used to assess mental health. The prevalence of stress, anxiety, and depression among IT professionals was found as 20.4 %, 44.7 %, and 35.9 %, respectively. Based on their BMI, the majority of the population was obese (63 %), and almost 57 % thought their body weight had increased during the lockdown. Participants doing any kind of physical activity significantly dropped down during the lockdown as compared to the pre-lockdown phase (p < 0.001). Stress levels were significantly higher among the obese participants (p < 0.01). Anxiety was observed to be significantly higher among the 20 to 34 year-old male participants (p < 0.05). Ready-to-eat snacks, instant noodles and easy to cook foods, Indian sweets, and confectionery showed a significant positive correlation with high levels of stress, anxiety, and depression (p < 0.05). Thus, a negative impact of COVID-19 and a subsequent lockdown was observed on the mental health and eating patterns among IT professionals.
各国政府采取了封锁等预防措施,以遏制全球COVID-19大流行的蔓延,疫情影响了许多人的心理健康、饮食行为和身体活动。这项研究的重点是评估新冠肺炎疫情对IT专业人员在这些方面的影响,考虑到他们的工作模式发生了变化。这是一项在浦那市进行的基于网络的横断面研究。共有103名参与者通过在各种社交媒体平台上共享的在线结构化问卷参与了这项研究。收集了他们的生命体征、身体活动和饮食行为等信息。采用DASS-21量表进行心理健康评估。在IT专业人士中,压力、焦虑和抑郁的患病率分别为20.4%、44.7%和35.9%。根据他们的身体质量指数,大多数人肥胖(63%),近57%的人认为他们的体重在封锁期间增加了。与封锁前阶段相比,在封锁期间进行任何类型体力活动的参与者显著下降(p < 0.001)。肥胖参与者的压力水平显著高于肥胖参与者(p < 0.01)。20 ~ 34岁男性被试的焦虑程度显著高于男性(p < 0.05)。即食零食、方便面和易煮食品、印度糖果和糖果与高水平的压力、焦虑和抑郁呈显著正相关(p < 0.05)。因此,新冠肺炎和随后的封锁对IT专业人员的心理健康和饮食模式产生了负面影响。
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引用次数: 0
The Insight of Patients and Their Parents Differ in the Early Phase of Psychosis 精神病早期患者与父母的看法不同
Q3 Medicine Pub Date : 2023-06-15 DOI: 10.20471/dec.2023.59.02.08
L. Goršić, S. Caratan, S. Kocijan-Lovko, Helena Goršić, I. Požgain, B. Restek-Petrović
The aim of this cross-sectional study was to investigate whether the insight of patients and their parents differ in the early phase of psychosis. Target population were the patients hospitalized with the diagnosis of the psychotic spectrum (F20- F29; ICD- 10th; disease duration ≤ 5 years), both sexes, with average age M = 25.4 (SD = 3.56, C = 25, min = 18, max = 32) and their parents. Insight into illness in patients was assessed using the Scale to assess Unawareness of mental Disorder (SUMD) abbreviated version. Parents’ insight into illness was assessed with a modified version of the SUMD with question rephrased to probe parents’ understanding of patients’ illness. The expression, structure and severity of psychotic symptoms was assessed by The Positive and Negative Syndrome Scale of Schizophrenia (PANSS- Five factor models) and Clinical global impression scale (CGI- s). The results indicated a statistically significant (Z = 2.99; p < 0.01) higher mean value on General Awareness of patients (M = 6.1, SD = 3.26) compared to parents (M = 5.0, SD = 2.99. A significant difference was obtained by the sex of parents too (z = -2.07, p < 0.05): fathers had better insight (M = 2.0, SD = 1.15) than mothers (M = 1.5, SD = 0.89). The results call for necessity to develop innovative and comprehensive program for early family interventions.
这项横断面研究的目的是调查患者及其父母在精神病早期的洞察力是否不同。目标人群是被诊断为精神病谱系(F20-F29;ICD-第10位;疾病持续时间≤5年)的住院患者,男女,平均年龄M=25.4(SD=3.56,C=25,min=18,max=32)及其父母。患者对疾病的洞察力使用量表来评估对精神障碍的不了解程度(SUMD)缩写版。家长对疾病的了解是用SUMD的修改版本进行评估的,问题被重新表述,以探究家长对患者疾病的理解。采用精神分裂症阳性和阴性综合征量表(PANSS-五因素模型)和临床总体印象量表(CGI-s)评定精神病症状的表达、结构和严重程度。结果表明,与父母(M=5.0,SD=2.99)相比,患者的一般意识平均值(M=6.1,SD=3.26)更高,具有统计学意义(Z=2.99;p<0.01)。父母性别也存在显著差异(z=2.07,p<0.05):父亲的洞察力(M=2.0,SD=1.15)优于母亲(M=1.5,SD=0.89)。
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引用次数: 0
Autoimmune Encephalitis 自身免疫性脑炎
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.09
Marijana Lisak, Bruno Špiljak, Hanna Pašić
The purpose of this paper is to provide a comprehensive review of recent literature data for autoimmune encephalitis (AIE). AIE refers to inflammatory, non-infectious, immune-mediated encephalitis characterised by neuroinflammation, synthesis of neuronal autoantibodies (NAAs), directed against surface, synaptic and intracellular antigens, with subsequent neuronal dysfunction. It is characterised by heterogeneous anatomic-clinical syndromes and prominent neuropsychiatric symptoms. Due to overlapping of different clinical and diagnostic biomarkers, AIE is often considered diagnosis of exclusion and requires an extensive work-up. Systematic search of the term «autoimmune encephalitis» in the PubMed database was performed, with limitation set for systematic review in papers English, published from 2004- 2022. Further analysis was performed by the search of the author’s reference list and Autoimmune Encephalitis Alliance (AEA) website. The analysis was conducted according to PRISMA (The Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Outcomes that were sought included: AIE classification and presentation; diagnostic processing; treatment. Preset search of published systematic reviews in PubMed database, derived eighty six papers. Further screening of derived data, author’s reference list and AEA website was performed, according to previously defined out- comes. Finally, sixteen papers were independently selected and thoroughly analysed, with relevant conclusions present- ed in this paper. AIE is a severe inflammatory central nervous system (CNS) disorder with a complex differential diagnosis that often remains unrecognised. AIE research has established a wide range of new autoimmune antibodies syndromes, clinical and diagnostic biomarkers, which have improved diagnostic approach and treatment. Initial application of immunotherapy improves the outcome of disease.
本文旨在对自身免疫性脑炎(AIE)的最新文献资料进行综述。AIE是指炎症性、非传染性、免疫介导的脑炎,其特征是神经炎症,神经元自身抗体(NAAs)的合成,针对表面、突触和细胞内抗原,随后出现神经元功能障碍。它的特点是异质解剖-临床综合征和突出的神经精神症状。由于不同临床和诊断生物标志物的重叠,AIE通常被认为是排除性诊断,需要广泛的检查。在PubMed数据库中对术语“自身免疫性脑炎”进行了系统搜索,对2004- 2022年发表的英文论文进行了系统评价。通过检索作者参考文献表和自身免疫性脑炎联盟(AEA)网站进行进一步分析。根据PRISMA(系统评价和荟萃分析首选报告项目)指南进行分析。所寻求的结果包括:AIE的分类和表现;诊断处理;治疗。预设检索PubMed数据库中已发表的系统综述,得到86篇论文。根据先前定义的结果,对衍生数据、作者参考文献表和AEA网站进行进一步筛选。最后,本文独立选取了16篇论文进行分析,得出了相关结论。AIE是一种严重的炎症性中枢神经系统(CNS)疾病,具有复杂的鉴别诊断,通常仍未被识别。AIE研究建立了广泛的新的自身免疫抗体综合征、临床和诊断生物标志物,改进了诊断方法和治疗方法。初次应用免疫疗法可改善疾病的预后。
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